CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)

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Gene: CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) Canis lupus familiaris

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Symbol:

CHRNA3

Name:

cholinergic receptor nicotinic alpha 3 subunit

RGD ID:

12204015

Description:

ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); activation of transmembrane receptor protein tyrosine kinase activity (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

neuronal acetylcholine receptor subunit alpha-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	38,330,287 - 38,343,142 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	38,328,814 - 38,346,246 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	38,289,178 - 38,306,359 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	38,802,608 - 38,819,775 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	38,802,250 - 38,833,013 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	38,493,778 - 38,510,924 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	38,603,187 - 38,616,744 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	39,078,181 - 39,095,376 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol dependence (ISO)

alcohol use disorder (ISO)

amyotrophic lateral sclerosis (ISO)

BLADDER DYSFUNCTION, AUTONOMIC, WITH IMPAIRED PUPILLARY REFLEX AND SECONDARY CAKUT (ISO)

Bloom syndrome (ISO)

Carbon Monoxide Poisoning (ISO)

chronic obstructive pulmonary disease (ISO)

cocaine dependence (ISO)

colorectal cancer (ISO)

depressive disorder (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

lung cancer (ISO)

lung carcinoma (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

lung small cell carcinoma (ISO)

nicotine dependence (ISO)

squamous cell carcinoma (ISO)

stomach cancer (ISO)

Tobacco Use Disorder (ISO)

Transplant Rejection (ISO)

visual epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine receptor signaling pathway (ISO)

activation of transmembrane receptor protein tyrosine kinase activity (ISO)

behavioral response to nicotine (IEA,ISO)

excitatory postsynaptic potential (IEA,ISO)

heart development (ISO)

locomotory behavior (ISO)

monoatomic ion transmembrane transport (IEA)

nervous system development (IEA)

presynaptic modulation of chemical synaptic transmission (ISO)

regulation of acetylcholine secretion, neurotransmission (ISO)

regulation of dendrite morphogenesis (ISO)

regulation of membrane potential (ISO)

regulation of muscle contraction (ISO)

regulation of postsynaptic membrane potential (IEA)

regulation of smooth muscle contraction (ISO)

response to acetylcholine (ISO)

response to carbon monoxide (ISO)

response to nicotine (ISO)

response to xenobiotic stimulus (ISO)

signal transduction (IEA)

synaptic transmission involved in micturition (IEA,ISO)

synaptic transmission, cholinergic (IEA,ISO)

Cellular Component

acetylcholine-gated channel complex (IEA,ISO)

cholinergic synapse (ISO)

dendrite (ISO)

dopaminergic synapse (ISO)

Golgi apparatus (IEA)

neuronal cell body (ISO)

nuclear speck (IEA)

plasma membrane (IEA)

plasma membrane raft (ISO)

postsynaptic membrane (IEA)

postsynaptic specialization membrane (ISO)

protein-containing complex (ISO)

synapse (IEA)

Molecular Function

acetylcholine binding (ISO)

acetylcholine receptor activity (IEA,ISO)

acetylcholine-gated monoatomic cation-selective channel activity (IEA,ISO)

heterocyclic compound binding (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

transmembrane signaling receptor activity (IEA)

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

nicotine pharmacodynamics pathway (ISO)

nicotine pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CHRNA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	38,330,287 - 38,343,142 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	38,328,814 - 38,346,246 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	38,289,178 - 38,306,359 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	38,802,608 - 38,819,775 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	38,802,250 - 38,833,013 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	38,493,778 - 38,510,924 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	38,603,187 - 38,616,744 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	39,078,181 - 39,095,376 (+)	NCBI		UU_Cfam_GSD_1.0

CHRNA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	78,593,052 - 78,620,996 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	78,593,052 - 78,621,295 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	78,885,394 - 78,913,338 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	76,674,706 - 76,700,377 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	76,674,706 - 76,700,377	NCBI
Celera	15	55,821,707 - 55,849,902 (-)	NCBI		Celera
Cytogenetic Map	15	q25.1	NCBI
HuRef	15	55,642,483 - 55,671,504 (-)	NCBI		HuRef
CHM1_1	15	79,003,962 - 79,032,196 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	76,455,721 - 76,484,482 (-)	NCBI		T2T-CHM13v2.0

Chrna3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	54,917,401 - 54,933,846 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	54,917,395 - 54,933,846 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	55,010,117 - 55,026,562 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	55,010,111 - 55,026,562 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	54,859,150 - 54,874,366 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	54,809,480 - 54,824,696 (-)	NCBI		MGSCv36	mm8
Celera	9	52,254,751 - 52,269,961 (-)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	29.84	NCBI

