RGD Reference Report - Association of steroid use with complicated sigmoid diverticulitis: potential role of activated CD68+/CD163+ macrophages. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Association of steroid use with complicated sigmoid diverticulitis: potential role of activated CD68+/CD163+ macrophages.

Authors: von Rahden, Burkhard H A  Kircher, Stefan  Thiery, Svenja  Landmann, Denise  Jurowich, Christian F  Germer, Christoph-Thomas  Grimm, Martin 
Citation: von Rahden BH, etal., Langenbecks Arch Surg. 2011 Aug;396(6):759-68. doi: 10.1007/s00423-011-0797-4. Epub 2011 May 7.
RGD ID: 40925945
Pubmed: PMID:21553154   (View Abstract at PubMed)
DOI: DOI:10.1007/s00423-011-0797-4   (Journal Full-text)


BACKGROUND: Immunosupression and, especially, intake of steroids have previously been identified as risk factors for complicated types of sigmoid diverticulitis. However, little is known about the underlying molecular and cellular mechanisms. We aimed to elucidate the potential role of activated macrophages in this respect.
METHODS: A consecutive series of n = 101 patients having undergone surgical resection for sigmoid diverticulitis at our institution was analyzed regarding the inflammatory infiltrate and prevalence of comorbid diseases as well as risk factors, including steroid use. Fifty-seven patients had complicated types of diverticulitis with severe inflammation (group A). Forty-four patients had moderate inflammation, most of whom had been operated for chronically recurrent diverticulitis (group B). Randomly selected 50 patients (n = 20/group A/n = 30 group B) underwent immunolabelling against CD68 and CD163.
RESULTS: Using immunofluorescence double labeling experiments we found a strong positive correlation of CD68 expression with CD163 expression (т = 0.934). High CD68 expression (x >= 23%) and high CD163 expression (x >= 22%) within stromal cells of the lamina propria was significantly associated with steroid use (CD68, p = 0.012 and CD163, p = 0.004, respectively) and complicated sigmoid diverticulitis with severe inflammation (CD68, p = 0.0001 and CD163, p = 0.001, respectively).
CONCLUSIONS: Inflammation, especially mediated by activated (CD68+/CD163+) macrophages in histopathological specimen might resemble the cellular link between steroid use and complicated types of sigmoid diverticulitis. Macrophages might be a suitable target for future supportive/preventive therapies. However, as long as we are lacking such strategies, we must bear in mind that steroid intake is a risk factor for complicated diverticulitis, especially when indicating surgical resection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD163Humandiverticulitis of colon exacerbatesIEP protein:increased expression:sigmoid colon (human)RGD 
CD68Humandiverticulitis of colon severityIEP associated with steroid use and protein:increased expression:sigmoid colon (human)RGD 
Cd163Ratdiverticulitis of colon exacerbatesISOCD163 (Homo sapiens)protein:increased expression:sigmoid colon (human)RGD 
Cd163Mousediverticulitis of colon exacerbatesISOCD163 (Homo sapiens)protein:increased expression:sigmoid colon (human)RGD 
Cd68Ratdiverticulitis of colon severityISOCD68 (Homo sapiens)associated with steroid use and protein:increased expression:sigmoid colon (human)RGD 
Cd68Mousediverticulitis of colon severityISOCD68 (Homo sapiens)associated with steroid use and protein:increased expression:sigmoid colon (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd163  (CD163 molecule)
Cd68  (Cd68 molecule)

Genes (Mus musculus)
Cd163  (CD163 antigen)
Cd68  (CD68 antigen)

Genes (Homo sapiens)
CD163  (CD163 molecule)
CD68  (CD68 molecule)


Additional Information