CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) - Rat Genome Database

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Gene: CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) Sus scrofa
Analyze
Symbol: CHRNA3
Name: cholinergic receptor nicotinic alpha 3 subunit
RGD ID: 13855889
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); activation of transmembrane receptor protein tyrosine kinase activity (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); BLADDER DYSFUNCTION, AUTONOMIC, WITH IMPAIRED PUPILLARY REFLEX AND SECONDARY CAKUT (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog); INTERACTS WITH (S)-nicotine; carbon dioxide; dioxygen
Type: protein-coding
RefSeq Status: MODEL
Also known as: cholinergic receptor, nicotinic, alpha 3 (neuronal); neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor alpha 3 subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,361,778 - 47,384,303 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,361,710 - 47,382,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,787,929 - 52,806,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:21536845   PMID:24825168  


Genomics

Comparative Map Data
CHRNA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,361,778 - 47,384,303 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,361,710 - 47,382,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,787,929 - 52,806,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1578,593,052 - 78,621,295 (-)EnsemblGRCh38hg38GRCh38
GRCh381578,593,052 - 78,620,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371578,885,394 - 78,913,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,674,706 - 76,700,377 (-)NCBINCBI36hg18NCBI36
Build 341576,674,706 - 76,700,377NCBI
Celera1555,821,707 - 55,849,902 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1555,642,483 - 55,671,504 (-)NCBIHuRef
CHM1_11579,003,962 - 79,032,196 (-)NCBICHM1_1
Chrna3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,917,401 - 54,933,846 (-)NCBIGRCm39mm39
GRCm39 Ensembl954,917,395 - 54,933,846 (-)Ensembl
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIGRCm37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBImm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
Chrna3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2855,401,981 - 55,415,012 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl855,401,702 - 55,415,165 (-)Ensembl
Rnor_6.0859,594,007 - 59,607,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,176,165 - 58,189,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,570,223 - 58,583,594 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,588,997 - 58,602,801 (-)NCBI
Celera854,888,972 - 54,929,562 (-)NCBICelera
Cytogenetic Map8q24NCBI
Chrna3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450977,075 - 1,011,372 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955450979,630 - 1,011,316 (-)NCBIChiLan1.0ChiLan1.0
CHRNA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11576,486,416 - 76,513,899 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,487,710 - 76,512,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01557,523,553 - 57,550,228 (-)NCBIMhudiblu_PPA_v0panPan3
CHRNA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,330,287 - 38,343,142 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,328,814 - 38,346,246 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,289,178 - 38,306,359 (+)NCBI
ROS_Cfam_1.01338,802,608 - 38,819,775 (+)NCBI
UMICH_Zoey_3.11338,493,778 - 38,510,924 (+)NCBI
UNSW_CanFamBas_1.01338,603,187 - 38,616,744 (+)NCBI
UU_Cfam_GSD_1.01339,078,181 - 39,095,376 (+)NCBI
Chrna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,579,566 - 118,599,906 (+)NCBI
SpeTri2.0NW_00493647136,427,598 - 36,447,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,721,145 - 4,747,694 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl264,722,489 - 4,737,164 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048137,048,285 - 137,075,017 (-)NCBIVero_WHO_p1.0
Chrna3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248942,324,480 - 2,357,389 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 1 7 2
Below cutoff 8 1 2 4 11 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001958   ⟹   ENSSSCP00000001909
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl747,361,778 - 47,382,736 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053544   ⟹   ENSSSCP00000040005
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl747,361,899 - 47,382,736 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000062231   ⟹   ENSSSCP00000034689
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl747,361,899 - 47,384,303 (+)Ensembl
RefSeq Acc Id: XM_001925760   ⟹   XP_001925795
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1747,361,710 - 47,382,743 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001925795 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC13375 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001925795   ⟸   XM_001925760
- UniProtKB: F1RKU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001909   ⟸   ENSSSCT00000001958
RefSeq Acc Id: ENSSSCP00000034689   ⟸   ENSSSCT00000062231
RefSeq Acc Id: ENSSSCP00000040005   ⟸   ENSSSCT00000053544
Protein Domains
Neur_chan_LBD   Neur_chan_memb


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070020096 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001909 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000034689 UniProtKB/TrEMBL
  ENSSSCP00000040005 UniProtKB/TrEMBL
  ENSSSCP00070033379 UniProtKB/TrEMBL
  ENSSSCP00070033384 UniProtKB/TrEMBL
  ENSSSCP00070033388 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001958 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053544 UniProtKB/TrEMBL
  ENSSSCT00000062231 UniProtKB/TrEMBL
  ENSSSCT00070039853 UniProtKB/TrEMBL
  ENSSSCT00070039858 UniProtKB/TrEMBL
  ENSSSCT00070039863 UniProtKB/TrEMBL
Gene3D-CATH 2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
KEGG Report ssc:100151989 UniProtKB/TrEMBL
NCBI Gene CHRNA3 ENTREZGENE
PANTHER PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/TrEMBL
UniProt A0A286ZT80_PIG UniProtKB/TrEMBL
  A0A287A7Z4_PIG UniProtKB/TrEMBL
  A0A4X1UVB8_PIG UniProtKB/TrEMBL
  A0A4X1UVC3_PIG UniProtKB/TrEMBL
  A0A4X1UX80_PIG UniProtKB/TrEMBL
  F1RKU8 ENTREZGENE, UniProtKB/TrEMBL
  O18763_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86669 ENTREZGENE