PGF (placental growth factor) - Rat Genome Database

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Gene: PGF (placental growth factor) Chlorocebus sabaeus
Analyze
Symbol: PGF
Name: placental growth factor
RGD ID: 18479797
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); cellular response to hormone stimulus (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); amyotrophic lateral sclerosis (ortholog); ankylosing spondylitis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: placenta growth factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,160,904 - 52,174,493 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,161,787 - 52,173,989 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,391,564 - 40,405,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 61 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGFGreen Monkeyamyotrophic lateral sclerosis  ISOPGF (Homo sapiens)9068941 RGDPMID:22119626 and REF_RGD_ID:6483573
PGFGreen Monkeyankylosing spondylitis  ISOPGF (Homo sapiens)9068941 RGDPMID:21873332 and REF_RGD_ID:6483576
PGFGreen Monkeyasthma  ISOPgf (Mus musculus)9068941 RGDPMID:22268141 and REF_RGD_ID:6483605
PGFGreen Monkeyasthma  ISOPGF (Homo sapiens)9068941 RGDPMID:22268141 and REF_RGD_ID:6483605
PGFGreen Monkeyatherosclerosis  ISOPgf (Mus musculus)9068941 RGDPMID:19952000 and REF_RGD_ID:6483589
PGFGreen Monkeybacterial pneumonia  ISOPgf (Mus musculus)9068941protein:increased expression:plasmaRGDPMID:16702604 and REF_RGD_ID:6483601
PGFGreen Monkeybrain ischemia  ISOPGF (Homo sapiens)9068941 RGDPMID:16901914 and REF_RGD_ID:6483783
PGFGreen Monkeybreast cancer disease_progressionISOPGF (Homo sapiens)9068941 RGDPMID:22270936 and REF_RGD_ID:6483604
PGFGreen Monkeycarotid artery disease severityISOPGF (Homo sapiens)9068941 RGDPMID:17157858 and REF_RGD_ID:6483596
PGFGreen Monkeycolitis  ISOPgf (Mus musculus)9068941 RGDPMID:20142801 and REF_RGD_ID:6483587
PGFGreen Monkeycongestive heart failure  ISOPgf (Rattus norvegicus)9068941 RGDPMID:19327525 and REF_RGD_ID:6483590
PGFGreen MonkeyCrohn's disease  ISOPGF (Homo sapiens)9068941protein:increased expression:serumRGDPMID:17980128 and REF_RGD_ID:6483592
PGFGreen MonkeyDiabetic Nephropathies disease_progressionISOPGF (Homo sapiens)9068941associated with Diabetes Mellitus and Type 1RGDPMID:21988672 and REF_RGD_ID:6483606
PGFGreen Monkeydiabetic neuropathy  ISOPGF (Homo sapiens)9068941associated with Diabetes Mellitus and ExperimentalRGDPMID:21056561 and REF_RGD_ID:6483583
PGFGreen Monkeydiabetic retinopathy  ISOPgf (Rattus norvegicus)9068941associated with Diabetes Mellitus and Type 2RGDPMID:21408222 and REF_RGD_ID:6483775
PGFGreen Monkeydilated cardiomyopathy  ISOPgf (Mus musculus)9068941 RGDPMID:21900081 and REF_RGD_ID:6483574
PGFGreen Monkeyend stage renal disease  ISOPgf (Rattus norvegicus)9068941 RGDPMID:16543713 and REF_RGD_ID:1642390
PGFGreen MonkeyEndotoxemia  ISOPgf (Mus musculus)9068941protein:increased expression:multipleRGDPMID:16702604 and REF_RGD_ID:6483601
PGFGreen Monkeyepilepsy  ISOPGF (Homo sapiens)9068941protein:increased expression:cerebrospinal fluidRGDPMID:22160787 and REF_RGD_ID:6483572
PGFGreen MonkeyExperimental Arthritis  ISOPgf (Mus musculus)9068941 RGDPMID:19180491 and REF_RGD_ID:6483591
1 to 20 of 61 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGFGreen Monkeyintellectual disability  ISOPGF (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and mildClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGFGreen MonkeyAcute Lung Injury  ISOPGF (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:39233289
PGFGreen MonkeySpontaneous Abortions  ISOPGF (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18539642


