Mgme1 (mitochondrial genome maintenance exonuclease 1) - Rat Genome Database

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Gene: Mgme1 (mitochondrial genome maintenance exonuclease 1) Rattus norvegicus
Analyze
Symbol: Mgme1
Name: mitochondrial genome maintenance exonuclease 1
RGD ID: 1307465
Description: Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in mitochondrial DNA replication. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 11. Orthologous to human MGME1 (mitochondrial genome maintenance exonuclease 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; indole-3-methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC296200; LOC296200; MGC105769; RGD1307465; similar to RIKEN cDNA 8430406I07; uncharacterized protein LOC296200
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83152,094,514 - 152,103,314 (+)NCBIGRCr8
mRatBN7.23131,640,770 - 131,649,933 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3131,640,944 - 131,649,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3135,565,121 - 135,573,771 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03144,149,217 - 144,157,867 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03141,852,397 - 141,861,047 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03138,397,925 - 138,406,672 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3138,398,011 - 138,406,666 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03144,832,022 - 144,840,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43132,798,031 - 132,806,688 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13132,703,603 - 132,712,259 (+)NCBI
Celera3130,536,933 - 130,545,590 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:23313956  


Genomics

Comparative Map Data
Mgme1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83152,094,514 - 152,103,314 (+)NCBIGRCr8
mRatBN7.23131,640,770 - 131,649,933 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3131,640,944 - 131,649,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3135,565,121 - 135,573,771 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03144,149,217 - 144,157,867 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03141,852,397 - 141,861,047 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03138,397,925 - 138,406,672 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3138,398,011 - 138,406,666 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03144,832,022 - 144,840,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43132,798,031 - 132,806,688 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13132,703,603 - 132,712,259 (+)NCBI
Celera3130,536,933 - 130,545,590 (+)NCBICelera
Cytogenetic Map3q41NCBI
MGME1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382017,968,590 - 17,991,122 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2017,969,018 - 17,991,122 (+)EnsemblGRCh38hg38GRCh38
GRCh372017,949,661 - 17,971,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362017,897,762 - 17,919,761 (+)NCBINCBI36Build 36hg18NCBI36
Build 342017,897,761 - 17,919,759NCBI
Celera2018,024,307 - 18,046,309 (+)NCBICelera
Cytogenetic Map20p11.23NCBI
HuRef2017,912,627 - 17,934,672 (+)NCBIHuRef
CHM1_12017,949,785 - 17,971,828 (+)NCBICHM1_1
T2T-CHM13v2.02018,019,713 - 18,042,263 (+)NCBIT2T-CHM13v2.0
Mgme1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392144,112,824 - 144,123,147 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2144,112,583 - 144,123,147 (+)EnsemblGRCm39 Ensembl
GRCm382144,270,904 - 144,281,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2144,270,663 - 144,281,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv372144,096,771 - 144,106,965 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362143,962,476 - 143,972,670 (+)NCBIMGSCv36mm8
Celera2145,459,335 - 145,469,510 (+)NCBICelera
Cytogenetic Map2G1NCBI
cM Map270.98NCBI
Mgme1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541526,805,396 - 26,828,702 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541526,805,883 - 26,814,485 (+)NCBIChiLan1.0ChiLan1.0
MGME1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22118,858,330 - 18,880,842 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12018,855,491 - 18,877,680 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02017,928,751 - 17,950,907 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12017,906,984 - 17,929,214 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2017,907,241 - 17,929,214 (+)Ensemblpanpan1.1panPan2
MGME1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1245,068,147 - 5,083,941 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha244,998,419 - 5,018,198 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0245,475,738 - 5,494,433 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl245,475,742 - 5,494,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1245,087,937 - 5,107,350 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0245,182,349 - 5,201,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0245,458,640 - 5,477,518 (-)NCBIUU_Cfam_GSD_1.0
Mgme1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640153,722,180 - 153,736,555 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364852,153,295 - 2,166,908 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364852,154,446 - 2,167,633 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGME1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1726,369,875 - 26,395,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11726,381,561 - 26,395,201 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21729,870,702 - 29,884,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MGME1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1247,028,568 - 47,050,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl247,029,329 - 47,050,948 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660781,697,258 - 1,719,374 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgme1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474118,975,410 - 18,987,301 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474118,974,534 - 18,983,246 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:93
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000038865
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH132897  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23131,649,624 - 131,649,804 (+)MAPPERmRatBN7.2
Rnor_6.03138,406,364 - 138,406,543NCBIRnor6.0
Rnor_5.03144,840,375 - 144,840,554UniSTSRnor5.0
RGSC_v3.43132,806,384 - 132,806,563UniSTSRGSC3.4
Celera3130,545,286 - 130,545,465UniSTS
RH 3.4 Map31182.3UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC087676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000038865   ⟹   ENSRNOP00000034141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3131,641,301 - 131,649,927 (+)Ensembl
Rnor_6.0 Ensembl3138,398,011 - 138,406,666 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098696   ⟹   ENSRNOP00000077075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3131,640,944 - 131,649,932 (+)Ensembl
RefSeq Acc Id: NM_001009655   ⟹   NP_001009655
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83152,094,653 - 152,103,310 (+)NCBI
mRatBN7.23131,641,272 - 131,649,929 (+)NCBI
Rnor_6.03138,398,011 - 138,406,668 (+)NCBI
Rnor_5.03144,832,022 - 144,840,683 (+)NCBI
RGSC_v3.43132,798,031 - 132,806,688 (+)RGD
Celera3130,536,933 - 130,545,590 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235120   ⟹   XP_006235182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83152,094,634 - 152,103,314 (+)NCBI
mRatBN7.23131,641,252 - 131,649,933 (+)NCBI
Rnor_6.03138,398,018 - 138,406,672 (+)NCBI
Rnor_5.03144,832,022 - 144,840,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235121   ⟹   XP_006235183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83152,094,514 - 152,103,314 (+)NCBI
mRatBN7.23131,640,770 - 131,649,933 (+)NCBI
Rnor_6.03138,397,925 - 138,406,672 (+)NCBI
Rnor_5.03144,832,022 - 144,840,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235123   ⟹   XP_006235185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83152,094,677 - 152,103,314 (+)NCBI
mRatBN7.23131,641,466 - 131,649,933 (+)NCBI
Rnor_6.03138,398,142 - 138,406,672 (+)NCBI
Rnor_5.03144,832,022 - 144,840,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104595   ⟹   XP_038960523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83152,094,634 - 152,103,314 (+)NCBI
mRatBN7.23131,641,263 - 131,649,009 (+)NCBI
RefSeq Acc Id: XM_063283344   ⟹   XP_063139414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83152,094,693 - 152,103,314 (+)NCBI
RefSeq Acc Id: XM_063283345   ⟹   XP_063139415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83152,094,514 - 152,103,314 (+)NCBI
RefSeq Acc Id: NP_001009655   ⟸   NM_001009655
- UniProtKB: Q5PPI6 (UniProtKB/TrEMBL),   A6K748 (UniProtKB/TrEMBL),   F7EWY8 (UniProtKB/TrEMBL),   A6K746 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235183   ⟸   XM_006235121
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006235182   ⟸   XM_006235120
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006235185   ⟸   XM_006235123
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000034141   ⟸   ENSRNOT00000038865
RefSeq Acc Id: XP_038960523   ⟸   XM_039104595
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000077075   ⟸   ENSRNOT00000098696
RefSeq Acc Id: XP_063139415   ⟸   XM_063283345
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139414   ⟸   XM_063283344
- Peptide Label: isoform X3
Protein Domains
PD-(D/E)XK endonuclease-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPI6-F1-model_v2 AlphaFold Q5PPI6 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692481
Promoter ID:EPDNEW_R3005
Type:initiation region
Name:Mgme1_1
Description:mitochondrial genome maintenance exonuclease 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03138,397,955 - 138,398,015EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307465 AgrOrtholog
BioCyc Gene G2FUF-47606 BioCyc
Ensembl Genes ENSRNOG00000028196 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038865.5 UniProtKB/TrEMBL
  ENSRNOT00000098696.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.320.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7319345 IMAGE-MGC_LOAD
InterPro Exonuc_phg/RecB_C UniProtKB/TrEMBL
  PDDEXK_AddAB-type UniProtKB/TrEMBL
  Restrct_endonuc-II-like UniProtKB/TrEMBL
KEGG Report rno:296200 UniProtKB/TrEMBL
MGC_CLONE MGC:105769 IMAGE-MGC_LOAD
NCBI Gene 296200 ENTREZGENE
PANTHER MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1 UniProtKB/TrEMBL
  MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1 UniProtKB/TrEMBL
Pfam PDDEXK_1 UniProtKB/TrEMBL
PhenoGen Mgme1 PhenoGen
RatGTEx ENSRNOG00000028196 RatGTEx
Superfamily-SCOP SSF52980 UniProtKB/TrEMBL
UniProt A6K746 ENTREZGENE, UniProtKB/TrEMBL
  A6K748 ENTREZGENE, UniProtKB/TrEMBL
  A6K749 ENTREZGENE, UniProtKB/TrEMBL
  F7EWY8 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPI6 ENTREZGENE
UniProt Secondary Q5PPI6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 Mgme1  mitochondrial genome maintenance exonuclease 1  RGD1307465  similar to RIKEN cDNA 8430406I07  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307465  similar to RIKEN cDNA 8430406I07  RGD1307465_predicted  similar to RIKEN cDNA 8430406I07 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307465_predicted  similar to RIKEN cDNA 8430406I07 (predicted)  LOC296200_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296200_predicted  similar to RIKEN cDNA 8430406I07 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL