RPS18 (ribosomal protein S18) - Rat Genome Database

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Gene: RPS18 (ribosomal protein S18) Homo sapiens
Analyze
Symbol: RPS18
Name: ribosomal protein S18
RGD ID: 1342484
HGNC Page HGNC:10401
Description: A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosol and nucleus. Part of cytosolic small ribosomal subunit. Is active in postsynaptic density.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 40S ribosomal protein S18; D6S218E; HKE3; KE-3; KE3; MGC117351; MGC126835; MGC126837; rhabdomyosarcoma antigen MU-RMS-40.21; S18; small ribosomal subunit protein uS13; uS13
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: RPS18P1   RPS18P10   RPS18P11   RPS18P12   RPS18P13   RPS18P14   RPS18P2   RPS18P3   RPS18P4   RPS18P5   RPS18P6   RPS18P7   RPS18P8   RPS18P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,272,075 - 33,276,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,272,075 - 33,276,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37633,239,852 - 33,244,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,347,830 - 33,352,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 34633,347,829 - 33,352,259NCBI
Celera634,794,207 - 34,798,639 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,981,509 - 32,985,938 (+)NCBIHuRef
CHM1_1633,241,785 - 33,246,217 (+)NCBICHM1_1
T2T-CHM13v2.0633,093,437 - 33,097,873 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dimethoxyphenol  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
actinomycin D  (EXP)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
antimycin A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenic trichloride  (EXP)
arsenite(3-)  (EXP)
azoxystrobin  (EXP)
benzalkonium chloride  (EXP)
benzatropine  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
chloropicrin  (EXP)
cisplatin  (EXP)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
deguelin  (EXP)
dexamethasone  (EXP)
dihydroartemisinin  (EXP)
dioxygen  (ISO)
ethanol  (ISO)
fenpyroximate  (EXP)
folic acid  (ISO)
furfural  (EXP)
genistein  (EXP)
gentamycin  (ISO)
indometacin  (EXP)
ivermectin  (EXP)
L-ethionine  (ISO)
lead diacetate  (ISO)
methylparaben  (EXP)
miconazole  (ISO)
N-nitrosodiethylamine  (ISO)
Nutlin-3  (EXP)
omeprazole  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrimidifen  (EXP)
rotenone  (EXP,ISO)
SB 431542  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium chloride  (EXP)
sunitinib  (EXP)
tebufenpyrad  (EXP)
temozolomide  (EXP)
thioacetamide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tungsten  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures of the human and Drosophila 80S ribosome. Anger AM, etal., Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104.
2. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, etal., Wiley Interdiscip Rev RNA. 2015 Mar-Apr;6(2):225-42. doi: 10.1002/wrna.1269. Epub 2014 Oct 27.
3. Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. O'Donohue MF, etal., J Cell Biol. 2010 Sep 6;190(5):853-66. doi: 10.1083/jcb.201005117.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1872840   PMID:6188845   PMID:7923143   PMID:8441687   PMID:8706699   PMID:8722009   PMID:9582194   PMID:11790298   PMID:11875025   PMID:12145273   PMID:12477932   PMID:12588972  
PMID:14574404   PMID:15189156   PMID:15532723   PMID:15635413   PMID:15883184   PMID:17361185   PMID:18259216   PMID:18457437   PMID:18685789   PMID:19056867   PMID:19167051   PMID:19738201  
PMID:19805454   PMID:19834535   PMID:19851445   PMID:19946888   PMID:20020773   PMID:20458337   PMID:21081503   PMID:21145461   PMID:21170055   PMID:21182203   PMID:21182205   PMID:21244100  
PMID:21256985   PMID:21319273   PMID:21423176   PMID:21575865   PMID:21630459   PMID:21832049   PMID:21873635   PMID:22113938   PMID:22145905   PMID:22623428   PMID:22658674   PMID:22681889  
PMID:22720776   PMID:22810585   PMID:22863883   PMID:22939629   PMID:23184937   PMID:23246001   PMID:23376485   PMID:23398456   PMID:23438482   PMID:23443559   PMID:23455922   PMID:23463506  
PMID:23979707   PMID:24248602   PMID:24625528   PMID:24711643   PMID:24725412   PMID:25144556   PMID:25147182   PMID:25324306   PMID:25437307   PMID:25798074   PMID:25817432   PMID:25900982  
