IRF5 (interferon regulatory factor 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: IRF5 (interferon regulatory factor 5) Homo sapiens
Analyze
Symbol: IRF5
Name: interferon regulatory factor 5
RGD ID: 1321354
HGNC Page HGNC
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; response to muramyl dipeptide; and response to peptidoglycan. Located in cytoplasm and nucleus. Implicated in herpes simplex; inflammatory bowel disease 14; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus. Biomarker of hepatitis C; liver cirrhosis; non-alcoholic steatohepatitis; and pneumonia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IRF-5; SLEB10
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: IRF5P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7128,937,457 - 128,950,038 (+)EnsemblGRCh38hg38GRCh38
GRCh387128,937,032 - 128,950,038 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377128,577,086 - 128,590,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,365,230 - 128,377,325 (+)NCBINCBI36hg18NCBI36
Build 347128,172,221 - 128,184,037NCBI
Celera7123,374,509 - 123,386,585 (+)NCBI
Cytogenetic Map7q32.1NCBI
HuRef7122,939,186 - 122,951,277 (+)NCBIHuRef
CHM1_17128,511,266 - 128,523,397 (+)NCBICHM1_1
CRA_TCAGchr7v27127,961,737 - 127,973,832 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISA)
cytoplasm  (IDA,ISO)
cytosol  (TAS)
nucleus  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal distention  (IAGP)
Abnormal bowel sounds  (IAGP)
Abnormal circulating lipid concentration  (IAGP)
Abnormality of the intrahepatic bile duct  (IAGP)
Abnormality of the thyroid gland  (IAGP)
Antinuclear antibody positivity  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Ascites  (IAGP)
Autoimmunity  (IAGP)
Biliary cirrhosis  (IAGP)
Carious teeth  (IAGP)
Celiac disease  (IAGP)
Cirrhosis  (IAGP)
Congestive heart failure  (IAGP)
Conjugated hyperbilirubinemia  (IAGP)
Contractures involving the joints of the feet  (IAGP)
Dermatographic urticaria  (IAGP)
Dyspareunia  (IAGP)
Dysphagia  (IAGP)
Dyspnea  (IAGP)
Elevated circulating alkaline phosphatase concentration  (IAGP)
Excessive daytime somnolence  (IAGP)
Fatigue  (IAGP)
Flexion contracture  (IAGP)
Gastroesophageal reflux  (IAGP)
Gastrointestinal inflammation  (IAGP)
Hepatic failure  (IAGP)
Hepatic fibrosis  (IAGP)
Hepatitis  (IAGP)
Hepatocellular carcinoma  (IAGP)
Hyperpigmentation of the skin  (IAGP)
Hypertensive crisis  (IAGP)
Hypoalbuminemia  (IAGP)
Hypopigmented skin patches  (IAGP)
Increased circulating IgA level  (IAGP)
Increased circulating IgM level  (IAGP)
Jaundice  (IAGP)
Joint contracture of the hand  (IAGP)
Malabsorption  (IAGP)
Mucosal telangiectasiae  (IAGP)
Muscle weakness  (IAGP)
Narrow foramen obturatorium  (IAGP)
Nausea and vomiting  (IAGP)
Oliguria  (IAGP)
Onychomycosis  (IAGP)
Orthostatic hypotension  (IAGP)
Osteolysis  (IAGP)
Osteoporosis  (IAGP)
Pleomorphic xanthoastrocytoma  (IAGP)
Portal hypertension  (IAGP)
Pruritus  (IAGP)
Pulmonary arterial hypertension  (IAGP)
Pulmonary fibrosis  (IAGP)
Pulmonary infiltrates  (IAGP)
Renal insufficiency  (IAGP)
Rheumatoid arthritis  (IAGP)
Skin ulcer  (IAGP)
Telangiectasia of the skin  (IAGP)
Xerostomia  (IAGP)
References

