HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2) - Rat Genome Database

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Gene: HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2) Chlorocebus sabaeus
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Symbol: HCN2
Name: hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
RGD ID: 18720162
Description: ENCODES a protein that exhibits molecular adaptor activity (ortholog); PDZ domain binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN ammonium transmembrane transport (ortholog); cellular response to aldosterone (ortholog); regulation of membrane potential (ortholog); ASSOCIATED WITH cardiomyopathy (ortholog); cerebral creatine deficiency syndrome (ortholog); Chronic Cerebral Hypoperfusion (ortholog); FOUND IN axon (ortholog); dendrite membrane (ortholog); dendritic shaft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hyperpolarization activated cyclic nucleotide gated potassium channel 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16326,437 - 358,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6324,517 - 358,119 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,626,637 - 8,752,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
HCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16326,437 - 358,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6324,517 - 358,119 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,626,637 - 8,752,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819589,881 - 617,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19589,881 - 617,159 (+)EnsemblGRCh38hg38GRCh38
GRCh3719589,881 - 617,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619540,893 - 568,159 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419540,892 - 568,157NCBI
Celera19200,463 - 228,092 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19373,968 - 384,301 (+)NCBIHuRef
CHM1_119589,749 - 616,575 (+)NCBICHM1_1
T2T-CHM13v2.019543,772 - 571,465 (+)NCBIT2T-CHM13v2.0
Hcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,552,468 - 79,571,942 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)EnsemblGRCm39 Ensembl
GRCm381079,716,634 - 79,736,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,179,379 - 79,198,853 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,119,763 - 79,139,237 (+)NCBIMGSCv36mm8
Celera1080,731,157 - 80,750,702 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Hcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,620,422 - 10,639,457 (-)NCBIGRCr8
mRatBN7.279,969,801 - 9,988,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,970,368 - 9,988,841 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,850,727 - 12,869,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,728,808 - 14,747,876 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,588,170 - 12,607,205 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,851,730 - 12,870,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,021,934 - 13,051,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,485,257 - 11,503,614 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,485,256 - 11,503,614 (-)NCBI
Celera78,143,888 - 8,161,946 (-)NCBICelera
Cytogenetic Map7q11NCBI
Hcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,124,640 - 7,194,223 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,124,060 - 7,143,730 (-)NCBIChiLan1.0ChiLan1.0
HCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,914,303 - 4,942,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,153,083 - 4,180,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019521,348 - 528,203 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119559,108 - 584,128 (+)NCBIpanpan1.1PanPan1.1panPan2
HCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,920,089 - 57,941,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,920,740 - 57,938,374 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,722,746 - 57,741,278 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,663,358 - 58,681,919 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,663,358 - 58,681,919 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,717,402 - 57,735,597 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,196,864 - 58,215,545 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,400,096 - 58,421,283 (-)NCBIUU_Cfam_GSD_1.0
Hcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,625,528 - 217,639,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588142,786 - 208,606 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588202,101 - 209,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,708,162 - 77,730,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,708,159 - 77,730,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Hcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,889,025 - 7,908,639 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,889,616 - 7,908,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000011066   ⟹   ENSCSAP00000009148
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl6324,517 - 358,119 (+)Ensembl
RefSeq Acc Id: XM_037994345   ⟹   XP_037850273
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660818,626,637 - 8,752,781 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037850273 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009148.1
Ensembl Acc Id: ENSCSAP00000009148   ⟸   ENSCSAT00000011066
RefSeq Acc Id: XP_037850273   ⟸   XM_037994345
- UniProtKB: A0A0D9RKK9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012996 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011066.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/TrEMBL
  K/Na_HCN_channel UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene HCN2 ENTREZGENE
PANTHER I[[H]] CHANNEL, ISOFORM E UniProtKB/TrEMBL
  POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/TrEMBL
PRINTS EAGCHANLFMLY UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9RKK9 ENTREZGENE, UniProtKB/TrEMBL