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Gene: Mep1b (meprin A subunit beta) Ictidomys tridecemlineatus

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Symbol:

Mep1b

Name:

meprin A subunit beta

RGD ID:

12610467

Description:

ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); protein domain specific binding (ortholog); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH intellectual disability (ortholog); FOUND IN membrane (inferred); meprin A complex (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEP1B (meprin A subunit beta)	NCBI	Ortholog
Mus musculus (house mouse):	Mep1b (meprin 1 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mep1b (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mep1b (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEP1B (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEP1B (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEP1B (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEP1B (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mep1b (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	53,099,990 - 53,130,877 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936682	1,105,243 - 1,132,404 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936682	1,102,365 - 1,132,404 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

Cellular Component

membrane (IEA)

meprin A complex (IEA)

plasma membrane (IEA)

Molecular Function

identical protein binding (IEA)

metal ion binding (IEA)

metalloendopeptidase activity (IEA,ISO)

metallopeptidase activity (IEA)

protein binding (ISO)

protein domain specific binding (ISO)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Mep1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	53,099,990 - 53,130,877 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936682	1,105,243 - 1,132,404 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936682	1,102,365 - 1,132,404 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEP1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	32,190,039 - 32,220,404 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	32,185,069 - 32,220,404 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	29,770,002 - 29,800,367 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	28,023,985 - 28,054,365 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	28,023,985 - 28,054,362	NCBI
Celera	18	26,576,994 - 26,607,343 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI
HuRef	18	26,626,575 - 26,656,944 (+)	NCBI		HuRef
CHM1_1	18	29,697,554 - 29,727,904 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	32,380,357 - 32,410,718 (+)	NCBI		T2T-CHM13v2.0

Mep1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	21,205,401 - 21,233,256 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	21,194,980 - 21,233,256 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	21,072,344 - 21,100,199 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	21,061,923 - 21,100,199 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	21,230,845 - 21,258,700 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	21,215,354 - 21,243,199 (+)	NCBI		MGSCv36	mm8
Celera	18	21,568,002 - 21,595,856 (+)	NCBI		Celera
Cytogenetic Map	18	A2	NCBI
cM Map	18	11.81	NCBI

Mep1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	12,641,041 - 12,667,759 (+)	NCBI		GRCr8
mRatBN7.2	18	12,366,126 - 12,392,840 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	12,365,289 - 12,392,840 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	12,549,574 - 12,575,989 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	13,337,224 - 13,363,645 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	12,608,782 - 12,635,267 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	15,063,159 - 15,090,877 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	15,063,079 - 15,089,988 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	14,847,661 - 14,874,235 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	18	12,357,847 - 12,384,551 (+)	NCBI		Celera
RH 3.4 Map	18	131.4	RGD
Cytogenetic Map	18	p12	NCBI

Mep1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	19,404,096 - 19,433,044 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	19,404,026 - 19,432,724 (+)	NCBI	ChiLan1.0	ChiLan1.0

MEP1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	49,554,834 - 49,605,537 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	35,247,431 - 35,288,816 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	25,396,288 - 25,427,530 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	28,991,439 - 29,021,928 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	28,991,439 - 29,021,928 (+)	Ensembl	panpan1.1		panPan2

MEP1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	57,456,414 - 57,476,238 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	57,456,530 - 57,478,337 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	56,888,238 - 56,911,333 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	57,436,320 - 57,459,609 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	57,436,464 - 57,459,701 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	57,114,830 - 57,136,681 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	57,132,324 - 57,155,413 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	57,429,048 - 57,452,158 (-)	NCBI		UU_Cfam_GSD_1.0

MEP1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	116,015,021 - 116,049,791 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	116,015,021 - 116,049,796 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	108,695,842 - 108,729,740 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEP1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	48,519,933 - 48,551,223 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	48,518,403 - 48,550,604 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	23,072,664 - 23,101,070 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mep1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	757,711 - 806,330 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	757,626 - 806,289 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005337471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000002302 ⟹ ENSSTOP00000002059

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936682	1,105,243 - 1,132,404 (-)	Ensembl

RefSeq Acc Id:

XM_005337471 ⟹ XP_005337528

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404944	53,099,990 - 53,130,877 (-)	NCBI
SpeTri2.0	NW_004936682	1,102,365 - 1,132,404 (-)	NCBI

Sequence:

show sequence

ATGGATTCATGGTCTCTGTCTTGGTTTCTGTTCCTGGGCAACCTTCTCATGGTTTCTGGCTGGC
CAGTTCAAGAAAACTTTGATATAGATGGTGGAACTGAGCAGGACATTTTCAATATCAATGAAGA
TTTGCATCTGGATCTTTTTGAGGGAGACATCAAACTTGATGGGGCACAAGACAGAAATTCTATT
ATTGGAGATAAATACAGATGGCCTCACGTCGTTCCATATGTTCTAGAGGATAGCTTGGGTGTGA
ATGCTAAAGGGGTTATCCTCCAGGCATTTGATCGCTATCGCCTGAAAACTTGCCTTGACTTCAA
GCCTTGGTCTGGGGAAGATAACTATATAGCATTTTTCAAGGGCACTGGCTGCTGGTCCTCGATA
GGAAACAAACGTCAGGGGAAGCAGGAACTTTCCATTGGGAACAATTGTGACAGGATAGGAACCG
TGCAGCATGAGCTCTTACACGCGCTGGGATTCTGGCATGAGCAGTCTCGTTCTGATCGGGATGA
CTATATCCAGATAATGTGGAACAGAATTAAACCAGGTCGAGAGCATAATTTTAATATTCATAAT
GACAAAGAATCCGATTTCCTGAATGTTCCCTACGATTACTTTTCTGTAATGCACTACAGTAAAA
TTGCATTCAAAAGAGGACAAGACCCTACAATTATAACAAAGATGGCAGTCTTTGAGGATCTGAT
TGGCCAACGCATGGATTTCAGTGACTATGATCTCCAAAAGTTGAATCGACTGTATAACTGCTCC
TCTTCCTTGAGTTTTATGGACTCATGCAATTTTGAACTGGAAAACATATGTGGAATGATACAAA
GTTCAGAAGATAAGACTGACTGGAAGCGAGTTTCAAATGTTTCTGGGGGTCCAAAGACTGATTA
TTCCAACATGGGAAAGTGTAAAGGTTATGGTTTCTTCATGCATTTTAACAGTAGCTCTGTAAGT
GAGGGACACACAGCAGTGATGGAAACTAGGATGCTGTACCCTAAAAGAGAATTTCAATGCTTGG
AATTTTATTTGTATAACAGTGGAAGTATAAATGACCACCTGAACATATACGTCAGGAATTATAC
TGCAGATGATGTAAGTGGTCATCGGACCCTTGTGAAACAAATAAAAGAAATTCCCATTGGGATC
TGGGAACTTTACTACATACCACTGAAAATGGTCAACAAATTTAGAGTGGTGTTTGAAGGACTCA
GGGGCTCTGGTGCATCATCAGGTGGTCTGTCTATTGATGACATCAATCTTTCGGAAACACAGTG
CCCTGAACATGTGTGGCACATAAGGAATTTCGAAGAGACCATTGACAAAGAAAATGGAATTCTA
TTAAGCCCTCCATTTTATTCTCCTAAAGGTTATGCTTTTCAGATTCAATTCAGTCTAAAACCTT
CGACAGATGCACAGATATATCTCCATTTGGTCTCTGGAGGCAATGATGATTATTTAAAGTGGCC
ATGTCCTTGGCAACAAATCACGATAACACTCTTGGATCAAAATTCTGACATTCTACGGCGTATG
TCCAACCAGCTGAGTGTAACTACAGACCCATTTCTGCTTGATGATACAAAGTATTTTTGGGACA
GGCCTTCTAAAGTGGGAATACAGACTGTTTACCCTAATGGAACTGAGTATATGATGAACAAAGG
CTATGGGAGCAGTGTCTTCATAAGCCATAGCAGGCTACACAGCAGAGAGTTCATAAAAGGAAAT
GATGTTTATATCCTACTGACCACGAATGACCGATCTGACCTCGCTCAAACACCGGATCAGAGTA
ACCCAACCTCTGATCCCCATGACCTGTGCTCAGTCGTCGTATGTGAAAATGGTGGCATGTGCTC
CATCCAGAATGGCAAGGCTGAGTGCTGGTGTCCTTCTGGGGAAGACTGGTGGTACATGGGAGAA
AGGTGTGAGAAGAGAGGTTCAACCCGTGACACCATTGTCATTGCTGTTTCTTCCACCGCTGCTG
TGTTTGTCCTGATGCTGATAGTCACCCTCATCAGTGTTTACTGTACCCGGAGGAGATATCGCCA
AAGGCCAAATTCAAATATTGCGAATATCACTCTGGAAAATCAACACCAGGCTTTTTGA

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Protein Sequences


Protein RefSeqs	XP_005337528	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000002059.3
GenBank Protein	KAG3294015	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005337528 ⟸ XM_005337471

- UniProtKB:

I3M059 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDSWSLSWFLFLGNLLMVSGWPVQENFDIDGGTEQDIFNINEDLHLDLFEGDIKLDGAQDRNSI
IGDKYRWPHVVPYVLEDSLGVNAKGVILQAFDRYRLKTCLDFKPWSGEDNYIAFFKGTGCWSSI
GNKRQGKQELSIGNNCDRIGTVQHELLHALGFWHEQSRSDRDDYIQIMWNRIKPGREHNFNIHN
DKESDFLNVPYDYFSVMHYSKIAFKRGQDPTIITKMAVFEDLIGQRMDFSDYDLQKLNRLYNCS
SSLSFMDSCNFELENICGMIQSSEDKTDWKRVSNVSGGPKTDYSNMGKCKGYGFFMHFNSSSVS
EGHTAVMETRMLYPKREFQCLEFYLYNSGSINDHLNIYVRNYTADDVSGHRTLVKQIKEIPIGI
WELYYIPLKMVNKFRVVFEGLRGSGASSGGLSIDDINLSETQCPEHVWHIRNFEETIDKENGIL
LSPPFYSPKGYAFQIQFSLKPSTDAQIYLHLVSGGNDDYLKWPCPWQQITITLLDQNSDILRRM
SNQLSVTTDPFLLDDTKYFWDRPSKVGIQTVYPNGTEYMMNKGYGSSVFISHSRLHSREFIKGN
DVYILLTTNDRSDLAQTPDQSNPTSDPHDLCSVVVCENGGMCSIQNGKAECWCPSGEDWWYMGE
RCEKRGSTRDTIVIAVSSTAAVFVLMLIVTLISVYCTRRRYRQRPNSNIANITLENQHQAF

hide sequence

Ensembl Acc Id:

ENSSTOP00000002059 ⟸ ENSSTOT00000002302

Protein Domains

EGF-like MAM MATH Peptidase M12A

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000002298	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000002302.3	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/TrEMBL
InterPro	ConA-like_dom_sf	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	MAM_dom	UniProtKB/TrEMBL
	MATH/TRAF_dom	UniProtKB/TrEMBL
	Meprin	UniProtKB/TrEMBL
	MetalloPept_cat_dom_sf	UniProtKB/TrEMBL
	Peptidase_M12A	UniProtKB/TrEMBL
	Peptidase_Metallo	UniProtKB/TrEMBL
	TRAF-like	UniProtKB/TrEMBL
NCBI Gene	Mep1b	ENTREZGENE
PANTHER	DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING	UniProtKB/TrEMBL
	PTHR10127:SF814	UniProtKB/TrEMBL
Pfam	Astacin	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
	MATH_2	UniProtKB/TrEMBL
PIRSF	Meprin	UniProtKB/TrEMBL
PRINTS	ASTACIN	UniProtKB/TrEMBL
	MAMDOMAIN	UniProtKB/TrEMBL
PROSITE	ASTACIN	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	MAM_2	UniProtKB/TrEMBL
	MATH	UniProtKB/TrEMBL
SMART	MAM	UniProtKB/TrEMBL
	ZnMc	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
	SSF49899	UniProtKB/TrEMBL
	TRAF domain-like	UniProtKB/TrEMBL
UniProt	I3M059	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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