References - curated
1. Alzaid F, etal., JCI Insight. 2016 Dec 8;1(20):e88689. doi: 10.1172/jci.insight.88689.
2. Bo M, etal., Clin Exp Rheumatol. 2018 May-Jun;36(3):376-381. Epub 2018 Jan 15.
3. Bo M, etal., J Transl Autoimmun. 2020 Mar 17;3:100048. doi: 10.1016/j.jtauto.2020.100048. eCollection 2020.
4. Bo M, etal., Sci Rep. 2018 Jan 29;8(1):1789. doi: 10.1038/s41598-018-19957-z.
5. Chen X, etal., J Biol Chem. 2017 Dec 29;292(52):21291-21303. doi: 10.1074/jbc.M117.805937. Epub 2017 Oct 18.
6. Cossu D, etal., Mult Scler. 2015 Jul;21(8):984-95. doi: 10.1177/1352458514557304. Epub 2014 Nov 12.
7. Fabié A, etal., Cell Rep. 2018 Jul 31;24(5):1163-1175. doi: 10.1016/j.celrep.2018.06.107.
8. GOA_HUMAN data from the GO Consortium
9. Huang YH, etal., J Surg Res. 2011 Sep;170(1):e47-55. doi: 10.1016/j.jss.2011.05.033. Epub 2011 Jun 15.
10. Lu H, etal., Phytomedicine. 2019 Sep;62:152976. doi: 10.1016/j.phymed.2019.152976. Epub 2019 May 31.
11. Mai LT, etal., Front Immunol. 2020 Jan 21;10:3071. doi: 10.3389/fimmu.2019.03071. eCollection 2019.
12. Mapplebeck JCS, etal., Pain. 2018 Sep;159(9):1752-1763. doi: 10.1097/j.pain.0000000000001265.
13. Nie S, etal., Clin Immunol. 2019 Oct;207:24-35. doi: 10.1016/j.clim.2019.07.002. Epub 2019 Jul 4.
14. OMIM Disease Annotation Pipeline
15. Pipeline to import KEGG annotations from KEGG into RGD
16. Proenca-Modena JL, etal., J Virol. 2015 Oct 14;90(1):189-205. doi: 10.1128/JVI.02276-15.
17. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. RGD automated import pipeline for gene-chemical interactions
19. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
20. Thackray LB, etal., J Virol. 2014 Oct;88(19):11007-21. doi: 10.1128/JVI.01545-14. Epub 2014 Jul 16.
21. Urdzíková LM, etal., Int J Mol Sci. 2014 Jun 25;15(7):11275-93. doi: 10.3390/ijms150711275.
22. Vandenbroeck K, etal., Genes Immun. 2011 Jan;12(1):40-5. doi: 10.1038/gene.2010.46. Epub 2010 Sep 23.
23. Wang X, etal., Med Sci Monit. 2018 May 30;24:3620-3630. doi: 10.12659/MSM.910756.
24. Xiao Y, etal., Mol Med. 2017 Sep;23:166-176. doi: 10.2119/molmed.2016.00243. Epub 2017 Jun 14.
25. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
26. Zhang M, etal., Mol Med Rep. 2017 Apr;15(4):2318-2324. doi: 10.3892/mmr.2017.6229. Epub 2017 Feb 22.
Additional References at PubMed
PMID:9865487   PMID:11303025   PMID:11846976   PMID:11997525   PMID:12138184   PMID:12477932   PMID:12600985   PMID:12690205   PMID:14559832   PMID:15308637   PMID:15489334   PMID:15556946  
PMID:15657875   PMID:15665823   PMID:15695821   PMID:15805103   PMID:16642019   PMID:17121613   PMID:17133578   PMID:17158136   PMID:17166181   PMID:17189288   PMID:17389033   PMID:17393452  
PMID:17412832   PMID:17476532   PMID:17557928   PMID:17568788   PMID:17599733   PMID:17609264   PMID:17703412   PMID:17881657   PMID:18050197   PMID:18063667   PMID:18200047   PMID:18204098  
PMID:18204446   PMID:18260169   PMID:18285424   PMID:18288123   PMID:18311811   PMID:18323517   PMID:18332133   PMID:18408250   PMID:18438842   PMID:18505922   PMID:18579578   PMID:18668568  
PMID:18752149   PMID:18824541   PMID:18836453   PMID:18843782   PMID:18843785   PMID:19019891   PMID:19028697   PMID:19043711   PMID:19092842   PMID:19116937   PMID:19129183   PMID:19228650  
PMID:19258923   PMID:19274049   PMID:19430534   PMID:19479858   PMID:19565491   PMID:19567624   PMID:19644876   PMID:19644887   PMID:19758313   PMID:19778284   PMID:19786094   PMID:19816589  
PMID:19838193   PMID:19851296   PMID:19854706   PMID:19877059   PMID:19913121   PMID:19918036   PMID:20015215   PMID:20049410   PMID:20080916   PMID:20090783   PMID:20112383   PMID:20127100  
PMID:20131273   PMID:20137629   PMID:20197570   PMID:20198315   PMID:20211142   PMID:20231204   PMID:20237317   PMID:20351107   PMID:20383147   PMID:20439292   PMID:20453440   PMID:20453842  
PMID:20479942   PMID:20503287   PMID:20588308   PMID:20616560   PMID:20628086   PMID:20639879   PMID:20639880   PMID:20695768   PMID:20797713   PMID:20848568   PMID:20861858   PMID:20881011  
PMID:20935208   PMID:20962850   PMID:20980283   PMID:21040166   PMID:21133648   PMID:21156761   PMID:21239750   PMID:21297633   PMID:21399635   PMID:21408207   PMID:21454650   PMID:21471993  
PMID:21627826   PMID:21750679   PMID:21779181   PMID:21807777   PMID:21834935   PMID:21873635   PMID:21898142   PMID:21903422   PMID:21968701   PMID:21988832   PMID:22025054   PMID:22053985  
PMID:22088620   PMID:22179739   PMID:22194884   PMID:22257839   PMID:22412986   PMID:22440820   PMID:22500098   PMID:22507190   PMID:22544929   PMID:22674082   PMID:22730365   PMID:22816737  
PMID:22909381   PMID:23053960   PMID:23073787   PMID:23128233   PMID:23154183   PMID:23236436   PMID:23273568   PMID:23288367   PMID:23302156   PMID:23332764   PMID:23349905   PMID:23372721  
