Gene: HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2) Homo sapiens | ![]() Analyze |
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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of HCN2 mRNA | CTD | PMID:23019147 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RGD:620689 | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HCN2 mRNA | CTD | PMID:21394737 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732306 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HCN2 mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | ISO | RGD:620689 | 6480464 | 2,6-dinitrotoluene affects the expression of HCN2 mRNA | CTD | PMID:21346803 | 3,3',5-triiodo-L-thyronine | increases expression | ISO | RGD:732306 | 6480464 | Triiodothyronine results in increased expression of HCN2 mRNA | CTD | PMID:25172293 | 4-amino-2,6-dinitrotoluene | affects expression | ISO | RGD:620689 | 6480464 | 4-amino-2,6-dinitrotoluene affects the expression of HCN2 mRNA | CTD | PMID:21346803 | 6-propyl-2-thiouracil | decreases expression | ISO | RGD:620689 | 6480464 | Propylthiouracil results in decreased expression of HCN2 mRNA | CTD | PMID:24780913 | amiodarone | decreases expression | ISO | RGD:620689 | 6480464 | Amiodarone results in decreased expression of HCN2 mRNA | CTD | PMID:17711693 | ammonium chloride | affects expression | ISO | RGD:620689 | 6480464 | Ammonium Chloride affects the expression of HCN2 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of HCN2 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | decreases expression | ISO | RGD:732306 | 6480464 | Benzo(a)pyrene results in decreased expression of HCN2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:732306 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of HCN2 mRNA] | CTD | PMID:22228805 | bisphenol A | decreases expression | ISO | RGD:620689 | 6480464 | bisphenol A results in decreased expression of HCN2 mRNA | CTD | PMID:25181051 | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of HCN2 mRNA | CTD | PMID:26079696 | cadmium dichloride | increases methylation | ISO | RGD:620689 | 6480464 | Cadmium Chloride results in increased methylation of HCN2 promoter | CTD | PMID:22457795 | casticin | decreases expression | EXP | | 6480464 | casticin results in decreased expression of HCN2 mRNA | CTD | PMID:27862857 | chloroform | decreases activity | EXP | | 6480464 | Chloroform results in decreased activity of HCN2 protein | CTD | PMID:22024336 | clofibrate | decreases expression | ISO | RGD:732306 | 6480464 | Clofibrate results in decreased expression of HCN2 mRNA | CTD | PMID:17585979 | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of HCN2 mRNA | CTD | PMID:18000554 | copper atom | increases expression | ISO | RGD:620689 | 6480464 | Copper deficiency results in increased expression of HCN2 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | ISO | RGD:620689 | 6480464 | Copper deficiency results in increased expression of HCN2 mRNA | CTD | PMID:26033743 | copper(2+) | increases expression | ISO | RGD:620689 | 6480464 | Copper deficiency results in increased expression of HCN2 mRNA | CTD | PMID:26033743 | crocidolite asbestos | multiple interactions | ISO | RGD:732306 | 6480464 | Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of HCN2 mRNA] | CTD | PMID:19446018 | cyclosporin A | decreases methylation | EXP | | 6480464 | Cyclosporine results in decreased methylation of HCN2 promoter | CTD | PMID:27989131 | doxorubicin | affects expression | EXP | | 6480464 | Doxorubicin affects the expression of HCN2 mRNA | CTD | PMID:25529476 | fluoranthene | multiple interactions | ISO | RGD:732306 | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in decreased expression of HCN2 mRNA | CTD | PMID:28329830 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of HCN2 mRNA | CTD | PMID:23019147 | gentamycin | decreases expression | ISO | RGD:620689 | 6480464 | Gentamicins results in decreased expression of HCN2 mRNA | CTD | PMID:22061828 | lead(0) | affects