ARL2BP (ARF like GTPase 2 binding protein) - Rat Genome Database

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Gene: ARL2BP (ARF like GTPase 2 binding protein) Homo sapiens
Analyze
Symbol: ARL2BP
Name: ARF like GTPase 2 binding protein (Ensembl:ADP ribosylation factor like GTPase 2 binding protein)
RGD ID: 1344137
HGNC Page HGNC:17146
Description: Enables transcription coactivator activity. Involved in maintenance of protein location in nucleus and positive regulation of tyrosine phosphorylation of STAT protein. Located in several cellular components, including microtubule organizing center; midbody; and mitochondrial intermembrane space. Implicated in retinitis pigmentosa with or without situs inversus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ADP ribosylation factor like GTPase 2 binding protein; ADP-ribosylation factor-like protein 2-binding protein; Arf-like 2 binding protein BART1; ARF-like 2-binding protein; ARL2-binding protein; BART; BART1; binder of ARF2 protein 1; binder of Arl Two; binder of Arl2; retinitis pigmentosa 66 (autosomal recessive); RP66; RP82
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: ARL2BPP1   ARL2BPP10   ARL2BPP2   ARL2BPP3   ARL2BPP4   ARL2BPP5   ARL2BPP6   ARL2BPP7   ARL2BPP8   ARL2BPP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,245,259 - 57,253,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,245,259 - 57,253,635 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,279,171 - 57,287,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,836,539 - 55,845,046 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,836,538 - 55,845,046NCBI
Celera1641,778,726 - 41,787,233 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1643,148,688 - 43,157,185 (+)NCBIHuRef
CHM1_11658,687,284 - 58,695,791 (+)NCBICHM1_1
T2T-CHM13v2.01663,041,248 - 63,049,621 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 24 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ARL2BPHumanBardet-Biedl syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:11285252 more ...
ARL2BPHumanChromosome 16q12 Duplication Syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868
ARL2BPHumandevelopmental and epileptic encephalopathy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:11285252 more ...
ARL2BPHumanearly infantile epileptic encephalopathy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:11285252 more ...
ARL2BPHumanfundus dystrophy  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:28492532
ARL2BPHumanfundus dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868
ARL2BPHumanfundus dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868 and PMID:28492532
ARL2BPHumanfundus dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868 more ...
ARL2BPHumanfundus dystrophy  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Retinal dystrophyClinVar 
ARL2BPHumangenetic disease  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
ARL2BPHumangenetic disease  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
ARL2BPHumangenetic disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
ARL2BPHumanretinitis pigmentosa  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVar 
ARL2BPHumanretinitis pigmentosa  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVarPMID:25741868 more ...
ARL2BPHumanretinitis pigmentosa  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive retinitis pigmentosaClinVarPMID:27790702
ARL2BPHumanretinitis pigmentosa  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVarPMID:23849777
ARL2BPHumanretinitis pigmentosa with or without situs inversus  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: ARL2BP-related conditionClinVarPMID:28492532
ARL2BPHumanretinitis pigmentosa with or without situs inversus  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosa with or without situs inversusClinVarPMID:25741868 more ...
ARL2BPHumanretinitis pigmentosa with or without situs inversus  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosa with or without situs inversusClinVarPMID:38649918
ARL2BPHumanretinitis pigmentosa with or without situs inversus  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosa with or without situs inversusClinVarPMID:25741868 more ...
1 to 20 of 24 rows
Object Symbol
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Reference
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Original Reference(s)
ARL2BPHumanmale infertility  ISSArl2bp (Mus musculus)13592920 MouseDO 
ARL2BPHumanretinitis pigmentosa with or without situs inversus  ISSArl2bp (Mus musculus)13592920OMIM:615434MouseDO 
Object Symbol
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Qualifier
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Reference
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Original Reference(s)
ARL2BPHumanretinitis pigmentosa with or without situs inversus  IAGP 7240710 OMIM 