PMID:23392701   PMID:23616277   PMID:23740937   PMID:23801380   PMID:23883595   PMID:23941291   PMID:23971939   PMID:23985571   PMID:23990993   PMID:24014567   PMID:24116155   PMID:24350899  
PMID:24445143   PMID:24532789   PMID:24582590   PMID:24697319   PMID:24697591   PMID:24871463   PMID:24928322   PMID:24943672   PMID:25011482   PMID:25036352   PMID:25084355   PMID:25205108  
PMID:25263394   PMID:25284481   PMID:25288773   PMID:25326418   PMID:25326420   PMID:25337792   PMID:25533286   PMID:25557482   PMID:25564941   PMID:25565375   PMID:25572744   PMID:25649192  
PMID:26004104   PMID:26112714   PMID:26233721   PMID:26279299   PMID:26294277   PMID:26519527   PMID:26613957   PMID:26638075   PMID:26712637   PMID:27092776   PMID:27363262   PMID:27484157  
PMID:27545875   PMID:27798840   PMID:27980689   PMID:28059021   PMID:28185859   PMID:28473536   PMID:28531253   PMID:28562332   PMID:28746869   PMID:28818665   PMID:28924041   PMID:29079574  
PMID:29274624   PMID:29339435   PMID:29361124   PMID:29375210   PMID:29423720   PMID:29860420   PMID:29867973   PMID:29971953   PMID:30006439   PMID:30021884   PMID:30168487   PMID:30176312  
PMID:30199605   PMID:30297339   PMID:30593537   PMID:30645688   PMID:31018759   PMID:31024565   PMID:31086271   PMID:31169264   PMID:31243648   PMID:31421124   PMID:31447002   PMID:31718015  
PMID:31733719   PMID:31877114   PMID:31916109   PMID:32188105   PMID:32205184   PMID:32433612   PMID:32441646   PMID:32464244   PMID:32494619   PMID:32610123   PMID:32897883   PMID:32970801  
PMID:33583939   PMID:33780016   PMID:33802675   PMID:34282144  


Genomics

Comparative Map Data
IRF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7128,937,457 - 128,950,038 (+)EnsemblGRCh38hg38GRCh38
GRCh387128,937,032 - 128,950,038 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377128,577,086 - 128,590,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,365,230 - 128,377,325 (+)NCBINCBI36hg18NCBI36
Build 347128,172,221 - 128,184,037NCBI
Celera7123,374,509 - 123,386,585 (+)NCBI
Cytogenetic Map7q32.1NCBI
HuRef7122,939,186 - 122,951,277 (+)NCBIHuRef
CHM1_17128,511,266 - 128,523,397 (+)NCBICHM1_1
CRA_TCAGchr7v27127,961,737 - 127,973,832 (+)NCBI
Irf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,526,129 - 29,541,874 (+)NCBIGRCm39mm39
GRCm39 Ensembl629,526,624 - 29,541,870 (+)Ensembl
GRCm38629,526,130 - 29,541,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,526,625 - 29,541,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,476,733 - 29,487,319 (+)NCBIGRCm37mm9NCBIm37
MGSCv36629,476,743 - 29,487,329 (+)NCBImm8
Celera629,535,579 - 29,546,163 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
Irf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2458,127,577 - 58,140,665 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl458,127,640 - 58,139,267 (+)Ensembl
Rnor_6.0456,804,477 - 56,816,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,805,132 - 56,820,543 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,571,823 - 56,583,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,407,560 - 56,418,694 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1456,666,980 - 56,677,876 (+)NCBI
Celera453,236,000 - 53,247,024 (+)NCBICelera
Cytogenetic Map4q22NCBI
IRF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17133,415,170 - 133,426,356 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,415,170 - 133,426,356 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07120,889,752 - 120,902,096 (+)NCBIMhudiblu_PPA_v0panPan3
IRF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,724,168 - 7,734,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,724,780 - 7,742,795 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha147,411,116 - 7,421,966 (-)NCBI
ROS_Cfam_1.0147,490,116 - 7,500,966 (-)NCBI
UMICH_Zoey_3.1147,695,157 - 7,706,007 (-)NCBI
UNSW_CanFamBas_1.0147,437,183 - 7,448,035 (-)NCBI
UU_Cfam_GSD_1.0147,582,360 - 7,592,901 (-)NCBI
Irf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,005,766 - 26,016,934 (-)NCBI
SpeTri2.0NW_0049365796,138,372 - 6,149,531 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,678,686 - 19,691,154 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11819,678,377 - 19,691,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,748,271 - 20,760,087 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,536,803 - 97,549,576 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,537,790 - 97,549,945 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660425,852,040 - 5,864,687 (-)NCBIVero_WHO_p1.0
Irf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247837,267,680 - 7,275,918 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
