Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hook1 | Mouse | (-)-demecolcine | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of HOOK1 mRNA | CTD | PMID:23649840 | Hook1 | Mouse | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HOOK1 mRNA | CTD | PMID:36331819 | Hook1 | Mouse | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of HOOK1 mRNA | CTD | PMID:28960355 | Hook1 | Mouse | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of HOOK1 mRNA | CTD | PMID:22206623 | Hook1 | Mouse | 17beta-estradiol | multiple interactions | ISO | HOOK1 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of HOOK1 mRNA | CTD | PMID:30165855 | Hook1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HOOK1 mRNA | CTD | PMID:19465110 | Hook1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Hook1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HOOK1 mRNA | CTD | PMID:33387578 | Hook1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HOOK1 mRNA | CTD | PMID:20106945 and PMID:21632981 | Hook1 | Mouse | 3H-1,2-dithiole-3-thione | decreases expression | ISO | Hook1 (Rattus norvegicus) | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of HOOK1 mRNA | CTD | PMID:19162173 | Hook1 | Mouse | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of HOOK1 mRNA | CTD | PMID:28973697 | Hook1 | Mouse | acetamide | decreases expression | ISO | Hook1 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of HOOK1 mRNA | CTD | PMID:31881176 | Hook1 | Mouse | aflatoxin B1 | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of HOOK1 mRNA | CTD | PMID:27153756 | Hook1 | Mouse | aflatoxin B1 | decreases methylation | ISO | HOOK1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of HOOK1 gene | CTD | PMID:27153756 | Hook1 | Mouse | all-trans-retinoic acid | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of HOOK1 mRNA | CTD | PMID:23724009 | Hook1 | Mouse | amphotericin B | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Amphotericin B analog results in decreased expression of HOOK1 mRNA | CTD | PMID:28534445 | Hook1 | Mouse | aristolochic acid A | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HOOK1 mRNA | CTD | PMID:33212167 | Hook1 | Mouse | benzo[a]pyrene | increases expression | ISO | Hook1 (Rattus norvegicus) | 6480464 | Benzo(a)pyrene results in increased expression of HOOK1 mRNA | CTD | PMID:21839799 | Hook1 | Mouse | benzo[a]pyrene | decreases methylation | ISO | HOOK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of HOOK1 exon | CTD | PMID:27901495 | Hook1 | Mouse | benzo[a]pyrene | increases methylation | ISO | HOOK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of HOOK1 3' UTR | CTD | PMID:27901495 | Hook1 | Mouse | bisphenol A | affects expression | ISO | Hook1 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of HOOK1 mRNA | CTD | PMID:25181051 | Hook1 | Mouse | bisphenol A | decreases expression | ISO | Hook1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of HOOK1 mRNA | CTD | PMID:34947998 | Hook1 | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HOOK1 mRNA | CTD | PMID:25594700 | Hook1 | Mouse | bisphenol F | increases expression | EXP | | 6480464 | bisphenol F results in increased expression of HOOK1 mRNA | CTD | PMID:38685157 | Hook1 | Mouse | bisphenol F | multiple interactions | ISO | HOOK1 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of HOOK1 gene | CTD | PMID:31601247 | Hook1 | Mouse | butanal | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of HOOK1 mRNA | CTD | PMID:26079696 | Hook1 | Mouse | cadmium dichloride | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of HOOK1 mRNA | CTD | PMID:38568856 | Hook1 | Mouse | caffeine | decreases phosphorylation | ISO | HOOK1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of HOOK1 protein | CTD | PMID:35688186 | Hook1 | Mouse | calcitriol | increases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of HOOK1 mRNA | CTD | PMID:26485663 | Hook1 | Mouse | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon results in increased expression of HOOK1 mRNA | CTD | PMID:25620056 | Hook1 | Mouse | CGP 52608 | multiple interactions | ISO | HOOK1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HOOK1 gene] | CTD | PMID:28238834 | Hook1 | Mouse | cyclosporin A | increases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of HOOK1 mRNA | CTD | PMID:27989131 | Hook1 | Mouse | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of HOOK1 mRNA | CTD | PMID:21266533 | Hook1 | Mouse | dicrotophos | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of HOOK1 mRNA | CTD | PMID:28302478 | Hook1 | Mouse | doxorubicin | increases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of HOOK1 mRNA | CTD | PMID:29803840 | Hook1 | Mouse | elemental selenium | multiple interactions | ISO | HOOK1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of HOOK1 mRNA | CTD | PMID:19244175 | Hook1 | Mouse | elemental selenium | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Selenium results in decreased expression of HOOK1 mRNA | CTD | PMID:19244175 | Hook1 | Mouse | entinostat | increases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | entinostat results in increased expression of HOOK1 mRNA | CTD | PMID:27188386 | Hook1 | Mouse | folic acid | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of HOOK1 mRNA | CTD | PMID:21867686 | Hook1 | Mouse | formaldehyde | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of HOOK1 mRNA | CTD | PMID:23649840 | Hook1 | Mouse | FR900359 | decreases phosphorylation | ISO | HOOK1 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of HOOK1 protein | CTD | PMID:37730182 | Hook1 | Mouse | fulvestrant | multiple interactions | ISO | HOOK1 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of HOOK1 gene | CTD | PMID:31601247 | Hook1 | Mouse | hexane | decreases methylation | ISO | Hook1 (Rattus norvegicus) | 6480464 | n-hexane results in decreased methylation of HOOK1 promoter | CTD | PMID:23740543 | Hook1 | Mouse | maneb | multiple interactions | EXP | | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of HOOK1 mRNA | CTD | PMID:36117858 | Hook1 | Mouse | methoxychlor | affects methylation | ISO | Hook1 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of HOOK1 gene | CTD | PMID:35440735 | Hook1 | Mouse | methylmercury chloride | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of HOOK1 mRNA | CTD | PMID:23179753 and PMID:27188386 | Hook1 | Mouse | Nivalenol | increases expression | EXP | | 6480464 | nivalenol results in increased expression of HOOK1 mRNA | CTD | PMID:35016910 | Hook1 | Mouse | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of HOOK1 mRNA | CTD | PMID:34911549 | Hook1 | Mouse | paclitaxel | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Paclitaxel results in decreased expression of HOOK1 mRNA | CTD | PMID:19682730 | Hook1 | Mouse | paracetamol | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of HOOK1 mRNA | CTD | PMID:21420995 and PMID:29067470 | Hook1 | Mouse | paraquat | multiple interactions | EXP | | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of HOOK1 mRNA | CTD | PMID:36117858 | Hook1 | Mouse | perfluorooctane-1-sulfonic acid | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of HOOK1 mRNA | CTD | PMID:27153767 | Hook1 | Mouse | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HOOK1 mRNA | CTD | PMID:36331819 | Hook1 | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of HOOK1 mRNA | CTD | PMID:18301758 | Hook1 | Mouse | potassium dichromate | decreases expression | EXP | | 6480464 | Potassium Dichromate results in decreased expression of HOOK1 mRNA | CTD | PMID:23608068 | Hook1 | Mouse | quercetin | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of HOOK1 mRNA | CTD | PMID:21632981 | Hook1 | Mouse | resveratrol | multiple interactions | ISO | HOOK1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of HOOK1 mRNA | CTD | PMID:23557933 | Hook1 | Mouse | selenium atom | multiple interactions | ISO | HOOK1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of HOOK1 mRNA | CTD | PMID:19244175 | Hook1 | Mouse | selenium atom | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Selenium results in decreased expression of HOOK1 mRNA | CTD | PMID:19244175 | Hook1 | Mouse | silicon dioxide | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of HOOK1 mRNA | CTD | PMID:25895662 | Hook1 | Mouse | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of HOOK1 mRNA | CTD | PMID:37682722 | Hook1 | Mouse | sunitinib | increases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of HOOK1 mRNA | CTD | PMID:31533062 | Hook1 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of HOOK1 promoter | CTD | PMID:35295148 | Hook1 | Mouse | triphenyl phosphate | affects expression | ISO | HOOK1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of HOOK1 mRNA | CTD | PMID:37042841 | Hook1 | Mouse | tunicamycin | increases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of HOOK1 mRNA | CTD | PMID:22378314 | Hook1 | Mouse | valproic acid | decreases methylation | ISO | HOOK1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of HOOK1 gene | CTD | PMID:29154799 | Hook1 | Mouse | valproic acid | affects expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HOOK1 mRNA | CTD | PMID:25979313 | Hook1 | Mouse | valproic acid | increases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HOOK1 mRNA | CTD | PMID:23179753 more ... | Hook1 | Mouse | vincristine | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of HOOK1 mRNA | CTD | PMID:23649840 | Hook1 | Mouse | vitamin E | multiple interactions | ISO | HOOK1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of HOOK1 mRNA | CTD | PMID:19244175 | Hook1 | Mouse | vitamin E | decreases expression | ISO | HOOK1 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of HOOK1 mRNA | CTD | PMID:19244175 | |