Mep1b (meprin A subunit beta) - Rat Genome Database

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Gene: Mep1b (meprin A subunit beta) Chinchilla lanigera
Analyze
Symbol: Mep1b
Name: meprin A subunit beta
RGD ID: 8903113
Description: ENCODES a protein that exhibits identical protein binding (ortholog); metalloendopeptidase activity (ortholog); protein domain specific binding (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); FOUND IN membrane (ortholog); meprin A complex (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: meprin A, beta
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540219,404,096 - 19,433,044 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540219,404,026 - 19,432,724 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mep1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540219,404,096 - 19,433,044 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540219,404,026 - 19,432,724 (+)NCBIChiLan1.0ChiLan1.0
MEP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381832,190,039 - 32,220,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1832,185,069 - 32,220,404 (+)EnsemblGRCh38hg38GRCh38
GRCh371829,770,002 - 29,800,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361828,023,985 - 28,054,365 (+)NCBINCBI36Build 36hg18NCBI36
Build 341828,023,985 - 28,054,362NCBI
Celera1826,576,994 - 26,607,343 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1826,626,575 - 26,656,944 (+)NCBIHuRef
CHM1_11829,697,554 - 29,727,904 (+)NCBICHM1_1
T2T-CHM13v2.01832,380,357 - 32,410,718 (+)NCBIT2T-CHM13v2.0
Mep1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391821,205,401 - 21,233,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1821,194,980 - 21,233,256 (+)EnsemblGRCm39 Ensembl
GRCm381821,072,344 - 21,100,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1821,061,923 - 21,100,199 (+)EnsemblGRCm38mm10GRCm38
MGSCv371821,230,845 - 21,258,700 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361821,215,354 - 21,243,199 (+)NCBIMGSCv36mm8
Celera1821,568,002 - 21,595,856 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.81NCBI
Mep1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,641,041 - 12,667,759 (+)NCBIGRCr8
mRatBN7.21812,366,126 - 12,392,840 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1812,365,289 - 12,392,840 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1812,549,574 - 12,575,989 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01813,337,224 - 13,363,645 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01812,608,782 - 12,635,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01815,063,159 - 15,090,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,063,079 - 15,089,988 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01814,847,661 - 14,874,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1812,357,847 - 12,384,551 (+)NCBICelera
RH 3.4 Map18131.4RGD
Cytogenetic Map18p12NCBI
MEP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21749,554,834 - 49,605,537 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11835,247,431 - 35,288,816 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01825,396,288 - 25,427,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,991,439 - 29,021,928 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,991,439 - 29,021,928 (+)Ensemblpanpan1.1panPan2
MEP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,456,414 - 57,476,238 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,456,530 - 57,478,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha756,888,238 - 56,911,333 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0757,436,320 - 57,459,609 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl757,436,464 - 57,459,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,114,830 - 57,136,681 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,132,324 - 57,155,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0757,429,048 - 57,452,158 (-)NCBIUU_Cfam_GSD_1.0
Mep1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,099,990 - 53,130,877 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,105,243 - 1,132,404 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,102,365 - 1,132,404 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6116,015,021 - 116,049,791 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16116,015,021 - 116,049,796 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,695,842 - 108,729,740 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11848,519,933 - 48,551,223 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1848,518,403 - 48,550,604 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605023,072,664 - 23,101,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mep1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624770757,711 - 806,330 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624770757,626 - 806,289 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000011150   ⟹   ENSCLAP00000011015
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540219,404,096 - 19,430,427 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000011151   ⟹   ENSCLAP00000011016
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540219,406,088 - 19,433,044 (+)Ensembl
RefSeq Acc Id: XM_005372753   ⟹   XP_005372810
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540219,404,026 - 19,432,724 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005372810 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000011015.1
  ENSCLAP00000011016
  ENSCLAP00000011016.1
RefSeq Acc Id: XP_005372810   ⟸   XM_005372753
- UniProtKB: A0A8C2YN74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000011016   ⟸   ENSCLAT00000011151
RefSeq Acc Id: ENSCLAP00000011015   ⟸   ENSCLAT00000011150
Protein Domains
EGF-like   MAM   MATH   Peptidase M12A


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000011150.1 UniProtKB/TrEMBL
  ENSCLAT00000011151 ENTREZGENE
  ENSCLAT00000011151.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  MATH/TRAF_dom UniProtKB/TrEMBL
  Meprin UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
  TRAF_MEP1_MATH_dom UniProtKB/TrEMBL
NCBI Gene Mep1b ENTREZGENE
PANTHER DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING UniProtKB/TrEMBL
  PTHR10127:SF814 UniProtKB/TrEMBL
Pfam Astacin UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  TRAF-mep_MATH UniProtKB/TrEMBL
PIRSF Meprin UniProtKB/TrEMBL
PRINTS ASTACIN UniProtKB/TrEMBL
  MAMDOMAIN UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MAM_1 UniProtKB/TrEMBL
  MAM_2 UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
SMART MAM UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/TrEMBL
UniProt A0A8C2V6V4_CHILA UniProtKB/TrEMBL
  A0A8C2YN74 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Mep1b  meprin A subunit beta    meprin A, beta  Symbol and/or name change 5135510 APPROVED