expression | EXP | | 6480464 | Lead affects the expression of HCN2 mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | EXP | | 6480464 | Lead affects the expression of HCN2 mRNA | CTD | PMID:28903495 | levetiracetam | decreases expression | ISO | RGD:620689 | 6480464 | Levetiracetam results in decreased expression of HCN2 mRNA | CTD | PMID:20345932 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of HCN2 mRNA | CTD | PMID:24810058 | paracetamol | affects expression | ISO | RGD:732306 | 6480464 | Acetaminophen affects the expression of HCN2 mRNA | CTD | PMID:17562736 | urethane | increases expression | EXP | | 6480464 | Urethane results in increased expression of HCN2 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of HCN2 gene | CTD | PMID:29154799 | |
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1. | Acosta C, etal., PLoS One. 2012;7(12):e50442. doi: 10.1371/journal.pone.0050442. Epub 2012 Dec 7. |
2. | Brewster AL, etal., Neurobiol Dis. 2005 Jun-Jul;19(1-2):200-7. |
3. | Cho HJ, etal., Neuroscience. 2009 Aug 18;162(2):453-61. Epub 2009 May 3. |
4. | GOA_HUMAN data from the GO Consortium |
5. | Li CJ, etal., Mol Neurobiol. 2014 Oct;50(2):704-20. doi: 10.1007/s12035-014-8736-3. Epub 2014 May 18. |
6. | Lin H, etal., Cell Physiol Biochem. 2009;23(4-6):317-26. doi: 10.1159/000218178. Epub 2009 May 6. |
7. | RGD automated import pipeline for gene-chemical interactions |
8. | Tu H, etal., Neuroscience. 2010 Jan 13;165(1):39-52. doi: 10.1016/j.neuroscience.2009.10.002. Epub 2009 Oct 6. |
9. | Wells JE, etal., Int Endod J. 2007 Sep;40(9):715-21. Epub 2007 Jul 23. |
10. | Zha Q, etal., J Neurochem. 2008 Apr;105(1):68-77. Epub 2007 Nov 5. |
PubMed | 9405696 9630217 9921901 10228147 10524219 11076863 11133998 12034718 12194012 12477932 12640457 12813043 12890777 12928435 15057824 15687126 15932727 15961404 15980171 16382102 16777944 17043149 17474147 17931874 18768480 19584315 19913121 20437590 20628086 21615589 22006928 22094222 22131395 22748890 23395072 23907424 24324597 24525276 25197093 25423599 26005035 26304511 26404789 26496610 26966193 27212063 28017718 28864772 29054409 29064616 |
HCN2 has been annotated in the following RGD Disease Portals. |
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HCN2 (Homo sapiens - human) |
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Hcn2 (Mus musculus - house mouse) |
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Hcn2 (Rattus norvegicus - Norway rat) |
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Hcn2 (Chinchilla lanigera - long-tailed chinchilla) |
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HCN2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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Hcn2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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HCN2 (Sus scrofa - pig) |
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D19S814 |
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PMC196911P5 |
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The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
RefSeq Transcripts | NG_052810 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_001194 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC004449 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AC005559 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AF064877 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AF065164 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ012582 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ133727 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ133728 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ133729 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ133730 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ133731 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ133732 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ133733 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ133734 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC039619 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH471242 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
DQ854815 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JA696658 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
KF456465 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_001194 ⟹ NP_001185 | |||||||||||||||||||||||||||||
RefSeq Status: | REVIEWED | |||||||||||||||||||||||||||||
Type: | CODING | |||||||||||||||||||||||||||||
Position: |
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Sequence: |
GGCCGGCGGCGGCGGCGGCGGCTCCGCTCCGCACTGCCCGGCGCCGCCTCGCCATGGACGCGCGhide sequence |
Protein RefSeqs | NP_001185 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAC28444 | (Get FASTA) | NCBI Sequence Viewer |
AAC33280 | (Get FASTA) | NCBI Sequence Viewer | |
AAC39760 | (Get FASTA) | NCBI Sequence Viewer | |
ABI75145 | (Get FASTA) | NCBI Sequence Viewer | |
CAB42602 | (Get FASTA) | NCBI Sequence Viewer | |
CAB42630 | (Get FASTA) | NCBI Sequence Viewer | |
CCF23298 | (Get FASTA) | NCBI Sequence Viewer | |
EAW61179 | (Get FASTA) | NCBI Sequence Viewer | |
Q9UL51 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001185 ⟸ NM_001194 |
- UniProtKB: | Q9UL51 (UniProtKB/Swiss-Prot) |
- Sequence: |
MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEhide sequence |
RGD ID: | 7237699 | |||||||||
Promoter ID: | EPDNEW_H24595 | |||||||||
Type: | initiation region | |||||||||
Name: | HCN2_1 | |||||||||
Description: | hyperpolarization activated cyclic nucleotide gated potassiumchannel 2 | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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Name | Type | Condition(s) | Position(s) | Clinical significance |
NM_001194.3(HCN2):c.1571G>A (p.Gly524Glu) | single nucleotide variant | not specified [RCV000521631] | Chr19:610392 [GRCh38] Chr19:610392 [GRCh37] Chr19:19p13.3 |
uncertain significance |
GRCh38/hg38 19p13.3(chr19:259395-819679)x3 | copy number gain | Global developmental delay [RCV000051144]|See cases [RCV000051144] | Chr19:259395..819679 [GRCh38] Chr19:259395..819679 [GRCh37] Chr19:210395..770679 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:259395-2555149)x3 | copy number gain | Incoordination [RCV000051044]|See cases [RCV000051044] | Chr19:259395..2555149 [GRCh38] Chr19:259395..2555147 [GRCh37] Chr19:210395..2506147 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:591812-1358152)x3 | copy number gain | Polydactyly [RCV000052877]|See cases [RCV000052877] | Chr19:591812..1358152 [GRCh38] Chr19:591812..1358151 [GRCh37] Chr19:542812..1309151 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:259395-1952650)x3 | copy number gain | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052875]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052875]|See cases [RCV000052875] | Chr19:259395..1952650 [GRCh38] Chr19:259395..1952649 [GRCh37] Chr19:210395..1903649 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3-13.2(chr19:265917-8564134)x3 | copy number gain | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|See cases [RCV000052876] | Chr19:265917..8564134 [GRCh38] Chr19:265917..8629018 [GRCh37] Chr19:216917..8535018 [NCBI36] Chr19:19p13.3-13.2 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:233565-4699472)x3 | copy number gain | Nonsyndromic microcephaly [RCV000052575]|See cases [RCV000052575] | Chr19:233565..4699472 [GRCh38] Chr19:233565..4699484 [GRCh37] Chr19:184565..4650484 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:266117-1076399)x1 | copy number loss | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053911]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053911]|See cases [RCV000053911] | Chr19:266117..1076399 [GRCh38] Chr19:266117..1076398 [GRCh37] Chr19:217117..1027398 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:259195-1351363)x1 | copy number loss | Abnormality of the skull [RCV000053910]|See cases [RCV000053910] | Chr19:259195..1351363 [GRCh38] Chr19:259195..1351362 [GRCh37] Chr19:210195..1302362 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:421537-2897921)x3 | copy number gain | See cases [RCV000134894] | Chr19:421537..2897921 [GRCh38] Chr19:421537..2897919 [GRCh37] Chr19:372537..2848919 [NCBI36] Chr19:19p13.3 |
likely pathogenic |
GRCh38/hg38 19p13.3(chr19:259395-2068507)x3 | copy number gain | See cases [RCV000135433] | Chr19:259395..2068507 [GRCh38] Chr19:259395..2068506 [GRCh37] Chr19:210395..2019506 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:275925-1892276)x3 | copy number gain | See cases [RCV000141358] | Chr19:275925..1892276 [GRCh38] Chr19:275925..1892275 [GRCh37] Chr19:226925..1843275 [NCBI36] Chr19:19p13.3 |
pathogenic |
GRCh38/hg38 19p13.3(chr19:259395-6795611)x3 | copy number gain | See cases [RCV000142627] | Chr19:259395..6795611 [GRCh38] Chr19:259395..6795622 [GRCh37] Chr19:210395..6746622 [NCBI36] Chr19:19p13.3 |
pathogenic |
NM_001194.3(HCN2):c.2156_2164delCGCCGCCGC (p.Pro719_Pro721del) | deletion | not specified [RCV000239034] | Chr19:615960..615968 [GRCh38] Chr19:615960..615968 [GRCh37] Chr19:19p13.3 |
benign |
GRCh37/hg19 19p13.3(chr19:260912-1163934)x3 | copy number gain | See cases [RCV000239425] | Chr19:260912..1163934 [GRCh37] Chr19:19p13.3 |
pathogenic |
GRCh37/hg19 19p13.3(chr19:277373-2555164)x3 | copy number gain | See cases [RCV000240507] | Chr19:277373..2555164 [GRCh37] Chr19:19p13.3 |
pathogenic |
NM_001194.3(HCN2):c.2167G>A (p.Val723Ile) | single nucleotide variant | not specified [RCV000418676] | Chr19:615971 [GRCh38] Chr19:615971 [GRCh37] Chr19:19p13.3 |
uncertain significance |
NM_001194.3(HCN2):c.433G>C (p.Gly145Arg) | single nucleotide variant | not specified [RCV000440051] | Chr19:590378 [GRCh38] Chr19:590378 [GRCh37] Chr19:19p13.3 |
uncertain significance |
NM_001194.3(HCN2):c.1584+7C>T | single nucleotide variant | not specified [RCV000454612] | Chr19:610412 [GRCh38] Chr19:610412 [GRCh37] Chr19:19p13.3 |
likely benign |
NM_001194.3(HCN2):c.2332G>C (p.Ala778Pro) | single nucleotide variant | not specified [RCV000455083] | Chr19:616136 [GRCh38] Chr19:616136 [GRCh37] Chr19:19p13.3 |
uncertain significance |
NM_001194.3(HCN2):c.246C>T (p.Cys82=) | single nucleotide variant | not specified [RCV000455740] | Chr19:590191 [GRCh38] Chr19:590191 [GRCh37] Chr19:19p13.3 |
likely benign |
NM_001194.3(HCN2):c.1628C>T (p.Pro543Leu) | single nucleotide variant | not specified [RCV000478576] | Chr19:613291 [GRCh38] Chr19:613291 [GRCh37] Chr19:19p13.3 |
uncertain significance |
GRCh37/hg19 19p13.3(chr19:260911-1965786)x3 | copy number gain | See cases [RCV000511452] | Chr19:260911..1965786 [GRCh37] Chr19:19p13.3 |
likely pathogenic |
GRCh37/hg19 19p13.3(chr19:415092-715725)x3 | copy number gain | See cases [RCV000511102] | Chr19:415092..715725 [GRCh37] Chr19:19p13.3 |
likely benign |
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 | copy number gain | See cases [RCV000511289] | Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43 |
pathogenic |
GRCh37/hg19 19p13.3(chr19:259395-3152419) | copy number gain | Global developmental delay [RCV000626520]|Seizures [RCV000626520] | Chr19:259395..3152419 [GRCh37] Chr19:19p13.3 |
likely pathogenic |
GRCh37/hg19 19p13.3(chr19:266117-1094614)x3 | copy number gain | not provided [RCV000513059] | Chr19:266117..1094614 [GRCh37] Chr19:19p13.3 |
likely pathogenic |
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) | copy number gain | See cases [RCV000512296] | Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43 |
pathogenic |
GRCh37/hg19 19p13.3(chr19:260911-3200875)x3 | copy number gain | not provided [RCV000684094] | Chr19:260911..3200875 [GRCh37] Chr19:19p13.3 |
pathogenic |
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 | copy number gain | not provided [RCV000752439] | Chr19:68029..59110290 [GRCh37] Chr19:19p13.3-q13.43 |
pathogenic |
GRCh37/hg19 19p13.3(chr19:572671-622207)x3 | copy number gain | not provided [RCV000739938] | Chr19:572671..622207 [GRCh37] Chr19:19p13.3 |
benign |
