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Gene: Macf1 (microtubule-actin crosslinking factor 1) Mus musculus
Symbol: Macf1
Name: microtubule-actin crosslinking factor 1
Description: Exhibits ATPase activity; actin binding activity; and microtubule binding activity. Involved in several processes, including posttranslational protein targeting to endoplasmic reticulum membrane; regulation of focal adhesion assembly; and regulation of neuron projection arborization. Localizes to cytoplasm; cytoskeleton; and postsynaptic density. Predicted to colocalize with intermediate filament. Human ortholog(s) of this gene implicated in lissencephaly. Is expressed in several structures, including central nervous system; genitourinary system; limb segment; lung; and skeletal musculature. Orthologous to human MACF1 (microtubule actin crosslinking factor 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ABP620; Acf7; Aclp7; actin cross-linking family 7; actin-crosslinking protein 7; MACF; mACF7; microtubule-actin cross-linking factor 1; mKIAA0465; R74989; trabeculin alpha
Homo sapiens (human) : MACF1 (microtubule actin crosslinking factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Macf1 (microtubule-actin crosslinking factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Macf1 (microtubule actin crosslinking factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MACF1 (microtubule actin crosslinking factor 1)
Canis lupus familiaris (dog) : MACF1 (microtubule actin crosslinking factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Macf1 (microtubule actin crosslinking factor 1)
Sus scrofa (pig) : MACF1 (microtubule actin crosslinking factor 1)
Chlorocebus sabaeus (African green monkey) : MACF1 (microtubule actin crosslinking factor 1)
Heterocephalus glaber (naked mole-rat) : Macf1 (microtubule actin crosslinking factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl4123,349,633 - 123,684,360 (-)EnsemblGRCm38mm10GRCm38
GRCm384123,349,633 - 123,687,802 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374123,026,959 - 123,361,603 (-)NCBIGRCm37mm9NCBIm37
MGSCv364122,851,896 - 123,186,492 (-)NCBImm8
Celera4121,682,320 - 122,018,135 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Macf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314455
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.