Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | Erc2 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ERC2 mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ERC2 mRNA | CTD | PMID:36331819 | 1,1-dichloroethene | decreases expression | EXP | | 6480464 | vinylidene chloride results in decreased expression of ERC2 mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | increases expression | EXP | | 6480464 | ethylene dichloride results in increased expression of ERC2 mRNA | CTD | PMID:28960355 | 17beta-estradiol | multiple interactions | ISO | ERC2 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERC2 mRNA | CTD | PMID:19619570 | 17beta-estradiol | increases expression | ISO | ERC2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of ERC2 mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | ERC2 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERC2 mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ERC2 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | ERC2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ERC2 mRNA | CTD | PMID:19619570 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ERC2 mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of ERC2 gene | CTD | PMID:31683443 | 6-propyl-2-thiouracil | increases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of ERC2 mRNA | CTD | PMID:24780913 and PMID:36843608 | 6-propyl-2-thiouracil | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of ERC2 mRNA | CTD | PMID:30047161 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of ERC2 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ERC2 intron | CTD | PMID:30157460 | aflatoxin B1 | decreases expression | ISO | ERC2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of ERC2 mRNA | CTD | PMID:22100608 | Aflatoxin B2 alpha | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of ERC2 intron | CTD | PMID:30157460 | allethrin | multiple interactions | ISO | Erc2 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of ERC2 protein | CTD | PMID:34896426 | amitrole | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of ERC2 mRNA | CTD | PMID:30047161 | arsane | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of ERC2 gene | CTD | PMID:24525453 | arsane | decreases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Arsenic results in decreased methylation of ERC2 3' UTR | CTD | PMID:31135185 | arsane | affects methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ERC2 gene | CTD | PMID:25304211 | arsenic atom | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of ERC2 gene | CTD | PMID:24525453 | arsenic atom | decreases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Arsenic results in decreased methylation of ERC2 3' UTR | CTD | PMID:31135185 | arsenic atom | affects methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ERC2 gene | CTD | PMID:25304211 | arsenite(3-) | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | arsenite results in increased methylation of ERC2 promoter | CTD | PMID:23974009 | arsenous acid | increases expression | ISO | ERC2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of ERC2 mRNA | CTD | PMID:15761015 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of ERC2 mRNA | CTD | PMID:19770486 and PMID:21715664 | benzo[a]pyrene | affects methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ERC2 3' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ERC2 exon and Benzo(a)pyrene results in increased methylation of ERC2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects expression | ISO | ERC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the expression of ERC2 mRNA | CTD | PMID:21714911 | benzo[e]pyrene | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of ERC2 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ERC2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ERC2 mRNA | CTD | PMID:32156529 | bisphenol A | decreases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of ERC2 gene | CTD | PMID:31601247 | bisphenol A | affects methylation | ISO | ERC2 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of ERC2 gene | CTD | PMID:33391824 | bisphenol A | increases methylation | ISO | Erc2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of ERC2 gene | CTD | PMID:28505145 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | CGP 52608 | multiple interactions | ISO | ERC2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ERC2 gene] | CTD | PMID:28238834 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of ERC2 mRNA | CTD | PMID:25270620 | cyhalothrin | multiple interactions | ISO | Erc2 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of ERC2 protein | CTD | PMID:34896426 | cypermethrin | multiple interactions | ISO | Erc2 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of ERC2 protein | CTD | PMID:34896426 | diarsenic trioxide | increases expression | ISO | ERC2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of ERC2 mRNA | CTD | PMID:15761015 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of ERC2 mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | ERC2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERC2 mRNA | CTD | PMID:27188386 | endosulfan | increases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of ERC2 mRNA | CTD | PMID:29391264 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of ERC2 mRNA | CTD | PMID:19167417 | fenvalerate | multiple interactions | ISO | Erc2 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of ERC2 protein | CTD | PMID:34896426 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of ERC2 mRNA | CTD | PMID:25629700 | fonofos | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of ERC2 promoter | CTD | PMID:22847954 | iron dichloride | increases expression | ISO | ERC2 (Homo sapiens) | 6480464 | ferrous chloride results in increased expression of ERC2 mRNA | CTD | PMID:35984750 | lipopolysaccharide | increases expression | ISO | ERC2 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of ERC2 mRNA | CTD | PMID:35811015 | lipopolysaccharide | multiple interactions | ISO | ERC2 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | methapyrilene | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of ERC2 intron | CTD | PMID:30157460 | methimazole | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of