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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hint2 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HINT2 mRNA | CTD | PMID:36331819 | Hint2 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HINT2 mRNA | CTD | PMID:22206623 | Hint2 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HINT2 mRNA | CTD | PMID:17942748 | Hint2 | Rat | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Hint2 | Rat | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Hint2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HINT2 mRNA | CTD | PMID:17942748 | Hint2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HINT2 mRNA | CTD | PMID:33387578 | Hint2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hint2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HINT2 mRNA | CTD | PMID:21570461 | Hint2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HINT2 mRNA | CTD | PMID:21215274 and PMID:34747641 | Hint2 | Rat | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of HINT2 mRNA | CTD | PMID:21346803 | Hint2 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | HINT2 (Homo sapiens) | 6480464 | Decitabine affects the expression of HINT2 mRNA | CTD | PMID:23300844 | Hint2 | Rat | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of HINT2 mRNA | CTD | PMID:28959563 | Hint2 | Rat | acrylamide | decreases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of HINT2 mRNA | CTD | PMID:32763439 | Hint2 | Rat | aflatoxin B1 | increases expression | ISO | Hint2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of HINT2 mRNA | CTD | PMID:19770486 | Hint2 | Rat | aflatoxin B1 | decreases methylation | ISO | HINT2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of HINT2 gene | CTD | PMID:27153756 | Hint2 | Rat | Aroclor 1254 | increases expression | ISO | Hint2 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of HINT2 mRNA | CTD | PMID:23650126 | Hint2 | Rat | atrazine | decreases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of HINT2 mRNA | CTD | PMID:22378314 | Hint2 | Rat | benzo[a]pyrene | affects expression | ISO | HINT2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the expression of HINT2 mRNA | CTD | PMID:21714911 | Hint2 | Rat | benzo[a]pyrene | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of HINT2 protein | CTD | PMID:32717239 | Hint2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HINT2 mRNA | CTD | PMID:25181051 | Hint2 | Rat | bisphenol A | increases expression | ISO | Hint2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of HINT2 mRNA | CTD | PMID:33221593 | Hint2 | Rat | carbon nanotube | decreases expression | ISO | Hint2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Hint2 | Rat | chlorpyrifos | increases expression | ISO | Hint2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of HINT2 mRNA | CTD | PMID:37019170 | Hint2 | Rat | cisplatin | affects expression | ISO | HINT2 (Homo sapiens) | 6480464 | Cisplatin affects the expression of HINT2 mRNA | CTD | PMID:23300844 | Hint2 | Rat | cisplatin | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of HINT2 mRNA | CTD | PMID:27392435 and PMID:27594783 | Hint2 | Rat | cisplatin | multiple interactions | ISO | HINT2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of HINT2 mRNA | CTD | PMID:27392435 | Hint2 | Rat | copper(II) sulfate | decreases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of HINT2 mRNA | CTD | PMID:19549813 | Hint2 | Rat | cyclosporin A | decreases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of HINT2 mRNA | CTD | PMID:25562108 | Hint2 | Rat | cyclosporin A | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of HINT2 mRNA | CTD | PMID:27989131 | Hint2 | Rat | diuron | decreases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Diuron results in decreased expression of HINT2 mRNA | CTD | PMID:35967413 | Hint2 | Rat | doxorubicin | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of HINT2 mRNA | CTD | PMID:29803840 | Hint2 | Rat | epoxiconazole | increases expression | ISO | Hint2 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of HINT2 mRNA | CTD | PMID:35436446 | Hint2 | Rat | folic acid | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HINT2 mRNA | CTD | PMID:22206623 | Hint2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of HINT2 mRNA | CTD | PMID:33387578 | Hint2 | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of HINT2 mRNA | CTD | PMID:24136188 | Hint2 | Rat | hydralazine | multiple interactions | ISO | HINT2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of HINT2 mRNA | CTD | PMID:17183730 | Hint2 | Rat | inulin | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HINT2 mRNA | CTD | PMID:36331819 | Hint2 | Rat | ivermectin | decreases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of HINT2 protein | CTD | PMID:32959892 | Hint2 | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of HINT2 mRNA | CTD | PMID:24136188 | Hint2 | Rat | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of HINT2 mRNA | CTD | PMID:24136188 | Hint2 | Rat | ozone | multiple interactions | ISO | HINT2 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of HINT2 mRNA | CTD | PMID:35430440 | Hint2 | Rat | paracetamol | affects expression | ISO | Hint2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of HINT2 mRNA | CTD | PMID:17562736 | Hint2 | Rat | paracetamol | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of HINT2 mRNA | CTD | PMID:25704631 | Hint2 | Rat | PCB138 | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Hint2 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Hint2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HINT2 mRNA more ... | CTD | PMID:36331819 | Hint2 | Rat | perfluorooctanoic acid | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of HINT2 protein | CTD | PMID:26879310 | Hint2 | Rat | resveratrol | increases expression | ISO | Hint2 (Mus musculus) | 6480464 | resveratrol results in increased expression of HINT2 protein | CTD | PMID:25505154 | Hint2 | Rat | SB 431542 | multiple interactions | ISO | HINT2 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of HINT2 protein | CTD | PMID:37664457 | Hint2 | Rat | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of HINT2 protein | CTD | PMID:29459688 | Hint2 | Rat | sodium fluoride | decreases expression | ISO | Hint2 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of HINT2 protein | CTD | PMID:28918527 | Hint2 | Rat | sunitinib | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of HINT2 mRNA | CTD | PMID:31533062 | Hint2 | Rat | tetrachloromethane | decreases expression | ISO | Hint2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of HINT2 mRNA | CTD | PMID:31919559 | Hint2 | Rat | tetrahydropalmatine | decreases expression | ISO | HINT2 (Homo sapiens) | 6480464 | tetrahydropalmatine results in decreased expression of HINT2 protein | CTD | PMID:20109541 | Hint2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of HINT2 mRNA | CTD | PMID:34492290 | Hint2 | Rat | thiram | decreases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Thiram results in decreased expression of HINT2 mRNA | CTD | PMID:38568856 | Hint2 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of HINT2 mRNA | CTD | PMID:33387578 | Hint2 | Rat | tungsten | increases expression | ISO | Hint2 (Mus musculus) | 6480464 | Tungsten results in increased expression of HINT2 mRNA | CTD | PMID:30912803 | Hint2 | Rat | tunicamycin | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of HINT2 mRNA | CTD | PMID:29453283 | Hint2 | Rat | valproic acid | multiple interactions | ISO | HINT2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of HINT2 mRNA | CTD | PMID:17183730 | Hint2 | Rat | valproic acid | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HINT2 mRNA | CTD | PMID:23179753 | Hint2 | Rat | valproic acid | affects expression | ISO | HINT2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HINT2 mRNA | CTD | PMID:25979313 | Hint2 | Rat | zoledronic acid | increases expression | ISO | HINT2 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of HINT2 protein | CTD | PMID:28871336 | |