1 to 20 of 55 rows

  
Object Symbol
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Evidence
With
Reference
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Original Reference(s)
ARL2BPHuman1,2-dimethylhydrazine multiple interactionsISOArl2bp (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of ARL2BP mRNA]CTDPMID:22206623
ARL2BPHuman17alpha-ethynylestradiol affects expressionISOArl2bp (Mus musculus)6480464Ethinyl Estradiol affects the expression of ARL2BP mRNACTDPMID:17555576
ARL2BPHuman17alpha-ethynylestradiol multiple interactionsISOArl2bp (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARL2BP mRNACTDPMID:17942748
ARL2BPHuman17alpha-ethynylestradiol increases expressionISOArl2bp (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ARL2BP mRNACTDPMID:17942748
ARL2BPHuman17beta-estradiol increases expressionISOArl2bp (Mus musculus)6480464Estradiol results in increased expression of ARL2BP mRNACTDPMID:39298647
ARL2BPHuman2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOArl2bp (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARL2BP mRNACTDPMID:17942748
ARL2BPHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOArl2bp (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of ARL2BP mRNACTDPMID:33387578
ARL2BPHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionISOArl2bp (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ARL2BP mRNACTDPMID:26290441
ARL2BPHuman2,3,7,8-tetrachlorodibenzodioxine affects expressionISOArl2bp (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ARL2BP mRNACTDPMID:21570461 more ...
ARL2BPHuman2,3,7,8-tetrachlorodibenzodioxine affects expressionISOArl2bp (Rattus norvegicus)6480464Tetrachlorodibenzodioxin affects the expression of ARL2BP mRNACTDPMID:22298810
ARL2BPHuman3-isobutyl-1-methyl-7H-xanthine multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARL2BP mRNACTDPMID:28628672
ARL2BPHuman4,4'-sulfonyldiphenol increases expressionISOArl2bp (Mus musculus)6480464bisphenol S results in increased expression of ARL2BP mRNACTDPMID:39298647
ARL2BPHumanamitrole decreases expressionISOArl2bp (Rattus norvegicus)6480464Amitrole results in decreased expression of ARL2BP mRNACTDPMID:38685447
ARL2BPHumanantirheumatic drug increases expressionEXP 6480464Antirheumatic Agents results in increased expression of ARL2BP mRNACTDPMID:24449571
ARL2BPHumanbenzo[a]pyrene decreases expressionISOArl2bp (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of ARL2BP mRNACTDPMID:22228805
ARL2BPHumanbenzo[a]pyrene increases expressionISOArl2bp (Mus musculus)6480464Benzo(a)pyrene results in increased expression of ARL2BP mRNACTDPMID:22228805
ARL2BPHumanbenzo[a]pyrene diol epoxide I increases expressionEXP 64804647 more ...CTDPMID:19150397
ARL2BPHumanbisphenol A increases expressionISOArl2bp (Rattus norvegicus)6480464bisphenol A results in increased expression of ARL2BP mRNACTDPMID:25181051
ARL2BPHumanbisphenol A decreases expressionISOArl2bp (Rattus norvegicus)6480464bisphenol A results in decreased expression of ARL2BP mRNACTDPMID:34947998
ARL2BPHumanbisphenol F multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARL2BP mRNACTDPMID:28628672

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Biological Process

  

Cellular Component
1 to 20 of 23 rows

  
Object Symbol
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Term
Qualifier
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Source
Original Reference(s)
ARL2BPHumancell projection located_inIEAUniProtKB-KW:KW-0966150520179 UniProtGO_REF:0000043
ARL2BPHumancentrosome located_inIEAUniProtKB-SubCell:SL-0048150520179 UniProtGO_REF:0000044
ARL2BPHumancentrosome located_inIDA 150520179 PMID:16525022UniProtGO_REF:0000052 and PMID:16525022
ARL2BPHumanciliary basal body located_inIDA 150520179 HPAGO_REF:0000052
ARL2BPHumancilium located_inIEAUniProtKB-KW:KW-0969150520179 UniProtGO_REF:0000043
ARL2BPHumancilium located_inIEAUniRule:UR001426787150520179 UniProtGO_REF:0000104
ARL2BPHumancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
ARL2BPHumancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
ARL2BPHumancytoskeleton located_inIEAUniProtKB-KW:KW-0206150520179 UniProtGO_REF:0000043
ARL2BPHumancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-5250210 and Reactome:R-HSA-5250217
ARL2BPHumancytosol located_inIDA 150520179 HPAGO_REF:0000052
ARL2BPHumanmidbody located_inIDA 150520179 PMID:16525022UniProtPMID:16525022
ARL2BPHumanmitochondrial intermembrane space located_inIEAUniRule:UR001426787150520179 UniProtGO_REF:0000104
ARL2BPHumanmitochondrial intermembrane space is_active_inIBAPANTHER:PTN000397975 more ...150520179 GO_CentralGO_REF:0000033
ARL2BPHumanmitochondrial intermembrane space located_inIEAUniProtKB-SubCell:SL-0169150520179 UniProtGO_REF:0000044
ARL2BPHumanmitochondrial intermembrane space located_inIDA 150520179 PMID:11809823UniProtPMID:11809823
ARL2BPHumanmitochondrial matrix located_inTAS 150520179 ReactomeReactome:R-HSA-5250209 more ...
ARL2BPHumanmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
ARL2BPHumannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
ARL2BPHumannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
1 to 20 of 23 rows

