DERL3 (derlin 3) - Rat Genome Database

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Gene: DERL3 (derlin 3) Chlorocebus sabaeus
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Symbol: DERL3
Name: derlin 3
RGD ID: 18582852
Description: ENCODES a protein that exhibits misfolded protein binding (inferred); protein-containing complex binding (inferred); signal recognition particle binding (inferred); INVOLVED IN endoplasmic reticulum unfolded protein response (inferred); ERAD pathway (inferred); negative regulation of retrograde protein transport, ER to cytosol (inferred); ASSOCIATED WITH agammaglobulinemia 2 (ortholog); atypical teratoid rhabdoid tumor (ortholog); Coffin-Siris syndrome 3 (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); Hrd1p ubiquitin ligase ERAD-L complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: derlin-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,944,291 - 6,949,948 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,947,403 - 6,949,845 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100423,257 - 428,076 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DERL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,944,291 - 6,949,948 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,947,403 - 6,949,845 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100423,257 - 428,076 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DERL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,834,503 - 23,839,006 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,834,503 - 23,839,128 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,176,690 - 24,181,193 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,506,690 - 22,511,201 (-)NCBINCBI36Build 36hg18NCBI36
Build 342222,501,245 - 22,505,755NCBI
Celera228,015,749 - 8,020,256 (-)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,164,611 - 7,169,120 (-)NCBIHuRef
CHM1_12224,188,905 - 24,193,409 (-)NCBICHM1_1
T2T-CHM13v2.02224,281,689 - 24,286,190 (-)NCBIT2T-CHM13v2.0
Derl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,729,232 - 75,731,775 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,729,247 - 75,731,775 (+)EnsemblGRCm39 Ensembl
GRCm381075,893,398 - 75,895,941 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,893,413 - 75,895,941 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,356,143 - 75,358,686 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,337,114 - 75,339,657 (+)NCBIMGSCv36mm8
Celera1076,938,087 - 76,940,630 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.61NCBI
Derl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,753,926 - 12,766,478 (-)NCBIGRCr8
mRatBN7.22012,754,490 - 12,768,454 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,763,543 - 12,767,027 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,471,091 - 13,473,652 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,832,012 - 12,834,573 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,303,805 - 13,306,366 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,692,102 - 13,707,645 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,704,314 - 13,706,205 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,858,297 - 15,863,183 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,163,287 - 13,165,848 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2014,255,751 - 14,258,312 (-)NCBICelera
Cytogenetic Map20p12NCBI
Derl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,415,839 - 8,421,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,415,868 - 8,418,753 (+)NCBIChiLan1.0ChiLan1.0
DERL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22333,565,313 - 33,570,562 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,301,966 - 36,307,067 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,589,448 - 4,594,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,673,908 - 22,678,451 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,673,908 - 22,678,444 (-)Ensemblpanpan1.1panPan2
DERL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,688,307 - 28,690,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,688,106 - 28,690,400 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,761,400 - 27,763,725 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,093,061 - 30,095,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,093,129 - 30,095,386 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,174,380 - 28,176,705 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,792,314 - 27,794,639 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,780,177 - 28,785,974 (+)NCBIUU_Cfam_GSD_1.0
Derl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,478,848 - 141,482,070 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,271,797 - 1,275,214 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,271,980 - 1,275,212 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DERL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,871,218 - 49,877,672 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,871,077 - 49,875,022 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,313,332 - 53,315,464 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Derl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,357,627 - 10,359,779 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,357,560 - 10,359,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 20
Low 16 20 40
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000009368   ⟹   ENSCSAP00000007486
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl196,947,403 - 6,949,845 (-)Ensembl
RefSeq Acc Id: XM_007975104   ⟹   XP_007973295
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1196,947,596 - 6,949,941 (-)NCBI
Vero_WHO_p1.0NW_023666100423,293 - 425,468 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007975107   ⟹   XP_007973298
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1196,947,265 - 6,949,918 (-)NCBI
Vero_WHO_p1.0NW_023666100423,318 - 428,076 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007975108   ⟹   XP_007973299
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1196,947,265 - 6,949,936 (-)NCBI
Vero_WHO_p1.0NW_023666100423,302 - 428,076 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007975109   ⟹   XP_007973300
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1196,945,103 - 6,949,932 (-)NCBI
Vero_WHO_p1.0NW_023666100423,304 - 428,076 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037995403   ⟹   XP_037851331
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666100423,302 - 428,076 (+)NCBI
RefSeq Acc Id: XM_037995404   ⟹   XP_037851332
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666100423,257 - 425,468 (+)NCBI
RefSeq Acc Id: XP_007973300   ⟸   XM_007975109
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007973299   ⟸   XM_007975108
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007973298   ⟸   XM_007975107
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RFU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007973295   ⟸   XM_007975104
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000007486   ⟸   ENSCSAT00000009368
RefSeq Acc Id: XP_037851332   ⟸   XM_037995404
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037851331   ⟸   XM_037995403
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011282 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009368.1 UniProtKB/TrEMBL
InterPro DER1 UniProtKB/TrEMBL
  Rhomboid-like_sf UniProtKB/TrEMBL
NCBI Gene DERL3 ENTREZGENE
PANTHER DER1-LIKE PROTEIN, DERLIN UniProtKB/TrEMBL
  DERLIN-3 UniProtKB/TrEMBL
Pfam DER1 UniProtKB/TrEMBL
Superfamily-SCOP SSF144091 UniProtKB/TrEMBL
UniProt A0A0D9RFU7 ENTREZGENE, UniProtKB/TrEMBL