PMID:25901680   PMID:25963833   PMID:26209609   PMID:26344197   PMID:26381412   PMID:26496610   PMID:26527279   PMID:26643866   PMID:26673895   PMID:26693507   PMID:26725010   PMID:26816005  
PMID:26831064   PMID:26979993   PMID:27025967   PMID:27030811   PMID:27049334   PMID:27129302   PMID:27503909   PMID:27545878   PMID:27591049   PMID:27684187   PMID:27976729   PMID:28302793  
PMID:28416769   PMID:28514442   PMID:28515276   PMID:28524877   PMID:28581483   PMID:28685749   PMID:28700943   PMID:28902428   PMID:28927264   PMID:28977470   PMID:28977666   PMID:28986522  
PMID:29180619   PMID:29228324   PMID:29229926   PMID:29298432   PMID:29331416   PMID:29449217   PMID:29467282   PMID:29478914   PMID:29507755   PMID:29511261   PMID:29568061   PMID:29669786  
PMID:29676528   PMID:29721183   PMID:29735542   PMID:29777862   PMID:29802200   PMID:29844126   PMID:29845934   PMID:29955894   PMID:29991511   PMID:30021884   PMID:30033366   PMID:30209976  
PMID:30258100   PMID:30274258   PMID:30320934   PMID:30344098   PMID:30349055   PMID:30425250   PMID:30463901   PMID:30554943   PMID:30804502   PMID:30824926   PMID:30884312   PMID:30890647  
PMID:30948266   PMID:30997501   PMID:31046837   PMID:31048545   PMID:31091453   PMID:31180492   PMID:31253590   PMID:31300519   PMID:31324722   PMID:31363146   PMID:31409639   PMID:31476572  
PMID:31501420   PMID:31586073   PMID:31732153   PMID:31839598   PMID:31980649   PMID:32041737   PMID:32129710   PMID:32322062   PMID:32457219   PMID:32513696   PMID:32529326   PMID:32552912  
PMID:32665550   PMID:32694731   PMID:32698014   PMID:32807901   PMID:32905556   PMID:32929329   PMID:33080218   PMID:33194618   PMID:33226137   PMID:33239621   PMID:33306668   PMID:33417871  
PMID:33536335   PMID:33567341   PMID:33644029   PMID:33658012   PMID:33660365   PMID:33729478   PMID:33766124   PMID:33961781   PMID:34077860   PMID:34091597   PMID:34133714   PMID:34154657  
PMID:34185411   PMID:34186245   PMID:34349018   PMID:34373451   PMID:34462429   PMID:34537242   PMID:34650049   PMID:34709727   PMID:34901782   PMID:35013218   PMID:35031058   PMID:35063084  
PMID:35152003   PMID:35235311   PMID:35256949   PMID:35271311   PMID:35338135   PMID:35356984   PMID:35446349   PMID:35509820   PMID:35562734   PMID:35563538   PMID:35605301   PMID:35652658  
PMID:35676659   PMID:35819319   PMID:35850772   PMID:35864588   PMID:35915203   PMID:35944360   PMID:36042349   PMID:36057605   PMID:36059274   PMID:36114006   PMID:36180527   PMID:36180891  
PMID:36199071   PMID:36215168   PMID:36282215   PMID:36307841   PMID:36321656   PMID:36339263   PMID:36373674   PMID:36424410   PMID:36517590   PMID:36526897   PMID:36537216   PMID:36574265  
PMID:36590901   PMID:36636478   PMID:36762613   PMID:36897256   PMID:36912080   PMID:37054706   PMID:37071682   PMID:37108203   PMID:37117185   PMID:37120454   PMID:37132043   PMID:37211047  
PMID:37223481   PMID:37249651   PMID:37267103   PMID:37314180   PMID:37314216   PMID:37317656   PMID:37448957   PMID:37616343   PMID:37640791   PMID:37667382   PMID:37689310   PMID:37794589  
PMID:37820061   PMID:37827155   PMID:37929963   PMID:38113892   PMID:38172120   PMID:38177924   PMID:38334954   PMID:38492217   PMID:38697112   PMID:39066279   PMID:39231216   PMID:39238192  


Genomics

Comparative Map Data
RPS18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,272,075 - 33,276,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,272,075 - 33,276,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37633,239,852 - 33,244,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,347,830 - 33,352,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 34633,347,829 - 33,352,259NCBI
Celera634,794,207 - 34,798,639 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,981,509 - 32,985,938 (+)NCBIHuRef
CHM1_1633,241,785 - 33,246,217 (+)NCBICHM1_1
T2T-CHM13v2.0633,093,437 - 33,097,873 (+)NCBIT2T-CHM13v2.0
Rps18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,170,972 - 34,174,639 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,170,973 - 34,174,975 (-)EnsemblGRCm39 Ensembl
GRCm381733,951,998 - 33,955,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,951,999 - 33,956,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,088,944 - 34,092,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,562,453 - 33,566,095 (-)NCBIMGSCv36mm8
