CD68 (CD68 molecule) - Rat Genome Database

Name: CD68
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: CD68 (CD68 molecule) Chlorocebus sabaeus

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Symbol:

CD68

Name:

CD68 molecule

RGD ID:

18578531

Description:

INVOLVED IN autocrine signaling (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to nutrient levels (ortholog); ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); adult T-cell leukemia/lymphoma (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); late endosome membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

macrosialin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD68 (CD68 molecule)	NCBI	Ortholog
Mus musculus (house mouse):	Cd68 (CD68 antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cd68 (Cd68 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cd68 (CD68 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD68 (CD68 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD68 (CD68 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd68 (CD68 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD68 (CD68 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd68 (CD68 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	6,956,633 - 6,959,645 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	6,957,212 - 6,959,042 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	14,448,764 - 14,451,756 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acquired immunodeficiency syndrome (ISO)

adult T-cell leukemia/lymphoma (ISO)

amyotrophic lateral sclerosis type 1 (ISO)

common variable immunodeficiency (ISO)

congenital myasthenic syndrome 2A (ISO)

COVID-19 (ISO)

diverticulitis of colon (ISO)

dyskeratosis congenita (ISO)

end stage renal disease (ISO)

endometriosis of pelvic peritoneum (ISO)

Epstein-Barr virus infectious disease (ISO)

Experimental Colitis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

extrahepatic cholestasis (ISO)

hepatitis B (ISO)

hepatocellular carcinoma (ISO)

HIV Encephalitis (ISO)

Hodgkin's lymphoma (ISO)

human immunodeficiency virus infectious disease (ISO)

hyperinsulinism (ISO)

Insulin Resistance (ISO)

ischemia (ISO)

Li-Fraumeni syndrome (ISO)

Merkel cell carcinoma (ISO)

metabolic dysfunction and alcohol associated liver disease (ISO)

metabolic dysfunction-associated steatohepatitis (ISO)

obesity (ISO)

primary biliary cholangitis (ISO)

psoriatic arthritis (ISO)

severe acute respiratory syndrome (ISO)

Spontaneous Abortions (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

viral pneumonia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autocrine signaling (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to nutrient levels (ISO)

cellular response to oxidised low-density lipoprotein particle stimulus (ISO)

establishment of protein localization to organelle (IEA)

inflammatory response to antigenic stimulus (ISO)

negative regulation of dendritic cell antigen processing and presentation (ISO)

response to ethanol (ISO)

Cellular Component

endosome (IEA)

endosome membrane (IEA)

late endosome membrane (IEA)

lysosomal membrane (IEA)

lysosome (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CD68
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	6,956,633 - 6,959,645 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	6,957,212 - 6,959,042 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	14,448,764 - 14,451,756 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CD68
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	7,579,638 - 7,582,111 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	7,579,491 - 7,582,111 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	7,482,956 - 7,485,429 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	7,423,529 - 7,426,153 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	7,423,707 - 7,426,150	NCBI
Celera	17	7,509,128 - 7,511,752 (+)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,376,970 - 7,379,593 (+)	NCBI		HuRef
CHM1_1	17	7,491,734 - 7,494,362 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	7,483,886 - 7,486,361 (+)	NCBI		T2T-CHM13v2.0

Cd68
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	69,555,039 - 69,556,996 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	69,555,039 - 69,556,979 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	69,664,213 - 69,666,170 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,664,213 - 69,666,153 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	69,477,873 - 69,479,564 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	70,248,478 - 70,250,169 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	69,480,566 - 69,482,257 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.86	NCBI

Cd68
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	54,880,562 - 54,882,441 (-)	NCBI		GRCr8
mRatBN7.2	10	54,381,814 - 54,383,693 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,381,815 - 54,383,697 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	59,044,451 - 59,046,330 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	58,533,003 - 58,534,882 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	54,040,608 - 54,042,465 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	56,268,726 - 56,270,605 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,268,720 - 56,270,640 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	56,014,364 - 56,016,243 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	56,481,701 - 56,483,580 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	56,495,323 - 56,497,228 (-)	NCBI
Celera	10	53,536,351 - 53,538,212 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

Cd68
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	9,341,364 - 9,343,836 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	9,340,490 - 9,343,912 (-)	NCBI	ChiLan1.0	ChiLan1.0

CD68
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	15,174,231 - 15,176,798 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	17,140,359 - 17,142,865 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	7,610,725 - 7,613,696 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	7,596,995 - 7,599,981 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	7,596,947 - 7,599,981 (+)	Ensembl	panpan1.1		panPan2

CD68
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,500,899 - 32,503,355 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	32,501,380 - 32,503,183 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,640,582 - 32,642,831 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	32,606,269 - 32,608,583 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	32,606,541 - 32,608,348 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	32,573,887 - 32,576,133 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,530,349 - 32,532,594 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,709,456 - 32,711,701 (+)	NCBI		UU_Cfam_GSD_1.0

Cd68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	47,384,190 - 47,386,943 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936595	858,289 - 861,131 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD68
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	52,874,785 - 52,877,695 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	52,874,754 - 52,877,256 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	55,296,987 - 55,299,491 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Cd68
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624786	10,195,337 - 10,197,963 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008010174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000009531 ⟹ ENSCSAP00000007645

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	6,957,212 - 6,959,042 (+)	Ensembl

RefSeq Acc Id:

XM_008010174 ⟹ XP_008008365

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	6,956,633 - 6,959,645 (+)	NCBI
Vero_WHO_p1.0	NW_023666059	14,448,764 - 14,451,756 (-)	NCBI

