ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8) - Rat Genome Database

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Gene: ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8) Homo sapiens
Analyze
Symbol: ZDHHC8
Name: zinc finger DHHC-type palmitoyltransferase 8
RGD ID: 1318899
HGNC Page HGNC:18474
Description: Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation and positive regulation of cholesterol efflux. Located in Golgi apparatus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DHHC8; membrane-associated DHHC8 zinc finger protein; palmitoyltransferase ZDHHC8; probable palmitoyltransferase ZDHHC8; ZDHHCL1; zinc finger DHHC-type containing 8; zinc finger protein 378; zinc finger, DHHC domain like containing 1; zinc finger, DHHC-type containing 8; ZNF378
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: ZDHHC8BP  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,131,804 - 20,148,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,129,456 - 20,148,007 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,119,327 - 20,135,530 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,499,365 - 18,513,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,493,918 - 18,508,512NCBI
Celera223,971,414 - 3,987,580 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,740,057 - 3,756,143 (+)NCBIHuRef
CHM1_12220,119,055 - 20,135,221 (+)NCBICHM1_1
T2T-CHM13v2.02220,510,837 - 20,527,042 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
ZDHHC8Humanautism spectrum disorder  IAGPRGD:113454718554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868|PMID:27569545
ZDHHC8Humanautistic disorder  IAGPRGD:14351880|RGD:14351885|RGD:143518918554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
ZDHHC8Humanchromosome 22q11.2 deletion syndrome, distal  IAGPRGD:1552657338554872ClinVar Annotator: match by term: Chromosome 22q11.2 deletion syndrome, distalClinVarPMID:31690835
ZDHHC8Humanchromosome 22q11.2 microduplication syndrome  IAGPRGD:1552657358554872ClinVar Annotator: match by term: Chromosome 22q11.2 microduplication syndromeClinVarPMID:31690835
ZDHHC8Humanchromosome 22q11.2 microduplication syndrome  IAGPRGD:4017348988554872ClinVar Annotator: match by term: Chromosome 22q11.2 microduplication syndromeClinVarPMID:25741868
ZDHHC8HumanDiGeorge syndrome  IAGPRGD:1517964868554872ClinVar Annotator: match by term: DiGeorge syndromeClinVarPMID:21921585|PMID:25516202|PMID:28492532
ZDHHC8HumanDiGeorge syndrome  IAGPRGD:127234734|RGD:1272347538554872ClinVar Annotator: match by term: DiGeorge syndromeClinVarPMID:31690835
ZDHHC8HumanDiGeorge syndrome  IAGPRGD:3293494078554872ClinVar Annotator: match by term: 22q11.2 deletion syndromeClinVar 
ZDHHC8HumanDiGeorge syndrome  IAGPRGD:214049248554872ClinVar Annotator: match by term: DiGeorge syndromeClinVarPMID:32581362
ZDHHC8HumanDiGeorge syndrome  IAGPRGD:1272400248554872ClinVar Annotator: match by term: DiGeorge syndromeClinVarPMID:24826987|PMID:25205790|PMID:25516202|PMID:25860641|PMID:26805781|PMID:26805782|PMID:28492532|PMID:29500247|PMID:30245509
ZDHHC8Humanepilepsy  IAGPRGD:427234138554872ClinVar Annotator: match by term: EpilepsyClinVar 
ZDHHC8Humanhemorrhagic disease  IAGPRGD:149760068554872ClinVar Annotator: match by term: Abnormal bleedingClinVarPMID:25741868|PMID:31064749
ZDHHC8Humanintellectual disability  IAGPRGD:427234308554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
ZDHHC8Humanmegacolon  IAGPRGD:414075678554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
ZDHHC8HumanNeurodevelopmental Disorders  IAGPRGD:14698286|RGD:14698287|RGD:146982888554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
ZDHHC8Humanprimary immunodeficiency disease  IAGPRGD:253275948554872ClinVar Annotator: match by term: Inherited Immunodeficiency DiseasesClinVarPMID:25741868
ZDHHC8Humanprostate cancer  IAGPRGD:96869858554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
