![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | PPIE | Human | (+)-schisandrin B | multiple interactions | ISO | Ppie (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PPIE mRNA] | CTD | PMID:31150632 | PPIE | Human | 1,2-dimethylhydrazine | increases expression | ISO | Ppie (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PPIE mRNA | CTD | PMID:22206623 | PPIE | Human | 1,2-dimethylhydrazine | multiple interactions | ISO | Ppie (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PPIE mRNA] | CTD | PMID:22206623 | PPIE | Human | 17alpha-ethynylestradiol | decreases expression | ISO | Ppie (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in decreased expression of PPIE mRNA | CTD | PMID:29097150 | PPIE | Human | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Ppie (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | PPIE | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ppie (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PPIE mRNA | CTD | PMID:21570461 and PMID:24680724 | PPIE | Human | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | Ppie (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:19954255 | PPIE | Human | 2-hydroxypropanoic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of PPIE mRNA | CTD | PMID:30851411 | PPIE | Human | 2-palmitoylglycerol | increases expression | EXP | | 6480464 | 2-palmitoylglycerol results in increased expression of PPIE mRNA | CTD | PMID:37199045 | PPIE | Human | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Ppie (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PPIE mRNA | CTD | PMID:20188158 | PPIE | Human | 3-chloropropane-1,2-diol | increases expression | ISO | Ppie (Rattus norvegicus) | 6480464 | alpha-Chlorohydrin results in increased expression of PPIE protein | CTD | PMID:34915118 | PPIE | Human | 5-fluorouracil | increases expression | EXP | | 6480464 | Fluorouracil results in increased expression of PPIE protein | CTD | PMID:16803524 | PPIE | Human | actinomycin D | multiple interactions | EXP | | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of PPIE protein | CTD | PMID:38460933 | PPIE | Human | antimycin A | increases expression | EXP | | 6480464 | Antimycin A results in increased expression of PPIE mRNA | CTD | PMID:33512557 | PPIE | Human | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of PPIE mRNA | CTD | PMID:22378314 | PPIE | Human | benzo[a]pyrene | multiple interactions | ISO | Ppie (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PPIE mRNA] | CTD | PMID:22228805 | PPIE | Human | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of PPIE 5' UTR and Benzo(a)pyrene affects the methylation of PPIE promoter | CTD | PMID:27901495 | PPIE | Human | benzo[a]pyrene | increases expression | ISO | Ppie (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PPIE mRNA | CTD | PMID:22228805 | PPIE | Human | bisphenol A | increases expression | ISO | Ppie (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PPIE mRNA | CTD | PMID:25181051 | PPIE | Human | chlorpyrifos | decreases expression | ISO | Ppie (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of PPIE mRNA | CTD | PMID:37019170 | PPIE | Human | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of PPIE protein | CTD | PMID:16803524 | PPIE | Human | clobetasol | increases expression | ISO | Ppie (Mus musculus) | 6480464 | Clobetasol results in increased expression of PPIE mRNA | CTD | PMID:27462272 | PPIE | Human | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of PPIE mRNA | CTD | PMID:19376846 | PPIE | Human | deguelin | increases expression | EXP | | 6480464 | deguelin results in increased expression of PPIE mRNA | CTD | PMID:33512557 | PPIE | Human | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPIE mRNA | CTD | PMID:27188386 | PPIE | Human | doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of PPIE mRNA | CTD | PMID:29803840 | PPIE | Human | ferroheme b | increases expression | ISO | Ppie (Mus musculus) | 6480464 | Heme metabolite results in increased expression of PPIE mRNA | CTD | PMID:19191707 | PPIE | Human | flutamide | increases expression | ISO | Ppie (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of PPIE mRNA | CTD | PMID:24136188 | PPIE | Human | folic acid | multiple interactions | ISO | Ppie (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PPIE mRNA] | CTD | PMID:22206623 | PPIE | Human | FR900359 | decreases phosphorylation | EXP | | 6480464 | FR900359 results in decreased phosphorylation of PPIE protein | CTD | PMID:37730182 | PPIE | Human | heme b | increases expression | ISO | Ppie (Mus musculus) | 6480464 | Heme metabolite results in increased expression of PPIE mRNA | CTD | PMID:19191707 | PPIE | Human | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of PPIE protein | CTD | PMID:32959892 | PPIE | Human | methyl methanesulfonate | increases expression | EXP | | 6480464 | Methyl Methanesulfonate results in increased expression of PPIE mRNA | CTD | PMID:23649840 | PPIE | Human | nefazodone | increases expression | ISO | Ppie (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of PPIE mRNA | CTD | PMID:24136188 | PPIE | Human | nitrates | multiple interactions | ISO | Ppie (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of PPIE mRNA | CTD | PMID:35964746 | PPIE | Human | Nutlin-3 | multiple interactions | EXP | | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of PPIE protein | CTD | PMID:38460933 | PPIE | Human | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PPIE mRNA | CTD | PMID:35430440 | PPIE | Human | rac-lactic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of PPIE mRNA | CTD | PMID:30851411 | PPIE | Human | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of PPIE mRNA | CTD | PMID:33512557 | PPIE | Human | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPIE mRNA | CTD | PMID:27188386 | PPIE | Human | sodium arsenite | multiple interactions | EXP | | 6480464 | sodium arsenite promotes the reaction [PPIE protein binds to CAPRIN1 protein] | CTD | PMID:33939924 | PPIE | Human | tebufenpyrad | increases expression | EXP | | 6480464 | 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of PPIE mRNA | CTD | PMID:33512557 | PPIE | Human | temozolomide | increases expression | EXP | | 6480464 | Temozolomide results in increased expression of PPIE mRNA | CTD | PMID:31758290 | PPIE | Human | tetrachloromethane | increases expression | ISO | Ppie (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of PPIE mRNA | CTD | PMID:31150632 | PPIE | Human | tetrachloromethane | multiple interactions | ISO | Ppie (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PPIE mRNA] | CTD | PMID:31150632 | PPIE | Human | thioacetamide | increases expression | ISO | Ppie (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of PPIE mRNA | CTD | PMID:23411599 and PMID:34492290 | PPIE | Human | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of PPIE mRNA | CTD | PMID:37042841 | PPIE | Human | triptonide | increases expression | ISO | Ppie (Mus musculus) | 6480464 | triptonide results in increased expression of PPIE mRNA | CTD | PMID:33045310 | PPIE | Human | trovafloxacin | decreases expression | ISO | Ppie (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of PPIE mRNA | CTD | PMID:35537566 | PPIE | Human | tungsten | increases expression | ISO | Ppie (Mus musculus) | 6480464 | Tungsten results in increased expression of PPIE mRNA | CTD | PMID:30912803 | PPIE | Human | tunicamycin | increases expression | EXP | | 6480464 | Tunicamycin results in increased expression of PPIE mRNA | CTD | PMID:22378314 | PPIE | Human | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of PPIE mRNA | CTD | PMID:25979313 | PPIE | Human | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of PPIE mRNA | CTD | PMID:23179753 and PMID:26272509 | PPIE | Human | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPIE mRNA | CTD | PMID:27188386 | PPIE | Human | Yessotoxin | decreases expression | EXP | | 6480464 | yessotoxin analog results in decreased expression of PPIE mRNA | CTD | PMID:30679557 | |