Chrna3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	64,297,755 - 64,311,251 (-)	NCBI		GRCr8
mRatBN7.2	8	55,401,668 - 55,415,165 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	55,401,702 - 55,415,165 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	60,943,296 - 60,956,354 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	59,222,294 - 59,235,355 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	57,086,538 - 57,099,598 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	59,594,007 - 59,607,122 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	59,592,403 - 59,607,275 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	58,176,165 - 58,189,008 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	58,570,223 - 58,583,594 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	58,588,997 - 58,602,801 (-)	NCBI
Celera	8	54,888,972 - 54,929,562 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Chrna3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	977,075 - 1,011,372 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	979,630 - 1,011,316 (-)	NCBI	ChiLan1.0	ChiLan1.0

CHRNA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	67,807,750 - 67,835,101 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	71,973,644 - 72,000,975 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	57,523,553 - 57,550,228 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	76,486,416 - 76,513,899 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	76,487,710 - 76,512,044 (-)	Ensembl	panpan1.1		panPan2

Chrna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	118,579,566 - 118,599,906 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	36,427,495 - 36,457,758 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	36,427,598 - 36,447,903 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	47,361,899 - 47,384,303 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	47,361,710 - 47,382,743 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	52,787,929 - 52,806,220 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRNA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	4,721,145 - 4,747,694 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	4,722,489 - 4,737,164 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	137,048,285 - 137,075,017 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrna3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624894	2,324,501 - 2,357,723 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624894	2,324,480 - 2,357,389 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CHRNA3
181 total Variants

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022426919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038493615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038555926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038619851	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038685458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000002686 ⟹ ENSCAFP00000002494

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	13	38,328,814 - 38,342,823 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000002688 ⟹ ENSCAFP00000002496

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	13	38,328,814 - 38,346,246 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845022940 ⟹ ENSCAFP00845017983

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	13	38,802,250 - 38,833,013 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845022969 ⟹ ENSCAFP00845018005

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	13	38,802,250 - 38,826,552 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845023021 ⟹ ENSCAFP00845018048

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	13	38,802,250 - 38,819,486 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845023043 ⟹ ENSCAFP00845018066

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	13	38,803,367 - 38,826,552 (+)	Ensembl

RefSeq Acc Id:

XM_022426919 ⟹ XP_022282627

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	13	38,330,287 - 38,343,142 (+)	NCBI
Dog10K_Boxer_Tasha	13	38,289,178 - 38,306,359 (+)	NCBI

Sequence:

show sequence

TGGTGCTTCCTGGAAGTGGTGGCCATACCTGGGCTGCGTAGCAGGTGAGGGGAGTGCTGGCTCT
CACCCCGGACCCCCCACTAGCAGCCCACCGAGTGGACAGAGGCGATGGATGCTCACAGGTAAAG
AAACAAGTTCCAAGCTTACGCAGCCTCCAGGCAGCCGGGCAGGGTTTGCACCAGATCTACCCAC
CTTCCAGCCCAGGCTTGTGACCACGGTCTCCCCCTGGATGTGTGACCCCGGCTGTCTCATGGGC
CTCAGTTTCCTTCTCTGTAACTCGGGGGGAGTGGGCCTCGTCTGAAGTTTGGAGCTCCACAGGC
CCGTGGTGAGACCGTGGTGGGTGGTGTCCCTGGCCAGGGAAGGGTGACGGCTGCTTCCCTCAGG
GGCCCTGGCCTCCGAGGCTGAGCACCGCCTGTTTGAGCGGCTGTTCGAGGATTACAACGAGATC
ATCCGGCCCGTGGCCAACGTATCGGAACCGGTCATCATCCAGTTCGAGGTGTCCATGTCTCAGC
TGGTGAAGGTGGACGAAGTAAACCAGATCATGGAGACCAACCTGTGGCTGAAACAAATCTGGAA
CGACTACAAGCTGAAGTGGAACCCCGCGGACTACGATGGGGCGGAGTTCATGCGCGTCCCTGCG
CAGAAGATCTGGAAGCCAGACATTGTGCTGTACAACAATGCTGTCGGGGACTTCCAGGTGGATG
ACAAGACCAAAGCTCTCCTCAAGTACACGGGGGAGGTGACTTGGATTCCTCCCGCCATCTTTAA
GAGCTCGTGCAAGATCGACGTGACCTACTTTCCATTTGATTACCAAAATTGCACCATGAAGTTC
GGCTCCTGGTCCTACGACAAGGCCAAAATCGACCTGGTCCTCATCGGCTCCTCCATGAACCTCA
AGGACTACTGGGAGAGCGGCGAGTGGGCCATCATCAAGGCCCCCGGCTACAAGCACGACATCAA
GTACAACTGCTGCGAGGAGATCTACCCCGACATCACGTACTCGCTCTACATCCGCCGCCTGCCG
CTCTTCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTCCTTCCTCACCGTGCTCGTCT
TCTACCTGCCGTCCGACTGCGGCGAGAAGGTGACGCTCTGCATCTCCGTGCTGCTGTCCCTGAC
CGTGTTTCTCCTGGTCATCACCGAGACCATCCCCTCCACCTCGCTGGTCATCCCGCTCATCGGC
GAGTACCTGCTTTTCACCATGATCTTCGTCACGCTGTCCATCGTCATCACGGTCTTCGTGCTCA
ACGTGCATTACAGAACCCCGACCACGCACACGATGCCCACGTGGGTGAAGACCATCTTCCTGCA
CTTGCTTCCCAGGGTCATGTTCATGACCCGTCCGGCAGGCAGCGACGGCCACGCCCAGAAGCCC
AGGCCCTCGTACCACGCAGAGCTCTCCACCCTGAACTGCTTCCGCCGCGCCGAGACCAGAGGCT
GCAAGGAAGGCTGCGCCTGCCAGGACGGCGCATGCAGCCACTGCCGCCACCGCAGGATAAAAAT
CTCCAACTTCAGCGCCAACCTCCCCAGGAGCTCCAGTTCTGAGTCCATCAGTGCCGCGCTATCC
CTCTCGGCCCTGTCACCGGAAATCAAAGAAGCCATCCAGAGCGTCAAGTATATCGCCGAGAACA
TGAAAGCACAAAACGACGCCAAAGAGATCCAGGACGACTGGAAGTATGTTGCCATGGTCATCGA
CCGCATTTTTCTGTGGGTTTTCATCCTGGTGTGCATTCTGGGCACCGCGGGGCTGTTTCTGCAA
CCCCTGCTGGCCAGGGACGACGCCTGAGCGCCCAGCGCTTGCCGGGGCCGTTCTCGTGGGGGGG
ATGGGCGGCTCTCCCGTGGGGAAGTGCACGGATCCGCGGCTGTTGCCATCTTCATCCTCTCTGG
GCGCGCAGGTCCTGGTGGGACACACCGTGGCGCTGCCACGCAGTCCCCCCACCCCCACCCCCGC
GCCCAGGTGCTCGGCTTGTAGGACCTCGCCTACCTTGCCCCACACGAGCCAACGCGCAGGGTCT
GTCCTTCTGTGACCAGCCTATTTCATGGATCAGAATGTCCTCAAGGCTCCGCCGTGTCGCAGCA
GGTGTCAGACGTCCTTGTCTCCAAGG

hide sequence

RefSeq Acc Id:

XM_038493615 ⟹ XP_038349543

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	13	38,493,778 - 38,510,924 (+)	NCBI

RefSeq Acc Id:

XM_038555926 ⟹ XP_038411854

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	13	39,078,181 - 39,095,376 (+)	NCBI

RefSeq Acc Id:

XM_038619851 ⟹ XP_038475779

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	13	38,603,187 - 38,616,744 (+)	NCBI

RefSeq Acc Id:

XM_038685458 ⟹ XP_038541386

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	13	38,802,608 - 38,819,775 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_022282627	(Get FASTA)	NCBI Sequence Viewer
	XP_038349543	(Get FASTA)	NCBI Sequence Viewer
	XP_038411854	(Get FASTA)	NCBI Sequence Viewer
	XP_038475779	(Get FASTA)	NCBI Sequence Viewer
	XP_038541386	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000002494.4
	ENSCAFP00000002496.5
	ENSCAFP00000070751.1
	ENSCAFP00000073481.1
	ENSCAFP00030010277.1
	ENSCAFP00030010299.1
	ENSCAFP00030010322.1
	ENSCAFP00030010340.1
	ENSCAFP00040035990.1
	ENSCAFP00040035996.1
	ENSCAFP00040036006.1
	ENSCAFP00040036021.1
	ENSCAFP00845017983.1
	ENSCAFP00845018005.1
	ENSCAFP00845018048
	ENSCAFP00845018048.1
	ENSCAFP00845018066.1

RefSeq Acc Id:

XP_022282627 ⟸ XM_022426919

- UniProtKB:

A0A8C0MDY6 (UniProtKB/TrEMBL), A0A8C0L9H4 (UniProtKB/TrEMBL), A0A8I3NK72 (UniProtKB/TrEMBL), A0A8C0Z4I5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPADYDGAEFMRVPAQKIWKPDIVLYNNAVGDF
QVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSS
MNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLT
VLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITV
FVLNVHYRTPTTHTMPTWVKTIFLHLLPRVMFMTRPAGSDGHAQKPRPSYHAELSTLNCFRRAE
TRGCKEGCACQDGACSHCRHRRIKISNFSANLPRSSSSESISAALSLSALSPEIKEAIQSVKYI
AENMKAQNDAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLLARDDA

hide sequence

Ensembl Acc Id:

ENSCAFP00000002494 ⟸ ENSCAFT00000002686

Ensembl Acc Id:

ENSCAFP00000002496 ⟸ ENSCAFT00000002688

RefSeq Acc Id:

XP_038349543 ⟸ XM_038493615

RefSeq Acc Id:

XP_038475779 ⟸ XM_038619851

RefSeq Acc Id:	XP_038541386 ⟸ XM_038685458
- UniProtKB:	A0A8C0MDY6 (UniProtKB/TrEMBL), A0A8C0L9H4 (UniProtKB/TrEMBL), A0A8I3NK72 (UniProtKB/TrEMBL), A0A8C0Z4I5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038411854 ⟸ XM_038555926
- UniProtKB:	A0A8C0L9H4 (UniProtKB/TrEMBL), A0A8C0MDY6 (UniProtKB/TrEMBL), A0A8C0Z4I5 (UniProtKB/TrEMBL), A0A8I3NK72 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845018005 ⟸ ENSCAFT00845022969

Ensembl Acc Id:

ENSCAFP00845018066 ⟸ ENSCAFT00845023043

Ensembl Acc Id:

ENSCAFP00845018048 ⟸ ENSCAFT00845023021

Ensembl Acc Id:

ENSCAFP00845017983 ⟸ ENSCAFT00845022940

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000001710	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030006401	UniProtKB/TrEMBL
	ENSCAFG00040022241	UniProtKB/TrEMBL
	ENSCAFG00845012908	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000002686.4	UniProtKB/TrEMBL
	ENSCAFT00000002688.6	UniProtKB/TrEMBL
	ENSCAFT00000099962.1	UniProtKB/TrEMBL
	ENSCAFT00000100095.1	UniProtKB/TrEMBL
	ENSCAFT00030011737.1	UniProtKB/TrEMBL
	ENSCAFT00030011760.1	UniProtKB/TrEMBL
	ENSCAFT00030011783.1	UniProtKB/TrEMBL
	ENSCAFT00030011801.1	UniProtKB/TrEMBL
	ENSCAFT00040041271.1	UniProtKB/TrEMBL
	ENSCAFT00040041279.1	UniProtKB/TrEMBL
	ENSCAFT00040041290.1	UniProtKB/TrEMBL
	ENSCAFT00040041304.1	UniProtKB/TrEMBL
	ENSCAFT00845022940.1	UniProtKB/TrEMBL
	ENSCAFT00845022969.1	UniProtKB/TrEMBL
	ENSCAFT00845023021	ENTREZGENE
	ENSCAFT00845023021.1	UniProtKB/TrEMBL
	ENSCAFT00845023043.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.390	UniProtKB/TrEMBL
	2.70.170.10	UniProtKB/TrEMBL
InterPro	Neur_chan_lig-bd	UniProtKB/TrEMBL
	Neur_chan_lig-bd_sf	UniProtKB/TrEMBL
	Neur_channel	UniProtKB/TrEMBL
	Neuro-gated_channel_TM_sf	UniProtKB/TrEMBL
	Neuro_actylchol_rec	UniProtKB/TrEMBL
	Neurotrans-gated_channel_TM	UniProtKB/TrEMBL
	Neurotransmitter_ion_chnl_CS	UniProtKB/TrEMBL
	Nicotinic_acetylcholine_rcpt	UniProtKB/TrEMBL
NCBI Gene	CHRNA3	ENTREZGENE
PANTHER	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3	UniProtKB/TrEMBL
	PTHR18945	UniProtKB/TrEMBL
Pfam	Neur_chan_LBD	UniProtKB/TrEMBL
	Neur_chan_memb	UniProtKB/TrEMBL
PRINTS	NICOTINICR	UniProtKB/TrEMBL
	NRIONCHANNEL	UniProtKB/TrEMBL
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63712	UniProtKB/TrEMBL
	SSF90112	UniProtKB/TrEMBL
UniProt	A0A8C0L9H4	ENTREZGENE
	A0A8C0MDY6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0MJG1_CANLF	UniProtKB/TrEMBL
	A0A8C0MK68_CANLF	UniProtKB/TrEMBL
	A0A8C0Z4I5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NK72	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NYJ7_CANLF	UniProtKB/TrEMBL
	A0A8I3NYN9_CANLF	UniProtKB/TrEMBL
	A0A8I3RZQ0_CANLF	UniProtKB/TrEMBL
	A0A8P0S7L2_CANLF	UniProtKB/TrEMBL
	A0A8P0S7L3_CANLF	UniProtKB/TrEMBL
	A0A8P0TNX2_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:39238	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB