LARS2 (leucyl-tRNA synthetase 2, mitochondrial) - Rat Genome Database

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Advanced Search (OLGA)
Gene: LARS2 (leucyl-tRNA synthetase 2, mitochondrial) Homo sapiens
Analyze
Symbol: LARS2
Name: leucyl-tRNA synthetase 2, mitochondrial
RGD ID: 1318191
HGNC Page HGNC:17095
Description: Enables leucine-tRNA ligase activity. Involved in leucyl-tRNA aminoacylation. Located in mitochondrion. Implicated in Perrault syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: HLASA; KIAA0028; leucine translase; leucine tRNA ligase 2, mitochondrial; leucine tRNA ligase 2, mitocondrial; leucine--tRNA ligase, mitochondrial; leucyl-tRNA synthetase 2; LEURS; MGC26121; mtLeuRS; PRLTS4; probable leucine--tRNA ligase, mitochondrial; probable leucyl-tRNA synthetase, mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38345,388,576 - 45,549,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl345,388,561 - 45,554,726 (+)EnsemblGRCh38hg38GRCh38
GRCh37345,430,068 - 45,590,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,405,079 - 45,565,332 (+)NCBINCBI36Build 36hg18NCBI36
Build 34345,405,078 - 45,565,332NCBI
Celera345,368,449 - 45,528,754 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef345,473,932 - 45,634,902 (+)NCBIHuRef
CHM1_1345,380,072 - 45,540,452 (+)NCBICHM1_1
T2T-CHM13v2.0345,404,942 - 45,565,766 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
LARS2Humangenetic disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532 and PMID:36413997
LARS2Humangenetic disease  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
LARS2Humangenetic disease  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
LARS2Humangenetic disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24033266 more ...
LARS2Humangenetic disease  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
LARS2Humangenetic disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24033266 more ...
LARS2Humangenetic disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:23541342 more ...
LARS2Humangenetic disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24033266 more ...
LARS2Humangenetic disease  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24033266 and PMID:28492532
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hydrops more ...ClinVarPMID:26537577
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: LARS2-related conditionClinVarPMID:28492532
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Hydrops more ...ClinVarPMID:25741868 and PMID:32442335
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens) more ...8554872ClinVar more ...ClinVarPMID:24033266 more ...
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: LARS2-related conditionClinVarPMID:24033266 and PMID:28492532
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: LARS2-related conditionClinVarPMID:24033266 more ...
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hydrops more ...ClinVarPMID:23541342 more ...
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: LARS2-related conditionClinVarPMID:24033266 more ...
LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hydrops more ...ClinVarPMID:25741868 more ...
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LARS2HumanHYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA  IAGP 7240710 OMIM 
LARS2HumanPerrault Syndrome 4  IAGP 7240710 OMIM 