GRCh37/hg19 19p13.3(chr19:572671-663929)x3 | copy number gain | not provided [RCV000739939] | Chr19:572671..663929 [GRCh37] Chr19:19p13.3 |
benign |
GRCh37/hg19 19p13.3(chr19:572671-757752)x3 | copy number gain | not provided [RCV000739940] | Chr19:572671..757752 [GRCh37] Chr19:19p13.3 |
benign |
GRCh37/hg19 19p13.3(chr19:578208-622207)x4 | copy number gain | not provided [RCV000739941] | Chr19:578208..622207 [GRCh37] Chr19:19p13.3 |
benign |
GRCh37/hg19 19p13.3(chr19:578208-675106)x3 | copy number gain | not provided [RCV000739942] | Chr19:578208..675106 [GRCh37] Chr19:19p13.3 |
benign |
GRCh37/hg19 19p13.3(chr19:578668-675106)x3 | copy number gain | not provided [RCV000739943] | Chr19:578668..675106 [GRCh37] Chr19:19p13.3 |
benign |
GRCh37/hg19 19p13.3(chr19:585805-622207)x4 | copy number gain | not provided [RCV000739944] | Chr19:585805..622207 [GRCh37] Chr19:19p13.3 |
benign |
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 | copy number gain | not provided [RCV000752444] | Chr19:260912..59097160 [GRCh37] Chr19:19p13.3-q13.43 |
pathogenic |
GRCh37/hg19 19p13.3(chr19:423160-1429367)x3 | copy number gain | not provided [RCV000752449] | Chr19:423160..1429367 [GRCh37] Chr19:19p13.3 |
uncertain significance |
GRCh37/hg19 19p13.3(chr19:454430-617466)x3 | copy number gain | not provided [RCV000752450] | Chr19:454430..617466 [GRCh37] Chr19:19p13.3 |
benign |
Database | Acc Id | Source(s) |
COSMIC | HCN2 | COSMIC |
Ensembl Genes | ENSG00000099822 | ENTREZGENE |
Ensembl Protein | ENSP00000251287 | ENTREZGENE |
Ensembl Transcript | ENST00000251287 | ENTREZGENE |
Gene3D-CATH | 2.60.120.10 | UniProtKB/Swiss-Prot |
GTEx | ENSG00000099822 | GTEx |
HGNC ID | HGNC:4846 | ENTREZGENE |
Human Proteome Map | HCN2 | Human Proteome Map |
InterPro | cNMP-bd-like | UniProtKB/Swiss-Prot |
cNMP-bd_CS | UniProtKB/Swiss-Prot | |
cNMP-bd_dom | UniProtKB/Swiss-Prot | |
Ion_trans | UniProtKB/Swiss-Prot | |
Ion_trans_N | UniProtKB/Swiss-Prot | |
K_chnl_volt-dep_EAG/ELK/ERG | UniProtKB/Swiss-Prot | |
RmlC-like_jellyroll | UniProtKB/Swiss-Prot | |
KEGG Report | hsa:610 | UniProtKB/Swiss-Prot |
NCBI Gene | 610 | ENTREZGENE |
OMIM | 602781 | OMIM |
Pfam | cNMP_binding | UniProtKB/Swiss-Prot |
Ion_trans | UniProtKB/Swiss-Prot | |
Ion_trans_N | UniProtKB/Swiss-Prot | |
PharmGKB | HCN2 | RGD, PharmGKB |
PRINTS | EAGCHANLFMLY | UniProtKB/Swiss-Prot |
PROSITE | CNMP_BINDING_1 | UniProtKB/Swiss-Prot |
CNMP_BINDING_3 | UniProtKB/Swiss-Prot | |
SMART | cNMP | UniProtKB/Swiss-Prot |
Superfamily-SCOP | cNMP_binding | UniProtKB/Swiss-Prot |
UniGene | Hs.124161 | ENTREZGENE |
UniProt | HCN2_HUMAN | UniProtKB/Swiss-Prot, ENTREZGENE |
UniProt Secondary | O60742 | UniProtKB/Swiss-Prot |
O60743 | UniProtKB/Swiss-Prot | |
O75267 | UniProtKB/Swiss-Prot | |
Q9UBS2 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2017-05-30 | HCN2 | hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 | hyperpolarization activated cyclic nucleotide gated potassium channel 2 | Symbol and/or name change | 5135510 | APPROVED | |
2015-01-20 | HCN2 | hyperpolarization activated cyclic nucleotide gated potassium channel 2 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | Symbol and/or name change | 5135510 | APPROVED | |
2011-08-17 | HCN2 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | HCN2 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | Symbol and/or name change | 5135510 | APPROVED |
2011-07-27 | HCN2 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | HCN2 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | Symbol and/or name change | 5135510 | APPROVED |
More on HCN2 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: hg19 hg38 |
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HGNC Report |
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NCBI Genome Data Viewer |
RGD Object Information | |
RGD ID: | 732305 |
Created: | 2004-01-12 |
Species: | Homo sapiens |
Last Modified: | 2019-02-05 |
Status: | ACTIVE |
© Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.