Tmed8 (transmembrane p24 trafficking protein family member 8) - Rat Genome Database

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Gene: Tmed8 (transmembrane p24 trafficking protein family member 8) Rattus norvegicus
Analyze
Symbol: Tmed8
Name: transmembrane p24 trafficking protein family member 8
RGD ID: 1589336
Description: Orthologous to human TMED8 (transmembrane p24 trafficking protein family member 8); INTERACTS WITH 17alpha-ethynylestradiol; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC681943; similar to transmembrane emp24 domain containing 8; transmembrane emp24 protein transport domain containing 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,537,921 - 112,572,199 (-)NCBIGRCr8
mRatBN7.26106,806,973 - 106,841,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,810,420 - 106,843,216 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06111,188,938 - 111,222,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,194,951 - 111,222,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,473,103 - 120,506,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6104,628,254 - 104,662,575 (-)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmed8Rathereditary sensory and autonomic neuropathy type 1C  ISOTMED8 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuropathy more ...ClinVarPMID:28492532

1 to 20 of 37 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmed8Rat1,2-dimethylhydrazine multiple interactionsISOTmed8 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of TMED8 mRNACTDPMID:22206623
Tmed8Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of TMED8 mRNACTDPMID:29097150
Tmed8Rat17beta-estradiol increases expressionISOTMED8 (Homo sapiens)6480464Estradiol results in increased expression of TMED8 mRNACTDPMID:31614463
Tmed8Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTmed8 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TMED8 mRNACTDPMID:21570461
Tmed8Rat3,4-methylenedioxymethamphetamine increases expressionISOTmed8 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of TMED8 mRNACTDPMID:20188158
Tmed8Ratafimoxifene multiple interactionsISOTMED8 (Homo sapiens)6480464afimoxifene inhibits the reaction [Estrogens results in increased expression of TMED8 mRNA]CTDPMID:21233418
Tmed8Rataflatoxin B1 increases expressionISOTMED8 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of TMED8 mRNACTDPMID:22100608
Tmed8Ratamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of TMED8 mRNACTDPMID:30779732
Tmed8Ratbenzo[a]pyrene increases expressionISOTmed8 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of TMED8 mRNACTDPMID:22228805
Tmed8Ratbenzo[a]pyrene diol epoxide I decreases expressionISOTMED8 (Homo sapiens)64804647 more ...CTDPMID:20018196
Tmed8Ratbis(2-ethylhexyl) phthalate increases expressionISOTmed8 (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of TMED8 mRNACTDPMID:34319233
Tmed8Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of TMED8 mRNACTDPMID:29097150
Tmed8Ratcaffeine increases phosphorylationISOTMED8 (Homo sapiens)6480464Caffeine results in increased phosphorylation of TMED8 proteinCTDPMID:35688186
Tmed8Ratcoumestrol multiple interactionsISOTMED8 (Homo sapiens)6480464[Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TMED8 mRNACTDPMID:19167446
Tmed8Ratcoumestrol increases expressionISOTMED8 (Homo sapiens)6480464Coumestrol results in increased expression of TMED8 mRNACTDPMID:19167446
Tmed8Ratdorsomorphin multiple interactionsISOTMED8 (Homo sapiens)6480464[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMED8 mRNACTDPMID:27188386
Tmed8Ratdoxorubicin decreases expressionISOTMED8 (Homo sapiens)6480464Doxorubicin results in decreased expression of TMED8 mRNACTDPMID:29803840
Tmed8RatEnterolactone multiple interactionsISOTMED8 (Homo sapiens)6480464[Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TMED8 mRNACTDPMID:19167446
Tmed8Ratepoxiconazole decreases expressionISOTmed8 (Mus musculus)6480464epoxiconazole results in decreased expression of TMED8 mRNACTDPMID:35436446
Tmed8Ratethanol affects splicingISOTmed8 (Mus musculus)6480464Ethanol affects the splicing of TMED8 mRNACTDPMID:30319688

1 to 20 of 37 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmed8Ratprotein binding enablesISOTMED8 (Homo sapiens)1624291UniProtKB:A2RU14 more ...RGDPMID:32296183


#
Reference Title
Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Tmed8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,537,921 - 112,572,199 (-)NCBIGRCr8
mRatBN7.26106,806,973 - 106,841,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,810,420 - 106,843,216 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06111,188,938 - 111,222,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,194,951 - 111,222,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,473,103 - 120,506,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6104,628,254 - 104,662,575 (-)NCBICelera
Cytogenetic Map6q31NCBI
TMED8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,335,021 - 77,377,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,335,029 - 77,377,094 (-)EnsemblGRCh38hg38GRCh38
GRCh371477,801,364 - 77,843,437 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361476,877,867 - 76,913,149 (-)NCBINCBI36Build 36hg18NCBI36
Build 341476,877,866 - 76,913,149NCBI
Celera1457,846,691 - 57,881,972 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1457,974,194 - 58,009,463 (-)NCBIHuRef
CHM1_11477,747,564 - 77,782,831 (-)NCBICHM1_1
T2T-CHM13v2.01471,544,384 - 71,586,469 (-)NCBIT2T-CHM13v2.0
Tmed8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,195,547 - 87,247,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1287,213,011 - 87,247,228 (-)EnsemblGRCm39 Ensembl
GRCm381287,166,242 - 87,200,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,166,237 - 87,200,454 (-)EnsemblGRCm38mm10GRCm38
MGSCv371288,507,192 - 88,541,179 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361288,055,345 - 88,089,332 (-)NCBIMGSCv36mm8
Celera1288,630,768 - 88,664,814 (-)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1241.36NCBI
Tmed8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554381,246,301 - 1,272,815 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554381,246,301 - 1,273,113 (-)NCBIChiLan1.0ChiLan1.0
TMED8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21578,418,890 - 78,461,242 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11477,635,394 - 77,677,746 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01457,888,235 - 57,930,615 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11477,089,637 - 77,132,037 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1477,096,398 - 77,132,037 (-)Ensemblpanpan1.1panPan2
TMED8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1850,149,099 - 50,163,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl850,156,060 - 50,164,339 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,836,775 - 49,869,837 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0850,382,641 - 50,415,947 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl850,387,795 - 50,415,938 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1850,045,477 - 50,078,545 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0850,068,840 - 50,101,841 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0850,466,520 - 50,499,588 (-)NCBIUU_Cfam_GSD_1.0
Tmed8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,892,367 - 25,911,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364886,165,874 - 6,176,595 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364886,159,119 - 6,176,584 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMED8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7100,411,264 - 100,449,298 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17100,411,259 - 100,449,350 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27106,507,882 - 106,540,567 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMED8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,595,024 - 54,636,235 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605342,781,717 - 42,828,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmed8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473424,526,414 - 24,562,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473424,526,410 - 24,569,901 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Tmed8
90 total Variants