Celera1736,704,880 - 36,708,531 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Rps18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,933,741 - 4,937,423 (+)NCBIGRCr8
mRatBN7.2204,931,427 - 4,935,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,931,768 - 4,938,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,655,349 - 5,659,060 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,017,094 - 5,020,805 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,497,879 - 5,501,592 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,441,875 - 5,445,553 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,441,876 - 5,445,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,500,487 - 7,504,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,083,626 - 5,087,304 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,083,852 - 5,087,531 (+)NCBI
Celera206,516,103 - 6,519,781 (+)NCBICelera
Cytogenetic Map20p12NCBI
Rps18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,833,125 - 1,838,827 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,833,338 - 1,838,776 (+)NCBIChiLan1.0ChiLan1.0
RPS18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,749,839 - 47,754,353 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,621,506 - 43,626,020 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,844,234 - 32,848,748 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,958,471 - 33,962,940 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,958,471 - 33,962,941 (+)Ensemblpanpan1.1panPan2
RPS18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,712,958 - 2,718,657 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,712,952 - 2,718,663 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,794,099 - 2,799,574 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,043,936 - 3,049,831 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,043,930 - 3,049,837 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,711,826 - 2,717,304 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,793,331 - 2,798,802 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,868,026 - 2,873,489 (+)NCBIUU_Cfam_GSD_1.0
Rps18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,365,797 - 38,370,494 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,589,814 - 25,593,905 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,589,769 - 25,594,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,638,833 - 29,642,912 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,638,856 - 29,642,912 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,142,621 - 34,146,677 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,800,532 - 38,805,005 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604433,107,166 - 33,111,637 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,544,043 - 23,548,301 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,544,042 - 23,548,935 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RPS18
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_022553.5(VPS52):c.148G>A (p.Asp50Asn) single nucleotide variant Malignant melanoma [RCV000067316] Chr6:33270226 [GRCh38]
Chr6:33238003 [GRCh37]
Chr6:33345981 [NCBI36]
Chr6:6p21.32		 not provided
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
NC_000006.11:g.(?_33131435)_(33419703_?)dup duplication Intellectual disability, autosomal dominant 5 [RCV000817954] Chr6:33163658..33451926 [GRCh38]
Chr6:33131435..33419703 [GRCh37]
Chr6:6p21.32		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NC_000006.12:g.(?_33173681)_(33451926_?)dup duplication Intellectual disability, autosomal dominant 5 [RCV001032258] Chr6:33141458..33419703 [GRCh37]
Chr6:6p21.32		 uncertain significance
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3 copy number gain not provided [RCV001005791] Chr6:31036397..34088832 [GRCh37]
Chr6:6p21.33-21.31		 likely pathogenic
GRCh37/hg19 6p21.32-21.31(chr6:33069892-33751391) copy number gain not specified [RCV002053566] Chr6:33069892..33751391 [GRCh37]
Chr6:6p21.32-21.31		 uncertain significance
NC_000006.11:g.(?_30695893)_(36953949_?)dup duplication Proteasome-associated autoinflammatory syndrome 1 [RCV003113679] Chr6:30695893..36953949 [GRCh37]
Chr6:6p21.33-21.2		 uncertain significance
NC_000006.11:g.(?_32148920)_(36953949_?)dup duplication not provided [RCV003154914] Chr6:32148920..36953949 [GRCh37]
Chr6:6p21.32-21.2		 uncertain significance
NC_000006.11:g.(?_33131455)_(33388128_?)dup duplication MHC class I deficiency [RCV004578657] Chr6:33131455..33388128 [GRCh37]
Chr6:6p21.32		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1572
Count of miRNA genes:241
Interacting mature miRNAs:247
Transcripts:ENST00000439602, ENST00000472218, ENST00000474626, ENST00000474973, ENST00000476222, ENST00000479802, ENST00000490191, ENST00000496813
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
596966564GWAS1086083_Hrheumatoid arthritis, multiple sclerosis QTL GWAS1086083 (human)4e-09rheumatoid arthritis, multiple sclerosis63327329933273300Human
597269401GWAS1365475_Hrheumatoid arthritis, multiple sclerosis QTL GWAS1365475 (human)4e-09rheumatoid arthritis, multiple sclerosis63327329933273300Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
597268509GWAS1364583_Hrheumatoid arthritis, irritable bowel syndrome QTL GWAS1364583 (human)3e-09rheumatoid arthritis, irritable bowel syndrome63327329933273300Human
597343549GWAS1439623_Hmonocyte measurement QTL GWAS1439623 (human)3e-15monocyte measurement63327209233272093Human
597118816GWAS1214890_HBRCA1 mutation carier status, breast carcinoma, triple-negative breast cancer QTL GWAS1214890 (human)9e-13mammary gland integrity trait (VT:0010552)63327209233272093Human
597199649GWAS1295723_Haspartate aminotransferase measurement QTL GWAS1295723 (human)1e-28aspartate aminotransferase measurementblood aspartate aminotransferase activity level (CMO:0000580)63327209233272093Human
596968972GWAS1088491_Hrheumatoid arthritis, irritable bowel syndrome QTL GWAS1088491 (human)3e-09rheumatoid arthritis, irritable bowel syndrome63327329933273300Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human

Markers in Region
RH77  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37633,243,915 - 33,244,040UniSTSGRCh37
Build 36633,351,893 - 33,352,018RGDNCBI36
Celera634,798,273 - 34,798,398RGD
Cytogenetic Map6p21.3UniSTS
HuRef632,985,572 - 32,985,697UniSTS
RH64826  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,915,496 - 149,915,599UniSTSGRCh37
GRCh373101,295,413 - 101,295,516UniSTSGRCh37
Build 363102,778,103 - 102,778,206RGDNCBI36
Celera6150,650,538 - 150,650,641UniSTS
Celera399,687,768 - 99,687,871RGD
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map6q25.1UniSTS
HuRef6147,482,134 - 147,482,237UniSTS
HuRef398,664,344 - 98,664,447UniSTS
D6S1905  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map6q25.1UniSTS
GeneMap99-GB4 RH Map6120.03UniSTS
GeneMap99-GB4 RH Map6145.45UniSTS
Whitehead-RH Map6178.2UniSTS
NCBI RH Map6509.1UniSTS
WI-15797  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map6q25.1UniSTS
GeneMap99-GB4 RH Map6596.81UniSTS
Whitehead-RH Map6810.4UniSTS
NCBI RH Map61598.0UniSTS
stSG602121  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21.3UniSTS
Sacm2l  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37633,239,375 - 33,240,428UniSTSGRCh37
Celera634,793,730 - 34,794,783UniSTS
HuRef632,981,032 - 32,982,085UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB055778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ223319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY536376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX248408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000439602   ⟹   ENSP00000393241
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl633,272,075 - 33,276,511 (+)Ensembl
Ensembl Acc Id: ENST00000472218
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl633,275,321 - 33,276,510 (+)Ensembl
Ensembl Acc Id: ENST00000474626
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl633,272,088 - 33,276,505 (+)Ensembl
Ensembl Acc Id: ENST00000474973   ⟹   ENSP00000434837
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl633,272,075 - 33,276,510 (+)Ensembl
Ensembl Acc Id: ENST00000476222
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl633,272,096 - 33,276,510 (+)Ensembl
Ensembl Acc Id: ENST00000479802
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl633,275,866 - 33,276,510 (+)Ensembl
Ensembl Acc Id: ENST00000490191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl633,272,132 - 33,276,510 (+)Ensembl
