Hint2 (histidine triad nucleotide binding protein 2) - Rat Genome Database

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Gene: Hint2 (histidine triad nucleotide binding protein 2) Rattus norvegicus
Analyze
Symbol: Hint2
Name: histidine triad nucleotide binding protein 2
RGD ID: 1308910
Description: Predicted to enable adenosine 5'-monophosphoramidase activity. Predicted to act upstream of or within lipid catabolic process and negative regulation of peptidyl-lysine acetylation. Predicted to be active in mitochondrion. Orthologous to human HINT2 (histidine triad nucleotide binding protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histidine triad nucleotide-binding protein 2, mitochondrial; LOC313491
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2557,904,613 - 57,906,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,884,698 - 59,886,953 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0561,703,512 - 61,705,767 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0561,674,738 - 61,676,993 (-)NCBIRnor_WKY
Rnor_6.0559,150,344 - 59,152,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,675,136 - 63,677,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,130,993 - 60,133,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,131,171 - 60,133,804 (-)NCBI
Celera556,485,081 - 56,487,336 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:14651853   PMID:18614015   PMID:26767982  


Genomics

Comparative Map Data
Hint2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2557,904,613 - 57,906,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,884,698 - 59,886,953 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0561,703,512 - 61,705,767 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0561,674,738 - 61,676,993 (-)NCBIRnor_WKY
Rnor_6.0559,150,344 - 59,152,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,675,136 - 63,677,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,130,993 - 60,133,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,131,171 - 60,133,804 (-)NCBI
Celera556,485,081 - 56,487,336 (-)NCBICelera
Cytogenetic Map5q22NCBI
HINT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,812,960 - 35,815,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl935,812,960 - 35,815,354 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,812,957 - 35,815,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,802,957 - 35,805,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,802,956 - 35,805,042NCBI
Celera935,746,489 - 35,748,574 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,768,969 - 35,771,054 (-)NCBIHuRef
CHM1_1935,813,345 - 35,815,430 (-)NCBICHM1_1
T2T-CHM13v2.0935,833,627 - 35,835,709 (-)NCBIT2T-CHM13v2.0
Hint2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,654,227 - 43,656,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm39 Ensembl
GRCm38443,654,227 - 43,656,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,667,099 - 43,669,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,675,327 - 43,677,551 (-)NCBIMGSCv36mm8
Celera443,688,832 - 43,691,050 (-)NCBICelera
Cytogenetic Map4A5NCBI
Hint2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955472500,845 - 503,067 (+)NCBIChiLan1.0ChiLan1.0
HINT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1936,465,806 - 36,468,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,465,806 - 36,468,325 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0935,663,433 - 35,666,479 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HINT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,342,564 - 52,344,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,342,567 - 52,344,947 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,910,135 - 50,912,566 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,407,581 - 53,410,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,407,584 - 53,409,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,952,089 - 51,954,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,936,313 - 51,938,949 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,637,771 - 52,640,202 (-)NCBIUU_Cfam_GSD_1.0
HINT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11236,532,316 - 236,535,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,257,330 - 264,259,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HINT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,790,455 - 44,792,571 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,790,416 - 44,792,625 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,894,686 - 41,897,216 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hint2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,969,085 - 4,971,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,969,076 - 4,971,336 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hint2
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:87
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000021387
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021387   ⟹   ENSRNOP00000021387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)Ensembl
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)Ensembl
RefSeq Acc Id: NM_001107955   ⟹   NP_001101425
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2557,904,613 - 57,906,868 (-)NCBI
Rnor_6.0559,150,344 - 59,152,599 (-)NCBI
Rnor_5.0563,675,136 - 63,677,391 (-)NCBI
RGSC_v3.4560,130,993 - 60,133,248 (-)RGD
Celera556,485,081 - 56,487,336 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101425 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98763 (Get FASTA)   NCBI Sequence Viewer  
  EDL98764 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101425   ⟸   NM_001107955
- UniProtKB: D4AB01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021387   ⟸   ENSRNOT00000021387
Protein Domains
HIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AB01-F1-model_v2 AlphaFold D4AB01 1-163 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693681
Promoter ID:EPDNEW_R4206
Type:multiple initiation site
Name:Hint2_1
Description:histidine triad nucleotide binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,152,614 - 59,152,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308910 AgrOrtholog
BioCyc Gene G2FUF-41497 BioCyc
Ensembl Genes ENSRNOG00000015866 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021387 ENTREZGENE
  ENSRNOP00000021387.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021387 ENTREZGENE
  ENSRNOT00000021387.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.428.10 UniProtKB/TrEMBL
InterPro His_triad-like_motif UniProtKB/TrEMBL
  Histidine_triad_CS UniProtKB/TrEMBL
  Histidine_triad_HIT UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/TrEMBL
KEGG Report rno:313491 UniProtKB/TrEMBL
NCBI Gene 313491 ENTREZGENE
PANTHER PTHR23089 UniProtKB/TrEMBL
Pfam HIT UniProtKB/TrEMBL
PhenoGen Hint2 PhenoGen
PRINTS HISTRIAD UniProtKB/TrEMBL
PROSITE HIT_1 UniProtKB/TrEMBL
  HIT_2 UniProtKB/TrEMBL
Superfamily-SCOP His_triad-like_motif UniProtKB/TrEMBL
UniProt D4AB01 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Hint2  histidine triad nucleotide binding protein 2   Hint2_predicted  histidine triad nucleotide binding protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hint2_predicted  histidine triad nucleotide binding protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED