Hint2 (histidine triad nucleotide binding protein 2) - Rat Genome Database

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Gene: Hint2 (histidine triad nucleotide binding protein 2) Heterocephalus glaber
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Symbol: Hint2
Name: histidine triad nucleotide binding protein 2
RGD ID: 18901287
Description: ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (ortholog); INVOLVED IN lipid catabolic process (ortholog); negative regulation of peptidyl-lysine acetylation (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histidine triad nucleotide-binding protein 2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,969,085 - 4,971,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,969,076 - 4,971,336 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hint2Naked Mole-Ratacromesomelic dysplasia, Maroteaux type  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Acromesomelic dysplasia 1 and Maroteaux typeClinVarPMID:28492532
Hint2Naked Mole-Ratanauxetic dysplasia  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Anauxetic dysplasiaClinVarPMID:28492532
Hint2Naked Mole-Ratautosomal recessive distal hereditary motor neuronopathy 2  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive distal spinal muscular atrophy 2ClinVarPMID:28492532
Hint2Naked Mole-Ratdistal arthrogryposis type 1A  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Arthrogryposis more ...ClinVarPMID:28492532
Hint2Naked Mole-Ratfrontotemporal dementia and/or amyotrophic lateral sclerosis 6  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Frontotemporal dementia and/or amyotrophic lateral sclerosis 6ClinVarPMID:28492532
Hint2Naked Mole-Ratgalactosemia  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferaseClinVarPMID:28492532
Hint2Naked Mole-Rathyperphosphatasia with impaired intellectual development syndrome 2  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 6ClinVarPMID:22683086 more ...
Hint2Naked Mole-Ratparaplegia  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:23332916 more ...
Hint2Naked Mole-Ratprimary ciliary dyskinesia  ISOHINT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
1 to 9 of 9 rows


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hint2Naked Mole-Ratlipid catabolic process acts_upstream_of_or_withinISOMGI:58120159068941 PMID:26767982MGIPMID:26767982
Hint2Naked Mole-Ratnegative regulation of peptidyl-lysine acetylation acts_upstream_of_or_withinISOMGI:58120159068941 PMID:26767982MGIPMID:26767982

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hint2Naked Mole-Ratmitochondrial matrix is_active_inISOHint2 (Mus musculus)9068941 PMID:29913563FlyBasePMID:29913563
Hint2Naked Mole-Ratmitochondrion located_inISOHINT2 (Homo sapiens)9068941 PMID:16762638HPAGO_REF:0000052 and PMID:16762638
Hint2Naked Mole-Ratmitochondrion located_inISOHINT2 (Homo sapiens)9068941 PMID:34800366FlyBasePMID:34800366
Hint2Naked Mole-Ratmitochondrion located_inISOHint2 (Mus musculus)9068941 PMID:14651853 and PMID:26767982MGIPMID:14651853 and PMID:26767982

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hint2Naked Mole-Ratadenosine 5'-monophosphoramidase activity enablesISOHINT2 (Homo sapiens)9068941 PMID:16762638 and PMID:31990367UniProtPMID:16762638 and PMID:31990367
Hint2Naked Mole-Ratcatalytic activity enablesIEAInterPro:IPR011146150520179 InterProGO_REF:0000002
Hint2Naked Mole-Ratprotein binding enablesISOUniProtKB:P135699068941 PMID:35156780IntActPMID:35156780

PMID:30032202  



Hint2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,969,085 - 4,971,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,969,076 - 4,971,336 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HINT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,812,960 - 35,815,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,812,960 - 35,815,354 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,812,957 - 35,815,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,802,957 - 35,805,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,802,956 - 35,805,042NCBI
Celera935,746,489 - 35,748,574 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,768,969 - 35,771,054 (-)NCBIHuRef
CHM1_1935,813,345 - 35,815,430 (-)NCBICHM1_1
T2T-CHM13v2.0935,833,627 - 35,836,146 (-)NCBIT2T-CHM13v2.0
Hint2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,654,227 - 43,656,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm39 Ensembl
GRCm38443,654,227 - 43,656,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,667,099 - 43,669,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,675,327 - 43,677,551 (-)NCBIMGSCv36mm8
Celera443,688,832 - 43,691,050 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Hint2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,700,383 - 62,702,638 (-)NCBIGRCr8
mRatBN7.2557,904,613 - 57,906,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,884,698 - 59,886,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,703,512 - 61,705,767 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,674,738 - 61,676,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,150,344 - 59,152,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,675,136 - 63,677,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,130,993 - 60,133,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,131,171 - 60,133,804 (-)NCBI
Celera556,485,081 - 56,487,336 (-)NCBICelera
Cytogenetic Map5q22NCBI
Hint2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955472500,845 - 503,067 (+)NCBIChiLan1.0ChiLan1.0
HINT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,773,684 - 88,775,887 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,779,754 - 88,781,825 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,663,433 - 35,666,479 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,465,806 - 36,468,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,465,806 - 36,468,325 (-)Ensemblpanpan1.1panPan2
HINT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,342,564 - 52,344,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,342,567 - 52,344,947 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,910,135 - 50,912,566 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,407,581 - 53,410,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,407,584 - 53,409,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,952,089 - 51,954,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,936,313 - 51,938,949 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,637,771 - 52,640,202 (-)NCBIUU_Cfam_GSD_1.0
HINT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11236,532,316 - 236,535,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,257,330 - 264,259,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HINT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,790,455 - 44,792,571 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,790,416 - 44,792,625 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,894,686 - 41,897,216 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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RefSeq Transcripts XM_004870124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01095248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01005291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000026660   ⟹   ENSHGLP00000026424
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248684,969,085 - 4,971,336 (+)Ensembl
RefSeq Acc Id: XM_004870124   ⟹   XP_004870181
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248684,969,076 - 4,971,336 (+)NCBI
Protein RefSeqs XP_004870181 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026424
GenBank Protein JAN98341 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004870181   ⟸   XM_004870124
- UniProtKB: A0AAX6Q8S8 (UniProtKB/TrEMBL),   G5BKY9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026424   ⟸   ENSHGLT00000026660



1 to 17 of 17 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000018803 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026660 ENTREZGENE
Gene3D-CATH 3.30.428.10 UniProtKB/TrEMBL
InterPro Histidine_triad_CS UniProtKB/TrEMBL
  Histidine_triad_HIT UniProtKB/TrEMBL
  HIT-like UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/TrEMBL
NCBI Gene Hint2 ENTREZGENE
PANTHER PTHR23089 UniProtKB/TrEMBL
Pfam HIT UniProtKB/TrEMBL
PRINTS HISTRIAD UniProtKB/TrEMBL
PROSITE HIT_1 UniProtKB/TrEMBL
  HIT_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54197 UniProtKB/TrEMBL
UniProt A0A0N8ET59_HETGA UniProtKB/TrEMBL
  A0AAX6Q8S8 ENTREZGENE, UniProtKB/TrEMBL
  G5BKY9 ENTREZGENE, UniProtKB/TrEMBL
1 to 17 of 17 rows