ZDHHC8Humanschizophrenia  IAGPRGD:14351831|RGD:14351839|RGD:14351853|RGD:14351861|RGD:14351867|RGD:14351873|RGD:14351876|RGD:143520508554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8Humanvelocardiofacial syndrome  IAGPRGD:3293494078554872ClinVar Annotator: match by term: 22q11.2 deletion syndromeClinVar 
ZDHHC8Humanvelocardiofacial syndrome  IAGPRGD:152981058|RGD:1529810698554872ClinVar Annotator: match by term: Velocardiofacial syndromeClinVarPMID:25741868
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Original Reference(s)
ZDHHC8Humanschizophrenia  IEA 1331525 GAD 

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Original Reference(s)
ZDHHC8Human1,2-dimethylhydrazine affects expressionISORGD:155792864804641,2-Dimethylhydrazine affects the expression of ZDHHC8 mRNACTDPMID:22206623
ZDHHC8Human1,2-dimethylhydrazine increases expressionISORGD:155792864804641,2-Dimethylhydrazine results in increased expression of ZDHHC8 mRNACTDPMID:22206623
ZDHHC8Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13088756480464Tetrachlorodibenzodioxin results in increased expression of ZDHHC8 mRNACTDPMID:32109520
ZDHHC8Human3,4-methylenedioxymethamphetamine increases expressionISORGD:15579286480464N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ZDHHC8 mRNACTDPMID:20188158
ZDHHC8Human4,4'-sulfonyldiphenol decreases expressionISORGD:15579286480464bisphenol S results in decreased expression of ZDHHC8 mRNACTDPMID:39298647
ZDHHC8Humanacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of ZDHHC8 mRNACTDPMID:32763439
ZDHHC8Humanaflatoxin B1 increases methylationEXP 6480464Aflatoxin B1 results in increased methylation of ZDHHC8 exonCTDPMID:30157460
ZDHHC8Humanall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of ZDHHC8 mRNACTDPMID:33167477
ZDHHC8Humanamphetamine decreases expressionISORGD:13088756480464Amphetamine results in decreased expression of ZDHHC8 mRNACTDPMID:30779732
ZDHHC8Humanantirheumatic drug increases expressionEXP 6480464Antirheumatic Agents results in increased expression of ZDHHC8 mRNACTDPMID:24449571
ZDHHC8Humanbenzo[a]pyrene decreases methylationEXP 6480464Benzo(a)pyrene results in decreased methylation of ZDHHC8 promoterCTDPMID:27901495
ZDHHC8Humanbisphenol A increases expressionISORGD:13088756480464bisphenol A results in increased expression of ZDHHC8 mRNACTDPMID:24988533|PMID:25181051
ZDHHC8Humanbutanal decreases expressionEXP 6480464butyraldehyde results in decreased expression of ZDHHC8 mRNACTDPMID:26079696
ZDHHC8Humancaffeine affects phosphorylationEXP 6480464Caffeine affects the phosphorylation of ZDHHC8 proteinCTDPMID:35688186
ZDHHC8Humancalyculin A decreases expressionISORGD:15579286480464calyculin A results in decreased expression of ZDHHC8 mRNACTDPMID:25270620
ZDHHC8Humanchlorpyrifos increases expressionISORGD:15579286480464Chlorpyrifos results in increased expression of ZDHHC8 mRNACTDPMID:37019170
ZDHHC8Humancisplatin multiple interactionsEXP 6480464[Cisplatin co-treated with jinfukang] results in increased expression of ZDHHC8 mRNACTDPMID:27392435
ZDHHC8Humancobalt dichloride decreases expressionEXP 6480464cobaltous chloride results in decreased expression of ZDHHC8 mRNACTDPMID:19320972
ZDHHC8Humancocaine affects expressionISORGD:13088756480464Cocaine affects the expression of ZDHHC8 mRNACTDPMID:20187946
ZDHHC8Humandicrotophos increases expressionEXP 6480464dicrotophos results in increased expression of ZDHHC8 mRNACTDPMID:28302478

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Biological Process

  
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Original Reference(s)
ZDHHC8Humanhigh-density lipoprotein particle assembly involved_inTAS 150520179 ReactomeReactome:R-HSA-8963896
ZDHHC8Humanlocomotory behavior acts_upstream_of_or_withinIEAUniProtKB:Q5Y5T5|ensembl:ENSMUSP00000076224150520179 EnsemblGO_REF:0000107
ZDHHC8Humanpeptidyl-L-cysteine S-palmitoylation involved_inIDA 150520179 PMID:19556522UniProtPMID:19556522
ZDHHC8Humanpositive regulation of cholesterol efflux involved_inIDA 150520179 PMID:19556522UniProtPMID:19556522
ZDHHC8Humanpositive regulation of cholesterol efflux involved_inIBAPANTHER:PTN002643668|UniProtKB:Q9ULC8150520179 GO_CentralGO_REF:0000033
ZDHHC8Humanpositive regulation of protein localization to plasma membrane involved_inICGO:0010875150520179 PMID:19556522UniProtPMID:19556522
ZDHHC8Humanprotein palmitoylation involved_inIDA 150520179 PMID:23034182UniProtPMID:23034182
ZDHHC8Humanregulation of postsynapse assembly involved_inIEAUniProtKB:Q5Y5T5|ensembl:ENSMUSP00000076224150520179 EnsemblGO_REF:0000107

Cellular Component
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Original Reference(s)
ZDHHC8Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-5682084
ZDHHC8Humanglutamatergic synapse is_active_inIEAUniProtKB:Q5Y5T5|ensembl:ENSMUSP00000076224150520179 EnsemblGO_REF:0000107
ZDHHC8HumanGolgi apparatus is_active_inIBAPANTHER:PTN002643668|UniProtKB:Q9ULC8150520179 GO_CentralGO_REF:0000033
ZDHHC8HumanGolgi apparatus located_inIEAUniProtKB-KW:KW-0333150520179 UniProtGO_REF:0000043
ZDHHC8HumanGolgi apparatus located_inIDA 150520179 PMID:16647879UniProtPMID:16647879
ZDHHC8HumanGolgi membrane located_inTAS 150520179 ReactomeReactome:R-HSA-9694341
ZDHHC8HumanGolgi membrane located_inIEAUniProtKB-SubCell:SL-0134150520179 UniProtGO_REF:0000044
ZDHHC8Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
ZDHHC8Humanmitochondrial membrane located_inIEAUniProtKB-SubCell:SL-0171150520179 UniProtGO_REF:0000044
ZDHHC8Humanmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
ZDHHC8Humanmitochondrion located_inIEAUniProtKB:Q5Y5T5|ensembl:ENSMUSP00000076224150520179 EnsemblGO_REF:0000107
ZDHHC8Humanpostsynapse is_active_inIEAUniProtKB:Q5Y5T5|ensembl:ENSMUSP00000076224150520179 EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
ZDHHC8Humanacyltransferase activity enablesIEAUniRule:UR000079119150520179 UniProtGO_REF:0000104
ZDHHC8Humanacyltransferase activity enablesIEAUniProtKB-KW:KW-0012150520179 UniProtGO_REF:0000043
ZDHHC8Humanpalmitoyltransferase activity enablesIDA 150520179 PMID:23034182UniProtPMID:23034182
ZDHHC8Humanpalmitoyltransferase activity enablesIBAMGI:1923573|PANTHER:PTN000525808|UniProtKB:Q9C0B5|UniProtKB:Q9ULC8150520179 GO_CentralGO_REF:0000033
ZDHHC8Humanpalmitoyltransferase activity enablesIEAInterPro:IPR001594150520179 InterProGO_REF:0000002
ZDHHC8Humanprotein binding enablesISOPR:Q9CZ139068941 PMID:18775783MGIPMID:18775783
ZDHHC8Humanprotein-cysteine S-palmitoyltransferase activity enablesIEAEC:2.3.1.225150520179 UniProtGO_REF:0000003
ZDHHC8Humanprotein-cysteine S-palmitoyltransferase activity enablesTAS 150520179 ReactomeReactome:R-HSA-5682084
ZDHHC8Humanprotein-cysteine S-palmitoyltransferase activity enablesIEARHEA:36683150520179 RHEAGO_REF:0000116
ZDHHC8Humanprotein-cysteine S-palmitoyltransferase activity enablesICGO:0018230150520179 PMID:19556522UniProtPMID:19556522
ZDHHC8Humantransferase activity enablesIEAUniProtKB-KW:KW-0808150520179 UniProtGO_REF:0000043
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1 to 18 of 18 rows
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Original Reference(s)
ZDHHC8HumanAbnormal bleeding  IAGPRGD:149760068554872ClinVar Annotator: match by term: Abnormal bleedingClinVarPMID:25741868|PMID:31064749
ZDHHC8HumanAutism  IAGPRGD:143518858554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanAutism  IAGPRGD:143518918554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanAutism  IAGPRGD:143518808554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanAutistic behavior  IAGPRGD:113454718554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868|PMID:27569545
ZDHHC8HumanDeep venous thrombosis  IAGPRGD:149760108554872ClinVar Annotator: match by term: Deep venous thrombosisClinVarPMID:25741868|PMID:31064749
ZDHHC8HumanIntellectual disability  IAGPRGD:427234308554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
ZDHHC8HumanMegacolon  IAGPRGD:414075678554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
ZDHHC8HumanProstate cancer  IAGPRGD:96869858554872ClinVar Annotator: match by term: Prostatic cancerClinVarPMID:23265383
ZDHHC8HumanSchizophrenia  IAGPRGD:143518618554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanSchizophrenia  IAGPRGD:143518318554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanSchizophrenia  IAGPRGD:143520508554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanSchizophrenia  IAGPRGD:143518738554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanSchizophrenia  IAGPRGD:143518538554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanSchizophrenia  IAGPRGD:143518678554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanSchizophrenia  IAGPRGD:143518398554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanSchizophrenia  IAGPRGD:143518768554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
ZDHHC8HumanSeizure  IAGPRGD:427234138554872ClinVar Annotator: match by term: EpilepsyClinVar 
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#
Reference Title
Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10574462   PMID:10591208   PMID:12477932   PMID:14702039   PMID:15184899   PMID:15461802   PMID:15489219   PMID:15489334   PMID:15631889   PMID:15992527   PMID:16150541   PMID:16225675  
PMID:16647879   PMID:16860541   PMID:17728672   PMID:18075473   PMID:18583979   PMID:19156168   PMID:19556522   PMID:19801377   PMID:20468064   PMID:20468065   PMID:20661937   PMID:21873635  
PMID:22763378   PMID:23034182   PMID:23403413   PMID:24068808   PMID:24912190   PMID:26186194   PMID:27365300   PMID:28514442   PMID:28562378   PMID:30194290   PMID:30639242   PMID:30945288  
PMID:31871319   PMID:33961781   PMID:34079125   PMID:34273398   PMID:34599882   PMID:34702444   PMID:35748872   PMID:38117590   PMID:38211651  



ZDHHC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,131,804 - 20,148,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,129,456 - 20,148,007 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,119,327 - 20,135,530 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,499,365 - 18,513,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,493,918 - 18,508,512NCBI
Celera223,971,414 - 3,987,580 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,740,057 - 3,756,143 (+)NCBIHuRef
CHM1_12220,119,055 - 20,135,221 (+)NCBICHM1_1
T2T-CHM13v2.02220,510,837 - 20,527,042 (+)NCBIT2T-CHM13v2.0
Zdhhc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,038,612 - 18,056,471 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,038,617 - 18,053,000 (-)EnsemblGRCm39 Ensembl
GRCm381618,220,748 - 18,235,153 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,220,753 - 18,235,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,220,846 - 18,235,229 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,134,316 - 18,148,699 (-)NCBIMGSCv36mm8
Celera1618,793,499 - 18,807,882 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.29NCBI
Zdhhc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,259,383 - 96,273,588 (+)NCBIGRCr8
mRatBN7.21182,755,110 - 82,769,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,755,143 - 82,767,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,483,528 - 91,496,137 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,144,756 - 84,157,365 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,198,271 - 83,210,880 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,903,122 - 86,917,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,903,122 - 86,915,715 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,997,052 - 90,011,199 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,748,939 - 84,762,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,789,663 - 84,801,365 (+)NCBI