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:70
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000074707
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat

1 to 10 of 23 rows
BE107021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26106,824,919 - 106,825,069 (+)MAPPERmRatBN7.2
Rnor_6.06111,206,984 - 111,207,133NCBIRnor6.0
Rnor_5.06120,491,014 - 120,491,163UniSTSRnor5.0
Celera6104,646,220 - 104,646,369UniSTS
RH 3.4 Map6743.8UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000074707   ⟹   ENSRNOP00000066645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6111,194,951 - 111,222,858 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099781   ⟹   ENSRNOP00000080284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6106,810,420 - 106,829,555 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119025   ⟹   ENSRNOP00000079812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6106,810,420 - 106,843,216 (-)Ensembl
RefSeq Acc Id: XM_039113336   ⟹   XP_038969264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,537,921 - 112,572,199 (-)NCBI
mRatBN7.26106,806,973 - 106,841,271 (-)NCBI
RefSeq Acc Id: XM_039113337   ⟹   XP_038969265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,537,921 - 112,572,196 (-)NCBI
mRatBN7.26106,806,973 - 106,841,257 (-)NCBI
RefSeq Acc Id: XM_063262691   ⟹   XP_063118761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,537,921 - 112,572,092 (-)NCBI
Protein RefSeqs NP_001419064 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969264 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969265 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079812.1
  ENSRNOP00000080284.1
  ENSRNOP00000106950
  ENSRNOP00000111888
Ensembl Acc Id: ENSRNOP00000066645   ⟸   ENSRNOT00000074707
RefSeq Acc Id: XP_038969264   ⟸   XM_039113336
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038969265   ⟸   XM_039113337
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZPG0 (UniProtKB/TrEMBL),   A6JE87 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079812   ⟸   ENSRNOT00000119025
Ensembl Acc Id: ENSRNOP00000080284   ⟸   ENSRNOT00000099781
GOLD

Name Modeler Protein Id AA Range Protein Structure
AF-M0RAT6-F1-model_v2 AlphaFold M0RAT6 1-326 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694759
Promoter ID:EPDNEW_R5279
Type:multiple initiation site
Name:Tmed8_1
Description:Protein TMED8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06111,222,889 - 111,222,949EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36725 BioCyc
Ensembl Genes ENSRNOG00000045857 Ensembl
  ENSRNOG00000064799 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000077115 ENTREZGENE
Ensembl Transcript ENSRNOT00000099781.1 UniProtKB/TrEMBL
  ENSRNOT00000119025.1 UniProtKB/TrEMBL
  ENSRNOT00000134324 ENTREZGENE
  ENSRNOT00000165449 ENTREZGENE
Gene3D-CATH GOLD domain UniProtKB/TrEMBL
InterPro GOLD_dom UniProtKB/TrEMBL
  GOLD_dom_sf UniProtKB/TrEMBL
  Golgi-PI4KB_interaction UniProtKB/TrEMBL
NCBI Gene 681943 ENTREZGENE
PANTHER LD35087P UniProtKB/TrEMBL
  PROTEIN TMED8 UniProtKB/TrEMBL
Pfam GOLD_2 UniProtKB/TrEMBL
PhenoGen Tmed8 PhenoGen
PROSITE GOLD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045857 RatGTEx
  ENSRNOG00000064799 RatGTEx
  ENSRNOG00000077115 RatGTEx
Superfamily-SCOP SSF101576 UniProtKB/TrEMBL
UniProt A0A8I5ZNC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPG0 ENTREZGENE, UniProtKB/TrEMBL
  A6JE87 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Tmed8  transmembrane p24 trafficking protein family member 8  Tmed8  transmembrane p24 trafficking protein family member 8  Data merged from RGD:149736478 737654 PROVISIONAL
2021-08-09 Tmed8  transmembrane p24 trafficking protein family member 8      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-08-19 Tmed8  transmembrane p24 trafficking protein family member 8  Tmed8  transmembrane emp24 protein transport domain containing 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-10-03 Tmed8  transmembrane emp24 protein transport domain containing 8  LOC681943  similar to transmembrane emp24 domain containing 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681943  similar to transmembrane emp24 domain containing 8      Symbol and Name status set to provisional 70820 PROVISIONAL