Sequence:

show sequence

TTGGGCTGTGTTGCTTTCTTGTCACCATCTAAGAGTTCCCAGAGGCTGGAAAGCCATGTTCTCG
GTGATGCTGACTGGAATGCTGCCCCTCTGTAAAGGGCTGGGTGTGGATGATCACAAGCCCCTCA
CGTGCCTCAGCCAAGAGGAAGTACAGGGGTCAGCCCCGAGGTCCAGGGGAAAGGGGAGTGGAGA
CGCTGATTTCCCCACCACTGAGGGAGGGGCCTGGGTCTCAGCTGTTCCCATAGCCACCTGCCAC
AACTGCCAAGCAAGTTTTGCTGAGTTTGACACATGGATCCCTATGGATCAACTGCCCTAGGACT
CCCTTTCATGTACCCATGTGACCCTGTTGACTTTGCCCTGATGAAGCAGGGGCCAACAGTGCCC
TACCTTAATTACAAAAACTAATGACTAAGAGAGAGATGGCTAGAGCTGAGGCCCCTGAGTCAGG
CTGTGGGTGGGATCATCTCCAGTACAGGAAGTGAGACTTTCATTTCCTCCTTTCCAAGAGAGGG
CTGAGGGAGTAGAGCTGAGCAACTGGTGCAGACAGCCTCGCTGGACTCGGGGTGAGGTAGTTCA
GCCATGAGGCTGGCTGTGCTTTTCTTGGGGGCCCTGCTGGGGCTACTCGCAGCCCAGGGGACAG
GGAATGACTGTCCTCACAAAAAATCGGCCACTCTGCTGCCATCCTTCACGGTGACACCCACGGC
TACAGAGAGCACTGGAACAACCAGCCACAGGACTACCAAGAGCCACAAAACCACCACTCACAGG
ACAACCACCACAGGCACCACCAGCCACGGACCCACGACTGCCACGCACAACCCCACCACCACCA
GCCACAGAAACACCACGGTTCATCCAACAAGCAACAGCACTGCCACCAGCCAGGGACCCTCAAC
TGCCACTCACAGGCCTGCCACCACTAGTCATGGAAATGCCACGGTTCATCCAACAAGCAACAGC
ACTACCACCAGCCCAGGACTCACCAGTTCTGCCCACCCAGGACCACCTCCGCCCTCTCCGAGTC
CTAGCCCGGCCTCTAAGGAGACCATTGGAGACTACACATGGACCAATGGTTCCCAGCCCTGTGT
CCACCTCCAAGCCCAGATTCAGATTCGAGTCATGTACACAACCCAGGGTGGAGGAGAGGCCTGG
GGCATCTCTGTACTGAACCCCAACAAAACCAAGGTCCAGGGGAGCTGTGAGGGTGCCCATCCCC
ACCTGCTTCTCTCATTCCCCTATGGACACCTCAGCTTTGGATTCATGCAGGACCTCCAGCAGAG
GGTTGTCTACCTGAGCTACATGGCAGTGGAGTACAACGTGTCTTTCCCCCATGCAGCACAGTGG
ACATTCTCGGCTCAGAATGCATCCCTTCGAGATCTCCAAGCACCCCTGGGCCAGAGCTTCAGTT
GCAGCAACTCGAGCATCATTCTTTCACCAGCTGTCCACCTCGACCTGCTCTCCCTGAGGCTCCA
GGCTGCTCAGCTGCCCCACACAGGGGTCTTTGGGCAAAGTTTCTCCTGCCCCAGTGACCGGTCC
ATCTTGCTGCCTCTCATCATCGGCCTGGTCCTTCTTGGCCTCCTTGCCCTGGTGCTTATTGCCT
TCTGCATCGTCCGGAGACGCCCATCCGCCTACCAGGCCCTCTGAGCATTTGCTTCAAACCCCAG
GGCACTGAGGGGGTTGGGGTGTGGTGGGGGGGTCCCTTATTTCCTTGACATGCAACTGTCTCAA
AGACAAAGTTATTTTCCTTCCCTTTCTTGAAGAACTAAAATAGAGCCGGGCGCGATGGCTCATG
CCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTGGAGGTCAGAAGTTTAGAGA
CCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTAGCCGGGTGTG
GTGGCATAATCCCAGCAGGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCCTGAA
CCCAGGAGGTGGAGGTTGCAGTGAGCCGACATCACGCCACTGAGCCAAGATCGCGCCACTGCAC
TCCAGATTGGGCGACAGAGCCAGACTGTCTCAAATAAATAAACAAATAAGAGATAATGCAGTTG
GGAGGAGGGAGGGGAGAGAGTTTTATTAAATGTGACGAACTGTTCCCCCAAGAGGAGAGTAGCA
AAATATATGTGTATCTTTGACTTGGGGTTTTCCTTGTCCTGCCAGGATTAAAAGCCATGAGTTT
CTTGTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008008365	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000007645
	ENSCSAP00000007645.1

RefSeq Acc Id:	XP_008008365 ⟸ XM_008010174
- UniProtKB:	A0A0D9RGA6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000007645 ⟸ ENSCSAT00000009531

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000011452	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000009531.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.160.110	UniProtKB/TrEMBL
InterPro	Lamp2-like_luminal	UniProtKB/TrEMBL
	LAMP_CS	UniProtKB/TrEMBL
	Lysosome-assoc_membr_glycop	UniProtKB/TrEMBL
NCBI Gene	CD68	ENTREZGENE
PANTHER	MACROSIALIN	UniProtKB/TrEMBL
	PTHR11506	UniProtKB/TrEMBL
Pfam	Lamp	UniProtKB/TrEMBL
PRINTS	LYSASSOCTDMP	UniProtKB/TrEMBL
PROSITE	LAMP_2	UniProtKB/TrEMBL
	LAMP_3	UniProtKB/TrEMBL
UniProt	A0A0D9RGA6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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