Celera1181,532,206 - 81,544,662 (+)NCBICelera
Cytogenetic Map11q23NCBI
Zdhhc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,965,963 - 17,980,854 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,965,186 - 17,980,854 (-)NCBIChiLan1.0ChiLan1.0
ZDHHC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22329,758,722 - 29,775,502 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,306,195 - 32,322,379 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,891,738 - 2,894,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ZDHHC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,192,867 - 29,208,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,193,682 - 29,208,105 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,153,540 - 29,167,095 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,596,983 - 30,612,849 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,596,996 - 30,612,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,646,506 - 28,660,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,271,871 - 28,285,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,356,852 - 29,370,420 (-)NCBIUU_Cfam_GSD_1.0
Zdhhc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,705,995 - 138,722,077 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366194,032,659 - 4,048,155 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366194,032,665 - 4,048,079 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZDHHC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,503,114 - 51,516,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,503,074 - 51,517,577 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,140,126 - 55,154,612 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZDHHC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,591,311 - 5,607,448 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,589,090 - 5,607,387 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,326,410 - 1,342,682 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zdhhc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747739,594 - 754,989 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747740,352 - 755,891 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in ZDHHC8
89 total Variants

1 to 10 of 543 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh37/hg19 22q11.21(chr22:18915347-21463730)x1 copy number loss VATER association [RCV000520380] Chr22:18915347..21463730 [GRCh37]
Chr22:22q11.21		 likely pathogenic
GRCh37/hg19 22q11.21(chr22:18894835-21464119) copy number gain Global developmental delay [RCV001291954] Chr22:18894835..21464119 [GRCh37]
Chr22:22q11.21		 pathogenic
GRCh37/hg19 22q11.21(chr22:18894835-20311763) copy number loss Astigmatism [RCV000626527] Chr22:18894835..20311763 [GRCh37]
Chr22:22q11.21		 pathogenic
GRCh38/hg38 22q11.21(chr22:18339130-21207225)x3 copy number gain See cases [RCV000050271] Chr22:18339130..21207225 [GRCh38]
Chr22:18919942..21561514 [GRCh37]
Chr22:17299942..19891514 [NCBI36]
Chr22:22q11.21		 pathogenic
GRCh38/hg38 22q11.21(chr22:18339130-21207225)x1 copy number loss See cases [RCV000050273] Chr22:18339130..21207225 [GRCh38]
Chr22:18919942..21561514 [GRCh37]
Chr22:17299942..19891514 [NCBI36]
Chr22:22q11.21		 pathogenic
GRCh38/hg38 22q11.21(chr22:18339130-20671425)x1 copy number loss See cases [RCV000050290] Chr22:18339130..20671425 [GRCh38]
Chr22:18706001..21025713 [GRCh37]
Chr22:17086001..19355713 [NCBI36]
Chr22:22q11.21		 pathogenic
GRCh38/hg38 22q11.21(chr22:18339130-21086225)x3 copy number gain See cases [RCV000050991] Chr22:18339130..21086225 [GRCh38]
Chr22:18919942..21440514 [GRCh37]
Chr22:17299942..19770514 [NCBI36]
Chr22:22q11.21		 pathogenic
