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Gene: PLD4 (phospholipase D family member 4) Homo sapiens
Symbol: PLD4
Name: phospholipase D family member 4
Description: Predicted to have single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to localize to several cellular components, including cytoplasmic vesicle; endoplasmic reticulum membrane; and trans-Golgi network membrane; INTERACTS WITH diazinon; disodium selenite; fonofos.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5'-3' exonuclease PLD4; C14orf175; choline phosphatase 4; chromosome 14 open reading frame 175; phosphatidylcholine-hydrolyzing phospholipase D4; phospholipase D family, member 4; phospholipase D4; PLD 4
Mus musculus (house mouse) : Pld4 (phospholipase D family, member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pld4 (phospholipase D family, member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pld4 (phospholipase D family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PLD4 (phospholipase D family member 4)
Canis lupus familiaris (dog) : PLD4 (phospholipase D family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pld4 (phospholipase D family member 4)
Sus scrofa (pig) : PLD4 (phospholipase D family member 4)
Chlorocebus sabaeus (African green monkey) : PLD4 (phospholipase D family member 4)
Heterocephalus glaber (naked mole-rat) : Pld4 (phospholipase D family member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl14104,924,713 - 104,937,790 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl14104,924,713 - 104,937,761 (+)EnsemblGRCh38hg38GRCh38
GRCh3814104,924,301 - 104,937,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714105,391,153 - 105,399,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,462,232 - 104,470,618 (+)NCBINCBI36hg18NCBI36
Build 3414104,462,268 - 104,470,618NCBI
Celera1485,445,332 - 85,453,718 (+)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1485,585,008 - 85,593,394 (+)NCBIHuRef
CHM1_114105,328,617 - 105,337,037 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PLD4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347934
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.