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Gene: MGME1 (mitochondrial genome maintenance exonuclease 1) Homo sapiens
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Symbol: MGME1
Name: mitochondrial genome maintenance exonuclease 1
Description: Exhibits single-stranded DNA exodeoxyribonuclease activity. Involved in mitochondrial DNA replication and mitochondrial genome maintenance. Localizes to mitochondrion. Implicated in mitochondrial DNA depletion syndrome 11.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bA504H3.4; C20orf72; DDK1; FLJ14597; hypothetical protein LOC92667; MTDPS11; uncharacterized protein C20orf72
Orthologs:
Mus musculus (house mouse) : Mgme1 (mitochondrial genome maintenance exonuclease 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mgme1 (mitochondrial genome maintenance exonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mgme1 (mitochondrial genome maintenance exonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MGME1 (mitochondrial genome maintenance exonuclease 1)
Canis lupus familiaris (dog) : MGME1 (mitochondrial genome maintenance exonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mgme1 (mitochondrial genome maintenance exonuclease 1)
Sus scrofa (pig) : MGME1 (mitochondrial genome maintenance exonuclease 1)
Chlorocebus sabaeus (African green monkey) : MGME1 (mitochondrial genome maintenance exonuclease 1)
Heterocephalus glaber (naked mole-rat) : Mgme1 (mitochondrial genome maintenance exonuclease 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2017,969,018 - 17,991,122 (+)EnsemblGRCh38hg38GRCh38
GRCh382017,968,594 - 17,991,122 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372017,949,534 - 17,971,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362017,897,762 - 17,919,761 (+)NCBINCBI36hg18NCBI36
Build 342017,897,761 - 17,919,759NCBI
Celera2018,024,307 - 18,046,309 (+)NCBI
Cytogenetic Map20p11.23NCBI
HuRef2017,912,627 - 17,934,672 (+)NCBIHuRef
CHM1_12017,949,557 - 17,971,832 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MGME1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316675
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.