GRCh38/hg38 22q11.21(chr22:18339130-21086225)x1 copy number loss See cases [RCV000050992] Chr22:18339130..21086225 [GRCh38]
Chr22:18919942..21440514 [GRCh37]
Chr22:17299942..19770514 [NCBI36]
Chr22:22q11.21		 pathogenic
GRCh38/hg38 22q11.1-11.21(chr22:16916608-20324240)x3 copy number gain See cases [RCV000050858] Chr22:16916608..20324240 [GRCh38]
Chr22:17397498..20311763 [GRCh37]
Chr22:15777498..18691763 [NCBI36]
Chr22:22q11.1-11.21		 pathogenic
GRCh38/hg38 22q11.1-11.21(chr22:16916608-20324240)x1 copy number loss See cases [RCV000050859] Chr22:16916608..20324240 [GRCh38]
Chr22:17397498..20311763 [GRCh37]
Chr22:15777498..18691763 [NCBI36]
Chr22:22q11.1-11.21		 pathogenic
1 to 10 of 543 rows

Predicted Target Of
Summary Value
Count of predictions:4276
Count of miRNA genes:994
Interacting mature miRNAs:1239
Transcripts:ENST00000320602, ENST00000334554, ENST00000405930, ENST00000436518, ENST00000468112, ENST00000469212, ENST00000472497
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1581529BP71_HBlood pressure QTL 71 (human)20.001Blood pressurepulse pressure221109496637094966Human
597509375GWAS1605449_Hschizophrenia QTL GWAS1605449 (human)0.000005schizophrenia222014721620147217Human
597493038GWAS1589112_Hbody mass index QTL GWAS1589112 (human)7e-12body mass indexbody mass index (BMI) (CMO:0000105)222014003120140032Human
2289428BW313_HBody weight QTL 313 (human)2.090.0015Body weightBMI221134428437344284Human
597266625GWAS1362699_Heosinophil count QTL GWAS1362699 (human)3e-09eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)222013240720132408Human
597095309GWAS1191383_Hschizophrenia QTL GWAS1191383 (human)0.000008schizophrenia222014682720146828Human

A008R36  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372223,740,510 - 23,740,750UniSTSGRCh37
GRCh372220,132,289 - 20,132,531UniSTSGRCh37
Build 362218,512,289 - 18,512,531RGDNCBI36
Celera227,554,969 - 7,555,209UniSTS
Celera223,984,339 - 3,984,581RGD
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map22q11.21UniSTS
HuRef226,707,753 - 6,707,993UniSTS
HuRef223,752,902 - 3,753,144UniSTS
GeneMap99-GB4 RH Map2210.87UniSTS
RH91790  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372223,739,264 - 23,739,395UniSTSGRCh37
GRCh372220,133,710 - 20,133,841UniSTSGRCh37
Build 362218,513,710 - 18,513,841RGDNCBI36
Celera227,553,723 - 7,553,854UniSTS
Celera223,985,760 - 3,985,891RGD
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map22q11.21UniSTS
HuRef226,706,507 - 6,706,638UniSTS
HuRef223,754,323 - 3,754,454UniSTS
GeneMap99-GB4 RH Map2217.11UniSTS
SHGC-58939  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,132,641 - 20,132,754UniSTSGRCh37
Build 362218,512,641 - 18,512,754RGDNCBI36
Celera223,984,691 - 3,984,804RGD
Cytogenetic Map22q11.21UniSTS
TNG Radiation Hybrid Map221382.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2252 4974 1726 2351 6 624 1946 465 2270 7302 6468 53 3734 1 852 1744 1617 175 1



Ensembl Acc Id: ENST00000320602   ⟹   ENSP00000317804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2220,131,948 - 20,146,450 (+)Ensembl
Ensembl Acc Id: ENST00000334554   ⟹   ENSP00000334490
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2220,131,804 - 20,148,007 (+)Ensembl
Ensembl Acc Id: ENST00000405930   ⟹   ENSP00000384716
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2220,131,948 - 20,148,006 (+)Ensembl
Ensembl Acc Id: ENST00000436518   ⟹   ENSP00000412807
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2220,129,456 - 20,139,909 (+)Ensembl
Ensembl Acc Id: ENST00000468112
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2220,131,995 - 20,141,532 (+)Ensembl
Ensembl Acc Id: ENST00000469212
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2220,139,937 - 20,141,326 (+)Ensembl
Ensembl Acc Id: ENST00000472497
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2220,140,405 - 20,142,987 (+)Ensembl
RefSeq Acc Id: NM_001185024   ⟹   NP_001171953
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382220,131,804 - 20,148,007 (+)NCBI
GRCh372220,119,364 - 20,135,530 (+)ENTREZGENE
HuRef223,740,057 - 3,756,143 (+)ENTREZGENE
CHM1_12220,119,055 - 20,135,221 (+)NCBI
T2T-CHM13v2.02220,510,837 - 20,527,042 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013373   ⟹   NP_037505
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382220,131,804 - 20,148,007 (+)NCBI
GRCh372220,119,364 - 20,135,530 (+)ENTREZGENE
Build 362218,499,365 - 18,513,974 (+)NCBI Archive
HuRef223,740,057 - 3,756,143 (+)ENTREZGENE
CHM1_12220,119,055 - 20,135,221 (+)NCBI
T2T-CHM13v2.02220,510,837 - 20,527,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006724239   ⟹   XP_006724302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382220,131,804 - 20,148,007 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054325592   ⟹   XP_054181567
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02220,510,837 - 20,527,042 (+)NCBI
RefSeq Acc Id: NP_037505   ⟸   NM_013373
- Peptide Label: isoform 2
- UniProtKB: Q6ZNF5 (UniProtKB/Swiss-Prot),   Q6ICL1 (UniProtKB/Swiss-Prot),   Q2TGE9 (UniProtKB/Swiss-Prot),   Q7Z6L9 (UniProtKB/Swiss-Prot),   Q9ULC8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001171953   ⟸   NM_001185024
- Peptide Label: isoform 1
- UniProtKB: Q9ULC8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006724302   ⟸   XM_006724239
- Peptide Label: isoform X1
- UniProtKB: Q9ULC8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000317804   ⟸   ENST00000320602
Ensembl Acc Id: ENSP00000334490   ⟸   ENST00000334554
DHHC   Palmitoyltransferase DHHC

Name Modeler Protein Id AA Range Protein Structure
AF-Q9ULC8-F1-model_v2 AlphaFold Q9ULC8 1-765 view protein structure

RGD ID:6800502
Promoter ID:HG_KWN:41590
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000318567
Position:
Human AssemblyChrPosition (strand)Source
Build 362218,496,106 - 18,497,057 (+)MPROMDB
RGD ID:6800500
Promoter ID:HG_KWN:41591
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000334554,   NM_001185024,   OTTHUMT00000318564,   OTTHUMT00000318568
Position:
Human AssemblyChrPosition (strand)Source
Build 362218,498,456 - 18,499,397 (+)MPROMDB
RGD ID:13603268
Promoter ID:EPDNEW_H27818
Type:initiation region
Name:ZDHHC8_1
Description:zinc finger DHHC-type containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382220,131,813 - 20,131,873EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
COSMIC ZDHHC8 COSMIC
Ensembl Genes ENSG00000099904 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000320602.11 UniProtKB/Swiss-Prot
  ENST00000334554 ENTREZGENE
  ENST00000334554.12 UniProtKB/Swiss-Prot
  ENST00000405930 ENTREZGENE
  ENST00000405930.3 UniProtKB/Swiss-Prot
GTEx ENSG00000099904 GTEx
HGNC ID HGNC:18474 ENTREZGENE
Human Proteome Map ZDHHC8 Human Proteome Map
InterPro Palmitoyltrfase_DHHC UniProtKB/Swiss-Prot
KEGG Report hsa:29801 UniProtKB/Swiss-Prot
NCBI Gene 29801 ENTREZGENE
OMIM 608784 OMIM
PANTHER ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR12349:SF1 UniProtKB/Swiss-Prot
Pfam DHHC UniProtKB/Swiss-Prot
PharmGKB PA38339 PharmGKB
PROSITE DHHC UniProtKB/Swiss-Prot
UniProt C9JVM2_HUMAN UniProtKB/TrEMBL
  Q2TGE9 ENTREZGENE
  Q6ICL1 ENTREZGENE
  Q6ZNF5 ENTREZGENE
  Q7Z6L9 ENTREZGENE
  Q96GI9_HUMAN UniProtKB/TrEMBL
  Q9ULC8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q2TGE9 UniProtKB/Swiss-Prot
  Q6ICL1 UniProtKB/Swiss-Prot
  Q6ZNF5 UniProtKB/Swiss-Prot
  Q7Z6L9 UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-22 ZDHHC8  zinc finger DHHC-type palmitoyltransferase 8  ZDHHC8  zinc finger DHHC-type containing 8  Symbol and/or name change 5135510 APPROVED
2016-02-18 ZDHHC8  zinc finger DHHC-type containing 8    zinc finger, DHHC-type containing 8  Symbol and/or name change 5135510 APPROVED