1 to 20 of 46 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ARL2BPHumanAbnormal central response of multifocal electroretinogram  IAGP 8699517 HPOORPHA:791
ARL2BPHumanAbnormal electroretinogram  IAGP 8699517 HPOORPHA:791
ARL2BPHumanAbnormal full-field electroretinogram  IAGP 8699517 HPOORPHA:791
ARL2BPHumanAbnormal retinal vascular morphology  IAGP 8699517 HPOORPHA:791
ARL2BPHumanAbnormality of retinal pigmentation  IAGP 8699517 HPOORPHA:791
ARL2BPHumanAttenuation of retinal blood vessels  IAGP 8699517 HPOORPHA:791
ARL2BPHumanAutosomal recessive inheritance  IAGP 8699517 HPOMIM:615434
ARL2BPHumanBlindness  IAGP 8699517 HPOORPHA:791
ARL2BPHumanBone spicule pigmentation of the retina  IAGP 8699517 HPOORPHA:791
ARL2BPHumanBronchiectasis  IAGP 8699517 HPOMIM:615434
ARL2BPHumanColor vision defect  IAGP 8699517 HPOORPHA:791
ARL2BPHumanConductive hearing impairment  IAGP 8699517 HPOORPHA:791
ARL2BPHumanCystoid macular edema  IAGP 8699517 HPOORPHA:791
ARL2BPHumanDecreased nasal nitric oxide  IAGP 8699517 HPOMIM:615434
ARL2BPHumanGlaucoma  IAGP 8699517 HPOORPHA:791
ARL2BPHumanHyperinsulinemia  IAGP 8699517 HPOORPHA:791
ARL2BPHumanKeratoconus  IAGP 8699517 HPOORPHA:791
ARL2BPHumanMacular atrophy  IAGP 8699517 HPOMIM:615434
ARL2BPHumanNasal congestion  IAGP 8699517 HPOMIM:615434
ARL2BPHumanNeonatal onset  IAGP 8699517 HPOMIM:615434
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868 and PMID:28492532
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868 more ...
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:28492532
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVar 
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVar 
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVar 
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:28492532
ARL2BPHumanRetinal dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:28492532
ARL2BPHumanRod-cone dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVar 
ARL2BPHumanRod-cone dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVarPMID:25741868 more ...
ARL2BPHumanRod-cone dystrophy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVarPMID:23849777
1 to 12 of 12 rows

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
PMID:10488091   PMID:11303027   PMID:11809823   PMID:11847227   PMID:12477932   PMID:16525022   PMID:18234692   PMID:18981177   PMID:19322201   PMID:19368893   PMID:20301590   PMID:20936779  
PMID:21665939   PMID:21833473   PMID:21873635   PMID:21901094   PMID:21988832   PMID:22532868   PMID:22658674   PMID:22745590   PMID:23685147   PMID:23849777   PMID:24899173   PMID:25416956  
PMID:25502805   PMID:26135619   PMID:26186194   PMID:26455799   PMID:27107012   PMID:27173435   PMID:27790702   PMID:28514442   PMID:29997244   PMID:30210231   PMID:31425546   PMID:31515488  
PMID:32296183   PMID:32814053   PMID:33438581   PMID:33961781   PMID:34681596   PMID:34917906   PMID:35271311  



