MACF1 (microtubule actin crosslinking factor 1) - Rat Genome Database

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Gene: MACF1 (microtubule actin crosslinking factor 1) Sus scrofa
Analyze
Symbol: MACF1
Name: microtubule actin crosslinking factor 1
RGD ID: 13883570
Description: ENCODES a protein that exhibits actin filament binding (ortholog); microtubule binding (ortholog); microtubule minus-end binding (ortholog); INVOLVED IN establishment or maintenance of cell polarity (ortholog); Golgi to plasma membrane protein transport (ortholog); mesoderm formation (ortholog); ASSOCIATED WITH cerebellar hypoplasia (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); Dwarfism (ortholog); FOUND IN actin cytoskeleton (ortholog); cell junction (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: microtubule-actin cross-linking factor 1; microtubule-actin crosslinking factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl694,960,457 - 95,317,145 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1694,960,385 - 95,318,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2688,111,268 - 88,403,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712  


Genomics

Comparative Map Data
MACF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl694,960,457 - 95,317,145 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1694,960,385 - 95,318,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2688,111,268 - 88,403,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MACF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl139,081,316 - 39,487,177 (+)EnsemblGRCh38hg38GRCh38
GRCh38139,084,167 - 39,487,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37139,549,839 - 39,952,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36139,319,705 - 39,725,376 (+)NCBINCBI36hg18NCBI36
Build 34139,465,902 - 39,621,882NCBI
Celera137,828,167 - 38,234,164 (+)NCBI
Cytogenetic Map1p34.3NCBI
HuRef137,669,045 - 38,071,866 (+)NCBIHuRef
CHM1_1139,665,458 - 40,068,698 (+)NCBICHM1_1
Macf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394123,243,426 - 123,581,594 (-)NCBIGRCm39mm39
GRCm39 Ensembl4123,243,426 - 123,578,153 (-)Ensembl
GRCm384123,349,633 - 123,687,802 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4123,349,633 - 123,684,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv374123,026,959 - 123,361,603 (-)NCBIGRCm37mm9NCBIm37
MGSCv364122,851,896 - 123,186,492 (-)NCBImm8
Celera4121,682,320 - 122,018,135 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.42NCBI
Macf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25135,623,729 - 135,949,097 (-)NCBI
Rnor_6.0 Ensembl5141,039,468 - 141,363,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05141,039,455 - 141,363,524 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05144,829,588 - 145,151,477 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,659,726 - 142,986,873 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15142,667,739 - 142,701,960 (-)NCBI
Celera5134,162,059 - 134,482,913 (-)NCBICelera
Cytogenetic Map5q36NCBI
Macf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545216,798,911 - 17,024,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545216,684,784 - 17,025,940 (+)NCBIChiLan1.0ChiLan1.0
MACF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1139,820,066 - 40,097,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl139,820,394 - 40,096,558 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0138,369,021 - 38,771,911 (+)NCBIMhudiblu_PPA_v0panPan3
MACF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1153,361,887 - 3,703,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl153,362,867 - 3,573,325 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha153,601,727 - 3,942,472 (-)NCBI
ROS_Cfam_1.0153,482,603 - 3,548,295 (-)NCBI
UMICH_Zoey_3.1153,352,416 - 3,693,488 (-)NCBI
UNSW_CanFamBas_1.0153,419,561 - 3,761,243 (-)NCBI
UU_Cfam_GSD_1.0153,435,346 - 3,776,614 (-)NCBI
Macf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505855,228,978 - 55,576,554 (+)NCBI
SpeTri2.0NW_00493647421,053,755 - 21,401,336 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12093,413,111 - 93,814,388 (-)NCBI
Vero_WHO_p1.0NW_02366603323,023,831 - 23,431,976 (+)NCBI
Macf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476421,663,516 - 22,015,866 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004050   ⟹   ENSSSCP00000003959
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl694,960,457 - 95,304,034 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000039184   ⟹   ENSSSCP00000054118
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl694,960,457 - 95,304,034 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000040898   ⟹   ENSSSCP00000042274
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl694,960,457 - 95,317,145 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000043147   ⟹   ENSSSCP00000043834
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl694,960,457 - 95,317,142 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000056697   ⟹   ENSSSCP00000047546
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl694,964,178 - 94,976,582 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000059129   ⟹   ENSSSCP00000044694
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl695,070,466 - 95,132,997 (+)Ensembl
RefSeq Acc Id: XM_021095983   ⟹   XP_020951642
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1694,960,385 - 95,318,126 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020951642 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020951642   ⟸   XM_021095983
- Sequence:
RefSeq Acc Id: ENSSSCP00000054118   ⟸   ENSSSCT00000039184
RefSeq Acc Id: ENSSSCP00000042274   ⟸   ENSSSCT00000040898
RefSeq Acc Id: ENSSSCP00000044694   ⟸   ENSSSCT00000059129
RefSeq Acc Id: ENSSSCP00000047546   ⟸   ENSSSCT00000056697
RefSeq Acc Id: ENSSSCP00000003959   ⟸   ENSSSCT00000004050
RefSeq Acc Id: ENSSSCP00000043834   ⟸   ENSSSCT00000043147
Protein Domains
Calponin-homology (CH)   EF-hand   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003654 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003959 UniProtKB/TrEMBL
  ENSSSCP00000042274 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000043834 UniProtKB/TrEMBL
  ENSSSCP00000044694 UniProtKB/TrEMBL
  ENSSSCP00000047546 UniProtKB/TrEMBL
  ENSSSCP00000054118 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004050 UniProtKB/TrEMBL
  ENSSSCT00000039184 UniProtKB/TrEMBL
  ENSSSCT00000040898 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000043147 UniProtKB/TrEMBL
  ENSSSCT00000056697 UniProtKB/TrEMBL
  ENSSSCT00000059129 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  Desmoplakin_SH3 UniProtKB/TrEMBL
  Desmoplakin_Spectrin-like UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Plakin UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
NCBI Gene MACF1 ENTREZGENE
PANTHER PTHR23169 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  SH3_10 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
  Spectrin_like UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A287AEG1_PIG UniProtKB/TrEMBL
  A0A287AIW6_PIG UniProtKB/TrEMBL
  A0A287ALB5_PIG UniProtKB/TrEMBL
  A0A287ATX0_PIG UniProtKB/TrEMBL
  A0A287BDC2_PIG UniProtKB/TrEMBL
  F1SV22_PIG UniProtKB/TrEMBL
VGNC ID VGNC:98496 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 MACF1  microtubule actin crosslinking factor 1    microtubule-actin crosslinking factor 1  Symbol and/or name change 5135510 APPROVED