GDB:4585333  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377128,589,096 - 128,589,195UniSTSGRCh37
Build 367128,376,332 - 128,376,431RGDNCBI36
Celera7123,385,592 - 123,385,691RGD
Cytogenetic Map7q32UniSTS
HuRef7122,950,284 - 122,950,383UniSTS
CRA_TCAGchr7v27127,972,839 - 127,972,938UniSTS
STS-U51127  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377128,588,868 - 128,589,113UniSTSGRCh37
Build 367128,376,104 - 128,376,349RGDNCBI36
Celera7123,385,364 - 123,385,609RGD
Cytogenetic Map7q32UniSTS
HuRef7122,950,056 - 122,950,301UniSTS
CRA_TCAGchr7v27127,972,611 - 127,972,856UniSTS
GeneMap99-GB4 RH Map7590.81UniSTS
NCBI RH Map71183.9UniSTS
SHGC-63648  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377128,589,289 - 128,589,384UniSTSGRCh37
Build 367128,376,525 - 128,376,620RGDNCBI36
Celera7123,385,785 - 123,385,880RGD
Cytogenetic Map7q32UniSTS
HuRef7122,950,477 - 122,950,572UniSTS
CRA_TCAGchr7v27127,973,032 - 127,973,127UniSTS
TNG Radiation Hybrid Map757797.0UniSTS
IRF5_452  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377128,588,702 - 128,589,467UniSTSGRCh37
Build 367128,375,938 - 128,376,703RGDNCBI36
Celera7123,385,198 - 123,385,963RGD
HuRef7122,949,890 - 122,950,655UniSTS
CRA_TCAGchr7v27127,972,445 - 127,973,210UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR146Ahsa-miR-146a-3pMirecordsexternal_infoNANA19333922

Predicted Target Of
Summary Value
Count of predictions:6953
Count of miRNA genes:1116
Interacting mature miRNAs:1418
Transcripts:ENST00000249375, ENST00000357234, ENST00000402030, ENST00000461416, ENST00000464557, ENST00000465603, ENST00000467002, ENST00000473745, ENST00000473787, ENST00000477535, ENST00000479582, ENST00000488569, ENST00000489702
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 189 715 178 88 1590 42 1097 24 320 209 222 676 51 307 507 1
Low 2228 2104 1528 528 348 415 2801 1633 3269 207 1190 906 123 1 896 1887 3 2
Below cutoff 16 172 15 7 11 7 451 529 144 3 42 24 1 394

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001098627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001098629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001098630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001242452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001347928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001364314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB290013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC025594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY504946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY504947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY519978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY693665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY693666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY693667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY693668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY693669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU540632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU950658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA427676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA444548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC427600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ277633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ277634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ995491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ995492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ995493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ995494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ995495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ995496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU258895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU258896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU258897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU258898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ950681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ950682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ950683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ950684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ950685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP843545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000249375   ⟹   ENSP00000249375
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,938,217 - 128,950,030 (+)Ensembl
RefSeq Acc Id: ENST00000357234   ⟹   ENSP00000349770
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,927 - 128,950,038 (+)Ensembl
RefSeq Acc Id: ENST00000402030   ⟹   ENSP00000385352
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,989 - 128,950,035 (+)Ensembl
RefSeq Acc Id: ENST00000461416
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,981 - 128,947,745 (+)Ensembl
RefSeq Acc Id: ENST00000464557   ⟹   ENSP00000419056
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,972 - 128,945,967 (+)Ensembl
RefSeq Acc Id: ENST00000465603   ⟹   ENSP00000418534
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,940,838 - 128,949,388 (+)Ensembl
RefSeq Acc Id: ENST00000467002   ⟹   ENSP00000417454
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,940,206 - 128,942,259 (+)Ensembl
RefSeq Acc Id: ENST00000473745   ⟹   ENSP00000419149
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,940,672 - 128,949,388 (+)Ensembl
RefSeq Acc Id: ENST00000473787   ⟹   ENSP00000420274
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,991 - 128,946,556 (+)Ensembl
RefSeq Acc Id: ENST00000477535   ⟹   ENSP00000419950
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,940 - 128,948,832 (+)Ensembl
RefSeq Acc Id: ENST00000479582   ⟹   ENSP00000417770
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,962 - 128,946,540 (+)Ensembl
RefSeq Acc Id: ENST00000488569
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,937 - 128,946,942 (+)Ensembl
RefSeq Acc Id: ENST00000489702   ⟹   ENSP00000418037
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,612 - 128,950,027 (+)Ensembl
RefSeq Acc Id: ENST00000613821   ⟹   ENSP00000480058
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,940 - 128,947,256 (+)Ensembl
RefSeq Acc Id: ENST00000619830   ⟹   ENSP00000483292
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,940,838 - 128,948,982 (+)Ensembl
RefSeq Acc Id: ENST00000650798
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,938,217 - 128,947,256 (+)Ensembl
RefSeq Acc Id: ENST00000652142
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,938,029 - 128,947,295 (+)Ensembl
RefSeq Acc Id: ENST00000652525   ⟹   ENSP00000498293
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7128,937,457 - 128,942,224 (+)Ensembl
RefSeq Acc Id: NM_001098627   ⟹   NP_001092097
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,940,670 - 128,950,038 (+)NCBI
GRCh377128,577,976 - 128,590,089 (+)NCBI
Build 367128,368,008 - 128,377,325 (+)NCBI Archive
HuRef7122,939,186 - 122,951,277 (+)ENTREZGENE
CHM1_17128,513,996 - 128,523,404 (+)NCBI
CRA_TCAGchr7v27127,961,737 - 127,973,832 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001098629   ⟹   NP_001092099
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,937,927 - 128,950,038 (+)NCBI
GRCh377128,577,976 - 128,590,089 (+)NCBI
Build 367128,365,230 - 128,377,325 (+)NCBI Archive
HuRef7122,939,186 - 122,951,277 (+)ENTREZGENE
CHM1_17128,511,263 - 128,523,404 (+)NCBI
CRA_TCAGchr7v27127,961,737 - 127,973,832 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001098630   ⟹   NP_001092100
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,937,927 - 128,950,038 (+)NCBI
GRCh377128,577,976 - 128,590,089 (+)NCBI
Build 367128,365,230 - 128,377,325 (+)NCBI Archive
HuRef7122,939,186 - 122,951,277 (+)ENTREZGENE
CHM1_17128,511,263 - 128,523,404 (+)NCBI
CRA_TCAGchr7v27127,961,737 - 127,973,832 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001242452   ⟹   NP_001229381
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,937,927 - 128,950,038 (+)NCBI
GRCh377128,577,976 - 128,590,089 (+)NCBI
HuRef7122,939,186 - 122,951,277 (+)ENTREZGENE
CHM1_17128,511,263 - 128,523,404 (+)NCBI
CRA_TCAGchr7v27127,961,737 - 127,973,832 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001347928   ⟹   NP_001334857
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,937,032 - 128,950,038 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001364314   ⟹   NP_001351243
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,941,268 - 128,950,038 (+)NCBI
RefSeq Acc Id: NM_032643   ⟹   NP_116032
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,938,217 - 128,950,038 (+)NCBI
GRCh377128,577,976 - 128,590,089 (+)NCBI
Build 367128,365,507 - 128,377,325 (+)NCBI Archive
HuRef7122,939,186 - 122,951,277 (+)ENTREZGENE
CHM1_17128,511,543 - 128,523,404 (+)NCBI
CRA_TCAGchr7v27127,961,737 - 127,973,832 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006715974   ⟹   XP_006716037
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,938,050 - 128,950,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516158   ⟹   XP_011514460
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,940,557 - 128,950,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516159   ⟹   XP_011514461
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,941,162 - 128,950,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516160   ⟹   XP_011514462
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,937,737 - 128,950,038 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001092097 (Get FASTA)   NCBI Sequence Viewer  
  NP_001092099 (Get FASTA)   NCBI Sequence Viewer  
  NP_001092100 (Get FASTA)   NCBI Sequence Viewer  
  NP_001229381 (Get FASTA)   NCBI Sequence Viewer  
  NP_001334857 (Get FASTA)   NCBI Sequence Viewer  
  NP_001351243 (Get FASTA)   NCBI Sequence Viewer  
  NP_116032 (Get FASTA)   NCBI Sequence Viewer  
  XP_006716037 (Get FASTA)   NCBI Sequence Viewer  
  XP_011514460 (Get FASTA)   NCBI Sequence Viewer  
  XP_011514461 (Get FASTA)   NCBI Sequence Viewer  
  XP_011514462 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA96056 (Get FASTA)   NCBI Sequence Viewer  
  AAH04139 (Get FASTA)   NCBI Sequence Viewer  
  AAH04201 (Get FASTA)   NCBI Sequence Viewer  
  AAR90325 (Get FASTA)   NCBI Sequence Viewer  
  AAR90326 (Get FASTA)   NCBI Sequence Viewer  
  AAU12877 (Get FASTA)   NCBI Sequence Viewer  
  AAU12878 (Get FASTA)   NCBI Sequence Viewer  
  AAU12879 (Get FASTA)   NCBI Sequence Viewer  
  AAU12880 (Get FASTA)   NCBI Sequence Viewer  
  AAU12881 (Get FASTA)   NCBI Sequence Viewer  
  ABB88960 (Get FASTA)   NCBI Sequence Viewer  
  ABB88961 (Get FASTA)   NCBI Sequence Viewer  
  ABK41901 (Get FASTA)   NCBI Sequence Viewer  
  ABL96293 (Get FASTA)   NCBI Sequence Viewer  
  ABL96294 (Get FASTA)   NCBI Sequence Viewer  
  ABX54712 (Get FASTA)   NCBI Sequence Viewer  
  ABX54713 (Get FASTA)   NCBI Sequence Viewer  
  ABX54714 (Get FASTA)   NCBI Sequence Viewer  
  ABX54715 (Get FASTA)   NCBI Sequence Viewer  
  AFN70752 (Get FASTA)   NCBI Sequence Viewer  
  AFN70753 (Get FASTA)   NCBI Sequence Viewer  
  AFN70754 (Get FASTA)   NCBI Sequence Viewer  
  AFN70755 (Get FASTA)   NCBI Sequence Viewer  
  AFN70756 (Get FASTA)   NCBI Sequence Viewer  
  AKI32222 (Get FASTA)   NCBI Sequence Viewer  
  AKI32223 (Get FASTA)   NCBI Sequence Viewer  
  AKI32224 (Get FASTA)   NCBI Sequence Viewer  
  AKI32225 (Get FASTA)   NCBI Sequence Viewer  
  AKI32226 (Get FASTA)   NCBI Sequence Viewer  
  AKI32227 (Get FASTA)   NCBI Sequence Viewer  
  AKI32228 (Get FASTA)   NCBI Sequence Viewer  
  AKI32229 (Get FASTA)   NCBI Sequence Viewer  
  AKI32230 (Get FASTA)   NCBI Sequence Viewer  
  AKI32231 (Get FASTA)   NCBI Sequence Viewer  
  AKI32232 (Get FASTA)   NCBI Sequence Viewer  
  AKI32233 (Get FASTA)   NCBI Sequence Viewer  
  AKI32234 (Get FASTA)   NCBI Sequence Viewer  
  AKI32235 (Get FASTA)   NCBI Sequence Viewer  
  AKI32236 (Get FASTA)   NCBI Sequence Viewer  
  AKI32237 (Get FASTA)   NCBI Sequence Viewer  
  AKI32238 (Get FASTA)   NCBI Sequence Viewer  
  BAG59600 (Get FASTA)   NCBI Sequence Viewer  
  BAH11558 (Get FASTA)   NCBI Sequence Viewer  
  EAL24107 (Get FASTA)   NCBI Sequence Viewer  
  EAL24108 (Get FASTA)   NCBI Sequence Viewer  
  EAW83703 (Get FASTA)   NCBI Sequence Viewer  
  EAW83704 (Get FASTA)   NCBI Sequence Viewer  
  EAW83705 (Get FASTA)   NCBI Sequence Viewer  
  EAW83706 (Get FASTA)   NCBI Sequence Viewer  
  EAW83707 (Get FASTA)   NCBI Sequence Viewer  
  Q13568 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001092099   ⟸   NM_001098629
- Peptide Label: isoform d
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot),   C9JAU6 (UniProtKB/TrEMBL),   B7Z1M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001092100   ⟸   NM_001098630
- Peptide Label: isoform b
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot),   B7Z1M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001229381   ⟸   NM_001242452
- Peptide Label: isoform e
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot),   B7Z1M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_116032   ⟸   NM_032643
- Peptide Label: isoform b
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001092097   ⟸   NM_001098627
- Peptide Label: isoform b
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006716037   ⟸   XM_006715974
- Peptide Label: isoform X1
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot),   C9JAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514462   ⟸   XM_011516160
- Peptide Label: isoform X1
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot),   C9JAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514460   ⟸   XM_011516158
- Peptide Label: isoform X1
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot),   C9JAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514461   ⟸   XM_011516159
- Peptide Label: isoform X1
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot),   C9JAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001334857   ⟸   NM_001347928
- Peptide Label: isoform d
- UniProtKB: Q13568 (UniProtKB/Swiss-Prot),   A0A0G2USB5 (UniProtKB/TrEMBL),   C9JAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001351243   ⟸   NM_001364314
- Peptide Label: isoform d
RefSeq Acc Id: ENSP00000419950   ⟸   ENST00000477535
RefSeq Acc Id: ENSP00000419056   ⟸   ENST00000464557
RefSeq Acc Id: ENSP00000417770   ⟸   ENST00000479582
RefSeq Acc Id: ENSP00000418534   ⟸   ENST00000465603
RefSeq Acc Id: ENSP00000417454   ⟸   ENST00000467002
RefSeq Acc Id: ENSP00000385352   ⟸   ENST00000402030
RefSeq Acc Id: ENSP00000480058   ⟸   ENST00000613821
RefSeq Acc Id: ENSP00000498293   ⟸   ENST00000652525
RefSeq Acc Id: ENSP00000249375   ⟸   ENST00000249375
RefSeq Acc Id: ENSP00000483292   ⟸   ENST00000619830
RefSeq Acc Id: ENSP00000419149   ⟸   ENST00000473745
RefSeq Acc Id: ENSP00000420274   ⟸   ENST00000473787
RefSeq Acc Id: ENSP00000418037   ⟸   ENST00000489702
RefSeq Acc Id: ENSP00000349770   ⟸   ENST00000357234
Protein Domains
IRF tryptophan pentad repeat   IRF-3

Promoters
RGD ID:6805831
Promoter ID:HG_KWN:59646
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:ENST00000342930,   NM_001098629,   NM_001098630,   NM_032643,   UC010LLR.1,   UC010LLS.1,   UC010LLT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367128,364,876 - 128,365,376 (+)MPROMDB
RGD ID:6805824
Promoter ID:HG_KWN:59647
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:UC003VOJ.2,   UC003VOK.2,   UC010LLU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367128,367,086 - 128,368,042 (+)MPROMDB
RGD ID:6805825
Promoter ID:HG_KWN:59648
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:UC010LLV.1,   UC010LLW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367128,368,521 - 128,369,702 (+)MPROMDB
RGD ID:6815616
Promoter ID:HG_MRA:15360
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:AL713733,   CU678589
Position:
Human AssemblyChrPosition (strand)Source
Build 367128,375,921 - 128,377,272 (+)MPROMDB
RGD ID:7211891
Promoter ID:EPDNEW_H11692
Type:initiation region
Name:IRF5_1
Description:interferon regulatory factor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387128,937,981 - 128,938,041EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
IRF5, 5-BP INS, PROMOTER REGION insertion Inflammatory bowel disease 14, susceptibility to [RCV000003562]|Systemic lupus erythematosus 10 [RCV000003563] Chr7:7q32 risk factor
NM_001098629.3(IRF5):c.-12+198= single nucleotide variant Rheumatoid arthritis [RCV000003565]|Systemic lupus erythematosus 10 [RCV000003564] Chr7:128938247 [GRCh38]
Chr7:128578301 [GRCh37]
Chr7:7q32.1
pathogenic|risk factor|association
NM_001098629.3(IRF5):c.*555G>A single nucleotide variant Systemic lupus erythematosus 10 [RCV000003566] Chr7:128949373 [GRCh38]
Chr7:128589427 [GRCh37]
Chr7:7q32.1
risk factor
NM_001098629.3(IRF5):c.*128T>C single nucleotide variant Systemic lupus erythematosus, association with susceptibility to, 10 [RCV000003567] Chr7:128948946 [GRCh38]
Chr7:128589000 [GRCh37]
Chr7:7q32.1
risk factor
GRCh38/hg38 7q32.1-33(chr7:128747478-134018250)x3 copy number gain See cases [RCV000051072] Chr7:128747478..134018250 [GRCh38]
Chr7:128387532..133703003 [GRCh37]
Chr7:128174768..133353543 [NCBI36]
Chr7:7q32.1-33
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q31.33-32.3(chr7:126859732-132750936)x1 copy number loss See cases [RCV000054171] Chr7:126859732..132750936 [GRCh38]
Chr7:126499786..132435696 [GRCh37]
Chr7:126287022..132086236 [NCBI36]
Chr7:7q31.33-32.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q31.2-33(chr7:117326805-134790689)x1 copy number loss See cases [RCV000138226] Chr7:117326805..134790689 [GRCh38]
Chr7:116966859..134475440 [GRCh37]
Chr7:116754095..134125980 [NCBI36]
Chr7:7q31.2-33
pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q32.1(chr7:127817826-129237503)x3 copy number gain See cases [RCV000142106] Chr7:127817826..129237503 [GRCh38]
Chr7:127457880..128877344 [GRCh37]
Chr7:127245116..128664580 [NCBI36]
Chr7:7q32.1
likely benign|uncertain significance
GRCh38/hg38 7q31.33-33(chr7:124170657-134163594)x1 copy number loss See cases [RCV000142552] Chr7:124170657..134163594 [GRCh38]
Chr7:123810711..133848346 [GRCh37]
Chr7:123597947..133498886 [NCBI36]
Chr7:7q31.33-33
pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358)x1 copy number loss See cases [RCV000447722] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q32.1(chr7:128542838-128817136)x3 copy number gain not provided [RCV000747045] Chr7:128542838..128817136 [GRCh37]
Chr7:7q32.1
benign
NM_001098629.3(IRF5):c.249G>A (p.Pro83=) single nucleotide variant not provided [RCV000905998] Chr7:128945898 [GRCh38]
Chr7:128585952 [GRCh37]
Chr7:7q32.1
benign
NM_001098629.3(IRF5):c.1504G>A (p.Gly502Ser) single nucleotide variant not provided [RCV000970179] Chr7:128948777 [GRCh38]
Chr7:128588831 [GRCh37]
Chr7:7q32.1
likely benign
NM_001098629.3(IRF5):c.572_601del (p.Arg191_Leu200del) deletion not provided [RCV000947069] Chr7:128947298..128947327 [GRCh38]
Chr7:128587352..128587381 [GRCh37]
Chr7:7q32.1
benign
NM_001098629.3(IRF5):c.303C>T (p.Arg101=) single nucleotide variant not provided [RCV000927133] Chr7:128945952 [GRCh38]
Chr7:128586006 [GRCh37]
Chr7:7q32.1
likely benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NM_001098629.3(IRF5):c.447G>A (p.Glu149=) single nucleotide variant not provided [RCV000881012] Chr7:128946562 [GRCh38]
Chr7:128586616 [GRCh37]
Chr7:7q32.1
benign
NM_001098629.3(IRF5):c.729G>A (p.Leu243=) single nucleotide variant not provided [RCV000895015] Chr7:128947477 [GRCh38]
Chr7:128587531 [GRCh37]
Chr7:7q32.1
likely benign
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
NM_001098629.3(IRF5):c.576G>A (p.Pro192=) single nucleotide variant not provided [RCV000893678] Chr7:128947324 [GRCh38]
Chr7:128587378 [GRCh37]
Chr7:7q32.1
benign
GRCh37/hg19 7q31.32-32.2(chr7:121480906-129389003)x1 copy number loss not provided [RCV000847911] Chr7:121480906..129389003 [GRCh37]
Chr7:7q31.32-32.2
pathogenic
NM_001098629.3(IRF5):c.1050T>G (p.Leu350=) single nucleotide variant not provided [RCV000953256] Chr7:128947991 [GRCh38]
Chr7:128588045 [GRCh37]
Chr7:7q32.1
benign
NM_001098629.3(IRF5):c.354C>T (p.Tyr118=) single nucleotide variant not provided [RCV000890511] Chr7:128946003 [GRCh38]
Chr7:128586057 [GRCh37]
Chr7:7q32.1
likely benign
null single nucleotide variant not provided [RCV001669876] Chr7:128939612 [GRCh38]
Chr7:128579666 [GRCh37]
Chr7:7q32.1
benign
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6120 AgrOrtholog
COSMIC IRF5 COSMIC
Ensembl Genes ENSG00000128604 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000249375 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000349770 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385352 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000417454 UniProtKB/TrEMBL
  ENSP00000417770 UniProtKB/TrEMBL
  ENSP00000418037 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000418534 UniProtKB/Swiss-Prot
  ENSP00000419056 UniProtKB/TrEMBL
  ENSP00000419149 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000419950 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000420274 UniProtKB/TrEMBL
  ENSP00000480058 UniProtKB/TrEMBL
  ENSP00000483292 UniProtKB/Swiss-Prot
  ENSP00000498293 UniProtKB/TrEMBL
Ensembl Transcript ENST00000249375 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000357234 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000402030 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000464557 UniProtKB/TrEMBL
  ENST00000465603 UniProtKB/Swiss-Prot
  ENST00000467002 UniProtKB/TrEMBL
  ENST00000473745 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000473787 UniProtKB/TrEMBL
  ENST00000477535 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000479582 UniProtKB/TrEMBL
  ENST00000489702 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000613821 UniProtKB/TrEMBL
  ENST00000619830 UniProtKB/Swiss-Prot
  ENST00000652525 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000128604 GTEx
HGNC ID HGNC:6120 ENTREZGENE
Human Proteome Map IRF5 Human Proteome Map
InterPro Interferon_reg_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_reg_fact_DNA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_reg_factor-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3663 UniProtKB/Swiss-Prot
NCBI Gene 3663 ENTREZGENE
OMIM 607218 OMIM
  612245 OMIM
  612251 OMIM
PANTHER PTHR11949 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11949:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29919 PharmGKB
PRINTS INTFRNREGFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IRF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R756_HUMAN UniProtKB/TrEMBL
  A0A087WWA0_HUMAN UniProtKB/TrEMBL
  A0A0G2UM11_HUMAN UniProtKB/TrEMBL
  A0A0G2USB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2UUJ1_HUMAN UniProtKB/TrEMBL
  B7Z1M2 ENTREZGENE, UniProtKB/TrEMBL
  C9J7M2_HUMAN UniProtKB/TrEMBL
  C9JAU6 ENTREZGENE, UniProtKB/TrEMBL
  C9JB67_HUMAN UniProtKB/TrEMBL
  C9JYP7_HUMAN UniProtKB/TrEMBL
  F8WDH6_HUMAN UniProtKB/TrEMBL
  I6YQ35_HUMAN UniProtKB/TrEMBL
  I6Z0J2_HUMAN UniProtKB/TrEMBL
  I6ZKX6_HUMAN UniProtKB/TrEMBL
  I6ZU14_HUMAN UniProtKB/TrEMBL
  I6ZY36_HUMAN UniProtKB/TrEMBL
  IRF5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q64GA8_HUMAN UniProtKB/TrEMBL
  Q64GB0_HUMAN UniProtKB/TrEMBL
UniProt Secondary A0A024R763 UniProtKB/TrEMBL
  A4D1J8 UniProtKB/Swiss-Prot
  A8DUA8 UniProtKB/Swiss-Prot
  A8DUA9 UniProtKB/Swiss-Prot
  E7EQ16 UniProtKB/Swiss-Prot
  E7EW54 UniProtKB/Swiss-Prot
  Q1A7B4 UniProtKB/Swiss-Prot
  Q64GA9 UniProtKB/Swiss-Prot
  Q64GB1 UniProtKB/Swiss-Prot
  Q64GB2 UniProtKB/Swiss-Prot
  Q6RCM8 UniProtKB/Swiss-Prot
  Q9BQF0 UniProtKB/Swiss-Prot