RGD Reference Report - The functional deficiency of bone marrow mesenchymal stromal cells in ALS patients is proportional to disease progression rate. - Rat Genome Database

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The functional deficiency of bone marrow mesenchymal stromal cells in ALS patients is proportional to disease progression rate.

Authors: Koh, SH  Baik, W  Noh, MY  Cho, GW  Kim, HY  Kim, KS  Kim, SH 
Citation: Koh SH, etal., Exp Neurol. 2012 Jan;233(1):472-80. Epub 2011 Nov 19.
RGD ID: 6483573
Pubmed: PMID:22119626   (View Abstract at PubMed)
DOI: DOI:10.1016/j.expneurol.2011.11.021   (Journal Full-text)

Amyotrophic lateral sclerosis (ALS) is caused by motor neuron death. The relationship between the prognosis of ALS patients and the function of their bone marrow mesenchymal stromal cells (BM-MSCs) is unclear. We designed this study to assess the correlation between the progression rate of the ALS Functional Rating Scale-revised version (DeltaFS), which is reported to predict prognosis, and the pluripotency and trophic factor secreting capacity of ALS patients' BM-MSCs. We evaluated DeltaFS in 23 ALS patients and isolated BM-MSCs from those patients and five healthy people. Levels of Nanog, Oct-4, and Nestin mRNA were examined to evaluate pluripotency, and levels of BDNF, ECGF1, bFGF-2, HGF, IGF-1, PGF, TGF-1beta, SDF-1alpha, GDNF, VEGF, and ANG mRNA were examined to assess trophic factor secreting capacity. In addition, we measured the protein levels of Nanog, Oct-4, Nestin, SDF-1alpha, ANG, bFGF-2, VEGF, IGF-1, GDNF, and BDNF. mRNA levels of Nanog, Oct-4, ECGF1, bFGF-2, HGF, IGF-1, PGF, TGF-1beta, SDF-1alpha, GDNF, VEGF, and ANG were negatively correlations with DeltaFS. However, those of Nestin and BDNF were not significantly correlated with DeltaFS. Similarly, Nanog, Oct-4, SDF-1alpha, ANG, bFGF-2, VEGF, IGF-1, and GDNF protein levels had a significant negative correlation with DeltaFS. Results indicate that the pluripotency and trophic factor secreting capacity of the BM-MSCs of ALS patients are reduced in proportion to a poorer prognosis. We therefore suggest that healthy allogeneic BM-MSCs might be a better option for cell therapy in ALS patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
amyotrophic lateral sclerosis  IEP 6483573 RGD 
amyotrophic lateral sclerosis  ISOPGF (Homo sapiens)6483573; 6483573 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pgf  (placental growth factor)

Genes (Mus musculus)
Pgf  (placental growth factor)

Genes (Homo sapiens)
PGF  (placental growth factor)


Additional Information