Biological Process
1 to 20 of 28 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGFGreen Monkeyanimal organ regeneration  ISOPgf (Rattus norvegicus)9068941 RGDPMID:21088600 and REF_RGD_ID:6483778
PGFGreen Monkeybranching involved in ureteric bud morphogenesis acts_upstream_of_or_withinISOPgf (Mus musculus)9068941 PMID:13678594MGIPMID:13678594
PGFGreen Monkeycellular response to hormone stimulus  ISOPgf (Rattus norvegicus)9068941 RGDPMID:9400995 and REF_RGD_ID:1642393
PGFGreen Monkeyfemale pregnancy  ISOPgf (Rattus norvegicus)9068941 RGDPMID:16131818 and REF_RGD_ID:1642392
PGFGreen Monkeygene expression acts_upstream_of_or_withinISOMGI:21834599068941 PMID:30179860MGIPMID:30179860
PGFGreen Monkeyglycogen metabolic process acts_upstream_of_or_withinISOMGI:884709068941 PMID:30179860MGIPMID:30179860
PGFGreen Monkeyglycogen metabolic process acts_upstream_of_or_withinISOMGI:21834599068941 PMID:30179860MGIPMID:30179860
PGFGreen Monkeyinduction of positive chemotaxis involved_inIEAPANTHER:PTN000246409150520179 TreeGrafterGO_REF:0000118
PGFGreen Monkeyplacenta development acts_upstream_of_or_withinISOMGI:21834599068941 PMID:30179860MGIPMID:30179860
PGFGreen Monkeypositive chemotaxis involved_inIEAGO:0042056150520179 GOCGO_REF:0000108
PGFGreen Monkeypositive regulation of angiogenesis  ISOPgf (Rattus norvegicus)9068941 RGDPMID:21329947 and REF_RGD_ID:6483777
PGFGreen Monkeypositive regulation of angiogenesis involved_inIEAPANTHER:PTN000246409150520179 TreeGrafterGO_REF:0000118
PGFGreen Monkeypositive regulation of cell division involved_inIEAUniProtKB-KW:KW-0497150520179 UniProtGO_REF:0000043
PGFGreen Monkeypositive regulation of cell population proliferation involved_inIEAUniProtKB:P49763 and ensembl:ENSP00000451040150520179 EnsemblGO_REF:0000107
PGFGreen Monkeypositive regulation of cell population proliferation involved_inIEAARBA:ARBA00027538150520179 UniProtGO_REF:0000117
PGFGreen Monkeypositive regulation of endothelial cell proliferation  ISOPgf (Rattus norvegicus)9068941 RGDPMID:9400995 and REF_RGD_ID:1642393
PGFGreen Monkeypositive regulation of endothelial cell proliferation involved_inIEAPANTHER:PTN000246409150520179 TreeGrafterGO_REF:0000118
PGFGreen Monkeypositive regulation of mast cell chemotaxis involved_inIEAPANTHER:PTN000246409150520179 TreeGrafterGO_REF:0000118
PGFGreen Monkeyregulation of blood pressure acts_upstream_of_or_withinISOMGI:884709068941 PMID:30179860MGIPMID:30179860
PGFGreen Monkeyregulation of blood pressure acts_upstream_of_or_withinISOMGI:21834599068941 PMID:30179860MGIPMID:30179860
1 to 20 of 28 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGFGreen Monkeyextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
PGFGreen Monkeyextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
PGFGreen Monkeyextracellular space  ISOPgf (Rattus norvegicus)9068941 RGDPMID:17240241 and REF_RGD_ID:1642388
PGFGreen Monkeyextracellular space located_inIEAPANTHER:PTN000246409150520179 TreeGrafterGO_REF:0000118
PGFGreen Monkeymembrane located_inIEAInterPro:IPR000072150520179 InterProGO_REF:0000002

Molecular Function
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGFGreen Monkeychemoattractant activity enablesIEAPANTHER:PTN000246409150520179 TreeGrafterGO_REF:0000118
PGFGreen Monkeygrowth factor activity enablesIEAPANTHER:PTN000246409150520179 TreeGrafterGO_REF:0000118
PGFGreen Monkeygrowth factor activity enablesIEAUniProtKB-KW:KW-0339150520179 UniProtGO_REF:0000043
PGFGreen Monkeygrowth factor activity enablesIEAInterPro:IPR000072150520179 InterProGO_REF:0000002
PGFGreen Monkeygrowth factor activity enablesIEAUniProtKB:P49763 and ensembl:ENSP00000451040150520179 EnsemblGO_REF:0000107
PGFGreen Monkeyidentical protein binding  ISOPgf (Rattus norvegicus)9068941homodimerizationRGDPMID:7706320 and REF_RGD_ID:633657
PGFGreen Monkeyprotein binding enablesISOUniProtKB:P179489068941 PMID:14684734 and PMID:20660291IntActPMID:14684734 and PMID:20660291
PGFGreen Monkeyprotein-containing complex binding  ISOPgf (Rattus norvegicus)9068941heterodimerizationRGDPMID:7706320 and REF_RGD_ID:633657
PGFGreen Monkeyreceptor ligand activity enablesIEAARBA:ARBA00028558150520179 UniProtGO_REF:0000117
PGFGreen Monkeyvascular endothelial growth factor receptor binding enablesIEAPANTHER:PTN000246409150520179 TreeGrafterGO_REF:0000118
1 to 10 of 10 rows

