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Gene: HOOK3 (hook microtubule tethering protein 3) Homo sapiens
Symbol: HOOK3
Name: hook microtubule tethering protein 3
Description: Exhibits several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Involved in several processes, including cytoplasmic microtubule organization; early endosome to late endosome transport; and endosome to lysosome transport. Localizes to the FHF complex and cis-Golgi network. Colocalizes with the HOPS complex.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ31058; h-hook3; hHK3; HK3; hook homolog 3; hook microtubule-tethering protein 3
Mus musculus (house mouse) : Hook3 (hook microtubule tethering protein 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hook3 (hook microtubule-tethering protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hook3 (hook microtubule tethering protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : HOOK3 (hook microtubule tethering protein 3)
Canis lupus familiaris (dog) : HOOK3 (hook microtubule tethering protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hook3 (hook microtubule tethering protein 3)
Sus scrofa (pig) : HOOK3 (hook microtubule tethering protein 3)
Chlorocebus sabaeus (green monkey) : HOOK3 (hook microtubule tethering protein 3)
Heterocephalus glaber (naked mole-rat) : Hook3 (hook microtubule tethering protein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl842,896,946 - 43,030,535 (+)Ensembl
GRCh38842,896,978 - 43,030,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,752,033 - 42,885,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,871,190 - 42,994,084 (+)NCBINCBI36hg18NCBI36
Build 34842,871,189 - 42,994,084NCBI
Celera841,700,858 - 41,834,504 (+)NCBI
Cytogenetic Map8p11.21NCBI
HuRef841,275,201 - 41,408,559 (+)NCBIHuRef
CHM1_1842,798,954 - 42,932,603 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HOOK3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346925
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.