ARL2BP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,245,259 - 57,253,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,245,259 - 57,253,635 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,279,171 - 57,287,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,836,539 - 55,845,046 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,836,538 - 55,845,046NCBI
Celera1641,778,726 - 41,787,233 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1643,148,688 - 43,157,185 (+)NCBIHuRef
CHM1_11658,687,284 - 58,695,791 (+)NCBICHM1_1
T2T-CHM13v2.01663,041,248 - 63,049,621 (+)NCBIT2T-CHM13v2.0
Arl2bp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,393,228 - 95,401,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,393,228 - 95,401,053 (+)EnsemblGRCm39 Ensembl
GRCm38894,666,600 - 94,674,457 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,666,600 - 94,674,425 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,190,655 - 97,198,322 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,555,884 - 97,563,551 (+)NCBIMGSCv36mm8
Celera898,995,245 - 99,002,895 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.65NCBI
Arl2bp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,342,895 - 10,352,529 (-)NCBIGRCr8
mRatBN7.21910,336,921 - 10,346,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,336,921 - 10,346,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,300,195 - 10,309,713 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,067,044 - 11,076,562 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,353,992 - 10,363,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,753,670 - 10,763,247 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,753,681 - 10,763,110 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,747,782 - 10,757,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,777,163 - 10,786,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1910,226,305 - 10,235,761 (-)NCBICelera
Cytogenetic Map19p13NCBI
Arl2bp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543314,887,094 - 14,894,119 (+)NCBIChiLan1.0ChiLan1.0
ARL2BP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,714,280 - 66,722,836 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,635,053 - 72,643,602 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,520,140 - 37,528,634 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,653,883 - 56,661,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,653,742 - 56,661,404 (+)Ensemblpanpan1.1panPan2
ARL2BP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,127,139 - 59,133,993 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,128,323 - 59,133,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,754,660 - 55,762,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,664,788 - 59,672,205 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,665,634 - 59,672,310 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,496,410 - 56,503,621 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,503,458 - 57,510,873 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,397,522 - 58,404,950 (-)NCBIUU_Cfam_GSD_1.0
Arl2bp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,236,986 - 50,245,702 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,343,336 - 9,352,065 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,343,333 - 9,352,089 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARL2BP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,207,071 - 19,223,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,207,013 - 19,215,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,197,974 - 17,205,969 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARL2BP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,192,283 - 43,200,113 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,192,287 - 43,201,681 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,118,182 - 33,127,306 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arl2bp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474628,798,870 - 28,805,988 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in ARL2BP
98 total Variants

1 to 10 of 132 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_012106.4(ARL2BP):c.101-1G>C single nucleotide variant Autosomal recessive retinitis pigmentosa [RCV001257802]|Retinitis pigmentosa [RCV001002870]|Retinitis pigmentosa with or without situs inversus [RCV000055664] Chr16:57248536 [GRCh38]
Chr16:57282448 [GRCh37]
Chr16:16q13		 pathogenic
NM_012106.4(ARL2BP):c.134T>G (p.Met45Arg) single nucleotide variant Retinitis pigmentosa with or without situs inversus [RCV000055665]|not provided [RCV001235488] Chr16:57248570 [GRCh38]
Chr16:57282482 [GRCh37]
Chr16:16q13		 pathogenic|uncertain significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2		 pathogenic
GRCh38/hg38 16q12.2-21(chr16:55457477-63841622)x1 copy number loss See cases [RCV000133738] Chr16:55457477..63841622 [GRCh38]
Chr16:55491389..63875526 [GRCh37]
Chr16:54048890..62433027 [NCBI36]
Chr16:16q12.2-21		 pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3		 pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3		 uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Breast ductal adenocarcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2		 likely pathogenic|uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
1 to 10 of 132 rows

Predicted Target Of
Summary Value
Count of predictions:1066
Count of miRNA genes:529
Interacting mature miRNAs:565
Transcripts:ENST00000219204, ENST00000562023, ENST00000563234, ENST00000565794
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

G06868  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371657,287,133 - 57,287,466UniSTSGRCh37
Build 361655,844,634 - 55,844,967RGDNCBI36
Celera1641,786,821 - 41,787,154RGD
Cytogenetic Map16q13UniSTS
HuRef1643,156,773 - 43,157,106UniSTS
SHGC-33383  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371780,533,448 - 80,533,598UniSTSGRCh37
GRCh371657,286,689 - 57,286,838UniSTSGRCh37
Build 361655,844,190 - 55,844,339RGDNCBI36
Celera1641,786,377 - 41,786,526RGD
Celera1777,124,195 - 77,124,345UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map16q13UniSTS
HuRef1775,930,782 - 75,930,932UniSTS
HuRef1643,156,329 - 43,156,478UniSTS
TNG Radiation Hybrid Map1623552.0UniSTS
STS-W69175  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371657,286,576 - 57,286,823UniSTSGRCh37
Build 361655,844,077 - 55,844,324RGDNCBI36
Celera1641,786,264 - 41,786,511RGD
Cytogenetic Map16q13UniSTS
HuRef1643,156,216 - 43,156,463UniSTS
GeneMap99-GB4 RH Map16362.87UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2251 4972 1719 2345 6 618 1946 459 2270 7291 6464 53 3733 1 851 1743 1617 174 1