RGD Manual Annotations


  
PMID:22301074   PMID:30032202  



PGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,160,904 - 52,174,493 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,161,787 - 52,173,989 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,391,564 - 40,405,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,941,830 - 74,955,764 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,941,834 - 74,955,626 (-)EnsemblGRCh38hg38GRCh38
GRCh371475,408,533 - 75,422,467 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,478,290 - 74,492,044 (-)NCBINCBI36Build 36hg18NCBI36
Build 341474,478,292 - 74,492,044NCBI
Celera1455,446,919 - 55,460,674 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,576,546 - 55,590,481 (-)NCBIHuRef
CHM1_11475,347,700 - 75,361,635 (-)NCBICHM1_1
T2T-CHM13v2.01469,150,944 - 69,164,879 (-)NCBIT2T-CHM13v2.0
Pgf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,213,413 - 85,224,087 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,213,409 - 85,224,564 (-)EnsemblGRCm39 Ensembl
GRCm381285,166,637 - 85,177,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,166,635 - 85,177,790 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,507,591 - 86,518,235 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,055,744 - 86,066,388 (-)NCBIMGSCv36mm8
Celera1286,623,655 - 86,634,299 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.58NCBI
Pgf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,547,165 - 110,557,747 (-)NCBIGRCr8
mRatBN7.26104,816,102 - 104,826,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,816,104 - 104,826,685 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,985,728 - 104,996,309 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,284,901 - 105,295,482 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,654,265 - 104,664,846 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,994,016 - 109,004,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,994,018 - 109,004,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,552,660 - 116,563,242 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,215,540 - 109,226,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,218,997 - 109,229,578 (-)NCBI
Celera6102,639,061 - 102,649,643 (-)NCBICelera
RH 3.4 Map6731.99RGD
Cytogenetic Map6q31NCBI
Pgf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523616,154 - 627,713 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955523616,196 - 627,055 (+)NCBIChiLan1.0ChiLan1.0
PGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,024,811 - 76,038,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,241,311 - 75,255,228 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,494,152 - 55,508,066 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,338,976 - 74,352,964 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,338,976 - 74,352,964 (-)Ensemblpanpan1.1panPan2
PGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,059,554 - 48,110,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,059,552 - 48,075,170 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,743,752 - 47,795,118 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,287,229 - 48,338,603 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1847,958,057 - 48,009,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,979,365 - 48,030,910 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,377,990 - 48,429,367 (-)NCBIUU_Cfam_GSD_1.0
Pgf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,957,791 - 27,970,740 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,098,225 - 4,111,142 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,098,187 - 4,111,108 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,148,994 - 98,162,741 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,149,510 - 98,162,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,993,598 - 104,006,849 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pgf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,751,530 - 26,764,242 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,751,986 - 26,764,154 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in PGF
267 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20



Ensembl Acc Id: ENSCSAT00000010289   ⟹   ENSCSAP00000008384
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2452,161,787 - 52,173,989 (-)Ensembl
RefSeq Acc Id: XM_007987292   ⟹   XP_007985483
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12452,160,904 - 52,174,493 (-)NCBI
Vero_WHO_p1.0NW_02366605340,391,564 - 40,405,145 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007987293   ⟹   XP_007985484
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12452,160,904 - 52,174,493 (-)NCBI
Vero_WHO_p1.0NW_02366605340,391,564 - 40,405,145 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037984263   ⟹   XP_037840191
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605340,391,564 - 40,405,145 (-)NCBI
Protein RefSeqs XP_007985483 (Get FASTA)   NCBI Sequence Viewer  
  XP_007985484 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840191 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008384
  ENSCSAP00000008384.1
RefSeq Acc Id: XP_007985484   ⟸   XM_007987293
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007985483   ⟸   XM_007987292
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RIE5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000008384   ⟸   ENSCSAT00000010289
RefSeq Acc Id: XP_037840191   ⟸   XM_037984263
- Peptide Label: isoform X2



1 to 17 of 17 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000012223 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010289.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  PD_growth_factor_CS UniProtKB/TrEMBL
  PDGF/VEGF_dom UniProtKB/TrEMBL
  PDGF/VEGF_growth_factor UniProtKB/TrEMBL
KEGG Report csab:103229341 UniProtKB/TrEMBL
NCBI Gene PGF ENTREZGENE
PANTHER PLACENTA GROWTH FACTOR UniProtKB/TrEMBL
  VASCULAR ENDOTHELIAL GROWTH FACTOR UniProtKB/TrEMBL
Pfam PDGF UniProtKB/TrEMBL
PROSITE PDGF_1 UniProtKB/TrEMBL
  PDGF_2 UniProtKB/TrEMBL
SMART PDGF UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A0D9RIE5 ENTREZGENE, UniProtKB/TrEMBL
1 to 17 of 17 rows