RPTOR (regulatory associated protein of MTOR complex 1) - Rat Genome Database

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Gene: RPTOR (regulatory associated protein of MTOR complex 1) Pan paniscus
Analyze
Symbol: RPTOR
Name: regulatory associated protein of MTOR complex 1
RGD ID: 11887927
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN negative regulation of insulin secretion (ortholog); positive regulation of endothelial cell proliferation (ortholog); positive regulation of odontoblast differentiation (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH developmental coordination disorder (ortholog); genetic disease (ortholog); lung metastasis (ortholog); FOUND IN dendrite (ortholog); lysosomal membrane (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: regulatory-associated protein of mTOR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,125,522 - 97,543,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,025,309 - 102,442,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,973,420 - 75,389,339 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,705,544 - 81,118,708 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1780,705,544 - 81,118,708 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RPTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,125,522 - 97,543,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,025,309 - 102,442,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,973,420 - 75,389,339 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,705,544 - 81,118,708 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1780,705,544 - 81,118,708 (+)Ensemblpanpan1.1panPan2
RPTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,544,838 - 80,966,368 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,544,819 - 80,966,371 (+)EnsemblGRCh38hg38GRCh38
GRCh371778,518,638 - 78,940,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,133,220 - 76,554,768 (+)NCBINCBI36Build 36hg18NCBI36
Celera1775,147,295 - 75,567,674 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,954,508 - 74,378,467 (+)NCBIHuRef
CHM1_11778,604,958 - 79,026,514 (+)NCBICHM1_1
T2T-CHM13v2.01781,446,296 - 81,873,303 (+)NCBIT2T-CHM13v2.0
Rptor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,493,731 - 119,790,417 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,493,731 - 119,790,402 (+)EnsemblGRCm39 Ensembl
GRCm3811119,602,905 - 119,899,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,602,905 - 119,899,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711119,464,309 - 119,760,905 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,419,900 - 119,713,572 (+)NCBIMGSCv36mm8
Celera11131,343,545 - 131,633,430 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.96NCBI
Rptor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,376,943 - 105,675,416 (+)NCBIGRCr8
mRatBN7.210104,878,487 - 105,176,986 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,981,892 - 110,280,534 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,444,928 - 109,743,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,799,071 - 105,097,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,750,620 - 109,058,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,353,697 - 108,658,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,000,666 - 109,302,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,015,970 - 109,317,386 (+)NCBI
Celera10103,425,303 - 103,722,658 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
Rptor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,008,044 - 2,401,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555062,009,422 - 2,401,775 (-)NCBIChiLan1.0ChiLan1.0
RPTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,012,512 - 1,345,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,013,603 - 1,344,148 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,630,245 - 1,963,406 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,621,864 - 1,955,230 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,621,871 - 1,953,491 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,645,842 - 1,978,909 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,771,374 - 2,104,386 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,852,046 - 2,185,237 (-)NCBIUU_Cfam_GSD_1.0
Rptor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,653,875 - 1,984,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,427,169 - 4,760,120 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,427,225 - 4,758,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,709,128 - 1,991,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,709,121 - 1,991,844 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,614,075 - 1,710,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,513,593 - 72,916,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,513,619 - 72,918,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607743,826,714 - 44,287,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rptor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,677,307 - 10,048,719 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248019,676,965 - 10,053,311 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000062101   ⟹   ENSPPAP00000039192
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1780,705,544 - 81,118,708 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062117   ⟹   ENSPPAP00000039208
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1780,706,347 - 81,116,671 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062121   ⟹   ENSPPAP00000039212
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1780,706,347 - 81,116,671 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062126   ⟹   ENSPPAP00000039217
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1780,706,347 - 80,788,094 (+)Ensembl
RefSeq Acc Id: XM_003831138   ⟹   XP_003831186
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21997,125,523 - 97,543,425 (+)NCBI
NHGRI_mPanPan117102,025,309 - 102,442,783 (+)NCBI
Mhudiblu_PPA_v01774,973,422 - 75,389,339 (+)NCBI
PanPan1.11780,705,546 - 81,118,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055101956   ⟹   XP_054957931
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21997,206,039 - 97,543,425 (+)NCBI
NHGRI_mPanPan117102,105,755 - 102,442,783 (+)NCBI
RefSeq Acc Id: XM_063599478   ⟹   XP_063455548
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21997,125,522 - 97,543,425 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003831186 (Get FASTA)   NCBI Sequence Viewer  
  XP_054957931 (Get FASTA)   NCBI Sequence Viewer  
  XP_063455548 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000039192.1
  ENSPPAP00000039208.1
  ENSPPAP00000039212.1
  ENSPPAP00000039217.1
Reference Protein Sequences
RefSeq Acc Id: XP_003831186   ⟸   XM_003831138
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CM07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000039208   ⟸   ENSPPAT00000062117
RefSeq Acc Id: ENSPPAP00000039192   ⟸   ENSPPAT00000062101
RefSeq Acc Id: ENSPPAP00000039212   ⟸   ENSPPAT00000062121
RefSeq Acc Id: ENSPPAP00000039217   ⟸   ENSPPAT00000062126
RefSeq Acc Id: XP_054957931   ⟸   XM_055101956
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063455548   ⟸   XM_063599478
- Peptide Label: isoform X2
Protein Domains
Raptor N-terminal CASPase-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042241 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062101.1 UniProtKB/TrEMBL
  ENSPPAT00000062117.1 UniProtKB/TrEMBL
  ENSPPAT00000062121.1 UniProtKB/TrEMBL
  ENSPPAT00000062126.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT UniProtKB/TrEMBL
  Raptor UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100976440 UniProtKB/TrEMBL
NCBI Gene RPTOR ENTREZGENE
PANTHER PTHR12848 UniProtKB/TrEMBL
  REGULATORY-ASSOCIATED PROTEIN OF MTOR UniProtKB/TrEMBL
Pfam HEAT UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PRINTS F138DOMAIN UniProtKB/TrEMBL
  YEAST176DUF UniProtKB/TrEMBL
SMART Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A2R9CDY8_PANPA UniProtKB/TrEMBL
  A0A2R9CM07 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CM73_PANPA UniProtKB/TrEMBL
  A0A2R9CM79_PANPA UniProtKB/TrEMBL