Rptor (regulatory associated protein of MTOR complex 1) - Rat Genome Database

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Gene: Rptor (regulatory associated protein of MTOR complex 1) Ictidomys tridecemlineatus
Analyze
Symbol: Rptor
Name: regulatory associated protein of MTOR complex 1
RGD ID: 12700865
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN negative regulation of insulin secretion (ortholog); positive regulation of endothelial cell proliferation (ortholog); positive regulation of odontoblast differentiation (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH developmental coordination disorder (ortholog); lung metastasis (ortholog); nicotine dependence (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: regulatory-associated protein of mTOR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,653,875 - 1,984,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,427,169 - 4,760,120 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,427,225 - 4,758,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RptorSquirrellung metastasis  ISORGD:13234189068941 RGDPMID:29809146|REF_RGD_ID:152995516
RptorSquirrelnicotine dependence susceptibilityISORGD:16030199068941DNA:SNP:: (rs1062935) (human)RGDPMID:18438686|REF_RGD_ID:401851917
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RptorSquirreldevelopmental coordination disorder  ISORGD:16030199068941CTD Direct Evidence: therapeuticCTDPMID:32773031
RptorSquirrelnicotine dependence  ISORGD:16030199068941CTD Direct Evidence: marker/mechanismCTDPMID:18438686


Biological Process
1 to 20 of 28 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RptorSquirrelcellular response to amino acid stimulus involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelcellular response to amino acid stimulus involved_inIEAPANTHER:PTN000304106150520179 TreeGrafterGO_REF:0000118
RptorSquirrelcellular response to glucose stimulus involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelcellular response to L-leucine involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelcellular response to nutrient levels involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelcellular response to starvation involved_inIEAPANTHER:PTN000304106150520179 TreeGrafterGO_REF:0000118
RptorSquirrelnegative regulation of autophagy involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelnegative regulation of insulin secretion involved_inISORGD:13234189068941 PMID:23092880CACAOPMID:23092880
RptorSquirrelpositive regulation of cell growth involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelpositive regulation of cell growth involved_inIEAPANTHER:PTN000304106150520179 TreeGrafterGO_REF:0000118
RptorSquirrelpositive regulation of endothelial cell proliferation  ISORGD:13117849068941 RGDPMID:17110594|REF_RGD_ID:2307383
RptorSquirrelpositive regulation of G1/S transition of mitotic cell cycle involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelpositive regulation of odontoblast differentiation involved_inISORGD:13234189068941 PMID:30984011UniProtPMID:30984011
RptorSquirrelpositive regulation of osteoclast differentiation involved_inISORGD:13234189068941 PMID:27879318UniProtPMID:27879318
RptorSquirrelpositive regulation of TOR signaling involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelpositive regulation of transcription by RNA polymerase III involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelregulation of autophagy involved_inIEAPANTHER:PTN000304106150520179 TreeGrafterGO_REF:0000118
RptorSquirrelregulation of cell growth involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelregulation of cell size involved_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelregulation of phosphorylation  ISORGD:13117849068941 RGDPMID:17110594|REF_RGD_ID:2307383
1 to 20 of 28 rows

Cellular Component
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RptorSquirrelcytoplasm located_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelcytoplasm located_inIEAPANTHER:PTN000304106150520179 TreeGrafterGO_REF:0000118
RptorSquirrelcytoplasmic stress granule located_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelcytosol located_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirreldendrite located_inISORGD:13117849068941 RGDPMID:15525761|REF_RGD_ID:2307416
RptorSquirrellysosomal membrane is_active_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrellysosome located_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelneuronal cell body located_inISORGD:13117849068941 RGDPMID:15525761|REF_RGD_ID:2307416
RptorSquirrelnucleoplasm located_inIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelserine/threonine protein kinase complex part_ofIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelTORC1 complex part_ofIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelTORC1 complex part_ofIEAPANTHER:PTN000304106150520179 TreeGrafterGO_REF:0000118
RptorSquirrelTORC1 complex part_ofIEAInterPro:IPR004083150520179 InterProGO_REF:0000002
1 to 13 of 13 rows

Molecular Function
1 to 20 of 37 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RptorSquirrel14-3-3 protein binding enablesIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelenzyme-substrate adaptor activity enablesIEAUniProtKB:Q8N122|ensembl:ENSP00000307272150520179 EnsemblGO_REF:0000107
RptorSquirrelprotein binding enablesISOUniProtKB:O753859068941 PMID:25686248IntActPMID:25686248
RptorSquirrelprotein binding enablesISOUniProtKB:Q9JLN99068941 PMID:18664580, PMID:20801936, PMID:21045808, PMID:23966835IntActPMID:18664580|PMID:20801936|PMID:21045808|PMID:23966835
RptorSquirrelprotein binding enablesISOUniProtKB:Q008999068941 PMID:18046414IntActPMID:18046414
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:Q8TCU69068941 PMID:17565979IntActPMID:17565979
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:P628209068941 PMID:25446900IntActPMID:25446900
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:Q9BVC49068941 PMID:12408816IntActPMID:12408816
RptorSquirrelprotein binding enablesISOUniProtKB:P23443|UniProtKB:P42345|UniProtKB:Q135419068941 PMID:12150926UniProtPMID:12150926
RptorSquirrelprotein binding enablesISOUniProtKB:Q9BVC49068941 PMID:20562859IntActPMID:20562859
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:P459839068941 PMID:27043084IntActPMID:27043084
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:Q9P2J59068941 PMID:22424946IntActPMID:22424946
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:Q13283|UniProtKB:Q96R069068941 PMID:23953116IntActPMID:23953116
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:Q9JLN99068941 PMID:24036451IntActPMID:24036451
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:Q9BVC4|UniProtKB:Q9NWS0|UniProtKB:Q9Y4R89068941 PMID:24036451UniProtPMID:24036451
RptorSquirrelprotein binding enablesISOUniProtKB:Q8TCU69068941 PMID:21339740IntActPMID:21339740
RptorSquirrelprotein binding enablesISOUniProtKB:Q135419068941 PMID:18337751IntActPMID:18337751
RptorSquirrelprotein binding enablesISOUniProtKB:P42345|UniProtKB:P67999|UniProtKB:Q13541|UniProtKB:Q9JLN99068941 PMID:12150926IntActPMID:12150926
RptorSquirrelprotein binding enablesISOUniProtKB:Q9NVC39068941 PMID:35561222UniProtPMID:35561222
RptorSquirrelprotein binding enablesISOUniProtKB:Q136159068941 PMID:26787466IntActPMID:26787466
1 to 20 of 37 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RptorSquirrelmTOR signaling pathway   ISORGD:13117849068941 RGDPMID:17110594|REF_RGD_ID:2307383
RptorSquirrelmTOR signaling pathway   ISORGD:16030199068941 RGDPMID:16885148|PMID:19339977|PMID:22500797|REF_RGD_ID:11535033|REF_RGD_ID:1625616|REF_RGD_ID:2308795

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RptorSquirrelmTOR signaling pathway   ISORGD:16030199068941 PIDPID:200096
PMID:22301074   PMID:30032202  



Rptor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,653,875 - 1,984,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,427,169 - 4,760,120 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,427,225 - 4,758,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,544,838 - 80,966,368 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,544,819 - 80,966,371 (+)EnsemblGRCh38hg38GRCh38
GRCh371778,518,638 - 78,940,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,133,220 - 76,554,768 (+)NCBINCBI36Build 36hg18NCBI36
Celera1775,147,295 - 75,567,674 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,954,508 - 74,378,467 (+)NCBIHuRef
CHM1_11778,604,958 - 79,026,514 (+)NCBICHM1_1
T2T-CHM13v2.01781,446,296 - 81,873,303 (+)NCBIT2T-CHM13v2.0
Rptor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,493,731 - 119,790,417 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,493,731 - 119,790,402 (+)EnsemblGRCm39 Ensembl
GRCm3811119,602,905 - 119,899,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,602,905 - 119,899,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711119,464,309 - 119,760,905 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,419,900 - 119,713,572 (+)NCBIMGSCv36mm8
Celera11131,343,545 - 131,633,430 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.96NCBI
Rptor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,376,943 - 105,675,416 (+)NCBIGRCr8
mRatBN7.210104,878,487 - 105,176,986 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,981,892 - 110,280,534 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,444,928 - 109,743,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,799,071 - 105,097,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,750,620 - 109,058,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,353,697 - 108,658,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,000,666 - 109,302,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,015,970 - 109,317,386 (+)NCBI
Celera10103,425,303 - 103,722,658 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
Rptor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,008,044 - 2,401,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555062,009,422 - 2,401,775 (-)NCBIChiLan1.0ChiLan1.0
RPTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,125,522 - 97,543,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,025,309 - 102,442,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,973,420 - 75,389,339 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,705,544 - 81,118,708 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1780,705,544 - 81,118,708 (+)Ensemblpanpan1.1panPan2
RPTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,012,512 - 1,345,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,013,603 - 1,344,148 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,630,245 - 1,963,406 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,621,864 - 1,955,230 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,621,871 - 1,953,491 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,645,842 - 1,978,909 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,771,374 - 2,104,386 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,852,046 - 2,185,237 (-)NCBIUU_Cfam_GSD_1.0
RPTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,709,128 - 1,991,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,709,121 - 1,991,844 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,614,075 - 1,710,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,513,593 - 72,916,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,513,619 - 72,918,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607743,826,714 - 44,287,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rptor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,677,307 - 10,048,719 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248019,676,965 - 10,053,311 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSSTOT00000002931   ⟹   ENSSTOP00000002621
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365944,428,052 - 4,756,076 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000043214   ⟹   ENSSTOP00000031203
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365944,427,169 - 4,760,120 (+)Ensembl
RefSeq Acc Id: XM_005332637   ⟹   XP_005332694
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244056021,653,875 - 1,984,718 (-)NCBI
SpeTri2.0NW_0049365944,427,225 - 4,758,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040268365   ⟹   XP_040124299
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244056021,653,875 - 1,983,869 (-)NCBI
Protein RefSeqs XP_005332694 (Get FASTA)   NCBI Sequence Viewer  
  XP_040124299 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002621.3
  ENSSTOP00000031203.1
RefSeq Acc Id: XP_005332694   ⟸   XM_005332637
- Peptide Label: isoform X1
- UniProtKB: A0A287DCD3 (UniProtKB/TrEMBL),   I3M1D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040124299   ⟸   XM_040268365
- Peptide Label: isoform X2
- UniProtKB: I3M1D6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000002621   ⟸   ENSSTOT00000002931
Ensembl Acc Id: ENSSTOP00000031203   ⟸   ENSSTOT00000043214


1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000002905 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002931.3 UniProtKB/TrEMBL
  ENSSTOT00000043214.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT UniProtKB/TrEMBL
  Raptor UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene Rptor ENTREZGENE
PANTHER PTHR12848 UniProtKB/TrEMBL
  REGULATORY-ASSOCIATED PROTEIN OF MTOR UniProtKB/TrEMBL
Pfam HEAT UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PRINTS YEAST176DUF UniProtKB/TrEMBL
SMART Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A287DCD3 ENTREZGENE, UniProtKB/TrEMBL
  I3M1D6 ENTREZGENE, UniProtKB/TrEMBL
1 to 26 of 26 rows