Hcn2 (hyperpolarization-activated, cyclic nucleotide-gated K+ 2) - Rat Genome Database

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Gene: Hcn2 (hyperpolarization-activated, cyclic nucleotide-gated K+ 2) Mus musculus
Analyze
Symbol: Hcn2
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
RGD ID: 732306
MGI Page MGI
Description: Predicted to have several functions, including PDZ domain binding activity; cation channel activity; and identical protein binding activity. Involved in regulation of membrane potential. Predicted to localize to several cellular components, including HCN channel complex; dendrite; and neuronal cell body. Is expressed in heart; heart ventricle; spinal cord; and ventral grey horn. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5-triiodo-L-thyronine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BCNG-2; BCNG2; brain cyclic nucleotide-gated channel 2; HAC; HAC-1; HAC1; hyperpolarization-activated cation channel 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; t; trls
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,552,468 - 79,571,942 (+)NCBIGRCm39mm39
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)Ensembl
GRCm381079,716,634 - 79,736,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,179,379 - 79,198,853 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,119,763 - 79,139,237 (+)NCBImm8
Celera1080,731,157 - 80,750,702 (+)NCBICelera
Cytogenetic Map10C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:9405696   PMID:9630217   PMID:9634236   PMID:10962006   PMID:11096117   PMID:11420311   PMID:11553787   PMID:11741901   PMID:12121985   PMID:12193608   PMID:12433951  
PMID:12514127   PMID:12562911   PMID:12928435   PMID:12968185   PMID:14633990   PMID:14726518   PMID:15240882   PMID:15292205   PMID:15525777   PMID:15564593   PMID:15644313   PMID:15687126  
PMID:16079136   PMID:16177047   PMID:16500960   PMID:16542642   PMID:16602821   PMID:16760342   PMID:16777944   PMID:16806719   PMID:16923750   PMID:16985003   PMID:17074978   PMID:17114649  
PMID:17261842   PMID:17473172   PMID:17482496   PMID:17553794   PMID:17562313   PMID:17578902   PMID:18033814   PMID:18252758   PMID:18579800   PMID:18768480   PMID:19150498   PMID:19171659  
PMID:19269964   PMID:19421833   PMID:19524546   PMID:19570998   PMID:19574228   PMID:20130205   PMID:20140458   PMID:20623157   PMID:21076425   PMID:21147989   PMID:21187420   PMID:21267068  
PMID:21347269   PMID:21354395   PMID:21593326   PMID:21903816   PMID:21945247   PMID:22090507   PMID:22279546   PMID:22550182   PMID:22652004   PMID:22662315   PMID:22880098   PMID:22948144  
PMID:23048023   PMID:23525108   PMID:23609807   PMID:24085296   PMID:24638995   PMID:24958877   PMID:25042871   PMID:25423599   PMID:25562801   PMID:25761792   PMID:25800552   PMID:25917818  
PMID:26559974   PMID:27137910   PMID:27568927   PMID:27956497   PMID:28671696   PMID:28767511   PMID:28954930   PMID:29107716   PMID:29256865   PMID:29466436   PMID:29519998   PMID:29980633  
PMID:30270038   PMID:30877792   PMID:31045576   PMID:31087220   PMID:31290157   PMID:31496517   PMID:31615893   PMID:32184125   PMID:32325033   PMID:32341127   PMID:32581705  


Genomics

Comparative Map Data
Hcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,552,468 - 79,571,942 (+)NCBIGRCm39mm39
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)Ensembl
GRCm381079,716,634 - 79,736,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,179,379 - 79,198,853 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,119,763 - 79,139,237 (+)NCBImm8
Celera1080,731,157 - 80,750,702 (+)NCBICelera
Cytogenetic Map10C1NCBI
HCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl19589,881 - 617,159 (+)EnsemblGRCh38hg38GRCh38
GRCh3819589,881 - 617,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719589,881 - 617,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619540,893 - 568,159 (+)NCBINCBI36hg18NCBI36
Build 3419540,892 - 568,157NCBI
Celera19200,463 - 228,092 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef19373,968 - 384,301 (+)NCBIHuRef
CHM1_119589,749 - 616,575 (+)NCBICHM1_1
Hcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,969,801 - 9,988,839 (-)NCBI
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0712,851,730 - 12,870,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0713,021,934 - 13,051,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,485,257 - 11,503,614 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,485,256 - 11,503,614 (-)NCBI
Celera78,143,888 - 8,161,946 (-)NCBICelera
Cytogenetic Map7q11NCBI
Hcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,124,640 - 7,194,223 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,124,060 - 7,143,730 (-)NCBIChiLan1.0ChiLan1.0
HCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.119559,108 - 584,128 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v019521,348 - 528,203 (-)NCBIMhudiblu_PPA_v0panPan3
HCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,920,089 - 57,941,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,920,740 - 57,938,374 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,722,746 - 57,741,278 (-)NCBI
ROS_Cfam_1.02058,663,358 - 58,681,919 (-)NCBI
UMICH_Zoey_3.12057,717,402 - 57,735,597 (-)NCBI
UNSW_CanFamBas_1.02058,196,864 - 58,215,545 (-)NCBI
UU_Cfam_GSD_1.02058,400,096 - 58,421,283 (-)NCBI
Hcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,625,528 - 217,639,390 (-)NCBI
SpeTri2.0NW_004936588202,101 - 209,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,708,161 - 77,730,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,708,159 - 77,730,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HCN2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16326,437 - 358,119 (+)NCBI
ChlSab1.1 Ensembl6324,517 - 358,119 (+)Ensembl
Hcn2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,889,616 - 7,908,855 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302060El3_mepilepsy 3 (mouse)Not determined106565510499655287Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073671039107671185Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075502706109502905Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75502706109502905Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1074151384125680038Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7415138482655287Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067500000111900000Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1064100000116100000Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106701240892422811Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106565510499655287Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078545406112545406Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075502706109502905Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1074151384125680038Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1068000000125000000Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106565510499655287Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:514
Count of miRNA genes:224
Interacting mature miRNAs:245
Transcripts:ENSMUST00000020581, ENSMUST00000099513
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000020581   ⟹   ENSMUSP00000020581
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)Ensembl
RefSeq Acc Id: ENSMUST00000099513   ⟹   ENSMUSP00000097113
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)Ensembl
RefSeq Acc Id: NM_008226   ⟹   NP_032252
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,552,468 - 79,571,942 (+)NCBI
GRCm381079,716,634 - 79,736,108 (+)ENTREZGENE
MGSCv371079,179,379 - 79,198,853 (+)RGD
Celera1080,731,157 - 80,750,702 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032252   ⟸   NM_008226
- UniProtKB: O88703 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000097113   ⟸   ENSMUST00000099513
RefSeq Acc Id: ENSMUSP00000020581   ⟸   ENSMUST00000020581
Protein Domains
Cyclic nucleotide-binding

Promoters
RGD ID:6819425
Promoter ID:MM_KWN:4777
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:ENSMUST00000020581,   NM_008226
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,178,681 - 79,179,937 (+)MPROMDB
RGD ID:8672540
Promoter ID:EPDNEW_M14300
Type:initiation region
Name:Hcn2_1
Description:Mus musculus hyperpolarization-activated, cyclic nucleotide-gatedK+ 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381079,716,607 - 79,716,667EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1298210 AgrOrtholog
Ensembl Genes ENSMUSG00000020331 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000020581 UniProtKB/Swiss-Prot
  ENSMUSP00000097113 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020581 UniProtKB/Swiss-Prot
  ENSMUST00000099513 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15166 UniProtKB/Swiss-Prot
MGD MGI:1298210 ENTREZGENE
NCBI Gene 15166 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HCN2 RGD
PhenoGen Hcn2 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C9K0Z8_MOUSE UniProtKB/TrEMBL
  HCN2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O70506 UniProtKB/Swiss-Prot