RGD Reference Report - IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection. - Rat Genome Database

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IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.

Authors: Fabié, Aymeric  Mai, Linh Thuy  Dagenais-Lussier, Xavier  Hammami, Akil  van Grevenynghe, Julien  Stäger, Simona 
Citation: Fabié A, etal., Cell Rep. 2018 Jul 31;24(5):1163-1175. doi: 10.1016/j.celrep.2018.06.107.
RGD ID: 40924629
Pubmed: PMID:30067973   (View Abstract at PubMed)
DOI: DOI:10.1016/j.celrep.2018.06.107   (Journal Full-text)

The transcription factor interferon regulatory factor 5 (IRF-5) plays an important function in innate immunity and in initiating pro-inflammatory responses against pathogens. IRF-5 is constitutively expressed in several cell types, including plasmacytoid dendritic cells, monocytes, and B cells. We have previously reported that IRF-5 is also expressed in T cells during infection. The role of IRF-5 in T cells is yet unknown. Here, we demonstrate that IRF-5 is increasingly expressed in interferon (IFN)-γ+ CD4 T cells over the course of L. donovani infection. This transcription factor is induced by apoptotic material via Toll-like receptor 7 (TLR7) and promotes the expression of death receptor 5 (DR5). IRF-5 activation sensitizes CD4 T cells to cell death. Because tissue disruption and chronic inflammation are common characteristics of persistent infections, activation of IRF-5 in CD4 T cells may represent a common pathway that leads to suppression of protective CD4 T cell responses, favoring the establishment of chronic infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IRF5Humanvisceral leishmaniasis  ISOIrf5 (Mus musculus)protein:increased expression:CD4 T cell and nucleusRGD 
Irf5Ratvisceral leishmaniasis  ISOIrf5 (Mus musculus)protein:increased expression:CD4 T cell and nucleusRGD 
Irf5Mousevisceral leishmaniasis  IEP protein:increased expression:CD4 T cell and nucleusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Irf5  (interferon regulatory factor 5)

Genes (Mus musculus)
Irf5  (interferon regulatory factor 5)

Genes (Homo sapiens)
IRF5  (interferon regulatory factor 5)


Additional Information