Rptor (regulatory associated protein of MTOR complex 1) - Rat Genome Database

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Gene: Rptor (regulatory associated protein of MTOR complex 1) Chinchilla lanigera
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Symbol: Rptor
Name: regulatory associated protein of MTOR complex 1
RGD ID: 8737328
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); enzyme-substrate adaptor activity (ortholog); protein kinase activator activity (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to glucose stimulus (ortholog); cellular response to L-leucine (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH developmental coordination disorder (ortholog); lung metastasis (ortholog); nicotine dependence (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: regulatory associated protein of MTOR, complex 1; regulatory-associated protein of mTOR
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,008,044 - 2,401,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555062,009,422 - 2,401,775 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rptor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,008,044 - 2,401,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555062,009,422 - 2,401,775 (-)NCBIChiLan1.0ChiLan1.0
RPTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,544,838 - 80,966,368 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,544,819 - 80,966,371 (+)EnsemblGRCh38hg38GRCh38
GRCh371778,518,638 - 78,940,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,133,220 - 76,554,768 (+)NCBINCBI36Build 36hg18NCBI36
Celera1775,147,295 - 75,567,674 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,954,508 - 74,378,467 (+)NCBIHuRef
CHM1_11778,604,958 - 79,026,514 (+)NCBICHM1_1
T2T-CHM13v2.01781,446,296 - 81,873,303 (+)NCBIT2T-CHM13v2.0
Rptor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,493,731 - 119,790,417 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,493,731 - 119,790,402 (+)EnsemblGRCm39 Ensembl
GRCm3811119,602,905 - 119,899,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,602,905 - 119,899,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711119,464,309 - 119,760,905 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,419,900 - 119,713,572 (+)NCBIMGSCv36mm8
Celera11131,343,545 - 131,633,430 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.96NCBI
Rptor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,376,943 - 105,675,416 (+)NCBIGRCr8
mRatBN7.210104,878,487 - 105,176,986 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,878,487 - 105,176,983 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,981,892 - 110,280,534 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,444,928 - 109,743,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,799,071 - 105,097,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,750,620 - 109,058,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,750,620 - 109,058,691 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,353,697 - 108,658,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,000,666 - 109,302,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,015,970 - 109,317,386 (+)NCBI
Celera10103,425,303 - 103,722,658 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
RPTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,125,522 - 97,543,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,025,309 - 102,442,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,973,420 - 75,389,339 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,705,544 - 81,118,708 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1780,705,544 - 81,118,708 (+)Ensemblpanpan1.1panPan2
RPTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,012,512 - 1,345,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,013,603 - 1,344,148 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,630,245 - 1,963,406 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,621,864 - 1,955,230 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,621,871 - 1,953,491 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,645,842 - 1,978,909 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,771,374 - 2,104,386 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,852,046 - 2,185,237 (-)NCBIUU_Cfam_GSD_1.0
Rptor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,653,875 - 1,984,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,427,169 - 4,760,120 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,427,225 - 4,758,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,709,128 - 1,991,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,709,121 - 1,991,844 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,614,075 - 1,710,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,513,593 - 72,916,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,513,619 - 72,918,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607743,826,714 - 44,287,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rptor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,677,307 - 10,048,719 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248019,676,965 - 10,053,311 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000012681   ⟹   ENSCLAP00000012535
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555062,008,044 - 2,401,775 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000012682   ⟹   ENSCLAP00000012536
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555062,011,390 - 2,401,752 (-)Ensembl
RefSeq Acc Id: XM_005407317   ⟹   XP_005407374
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555062,009,422 - 2,401,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005407318   ⟹   XP_005407375
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555062,009,422 - 2,401,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506089   ⟹   XP_013361543
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555062,009,422 - 2,165,656 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005407374 (Get FASTA)   NCBI Sequence Viewer  
  XP_005407375 (Get FASTA)   NCBI Sequence Viewer  
  XP_013361543 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000012535
  ENSCLAP00000012535.1
  ENSCLAP00000012536.1
RefSeq Acc Id: XP_005407374   ⟸   XM_005407317
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VGG4 (UniProtKB/TrEMBL),   A0A8C2VCC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005407375   ⟸   XM_005407318
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VCC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013361543   ⟸   XM_013506089
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSCLAP00000012536   ⟸   ENSCLAT00000012682
Ensembl Acc Id: ENSCLAP00000012535   ⟸   ENSCLAT00000012681
Protein Domains
Raptor N-terminal CASPase-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008668 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000012681 ENTREZGENE
  ENSCLAT00000012681.1 UniProtKB/TrEMBL
  ENSCLAT00000012682.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT UniProtKB/TrEMBL
  Raptor UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene Rptor ENTREZGENE
PANTHER PTHR12848 UniProtKB/TrEMBL
  REGULATORY-ASSOCIATED PROTEIN OF MTOR UniProtKB/TrEMBL
Pfam HEAT UniProtKB/TrEMBL
  Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PRINTS YEAST176DUF UniProtKB/TrEMBL
SMART Raptor_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A8C2VCC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VGG4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Rptor  regulatory associated protein of MTOR complex 1    regulatory associated protein of MTOR, complex 1  Symbol and/or name change 5135510 APPROVED