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Gene: DERL3 (derlin 3) Homo sapiens
Symbol: DERL3
Name: derlin 3
Description: Predicted to have misfolded protein binding activity and ubiquitin-specific protease binding activity. Involved in cellular protein metabolic process; endoplasmic reticulum unfolded protein response; and negative regulation of retrograde protein transport, ER to cytosol. Localizes to integral component of endoplasmic reticulum membrane. Colocalizes with signal recognition particle and signal recognition particle receptor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C22orf14; degradation in endoplasmic reticulum protein 3; Der1-like domain family, member 3; der1-like protein 3; derlin-3; DERtrin 3; DERtrin-3; IZP6; LLN2; MGC71803
Mus musculus (house mouse) : Derl3 (Der1-like domain family, member 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Derl3 (derlin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Derl3 (derlin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DERL3 (derlin 3)
Canis lupus familiaris (dog) : DERL3 (derlin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Derl3 (derlin 3)
Sus scrofa (pig) : DERL3 (derlin 3)
Chlorocebus sabaeus (African green monkey) : DERL3 (derlin 3)
Heterocephalus glaber (naked mole-rat) : Derl3 (derlin 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2223,834,503 - 23,839,128 (-)EnsemblGRCh38hg38GRCh38
GRCh382223,834,498 - 23,839,348 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,176,690 - 24,181,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,506,690 - 22,511,201 (-)NCBINCBI36hg18NCBI36
Build 342222,501,245 - 22,505,755NCBI
Celera228,015,749 - 8,020,256 (-)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,164,611 - 7,169,120 (-)NCBIHuRef
CHM1_12224,188,905 - 24,193,409 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DERL3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353725
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.