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LARS2Human(+)-schisandrin B multiple interactionsISOLars2 (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of LARS2 mRNA]CTDPMID:31150632
LARS2Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of LARS2 mRNACTDPMID:11489354
LARS2Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOLars2 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of LARS2 mRNACTDPMID:33387578
LARS2Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOLars2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of LARS2 mRNACTDPMID:21570461 and PMID:28922406
LARS2Human2-methylcholine affects expressionEXP 6480464beta-methylcholine affects the expression of LARS2 mRNACTDPMID:21179406
LARS2Human4,4'-sulfonyldiphenol increases methylationEXP 6480464bisphenol S results in increased methylation of LARS2 geneCTDPMID:31601247
LARS2Humanaflatoxin B1 increases methylationEXP 6480464Aflatoxin B1 results in increased methylation of LARS2 geneCTDPMID:27153756
LARS2HumanAflatoxin B2 alpha decreases methylationEXP 6480464aflatoxin B2 results in decreased methylation of LARS2 intronCTDPMID:30157460
LARS2Humanall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of LARS2 mRNACTDPMID:33167477
LARS2Humanamiodarone increases expressionISOLars2 (Mus musculus)6480464Amiodarone results in increased expression of LARS2 mRNACTDPMID:24489787
LARS2Humanarsenite(3-) multiple interactionsEXP 6480464arsenite inhibits the reaction [G3BP1 protein binds to LARS2 mRNA]CTDPMID:32406909
LARS2Humanatrazine decreases expressionEXP 6480464Atrazine results in decreased expression of LARS2 mRNACTDPMID:22378314
LARS2Humanbenzo[a]pyrene decreases expressionEXP 6480464Benzo(a)pyrene results in decreased expression of LARS2 mRNACTDPMID:20064835
LARS2Humanbenzo[a]pyrene affects methylationEXP 6480464Benzo(a)pyrene affects the methylation of LARS2 intronCTDPMID:30157460
LARS2Humanbenzo[a]pyrene increases expressionISOLars2 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of LARS2 mRNACTDPMID:22228805
LARS2Humanbenzo[a]pyrene multiple interactionsISOLars2 (Mus musculus)6480464AHR protein affects the reaction [Benzo(a)pyrene affects the expression of LARS2 mRNA]CTDPMID:22228805
LARS2Humanbenzo[a]pyrene diol epoxide I decreases expressionEXP 64804647 more ...CTDPMID:19150397
LARS2Humanbis(2-ethylhexyl) phthalate decreases expressionISOLars2 (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of LARS2 mRNACTDPMID:33754040
LARS2Humanbisphenol A decreases expressionISOLars2 (Mus musculus)6480464bisphenol A results in decreased expression of LARS2 mRNACTDPMID:23798566 more ...
LARS2Humanbisphenol A increases expressionISOLars2 (Mus musculus)6480464bisphenol A results in increased expression of LARS2 mRNACTDPMID:38701888

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Biological Process

  
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Original Reference(s)
LARS2Humanaminoacyl-tRNA metabolism involved in translational fidelity involved_inIEAGO:0002161150520179 GOCGO_REF:0000108
LARS2Humanleucyl-tRNA aminoacylation involved_inIDA 150520179 PMID:10684970HGNCPMID:10684970
LARS2Humanleucyl-tRNA aminoacylation involved_inIBACGD:CAL0000195709 more ...150520179 GO_CentralGO_REF:0000033
LARS2Humanleucyl-tRNA aminoacylation involved_inIEAInterPro:IPR002302150520179 InterProGO_REF:0000002
LARS2Humanmitochondrial translation involved_inIBAPANTHER:PTN000236416 and SGD:S000004374150520179 GO_CentralGO_REF:0000033
LARS2Humantranslation involved_inIEAUniProtKB-KW:KW-0648150520179 UniProtGO_REF:0000043
LARS2HumantRNA aminoacylation for protein translation involved_inTAS 150520179 ReactomeReactome:R-HSA-379726
LARS2HumantRNA aminoacylation for protein translation involved_inIEAInterPro:IPR001412 more ...150520179 InterProGO_REF:0000002

Cellular Component

  
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Original Reference(s)
LARS2Humancytoplasm located_inIEAARBA:ARBA00026971150520179 UniProtGO_REF:0000117
LARS2Humanmitochondrial matrix located_inTAS 150520179 ReactomeReactome:R-HSA-380200
LARS2Humanmitochondrial matrix located_inIEAUniProtKB-SubCell:SL-0170150520179 UniProtGO_REF:0000044
LARS2Humanmitochondrion located_inHTP 150520179 PMID:34800366FlyBasePMID:34800366
LARS2Humanmitochondrion is_active_inIBAPANTHER:PTN000236416 and SGD:S000004374150520179 GO_CentralGO_REF:0000033
LARS2Humanmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043

Molecular Function
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Original Reference(s)
LARS2Humanaminoacyl-tRNA deacylase activity enablesIEAInterPro:IPR009008 and InterPro:IPR025709150520179 InterProGO_REF:0000002
LARS2Humanaminoacyl-tRNA ligase activity enablesIEAUniProtKB-KW:KW-0030150520179 UniProtGO_REF:0000043
LARS2Humanaminoacyl-tRNA ligase activity enablesIEAInterPro:IPR001412 more ...150520179 InterProGO_REF:0000002
LARS2HumanATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
LARS2HumanATP binding enablesIEAInterPro:IPR001412 more ...150520179 InterProGO_REF:0000002
LARS2Humanleucine-tRNA ligase activity enablesIEARHEA:11688150520179 RHEAGO_REF:0000116
LARS2Humanleucine-tRNA ligase activity enablesIBACGD:CAL0000195709 more ...150520179 GO_CentralGO_REF:0000033
LARS2Humanleucine-tRNA ligase activity enablesIEAEC:6.1.1.4150520179 UniProtGO_REF:0000003
LARS2Humanleucine-tRNA ligase activity enablesTAS 150520179 ReactomeReactome:R-HSA-380200
LARS2Humanleucine-tRNA ligase activity enablesIDA 150520179 PMID:10684970 and PMID:26537577HGNCPMID:10684970 and PMID:26537577
LARS2Humanleucine-tRNA ligase activity enablesIEAInterPro:IPR002302150520179 InterProGO_REF:0000002
LARS2Humanligase activity enablesIEAUniProtKB-KW:KW-0436150520179 UniProtGO_REF:0000043
LARS2Humannucleotide binding enablesIEAInterPro:IPR001412 more ...150520179 InterProGO_REF:0000002
LARS2Humannucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
1 to 14 of 14 rows

Imported Annotations - KEGG (archival)

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Original Reference(s)
LARS2Humanvaline, leucine and isoleucine biosynthetic pathway  IEA 6907045 KEGGhsa:00290

External Pathway Database Links

KEGG Pathway Valine, leucine and isoleucine biosynthesis

1 to 20 of 51 rows
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Original Reference(s)
LARS2HumanAnemia  IAGP 8699517 HPOMIM:617021
LARS2HumanAntenatal onset  IAGP 8699517 HPOMIM:617021
LARS2HumanAscites  IAGP 8699517 HPOMIM:617021
LARS2HumanAutosomal recessive inheritance  IAGP 8699517 HPOMIM:617021
LARS2HumanAutosomal recessive inheritance  IAGP 8699517 HPOMIM:615300
LARS2HumanBicornuate uterus  IAGP 8699517 HPOMIM:615300
LARS2HumanCleft palate  IAGP 8699517 HPOMIM:615300
LARS2HumanCognitive impairment  IAGP 8699517 HPOMIM:615300
LARS2HumanCongenital onset  IAGP 8699517 HPOMIM:617021
LARS2HumanCubitus valgus  IAGP 8699517 HPOMIM:615300
LARS2HumanDecreased liver function  IAGP 8699517 HPOMIM:617021
LARS2HumanDecreased serum estradiol  IAGP 8699517 HPOMIM:615300
LARS2HumanDisproportionate tall stature  IAGP 8699517 HPOMIM:615300
LARS2HumanEEG abnormality  IAGP 8699517 HPOMIM:617021
LARS2HumanErythroid hyperplasia  IAGP 8699517 HPOMIM:617021
LARS2HumanExtramedullary hematopoiesis  IAGP 8699517 HPOMIM:617021
LARS2HumanFetal pericardial effusion  IAGP 8699517 HPOMIM:617021
LARS2HumanGait ataxia  IAGP 8699517 HPOMIM:615300
LARS2HumanHematuria  IAGP 8699517 HPOMIM:617021
LARS2HumanHypertension  IAGP 8699517 HPOMIM:617021
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Original Reference(s)
LARS2HumanPremature ovarian insufficiency  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Premature ovarian failureClinVarPMID:25741868

