CD68 (CD68 molecule) - Rat Genome Database

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Gene: CD68 (CD68 molecule) Canis lupus familiaris
Analyze
Symbol: CD68
Name: CD68 molecule
RGD ID: 13246215
Description: INVOLVED IN autocrine signaling (ortholog); cellular response to lipopolysaccharide (ortholog); cellular response to nutrient levels (ortholog); ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); adult T-cell leukemia/lymphoma (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN cytoplasm (inferred); endosome (inferred); endosome membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: macrosialin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,500,899 - 32,503,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,501,380 - 32,503,183 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,640,582 - 32,642,831 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,606,269 - 32,608,583 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,606,541 - 32,608,348 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,573,887 - 32,576,133 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,530,349 - 32,532,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,709,456 - 32,711,701 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CD68
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,500,899 - 32,503,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,501,380 - 32,503,183 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,640,582 - 32,642,831 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,606,269 - 32,608,583 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,606,541 - 32,608,348 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,573,887 - 32,576,133 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,530,349 - 32,532,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,709,456 - 32,711,701 (+)NCBIUU_Cfam_GSD_1.0
CD68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,579,638 - 7,582,111 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,579,491 - 7,582,111 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,482,956 - 7,485,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,423,529 - 7,426,153 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,423,707 - 7,426,150NCBI
Celera177,509,128 - 7,511,752 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,376,970 - 7,379,593 (+)NCBIHuRef
CHM1_1177,491,734 - 7,494,362 (+)NCBICHM1_1
T2T-CHM13v2.0177,483,886 - 7,486,361 (+)NCBIT2T-CHM13v2.0
Cd68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,555,039 - 69,556,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,555,039 - 69,556,979 (-)EnsemblGRCm39 Ensembl
GRCm381169,664,213 - 69,666,170 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,664,213 - 69,666,153 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,477,873 - 69,479,564 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,248,478 - 70,250,169 (-)NCBIMGSCv36mm8
MGSCv361169,480,566 - 69,482,257 (-)NCBIMGSCv36mm8
Cytogenetic Map11B3NCBI
cM Map1142.86NCBI
Cd68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,880,562 - 54,882,441 (-)NCBIGRCr8
mRatBN7.21054,381,814 - 54,383,693 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,381,815 - 54,383,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,044,451 - 59,046,330 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,533,003 - 58,534,882 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,040,608 - 54,042,465 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,268,726 - 56,270,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,268,720 - 56,270,640 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,014,364 - 56,016,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,481,701 - 56,483,580 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,495,323 - 56,497,228 (-)NCBI
Celera1053,536,351 - 53,538,212 (-)NCBICelera
Cytogenetic Map10q24NCBI
Cd68
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,341,364 - 9,343,836 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,340,490 - 9,343,912 (-)NCBIChiLan1.0ChiLan1.0
CD68
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,174,231 - 15,176,798 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,140,359 - 17,142,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,610,725 - 7,613,696 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,596,995 - 7,599,981 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,596,947 - 7,599,981 (+)Ensemblpanpan1.1panPan2
Cd68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,384,190 - 47,386,943 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936595858,289 - 861,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD68
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,874,785 - 52,877,695 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,874,754 - 52,877,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,296,987 - 55,299,491 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD68
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,956,633 - 6,959,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,957,212 - 6,959,042 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,448,764 - 14,451,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd68
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478610,195,337 - 10,197,963 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CD68
26 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000026361   ⟹   ENSCAFP00000024483
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,501,380 - 32,503,183 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845041659   ⟹   ENSCAFP00845032669
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl532,606,541 - 32,608,348 (+)Ensembl
RefSeq Acc Id: XM_022418524   ⟹   XP_022274232
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,500,899 - 32,503,355 (+)NCBI
Dog10K_Boxer_Tasha532,640,582 - 32,642,831 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038475537   ⟹   XP_038331465
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1532,573,887 - 32,576,133 (+)NCBI
RefSeq Acc Id: XM_038536706   ⟹   XP_038392634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0532,709,456 - 32,711,701 (+)NCBI
RefSeq Acc Id: XM_038600882   ⟹   XP_038456810
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0532,530,349 - 32,532,594 (+)NCBI
RefSeq Acc Id: XM_038665425   ⟹   XP_038521353
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0532,606,269 - 32,608,583 (+)NCBI
RefSeq Acc Id: XP_022274232   ⟸   XM_022418524
- UniProtKB: A0A8C0Q9Z4 (UniProtKB/TrEMBL),   A0A8P0NHV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000024483   ⟸   ENSCAFT00000026361
RefSeq Acc Id: XP_038331465   ⟸   XM_038475537
RefSeq Acc Id: XP_038456810   ⟸   XM_038600882
RefSeq Acc Id: XP_038521353   ⟸   XM_038665425
- UniProtKB: A0A8C0K4Q1 (UniProtKB/TrEMBL),   A0A8I3PFD2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038392634   ⟸   XM_038536706
- UniProtKB: A0A8C0Q9Z4 (UniProtKB/TrEMBL),   A0A8P0NHV1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845032669   ⟸   ENSCAFT00845041659
Promoters
RGD ID:13683230
Promoter ID:EPDNEW_C1297
Type:initiation region
Name:CD68_1
Description:CD68 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,501,374 - 32,501,434EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016641 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040005597 UniProtKB/TrEMBL
  ENSCAFG00845023581 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026361.4 UniProtKB/TrEMBL
  ENSCAFT00040010522.1 UniProtKB/TrEMBL
  ENSCAFT00845041659 ENTREZGENE
  ENSCAFT00845041659.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.110 UniProtKB/TrEMBL
InterPro Lamp2-like_luminal UniProtKB/TrEMBL
  Lysosome-assoc_membr_glycop UniProtKB/TrEMBL
NCBI Gene CD68 ENTREZGENE
PANTHER MACROSIALIN UniProtKB/TrEMBL
  PTHR11506 UniProtKB/TrEMBL
Pfam Lamp UniProtKB/TrEMBL
PRINTS LYSASSOCTDMP UniProtKB/TrEMBL
PROSITE LAMP_3 UniProtKB/TrEMBL
UniProt A0A8C0K4Q1 ENTREZGENE
  A0A8C0Q9Z4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PFD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NHV1 ENTREZGENE
UniProt Secondary A0A8P0NHV1 UniProtKB/TrEMBL
VGNC ID VGNC:49704 ENTREZGENE