HINT2 (histidine triad nucleotide binding protein 2) - Rat Genome Database

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Gene: HINT2 (histidine triad nucleotide binding protein 2) Canis lupus familiaris
Analyze
Symbol: HINT2
Name: histidine triad nucleotide binding protein 2
RGD ID: 12110868
Description: ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (inferred); catalytic activity (inferred); hydrolase activity (inferred); INVOLVED IN lipid catabolic process (ortholog); negative regulation of peptidyl-lysine acetylation (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histidine triad nucleotide-binding protein 2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,342,564 - 52,344,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,342,567 - 52,344,947 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,910,135 - 50,912,566 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,407,581 - 53,410,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,407,584 - 53,409,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,952,089 - 51,954,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,936,313 - 51,938,949 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,637,771 - 52,640,202 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
HINT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,342,564 - 52,344,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,342,567 - 52,344,947 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,910,135 - 50,912,566 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,407,581 - 53,410,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,407,584 - 53,409,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,952,089 - 51,954,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,936,313 - 51,938,949 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,637,771 - 52,640,202 (-)NCBIUU_Cfam_GSD_1.0
HINT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,812,960 - 35,815,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,812,960 - 35,815,354 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,812,957 - 35,815,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,802,957 - 35,805,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,802,956 - 35,805,042NCBI
Celera935,746,489 - 35,748,574 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,768,969 - 35,771,054 (-)NCBIHuRef
CHM1_1935,813,345 - 35,815,430 (-)NCBICHM1_1
T2T-CHM13v2.0935,833,627 - 35,836,146 (-)NCBIT2T-CHM13v2.0
Hint2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,654,227 - 43,656,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm39 Ensembl
GRCm38443,654,227 - 43,656,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,667,099 - 43,669,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,675,327 - 43,677,551 (-)NCBIMGSCv36mm8
Celera443,688,832 - 43,691,050 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Hint2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,700,383 - 62,702,638 (-)NCBIGRCr8
mRatBN7.2557,904,613 - 57,906,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,884,698 - 59,886,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,703,512 - 61,705,767 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,674,738 - 61,676,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,150,344 - 59,152,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,675,136 - 63,677,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,130,993 - 60,133,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,131,171 - 60,133,804 (-)NCBI
Celera556,485,081 - 56,487,336 (-)NCBICelera
Cytogenetic Map5q22NCBI
Hint2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955472500,845 - 503,067 (+)NCBIChiLan1.0ChiLan1.0
HINT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,773,684 - 88,775,887 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,779,754 - 88,781,825 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,663,433 - 35,666,479 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,465,806 - 36,468,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,465,806 - 36,468,325 (-)Ensemblpanpan1.1panPan2
HINT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11236,532,316 - 236,535,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,257,330 - 264,259,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HINT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,790,455 - 44,792,571 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,790,416 - 44,792,625 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,894,686 - 41,897,216 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hint2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,969,085 - 4,971,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,969,076 - 4,971,336 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HINT2
21 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003511   ⟹   ENSCAFP00000003255
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1152,342,567 - 52,344,947 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017616   ⟹   ENSCAFP00845013715
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1153,407,584 - 53,409,966 (-)Ensembl
RefSeq Acc Id: XM_038490675   ⟹   XP_038346603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11151,952,089 - 51,954,522 (-)NCBI
RefSeq Acc Id: XM_038552803   ⟹   XP_038408731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01152,637,771 - 52,640,202 (-)NCBI
RefSeq Acc Id: XM_038616663   ⟹   XP_038472591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01151,936,313 - 51,938,949 (-)NCBI
RefSeq Acc Id: XM_038682130   ⟹   XP_038538058
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01153,407,581 - 53,410,013 (-)NCBI
RefSeq Acc Id: XM_538721   ⟹   XP_538721
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11152,342,564 - 52,344,994 (-)NCBI
Dog10K_Boxer_Tasha1150,910,135 - 50,912,566 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_538721   ⟸   XM_538721
- UniProtKB: A0A8C0SF97 (UniProtKB/TrEMBL),   A0A8I3NC75 (UniProtKB/TrEMBL),   A0A8C0KVY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000003255   ⟸   ENSCAFT00000003511
RefSeq Acc Id: XP_038346603   ⟸   XM_038490675
RefSeq Acc Id: XP_038472591   ⟸   XM_038616663
RefSeq Acc Id: XP_038538058   ⟸   XM_038682130
- UniProtKB: A0A8C0SF97 (UniProtKB/TrEMBL),   A0A8I3NC75 (UniProtKB/TrEMBL),   A0A8C0KVY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408731   ⟸   XM_038552803
- UniProtKB: A0A8C0KVY1 (UniProtKB/TrEMBL),   A0A8C0SF97 (UniProtKB/TrEMBL),   A0A8I3NC75 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845013715   ⟸   ENSCAFT00845017616
Protein Domains
HIT

Promoters
RGD ID:13685254
Promoter ID:EPDNEW_C3321
Type:multiple initiation site
Name:HINT2_1
Description:histidine triad nucleotide binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11152,344,957 - 52,345,017EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002240 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008967 UniProtKB/TrEMBL
  ENSCAFG00040012888 UniProtKB/TrEMBL
  ENSCAFG00845010022 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003511.4 UniProtKB/TrEMBL
  ENSCAFT00030016558.1 UniProtKB/TrEMBL
  ENSCAFT00040023773.1 UniProtKB/TrEMBL
  ENSCAFT00845017616 ENTREZGENE
  ENSCAFT00845017616.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.428.10 UniProtKB/TrEMBL
InterPro Histidine_triad_CS UniProtKB/TrEMBL
  Histidine_triad_HIT UniProtKB/TrEMBL
  HIT-like UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/TrEMBL
NCBI Gene HINT2 ENTREZGENE
PANTHER HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR23089 UniProtKB/TrEMBL
Pfam HIT UniProtKB/TrEMBL
PRINTS HISTRIAD UniProtKB/TrEMBL
PROSITE HIT_1 UniProtKB/TrEMBL
  HIT_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54197 UniProtKB/TrEMBL
UniProt A0A8C0KVY1 ENTREZGENE
  A0A8C0SF97 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NC75 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49721 ENTREZGENE