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
PMID:1684970   PMID:7584026   PMID:7584028   PMID:9408748   PMID:10647888   PMID:10684970   PMID:12477932   PMID:12527375   PMID:12549915   PMID:12821328   PMID:15123417   PMID:15161933  
PMID:15489334   PMID:15737668   PMID:15919814   PMID:18796578   PMID:19129950   PMID:19847392   PMID:20194621   PMID:20877624   PMID:21873635   PMID:21903180   PMID:23541342   PMID:24413189  
PMID:24927181   PMID:25254289   PMID:25515538   PMID:25921289   PMID:26186194   PMID:26272616   PMID:26537577   PMID:26598620   PMID:26657938   PMID:26970254   PMID:28319085   PMID:28380382  
PMID:28514442   PMID:29071539   PMID:29205794   PMID:29507755   PMID:29564676   PMID:29568061   PMID:29762635   PMID:30021884   PMID:30033366   PMID:30737337   PMID:31056398   PMID:31091453  
PMID:31536960   PMID:31617661   PMID:31871319   PMID:31932471   PMID:32239614   PMID:32442335   PMID:32628020   PMID:32877691   PMID:33545068   PMID:33961781   PMID:34079125   PMID:34373451  
PMID:34800366   PMID:35032548   PMID:35256949   PMID:35509820   PMID:35585880   PMID:35659337   PMID:35748872   PMID:35750896   PMID:35831314   PMID:35944360   PMID:36168627   PMID:36215168  
PMID:36436798   PMID:37433992   PMID:37827155   PMID:38186093   PMID:39052101   PMID:39147351   PMID:39358380  



LARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38345,388,576 - 45,549,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl345,388,561 - 45,554,726 (+)EnsemblGRCh38hg38GRCh38
GRCh37345,430,068 - 45,590,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,405,079 - 45,565,332 (+)NCBINCBI36Build 36hg18NCBI36
Build 34345,405,078 - 45,565,332NCBI
Celera345,368,449 - 45,528,754 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef345,473,932 - 45,634,902 (+)NCBIHuRef
CHM1_1345,380,072 - 45,540,452 (+)NCBICHM1_1
T2T-CHM13v2.0345,404,942 - 45,565,766 (+)NCBIT2T-CHM13v2.0
Lars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,196,001 - 123,291,731 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,195,992 - 123,291,731 (+)EnsemblGRCm39 Ensembl
GRCm389123,366,927 - 123,462,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,366,927 - 123,462,666 (+)EnsemblGRCm38mm10GRCm38
MGSCv379123,276,058 - 123,371,782 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,215,638 - 123,311,362 (+)NCBIMGSCv36mm8
Celera9123,819,514 - 123,915,073 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.92NCBI
Lars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,887,728 - 131,983,866 (+)NCBIGRCr8
mRatBN7.28123,010,271 - 123,106,395 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,010,293 - 123,106,395 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,599,822 - 128,694,986 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,798,766 - 126,893,950 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,628,137 - 124,723,305 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,441,277 - 132,537,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,441,285 - 132,536,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,593,987 - 131,689,876 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,136,948 - 128,232,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,156,801 - 128,252,130 (+)NCBI
Celera8122,121,425 - 122,216,021 (+)NCBICelera
Cytogenetic Map8q32NCBI
Lars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542026,343,649 - 26,441,736 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542026,342,129 - 26,446,959 (-)NCBIChiLan1.0ChiLan1.0
LARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2245,353,155 - 45,513,037 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1345,357,921 - 45,517,809 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0345,296,129 - 45,455,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1346,405,636 - 46,564,994 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl346,405,636 - 46,564,994 (+)Ensemblpanpan1.1panPan2
LARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,891,823 - 43,080,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,892,801 - 43,081,197 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,808,439 - 42,996,879 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02043,376,360 - 43,565,565 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2043,376,366 - 43,565,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,616,558 - 42,805,467 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02043,024,169 - 43,213,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02043,299,029 - 43,487,924 (-)NCBIUU_Cfam_GSD_1.0
Lars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118198,001,624 - 198,139,721 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936695350,975 - 492,011 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936695353,965 - 492,014 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1328,524,796 - 28,692,327 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11328,524,778 - 28,692,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21331,530,356 - 31,641,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,861,105 - 7,021,325 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,861,006 - 7,020,009 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041160,147,025 - 160,307,861 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473075,228,316 - 75,335,052 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473075,228,638 - 75,335,045 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in LARS2
508 total Variants

1 to 10 of 555 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_015340.4(LARS2):c.2560C>A (p.Pro854Thr) single nucleotide variant Inborn genetic diseases [RCV004026939]|not provided [RCV000728062] Chr3:45547378 [GRCh38]
Chr3:45588870 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_015340.4(LARS2):c.2404+5G>A single nucleotide variant not specified [RCV000602584] Chr3:45524113 [GRCh38]
Chr3:45565605 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_015340.4(LARS2):c.1565C>A (p.Thr522Asn) single nucleotide variant Hydrops-lactic acidosis-sideroblastic anemia-multisystemic failure syndrome [RCV000235552]|LARS2-Related Disorders [RCV004689437]|LARS2-related disorder [RCV004730866]|Perrault syndrome 4 [RCV000049285]|Perrault syndrome [RCV000857234]|Rare genetic deafness [RCV000604453]|not provided [RCV000520936] Chr3:45496316 [GRCh38]
Chr3:45537808 [GRCh37]
Chr3:3p21.31		 pathogenic|likely pathogenic
NM_015340.4(LARS2):c.1886C>T (p.Thr629Met) single nucleotide variant Nonsyndromic genetic hearing loss [RCV001544530]|Perrault syndrome 4 [RCV000049286]|Perrault syndrome [RCV002513678] Chr3:45516118 [GRCh38]
Chr3:45557610 [GRCh37]
Chr3:3p21.31		 pathogenic|not provided
NM_015340.4(LARS2):c.1077del (p.Ile360fs) deletion Perrault syndrome 4 [RCV000049287]|Perrault syndrome [RCV002513679] Chr3:45485749 [GRCh38]
Chr3:45527241 [GRCh37]
Chr3:3p21.31		 pathogenic|not provided
NM_015340.3(LARS2):c.1167C>T (p.Thr389=) single nucleotide variant Malignant melanoma [RCV000066083] Chr3:45488740 [GRCh38]
Chr3:45530232 [GRCh37]
Chr3:45505236 [NCBI36]
Chr3:3p21.31		 not provided
NM_015340.4(LARS2):c.1584G>C (p.Trp528Cys) single nucleotide variant not provided [RCV000087224] Chr3:45496335 [GRCh38]
Chr3:45537827 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_015340.4(LARS2):c.457A>C (p.Asn153His) single nucleotide variant Hydrops-lactic acidosis-sideroblastic anemia-multisystemic failure syndrome [RCV000723297]|Perrault syndrome 4 [RCV001727613]|Perrault syndrome [RCV000857233]|not provided [RCV000171359] Chr3:45419670 [GRCh38]
Chr3:45461162 [GRCh37]
Chr3:3p21.31		 pathogenic|likely pathogenic|uncertain significance
NM_015340.4(LARS2):c.2493G>T (p.Glu831Asp) single nucleotide variant LARS2-related disorder [RCV003977559]|Perrault syndrome 4 [RCV001731434]|not provided [RCV000676573]|not specified [RCV000203053] Chr3:45541917 [GRCh38]
Chr3:45583409 [GRCh37]
Chr3:3p21.31		 benign
NM_015340.4(LARS2):c.1912G>A (p.Glu638Lys) single nucleotide variant Perrault syndrome 4 [RCV000203255] Chr3:45516144 [GRCh38]
Chr3:45557636 [GRCh37]
Chr3:3p21.31		 pathogenic
1 to 10 of 555 rows

Predicted Target Of
Summary Value
Count of predictions:2999
Count of miRNA genes:1010
Interacting mature miRNAs:1231
Transcripts:ENST00000265537, ENST00000414984, ENST00000415258, ENST00000430399, ENST00000431023, ENST00000467936, ENST00000474585, ENST00000485461
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 18 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597308890GWAS1404964_Hvaginal microbiome measurement QTL GWAS1404964 (human)0.000001vaginal microbiome measurement34546638445466385Human
1298487BFD1_HBody fluid distribution QTL 1 (human)3.94Body fluid distributionimpedance ratio33638071262380712Human
596978161GWAS1097680_Hbody height QTL GWAS1097680 (human)1e-08body height34543863245438633Human
597306462GWAS1402536_Hvaginal microbiome measurement QTL GWAS1402536 (human)0.0000009vaginal microbiome measurement34546638445466385Human
597061298GWAS1157372_Hadolescent idiopathic scoliosis QTL GWAS1157372 (human)5e-11adolescent idiopathic scoliosis34552688245526883Human
597428794GWAS1524868_Hprotein measurement QTL GWAS1524868 (human)2e-19protein measurement34539093145390932Human
597312029GWAS1408103_Hvaginal microbiome measurement QTL GWAS1408103 (human)0.000004vaginal microbiome measurement34546638445466385Human
597110334GWAS1206408_Hviral load QTL GWAS1206408 (human)4e-16viral load34552765045527651Human
1298489RA4_HRheumatoid arthritis QTL 4 (human)0.0283Joint/bone inflammationrheumatoid arthritis33638071262380712Human
1643509BW293_HBody Weight QTL 293 (human)1.42Body weightBMI33638071262380712Human

1 to 10 of 18 rows
STS-D21851  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,589,848 - 45,590,095UniSTSGRCh37
Build 36345,564,852 - 45,565,099RGDNCBI36
Celera345,528,274 - 45,528,521RGD
Cytogenetic Map3p21.3UniSTS
HuRef345,634,422 - 45,634,669UniSTS
GeneMap99-GB4 RH Map3143.0UniSTS
RH92625  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,521,594 - 45,521,679UniSTSGRCh37
Build 36345,496,598 - 45,496,683RGDNCBI36
Celera345,460,007 - 45,460,092RGD
Cytogenetic Map3p21.3UniSTS
HuRef345,565,777 - 45,565,862UniSTS
GeneMap99-GB4 RH Map3144.5UniSTS
SHGC-80871  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,557,493 - 45,557,798UniSTSGRCh37
Build 36345,532,497 - 45,532,802RGDNCBI36
Celera345,495,918 - 45,496,223RGD
Cytogenetic Map3p21.3UniSTS
HuRef345,602,023 - 45,602,328UniSTS
TNG Radiation Hybrid Map328846.0UniSTS
SHGC-86343  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,450,917 - 45,451,213UniSTSGRCh37
Build 36345,425,921 - 45,426,217RGDNCBI36
Celera345,389,289 - 45,389,585RGD
Cytogenetic Map3p21.3UniSTS
HuRef345,494,941 - 45,495,237UniSTS
TNG Radiation Hybrid Map328775.0UniSTS
D3S1358  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,582,205 - 45,582,335UniSTSGRCh37
Build 36345,557,209 - 45,557,339RGDNCBI36
Celera345,520,628 - 45,520,758RGD
Cytogenetic Map3p21.3UniSTS
HuRef345,626,776 - 45,626,906UniSTS
SHGC-12886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,589,434 - 45,589,771UniSTSGRCh37
Build 36345,564,438 - 45,564,775RGDNCBI36
Celera345,527,860 - 45,528,197RGD
Cytogenetic Map3p21.3UniSTS
HuRef345,634,008 - 45,634,345UniSTS
Stanford-G3 RH Map31990.0UniSTS
NCBI RH Map3438.6UniSTS
GeneMap99-G3 RH Map31888.0UniSTS
D3S2354  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,577,179 - 45,577,315UniSTSGRCh37
Build 36345,552,183 - 45,552,319RGDNCBI36
Celera345,515,602 - 45,515,736RGD
Cytogenetic Map3p21.3UniSTS
HuRef345,621,761 - 45,621,895UniSTS
Whitehead-YAC Contig Map3 UniSTS
RH25266  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,589,312 - 45,589,527UniSTSGRCh37
Build 36345,564,316 - 45,564,531RGDNCBI36
Celera345,527,738 - 45,527,953RGD
Cytogenetic Map3p21.3UniSTS
HuRef345,633,886 - 45,634,101UniSTS
GeneMap99-GB4 RH Map3146.51UniSTS
LARS2__6372  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37345,589,546 - 45,590,468UniSTSGRCh37
Build 36345,564,550 - 45,565,472RGDNCBI36
Celera345,527,972 - 45,528,894RGD
HuRef345,634,120 - 45,635,042UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 174 1


1 to 24 of 24 rows
RefSeq Transcripts NG_033907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011533554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047447829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047447830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC006515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ312685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK026113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI463427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D21851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF457627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 24 of 24 rows

Ensembl Acc Id: ENST00000265537   ⟹   ENSP00000265537
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,573 - 45,548,674 (+)Ensembl
Ensembl Acc Id: ENST00000414984   ⟹   ENSP00000412893
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,564 - 45,547,609 (+)Ensembl
Ensembl Acc Id: ENST00000430399   ⟹   ENSP00000401388
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,619 - 45,400,353 (+)Ensembl
Ensembl Acc Id: ENST00000431023
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,576 - 45,422,409 (+)Ensembl
Ensembl Acc Id: ENST00000467936
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,500,541 - 45,538,463 (+)Ensembl
Ensembl Acc Id: ENST00000474585
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,541,594 - 45,547,554 (+)Ensembl
Ensembl Acc Id: ENST00000485461   ⟹   ENSP00000494606
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,517,963 - 45,547,404 (+)Ensembl
Ensembl Acc Id: ENST00000642274   ⟹   ENSP00000495707
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,836 - 45,548,599 (+)Ensembl
Ensembl Acc Id: ENST00000645846   ⟹   ENSP00000495093
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,576 - 45,549,407 (+)Ensembl
Ensembl Acc Id: ENST00000650792   ⟹   ENSP00000498867
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,561 - 45,554,726 (+)Ensembl
Ensembl Acc Id: ENST00000651549   ⟹   ENSP00000499002
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,576 - 45,548,020 (+)Ensembl
Ensembl Acc Id: ENST00000652135   ⟹   ENSP00000499104
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl345,388,606 - 45,541,885 (+)Ensembl
RefSeq Acc Id: NM_001368263   ⟹   NP_001355192
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38345,388,576 - 45,549,407 (+)NCBI
T2T-CHM13v2.0345,404,942 - 45,565,766 (+)NCBI
Sequence:
RefSeq Acc Id: NM_015340   ⟹   NP_056155
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38345,388,576 - 45,549,407 (+)NCBI
GRCh37345,430,053 - 45,590,334 (+)NCBI
Build 36345,405,079 - 45,565,332 (+)NCBI Archive
HuRef345,473,932 - 45,634,902 (+)ENTREZGENE
CHM1_1345,380,072 - 45,540,452 (+)NCBI
T2T-CHM13v2.0345,404,942 - 45,565,766 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011533554   ⟹   XP_011531856
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38345,388,576 - 45,539,795 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017006042   ⟹   XP_016861531
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38345,388,576 - 45,549,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047447829   ⟹   XP_047303785
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38345,388,576 - 45,539,795 (+)NCBI
RefSeq Acc Id: XM_047447830   ⟹   XP_047303786
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38345,388,576 - 45,549,407 (+)NCBI
RefSeq Acc Id: XM_054345901   ⟹   XP_054201876
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0345,404,942 - 45,556,267 (+)NCBI
RefSeq Acc Id: XM_054345902   ⟹   XP_054201877
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0345,404,942 - 45,556,319 (+)NCBI
RefSeq Acc Id: XM_054345903   ⟹   XP_054201878
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0345,404,942 - 45,565,766 (+)NCBI
RefSeq Acc Id: XM_054345904   ⟹   XP_054201879
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0345,404,942 - 45,565,766 (+)NCBI
1 to 5 of 19 rows
1 to 5 of 19 rows
RefSeq Acc Id: NP_056155   ⟸   NM_015340
- UniProtKB: Q15031 (UniProtKB/Swiss-Prot),   E9PHM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011531856   ⟸   XM_011533554
- Peptide Label: isoform X1
- UniProtKB: E9PHM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016861531   ⟸   XM_017006042
- Peptide Label: isoform X2
- UniProtKB: E9PHM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001355192   ⟸   NM_001368263
- UniProtKB: Q15031 (UniProtKB/Swiss-Prot),   E9PHM2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000498867   ⟸   ENST00000650792
Aminoacyl-tRNA synthetase class Ia   Leucyl-tRNA synthetase editing   Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase

Name Modeler Protein Id AA Range Protein Structure
AF-Q15031-F1-model_v2 AlphaFold Q15031 1-903 view protein structure

RGD ID:6864160
Promoter ID:EPDNEW_H5245
Type:initiation region
Name:LARS2_1
Description:leucyl-tRNA synthetase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38345,388,576 - 45,388,636EPDNEW
RGD ID:6801233
Promoter ID:HG_KWN:44718
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000256884,   OTTHUMT00000345001,   OTTHUMT00000345004,   OTTHUMT00000345005,   UC010HIT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36345,404,839 - 45,405,339 (+)MPROMDB


1 to 40 of 41 rows
Database
Acc Id
Source(s)
COSMIC LARS2 COSMIC
Ensembl Genes ENSG00000011376 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000642274.1 UniProtKB/Swiss-Prot
  ENST00000645846 ENTREZGENE
  ENST00000645846.2 UniProtKB/Swiss-Prot
  ENST00000650792 ENTREZGENE
  ENST00000650792.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot
  Isoleucyl-tRNA Synthetase, Domain 1 UniProtKB/Swiss-Prot
GTEx ENSG00000011376 GTEx
HGNC ID HGNC:17095 ENTREZGENE
Human Proteome Map LARS2 Human Proteome Map
InterPro aa-tRNA-synth_I_CS UniProtKB/Swiss-Prot
  aa-tRNA-synth_Ia UniProtKB/Swiss-Prot
  Leu-tRNA-ligase UniProtKB/Swiss-Prot
  Leu_tRNA-synth_edit UniProtKB/Swiss-Prot
  M/V/L/I-tRNA-synth_anticd-bd UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
  tRNAsynth_Ia_anticodon-bd UniProtKB/Swiss-Prot
  Val/Leu/Ile-tRNA-synth_edit UniProtKB/Swiss-Prot
KEGG Report hsa:23395 UniProtKB/Swiss-Prot
NCBI Gene 23395 ENTREZGENE
OMIM 604544 OMIM
PANTHER LEUCINE--TRNA LIGASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR43740 UniProtKB/Swiss-Prot
Pfam Anticodon_1 UniProtKB/Swiss-Prot
  tRNA-synt_1 UniProtKB/Swiss-Prot
  tRNA-synt_1_2 UniProtKB/Swiss-Prot
PharmGKB PA134982982 PharmGKB
PRINTS TRNASYNTHLEU UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_I UniProtKB/Swiss-Prot
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/Swiss-Prot
  SSF47323 UniProtKB/Swiss-Prot
  SSF50677 UniProtKB/Swiss-Prot
UniProt A0A2R8Y581_HUMAN UniProtKB/TrEMBL
  A0A494C1E0_HUMAN UniProtKB/TrEMBL
  A0A494C1K2_HUMAN UniProtKB/TrEMBL
  A0A499FJL2_HUMAN UniProtKB/TrEMBL
  C9JYR8_HUMAN UniProtKB/TrEMBL
  E9PHM2 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 LARS2  leucyl-tRNA synthetase 2, mitochondrial  LARS2  leucyl-tRNA synthetase 2  Symbol and/or name change 5135510 APPROVED
2015-12-22 LARS2  leucyl-tRNA synthetase 2  LARS2  leucyl-tRNA synthetase 2, mitochondrial  Symbol and/or name change 5135510 APPROVED