Ensembl Acc Id: ENST00000496813
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl633,272,099 - 33,276,505 (+)Ensembl
RefSeq Acc Id: NM_022551   ⟹   NP_072045
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38633,272,075 - 33,276,511 (+)NCBI
GRCh37633,239,852 - 33,244,281 (+)RGD
Build 36633,347,830 - 33,352,259 (+)NCBI Archive
Celera634,794,207 - 34,798,639 (+)RGD
HuRef632,981,509 - 32,985,938 (+)RGD
CHM1_1633,241,785 - 33,246,217 (+)NCBI
T2T-CHM13v2.0633,093,437 - 33,097,873 (+)NCBI
Sequence:
RefSeq Acc Id: NP_072045   ⟸   NM_022551
- UniProtKB: Q5SUJ3 (UniProtKB/Swiss-Prot),   P25232 (UniProtKB/Swiss-Prot),   Q6IPF8 (UniProtKB/Swiss-Prot),   P62269 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000393241   ⟸   ENST00000439602
Ensembl Acc Id: ENSP00000434837   ⟸   ENST00000474973

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62269-F1-model_v2 AlphaFold P62269 1-152 view protein structure

Promoters
RGD ID:6872848
Promoter ID:EPDNEW_H9589
Type:initiation region
Name:RPS18_1
Description:ribosomal protein S18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38633,272,077 - 33,272,137EPDNEW
RGD ID:6804747
Promoter ID:HG_KWN:53183
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000076058,   OTTHUMT00000076059,   OTTHUMT00000276260,   OTTHUMT00000276261,   OTTHUMT00000276262,   UC010JUM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36633,347,674 - 33,348,174 (+)MPROMDB
RGD ID:6852780
Promoter ID:EP74205
Type:initiation region
Name:HS_RPS18
Description:Ribosomal protein S18.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36633,347,854 - 33,347,914EPD
RGD ID:6804748
Promoter ID:HG_KWN:53184
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000276259,   OTTHUMT00000276263
Position:
Human AssemblyChrPosition (strand)Source
Build 36633,350,211 - 33,351,822 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10401 AgrOrtholog
COSMIC RPS18 COSMIC
Ensembl Genes ENSG00000096150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000223367 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000226225 UniProtKB/Swiss-Prot
  ENSG00000227794 UniProtKB/TrEMBL
  ENSG00000231500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000235650 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000211372.9 UniProtKB/Swiss-Prot
  ENST00000434122.2 UniProtKB/Swiss-Prot
  ENST00000439602 ENTREZGENE
  ENST00000439602.7 UniProtKB/Swiss-Prot
  ENST00000440980.1 UniProtKB/TrEMBL
  ENST00000454021.6 UniProtKB/Swiss-Prot
  ENST00000457341.6 UniProtKB/Swiss-Prot
  ENST00000474973.5 UniProtKB/TrEMBL
  ENST00000476288.5 UniProtKB/TrEMBL
  ENST00000477055.5 UniProtKB/TrEMBL
  ENST00000484321.5 UniProtKB/TrEMBL
  ENST00000486781.5 UniProtKB/TrEMBL
  ENST00000494232.5 UniProtKB/TrEMBL
  ENST00000630000.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.910.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000096150 GTEx
  ENSG00000223367 GTEx
  ENSG00000226225 GTEx
  ENSG00000227794 GTEx
  ENSG00000231500 GTEx
  ENSG00000235650 GTEx
HGNC ID HGNC:10401 ENTREZGENE
Human Proteome Map RPS18 Human Proteome Map
InterPro 30s_Rbsml_prot_S13_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S13-like_H2TH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S13_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6222 UniProtKB/Swiss-Prot
NCBI Gene 6222 ENTREZGENE
OMIM 180473 OMIM
PANTHER 30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  40S RIBOSOMAL PROTEIN S18 UniProtKB/TrEMBL
  SMALL RIBOSOMAL SUBUNIT PROTEIN US13 UniProtKB/Swiss-Prot
Pfam Ribosomal_S13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34801 PharmGKB
PIRSF Ribosomal_S13 UniProtKB/Swiss-Prot
PROSITE RIBOSOMAL_S13_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOMAL_S13_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RNAcentral URS0002617B8A RNACentral
  URS000261837C RNACentral
  URS0002618467 RNACentral
Superfamily-SCOP SSF46946 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JQH2_HUMAN UniProtKB/TrEMBL
  J3JS69_HUMAN UniProtKB/TrEMBL
  P25232 ENTREZGENE
  P62269 ENTREZGENE
  Q5GGW2_HUMAN UniProtKB/TrEMBL
  Q5SUJ3 ENTREZGENE
  Q6IPF8 ENTREZGENE
  RS18_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A0A024RCS4 UniProtKB/TrEMBL
  P25232 UniProtKB/Swiss-Prot
  Q5SUJ3 UniProtKB/Swiss-Prot
  Q6IPF8 UniProtKB/Swiss-Prot