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Gene: Macf1 (microtubule-actin crosslinking factor 1) Mus musculus
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Symbol: Macf1
Name: microtubule-actin crosslinking factor 1
Description: Exhibits ATPase activity; actin binding activity; and microtubule binding activity. Involved in several processes, including posttranslational protein targeting to endoplasmic reticulum membrane; regulation of focal adhesion assembly; and regulation of neuron projection arborization. Localizes to cytoplasm; cytoskeleton; and postsynaptic density. Predicted to colocalize with intermediate filament. Human ortholog(s) of this gene implicated in lissencephaly. Is expressed in several structures, including central nervous system; genitourinary system; limb segment; lung; and skeletal musculature. Orthologous to human MACF1 (microtubule actin crosslinking factor 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ABP620; Acf7; Aclp7; actin cross-linking family 7; actin-crosslinking protein 7; MACF; mACF7; microtubule-actin cross-linking factor 1; mKIAA0465; R74989; trabeculin alpha
Orthologs:
Homo sapiens (human) : MACF1 (microtubule actin crosslinking factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Macf1 (microtubule-actin crosslinking factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Macf1 (microtubule actin crosslinking factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MACF1 (microtubule actin crosslinking factor 1)
Canis lupus familiaris (dog) : MACF1 (microtubule actin crosslinking factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Macf1 (microtubule actin crosslinking factor 1)
Sus scrofa (pig) : MACF1 (microtubule actin crosslinking factor 1)
Chlorocebus sabaeus (African green monkey) : MACF1 (microtubule actin crosslinking factor 1)
Heterocephalus glaber (naked mole-rat) : Macf1 (microtubule actin crosslinking factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl4123,349,633 - 123,684,360 (-)EnsemblGRCm38mm10GRCm38
GRCm384123,349,633 - 123,687,802 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374123,026,959 - 123,361,603 (-)NCBIGRCm37mm9NCBIm37
MGSCv364122,851,896 - 123,186,492 (-)NCBImm8
Celera4121,682,320 - 122,018,135 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Macf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314455
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.