CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) - Rat Genome Database

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Gene: CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) Chlorocebus sabaeus
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Symbol: CHRNA3
Name: cholinergic receptor nicotinic alpha 3 subunit
RGD ID: 18461352
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); activation of transmembrane receptor protein tyrosine kinase activity (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuronal acetylcholine receptor subunit alpha-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,721,145 - 4,747,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,722,489 - 4,737,164 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,048,285 - 137,075,017 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHRNA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,721,145 - 4,747,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,722,489 - 4,737,164 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,048,285 - 137,075,017 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CHRNA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,593,052 - 78,620,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,593,052 - 78,621,295 (-)EnsemblGRCh38hg38GRCh38
GRCh371578,885,394 - 78,913,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,674,706 - 76,700,377 (-)NCBINCBI36Build 36hg18NCBI36
Build 341576,674,706 - 76,700,377NCBI
Celera1555,821,707 - 55,849,902 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,642,483 - 55,671,504 (-)NCBIHuRef
CHM1_11579,003,962 - 79,032,196 (-)NCBICHM1_1
T2T-CHM13v2.01576,455,721 - 76,484,482 (-)NCBIT2T-CHM13v2.0
Chrna3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,917,401 - 54,933,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,917,395 - 54,933,846 (-)EnsemblGRCm39 Ensembl
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBIMGSCv36mm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
Chrna3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,297,755 - 64,311,251 (-)NCBIGRCr8
mRatBN7.2855,401,668 - 55,415,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,401,702 - 55,415,165 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,943,296 - 60,956,354 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,222,294 - 59,235,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,086,538 - 57,099,598 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,594,007 - 59,607,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,176,165 - 58,189,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,570,223 - 58,583,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,588,997 - 58,602,801 (-)NCBI
Celera854,888,972 - 54,929,562 (-)NCBICelera
Cytogenetic Map8q24NCBI
Chrna3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450977,075 - 1,011,372 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955450979,630 - 1,011,316 (-)NCBIChiLan1.0ChiLan1.0
CHRNA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,807,750 - 67,835,101 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,973,644 - 72,000,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,523,553 - 57,550,228 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,486,416 - 76,513,899 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,487,710 - 76,512,044 (-)Ensemblpanpan1.1panPan2
CHRNA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,330,287 - 38,343,142 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,328,814 - 38,346,246 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,289,178 - 38,306,359 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,802,608 - 38,819,775 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,802,250 - 38,833,013 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,493,778 - 38,510,924 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,603,187 - 38,616,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,078,181 - 39,095,376 (+)NCBIUU_Cfam_GSD_1.0
Chrna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,579,566 - 118,599,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,427,495 - 36,457,758 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,427,598 - 36,447,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,361,899 - 47,384,303 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,361,710 - 47,382,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,787,929 - 52,806,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Chrna3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,324,501 - 2,357,723 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248942,324,480 - 2,357,389 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSCSAT00000013087   ⟹   ENSCSAP00000011100
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl264,722,489 - 4,737,164 (+)Ensembl
RefSeq Acc Id: XM_008015706   ⟹   XP_008013897
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1264,721,145 - 4,747,694 (+)NCBI
Vero_WHO_p1.0NW_023666048137,048,285 - 137,075,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015707   ⟹   XP_008013898
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1264,721,297 - 4,747,694 (+)NCBI
Vero_WHO_p1.0NW_023666048137,048,285 - 137,074,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038010229   ⟹   XP_037866157
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666048137,059,992 - 137,075,017 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008013897 (Get FASTA)   NCBI Sequence Viewer  
  XP_008013898 (Get FASTA)   NCBI Sequence Viewer  
  XP_037866157 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011100.1
RefSeq Acc Id: XP_008013897   ⟸   XM_008015706
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RR61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008013898   ⟸   XM_008015707
- Peptide Label: isoform X3
Ensembl Acc Id: ENSCSAP00000011100   ⟸   ENSCSAT00000013087
RefSeq Acc Id: XP_037866157   ⟸   XM_038010229
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RR61 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014992 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013087.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
NCBI Gene CHRNA3 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 UniProtKB/TrEMBL
  PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
UniProt A0A0D9RR61 ENTREZGENE, UniProtKB/TrEMBL