Kcnn2 (potassium calcium-activated channel subfamily N member 2) - Rat Genome Database

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Gene: Kcnn2 (potassium calcium-activated channel subfamily N member 2) Ictidomys tridecemlineatus
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Symbol: Kcnn2
Name: potassium calcium-activated channel subfamily N member 2
RGD ID: 12626373
Description: ENCODES a protein that exhibits alpha-actinin binding (ortholog); calmodulin binding (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN membrane repolarization during atrial cardiac muscle cell action potential (ortholog); modulation of chemical synaptic transmission (ortholog); monoatomic ion transport (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); atrial fibrillation (ortholog); cardiac arrest (ortholog); FOUND IN cell surface (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: small conductance calcium-activated potassium channel protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mIctTri1.hap1 - mIctTri1.hap1 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11145,736,018 - 146,150,906 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024407213127,017,453 - 127,153,054 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937043134,301 - 161,686 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004937043133,981 - 269,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0



Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Kcnn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11145,736,018 - 146,150,906 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024407213127,017,453 - 127,153,054 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937043134,301 - 161,686 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004937043133,981 - 269,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385114,055,978 - 114,496,496 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5114,055,926 - 114,496,500 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh375113,391,675 - 113,832,193 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365113,725,915 - 113,860,096 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345113,797,125 - 113,860,096NCBI
Celera5109,645,171 - 109,779,247 (+)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5108,880,682 - 109,014,440 (+)NCBIHuRef
CHM1_15113,130,747 - 113,264,917 (+)NCBICHM1_1
T2T-CHM13v2.05114,568,913 - 115,009,369 (+)NCBIT2T-CHM13v2.0
Kcnn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391845,401,754 - 45,818,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1845,401,927 - 45,818,953 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381845,268,750 - 45,685,887 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1845,268,860 - 45,686,024 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371845,719,808 - 45,845,537 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361845,685,485 - 45,811,214 (+)NCBIMGSCv36mm8
Celera1846,932,460 - 47,057,444 (+)NCBICelera
Cytogenetic Map18B3- CNCBI
cM Map1824.34NCBI
Kcnn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81840,004,693 - 40,445,043 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1840,155,939 - 40,445,045 (+)EnsemblGRCr8
mRatBN7.21837,817,966 - 38,258,347 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1837,817,957 - 38,258,347 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1840,147,538 - 40,291,656 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01840,849,776 - 40,993,881 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01838,642,870 - 38,786,982 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1839,718,931 - 39,863,001 (+)NCBI
Lyon_Normotensive1839,983,358 - 40,127,466 (+)NCBI
Lyon_Hypertensive1840,157,408 - 40,301,484 (+)NCBI
F344_StmMcwi1839,897,792 - 40,041,927 (+)NCBI
Rnor_6.01839,331,894 - 39,479,574 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1839,335,377 - 39,479,257 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01838,822,146 - 38,864,110 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41839,560,962 - 39,705,037 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1836,394,877 - 36,538,795 (+)NCBICelera
Cytogenetic Map18q11NCBI
Kcnn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540834,109,334 - 34,368,114 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495540834,223,523 - 34,366,191 (+)NCBIChiLan1.0ChiLan1.0
KCNN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24108,932,344 - 109,759,429 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15107,774,104 - 107,913,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05109,722,916 - 109,862,747 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15115,522,363 - 115,661,398 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5115,522,443 - 115,661,079 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
KCNN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1114,279,362 - 4,423,080 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl114,154,746 - 4,423,078 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha114,114,348 - 4,574,043 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0114,259,813 - 4,403,473 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl114,258,999 - 4,403,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,914,674 - 4,366,142 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0114,295,183 - 4,439,054 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0114,237,744 - 4,692,269 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
KCNN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2118,439,403 - 118,882,295 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.12118,439,328 - 118,882,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22123,463,548 - 123,612,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12367,503,701 - 67,641,124 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603460,665,455 - 60,803,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12317,595,661 - 17,735,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2317,598,177 - 17,735,669 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Kcnn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247337,429,681 - 7,931,192 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247337,429,681 - 7,578,596 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl437,851,189 - 38,319,701 (+)Ensembl
Kcnn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11541,073,532 - 41,222,298 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000028753   ⟹   ENSSTOP00000020890
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004937043134,301 - 161,686 (-)Ensembl
RefSeq Acc Id: XM_078048849   ⟹   XP_077904975
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap11145,736,018 - 146,150,903 (-)NCBI
RefSeq Acc Id: XM_078048853   ⟹   XP_077904979
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap11145,736,018 - 145,871,323 (-)NCBI
RefSeq Acc Id: XM_078048854   ⟹   XP_077904980
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap11145,736,018 - 146,150,906 (-)NCBI
RefSeq Acc Id: XM_078048855   ⟹   XP_077904981
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap11145,736,018 - 145,830,041 (-)NCBI
Protein Sequences
Protein RefSeqs XP_077904975 (Get FASTA)   NCBI Sequence Viewer  
  XP_077904979 (Get FASTA)   NCBI Sequence Viewer  
  XP_077904980 (Get FASTA)   NCBI Sequence Viewer  
  XP_077904981 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000020890.2
GenBank Protein KAG3265837 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSSTOP00000020890   ⟸   ENSSTOT00000028753
RefSeq Acc Id: XP_077904980   ⟸   XM_078048854
- Peptide Label: isoform X3
RefSeq Acc Id: XP_077904975   ⟸   XM_078048849
- Peptide Label: isoform X1
RefSeq Acc Id: XP_077904979   ⟸   XM_078048853
- Peptide Label: isoform X2
RefSeq Acc Id: XP_077904981   ⟸   XM_078048855
- Peptide Label: isoform X4
- UniProtKB: I3N944 (UniProtKB/TrEMBL)
Protein Domains
Calmodulin-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000023163 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028753.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro CaM-bd_dom UniProtKB/TrEMBL
  CaM-bd_dom_sf UniProtKB/TrEMBL
  K_chnl_Ca-activ_SK UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/TrEMBL
NCBI Gene Kcnn2 ENTREZGENE
PANTHER PTHR10153 UniProtKB/TrEMBL
Pfam CaMBD UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/TrEMBL
SMART CaMBD UniProtKB/TrEMBL
Superfamily-SCOP SSF81327 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt I3N944 ENTREZGENE, UniProtKB/TrEMBL