MEP1B (meprin A subunit beta) - Rat Genome Database

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Gene: MEP1B (meprin A subunit beta) Pan paniscus
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Symbol: MEP1B
Name: meprin A subunit beta
RGD ID: 11973364
Description: ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); protein domain specific binding (ortholog); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH hepatocellular carcinoma (ortholog); melanoma (ortholog); nonpapillary renal cell carcinoma (ortholog); FOUND IN extracellular region (inferred); membrane (inferred); meprin A complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21749,554,834 - 49,605,537 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11835,247,431 - 35,288,816 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01825,396,288 - 25,427,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,991,439 - 29,021,928 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,991,439 - 29,021,928 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MEP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21749,554,834 - 49,605,537 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11835,247,431 - 35,288,816 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01825,396,288 - 25,427,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,991,439 - 29,021,928 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,991,439 - 29,021,928 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
MEP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381832,190,039 - 32,220,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1832,185,069 - 32,222,605 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371829,770,002 - 29,800,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361828,023,985 - 28,054,365 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341828,023,985 - 28,054,362NCBI
Celera1826,576,994 - 26,607,343 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1826,626,575 - 26,656,944 (+)NCBIHuRef
CHM1_11829,697,554 - 29,727,904 (+)NCBICHM1_1
T2T-CHM13v2.01832,380,357 - 32,410,718 (+)NCBIT2T-CHM13v2.0
Mep1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391821,205,401 - 21,233,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1821,194,980 - 21,233,256 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381821,072,344 - 21,100,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1821,061,923 - 21,100,199 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371821,230,845 - 21,258,700 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361821,215,354 - 21,243,199 (+)NCBIMGSCv36mm8
Celera1821,568,002 - 21,595,856 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.81NCBI
Mep1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,641,041 - 12,667,759 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1812,641,041 - 12,667,755 (+)EnsemblGRCr8
mRatBN7.21812,366,126 - 12,392,840 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1812,365,289 - 12,392,840 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1812,549,574 - 12,575,989 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01813,337,224 - 13,363,645 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01812,608,782 - 12,635,267 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1812,924,807 - 12,951,304 (+)NCBI
Lyon_Normotensive1812,527,676 - 12,554,173 (+)NCBI
Lyon_Hypertensive1812,527,081 - 12,553,580 (+)NCBI
F344_StmMcwi1812,543,699 - 12,570,072 (+)NCBI
Rnor_6.01815,063,159 - 15,090,877 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,063,079 - 15,089,988 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01814,847,661 - 14,874,235 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1812,357,847 - 12,384,551 (+)NCBICelera
RH 3.4 Map18131.4RGD
Cytogenetic Map18p12NCBI
Mep1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540219,404,096 - 19,433,044 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495540219,404,026 - 19,432,724 (+)NCBIChiLan1.0ChiLan1.0
MEP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,456,414 - 57,476,238 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,456,530 - 57,478,337 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha756,888,238 - 56,911,333 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0757,436,320 - 57,459,609 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl757,436,464 - 57,459,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,114,830 - 57,136,681 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,132,324 - 57,155,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0757,429,048 - 57,452,158 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mep1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11338,463,930 - 38,497,227 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440494453,099,990 - 53,130,877 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,105,243 - 1,132,404 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,102,365 - 1,132,404 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6116,015,021 - 116,049,791 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.16116,015,021 - 116,049,796 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,695,842 - 108,729,740 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11850,777,497 - 50,807,953 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366605023,072,664 - 23,101,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11848,519,933 - 48,551,223 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1848,518,403 - 48,550,604 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Mep1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624770757,626 - 806,289 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_004624770757,711 - 806,330 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl1847,631,851 - 47,672,628 (-)Ensembl
Mep1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11522,388,035 - 22,415,145 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003830251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000017626   ⟹   ENSPPAP00000003818
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1828,991,439 - 29,021,928 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000017635   ⟹   ENSPPAP00000003822
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1828,991,486 - 29,021,769 (+)Ensembl
RefSeq Acc Id: XM_003830251   ⟹   XP_003830299
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21749,554,834 - 49,605,537 (+)NCBI
NHGRI_mPanPan11835,247,431 - 35,288,816 (+)NCBI
Mhudiblu_PPA_v01825,396,288 - 25,427,530 (+)NCBI
PanPan1.11828,991,439 - 29,021,928 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003830299 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000003818.1
  ENSPPAP00000003822.1
  ENSPPAP00050016623
RefSeq Acc Id: XP_003830299   ⟸   XM_003830251
- UniProtKB: A0A2R8ZFM8 (UniProtKB/TrEMBL),   A0A2R8ZFP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000003818   ⟸   ENSPPAT00000017626
Ensembl Acc Id: ENSPPAP00000003822   ⟸   ENSPPAT00000017635
Protein Domains
EGF-like   MAM   MATH   Peptidase M12A


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000016080 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050012655 ENTREZGENE
Ensembl Transcript ENSPPAT00000017626.1 UniProtKB/TrEMBL
  ENSPPAT00000017635.1 UniProtKB/TrEMBL
  ENSPPAT00050026510 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  MATH/TRAF_dom UniProtKB/TrEMBL
  Meprin UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
  ZnMP_meprin UniProtKB/TrEMBL
KEGG Report pps:100991143 UniProtKB/TrEMBL
NCBI Gene MEP1B ENTREZGENE
PANTHER DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING UniProtKB/TrEMBL
  PTHR10127:SF814 UniProtKB/TrEMBL
Pfam Astacin UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  MATH_2 UniProtKB/TrEMBL
PIRSF Meprin UniProtKB/TrEMBL
PRINTS ASTACIN UniProtKB/TrEMBL
  MAMDOMAIN UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MAM_1 UniProtKB/TrEMBL
  MAM_2 UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
SMART MAM UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/TrEMBL
UniProt A0A2R8ZFM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZFP1 ENTREZGENE, UniProtKB/TrEMBL