ERC2 mRNA | CTD | PMID:30047161 | methoxychlor | affects methylation | ISO | Erc2 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of ERC2 gene | CTD | PMID:35440735 | mitomycin C | decreases expression | EXP | | 6480464 | Mitomycin results in decreased expression of ERC2 mRNA | CTD | PMID:25270620 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Erc2 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of ERC2 gene | CTD | PMID:33148267 | N-nitrosomorpholine | increases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | N-nitrosomorpholine results in increased expression of ERC2 protein | CTD | PMID:19716841 | paracetamol | increases expression | ISO | ERC2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of ERC2 mRNA | CTD | PMID:29067470 | parathion | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Parathion results in increased methylation of ERC2 promoter | CTD | PMID:22847954 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ERC2 mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of ERC2 mRNA | CTD | PMID:36331819 | permethrin | multiple interactions | ISO | Erc2 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of ERC2 gene | CTD | PMID:33148267 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of ERC2 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ERC2 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ERC2 mRNA | CTD | PMID:18301758 and PMID:20813756 | potassium dichromate | decreases expression | EXP | | 6480464 | Potassium Dichromate results in decreased expression of ERC2 mRNA | CTD | PMID:23608068 | progesterone | increases expression | EXP | | 6480464 | Progesterone results in increased expression of ERC2 mRNA | CTD | PMID:22238285 | propiconazole | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | propiconazole results in decreased expression of ERC2 mRNA | CTD | PMID:30047161 | pyrethrins | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Pyrethrins results in decreased expression of ERC2 protein | CTD | PMID:34896426 | resveratrol | decreases phosphorylation | ISO | ERC2 (Homo sapiens) | 6480464 | resveratrol results in decreased phosphorylation of ERC2 protein | CTD | PMID:25311616 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | ERC2 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | ERC2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERC2 mRNA | CTD | PMID:27188386 | serpentine asbestos | decreases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Asbestos and Serpentine results in decreased methylation of ERC2 3' UTR | CTD | PMID:29523930 | sulfadimethoxine | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of ERC2 mRNA | CTD | PMID:30047161 | terbufos | increases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | terbufos results in increased methylation of ERC2 promoter | CTD | PMID:22847954 | tetrachloromethane | multiple interactions | ISO | Erc2 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ERC2 mRNA] | CTD | PMID:31150632 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ERC2 mRNA | CTD | PMID:31919559 | tetrachloromethane | increases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of ERC2 mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of ERC2 mRNA | CTD | PMID:23411599 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of ERC2 mRNA | CTD | PMID:23409001 | trichostatin A | decreases expression | ISO | ERC2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of ERC2 mRNA | CTD | PMID:24935251 more ... | trichostatin A | multiple interactions | ISO | ERC2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERC2 mRNA | CTD | PMID:27188386 | valproic acid | affects expression | ISO | ERC2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ERC2 mRNA | CTD | PMID:25979313 | valproic acid | decreases methylation | ISO | ERC2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of ERC2 gene | CTD | PMID:29154799 | vinclozolin | increases expression | ISO | Erc2 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of ERC2 mRNA | CTD | PMID:23869203 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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Molecular Function
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 2. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 3. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10725249 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12163476 | PMID:12466851 | PMID:12477932 | PMID:12520002 | PMID:12693553 | PMID:14610273 |
| PMID:14691545 | PMID:15489334 | PMID:16141072 | PMID:16141073 | PMID:16602821 | PMID:16944949 | PMID:17114649 | PMID:17124501 | PMID:18799693 | PMID:19812333 | PMID:19874790 | PMID:21228161 |
| PMID:21267068 | PMID:21677750 | PMID:21873635 | PMID:22008794 | PMID:22577167 | PMID:22794259 | PMID:22933801 | PMID:23055939 | PMID:23791195 | PMID:23960145 | PMID:25209271 | PMID:25438880 |
| PMID:27035941 | PMID:27253063 | PMID:27256505 | PMID:27422015 | PMID:27507650 | PMID:27537483 | PMID:27626661 | PMID:27741242 | PMID:27889896 | PMID:28262416 | PMID:28634551 | PMID:28671696 |
| PMID:29398114 | PMID:29439199 | PMID:29518331 | PMID:29996090 | PMID:30190286 | PMID:30995482 | PMID:31996256 | PMID:32027825 | PMID:32251313 | PMID:32325033 | PMID:32521280 | PMID:33378226 |
| PMID:33601422 | PMID:34321999 | PMID:35176221 | PMID:36179691 | PMID:36398873 | PMID:36460641 | PMID:36482889 |
Genomics
Comparative Map Data
| Erc2 (Mus musculus - house mouse) |
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| ERC2 (Homo sapiens - human) |
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| Erc2 (Rattus norvegicus - Norway rat) |
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| Erc2 (Chinchilla lanigera - long-tailed chinchilla) |
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| ERC2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| ERC2 (Canis lupus familiaris - dog) |
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| Erc2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| ERC2 (Sus scrofa - pig) |
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| ERC2 (Chlorocebus sabaeus - green monkey) |
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| Erc2 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Erc2
27756 total Variants 
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