1 to 16 of 16 rows
RefSeq Transcripts NG_033905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054379979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF126062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX704815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF590083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENST00000219204   ⟹   ENSP00000219204
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1657,245,259 - 57,253,635 (+)Ensembl
Ensembl Acc Id: ENST00000562023   ⟹   ENSP00000457465
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1657,245,350 - 57,252,424 (+)Ensembl
Ensembl Acc Id: ENST00000563234   ⟹   ENSP00000454237
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1657,245,376 - 57,253,275 (+)Ensembl
Ensembl Acc Id: ENST00000565794
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1657,245,259 - 57,246,141 (+)Ensembl
RefSeq Acc Id: NM_012106   ⟹   NP_036238
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,245,259 - 57,253,635 (+)NCBI
GRCh371657,279,037 - 57,287,547 (+)NCBI
Build 361655,836,539 - 55,845,046 (+)NCBI Archive
Celera1641,778,726 - 41,787,233 (+)RGD
HuRef1643,148,688 - 43,157,185 (+)RGD
CHM1_11658,687,284 - 58,695,791 (+)NCBI
T2T-CHM13v2.01663,041,248 - 63,049,621 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047433883   ⟹   XP_047289839
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,245,793 - 57,253,635 (+)NCBI
RefSeq Acc Id: XM_054379979   ⟹   XP_054235954
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01663,041,782 - 63,049,621 (+)NCBI
RefSeq Acc Id: NP_036238   ⟸   NM_012106
- UniProtKB: B3KQJ5 (UniProtKB/Swiss-Prot),   Q504R0 (UniProtKB/Swiss-Prot),   Q9Y2Y0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000219204   ⟸   ENST00000219204
Ensembl Acc Id: ENSP00000457465   ⟸   ENST00000562023
Ensembl Acc Id: ENSP00000454237   ⟸   ENST00000563234
RefSeq Acc Id: XP_047289839   ⟸   XM_047433883
- Peptide Label: isoform X1
BART

Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y2Y0-F1-model_v2 AlphaFold Q9Y2Y0 1-163 view protein structure

RGD ID:6792805
Promoter ID:HG_KWN:23890
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000257334,   UC010CCY.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361655,836,171 - 55,836,671 (+)MPROMDB
RGD ID:7232315
Promoter ID:EPDNEW_H21903
Type:initiation region
Name:ARL2BP_1
Description:ADP ribosylation factor like GTPase 2 binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,245,259 - 57,245,319EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
COSMIC ARL2BP COSMIC
Ensembl Genes ENSG00000102931 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000219204 ENTREZGENE
  ENST00000219204.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1520.10 UniProtKB/Swiss-Prot
GTEx ENSG00000102931 GTEx
HGNC ID HGNC:17146 ENTREZGENE
Human Proteome Map ARL2BP Human Proteome Map
InterPro ARL2BP UniProtKB/Swiss-Prot
  BART_dom UniProtKB/Swiss-Prot
  BART_sf UniProtKB/Swiss-Prot
KEGG Report hsa:23568 UniProtKB/Swiss-Prot
NCBI Gene 23568 ENTREZGENE
OMIM 615407 OMIM
PANTHER ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR15487 UniProtKB/Swiss-Prot
Pfam ARL2_Bind_BART UniProtKB/Swiss-Prot
PharmGKB PA134904608 PharmGKB
UniProt AR2BP_HUMAN UniProtKB/Swiss-Prot
  B3KQJ5 ENTREZGENE
  H3BM52_HUMAN UniProtKB/TrEMBL
  H3BU49_HUMAN UniProtKB/TrEMBL
  Q504R0 ENTREZGENE
  Q9Y2Y0 ENTREZGENE
UniProt Secondary B3KQJ5 UniProtKB/Swiss-Prot
  Q504R0 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-10-31 ARL2BP  ARF like GTPase 2 binding protein  ARL2BP  ADP ribosylation factor like GTPase 2 binding protein  Symbol and/or name change 19259463 PROVISIONAL
2015-11-24 ARL2BP  ADP ribosylation factor like GTPase 2 binding protein  ARL2BP  ADP-ribosylation factor like GTPase 2 binding protein  Symbol and/or name change 5135510 APPROVED
2015-11-17 ARL2BP  ADP-ribosylation factor like GTPase 2 binding protein  ARL2BP  ADP-ribosylation factor-like 2 binding protein  Symbol and/or name change 5135510 APPROVED