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Gene: Ppp2cb (protein phosphatase 2 catalytic subunit beta) Ictidomys tridecemlineatus

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Symbol:

Ppp2cb

Name:

protein phosphatase 2 catalytic subunit beta

RGD ID:

12567428

Description:

ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN apoptotic mitochondrial changes (ortholog); negative regulation of gene expression (ortholog); negative regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN dopamine signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; FOUND IN cytoplasm (ortholog); FAR/SIN/STRIPAK complex (ortholog); protein phosphatase type 2A complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	56,729,981 - 56,742,299 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936792	622,105 - 633,800 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic mitochondrial changes (ISO)

chromatin remodeling (IEA)

negative regulation of gene expression (ISO)

negative regulation of NF-kappaB transcription factor activity (ISO)

negative regulation of Ras protein signal transduction (ISO)

negative regulation of tumor necrosis factor-mediated signaling pathway (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

protein dephosphorylation (ISO)

regulation of gene expression (ISO)

regulation of transcription by RNA polymerase II (IEA)

response to antibiotic (ISO)

response to endoplasmic reticulum stress (ISO)

response to hydrogen peroxide (ISO)

response to lead ion (ISO)

Cellular Component

chromosome (IEA)

chromosome, centromeric region (IEA)

cytoplasm (ISO)

cytoskeleton (IEA)

FAR/SIN/STRIPAK complex (ISO)

nucleus (IEA)

protein phosphatase type 2A complex (ISO)

spindle pole (IEA)

Molecular Function

calmodulin-dependent protein phosphatase activity (IEA)

histone H2AXS140 phosphatase activity (IEA)

MAP kinase serine/threonine phosphatase activity (IEA)

myosin phosphatase activity (IEA)

phosphoprotein phosphatase activity (IEA)

protein binding (ISO)

protein serine/threonine phosphatase activity (IEA,ISO)

RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity (IEA)

transmembrane transporter binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

dopamine signaling pathway (ISO)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ppp2cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	56,729,981 - 56,742,299 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936792	622,105 - 633,800 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPP2CB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	30,785,616 - 30,812,818 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	30,774,457 - 30,814,314 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	30,643,132 - 30,670,334 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	30,762,668 - 30,789,894 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	30,762,668 - 30,789,894	NCBI
Celera	8	29,603,219 - 29,630,439 (-)	NCBI		Celera
Cytogenetic Map	8	p12	NCBI
HuRef	8	29,189,574 - 29,216,794 (-)	NCBI		HuRef
CHM1_1	8	30,844,570 - 30,871,782 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	31,066,636 - 31,093,832 (-)	NCBI		T2T-CHM13v2.0

Ppp2cb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	34,089,672 - 34,109,831 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	34,089,653 - 34,109,469 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	33,599,621 - 33,619,804 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	33,599,625 - 33,619,441 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	34,710,093 - 34,730,276 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	35,065,560 - 35,085,738 (+)	NCBI		MGSCv36	mm8
Celera	8	36,244,600 - 36,253,763 (+)	NCBI		Celera
Cytogenetic Map	8	A4	NCBI
cM Map	8	20.63	NCBI

Ppp2cb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	65,261,178 - 65,282,658 (-)	NCBI		GRCr8
mRatBN7.2	16	58,558,119 - 58,579,325 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	58,558,122 - 58,579,576 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	63,895,707 - 63,916,635 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	67,309,372 - 67,330,300 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	62,529,938 - 62,550,866 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	62,273,276 - 62,294,767 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	62,273,276 - 62,294,769 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	61,933,984 - 61,955,475 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	62,330,513 - 62,351,968 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	62,330,587 - 62,352,043 (-)	NCBI
Celera	16	56,594,208 - 56,615,135 (-)	NCBI		Celera
Cytogenetic Map	16	q12.3	NCBI

Ppp2cb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	7,226,912 - 7,249,490 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955463	7,229,717 - 7,249,490 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPP2CB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	49,358,884 - 49,386,294 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	25,074,866 - 25,102,081 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	30,099,605 - 30,126,917 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	27,288,250 - 27,302,606 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	27,288,263 - 27,302,606 (-)	Ensembl	panpan1.1		panPan2

PPP2CB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	33,532,703 - 33,567,011 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	33,532,958 - 33,566,640 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	33,992,179 - 34,026,212 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	35,558,843 - 35,592,945 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	35,558,838 - 35,592,943 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	33,657,510 - 33,691,593 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	34,231,924 - 34,265,951 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	34,350,519 - 34,384,589 (+)	NCBI		UU_Cfam_GSD_1.0

PPP2CB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	54,296,113 - 54,325,213 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	54,295,786 - 54,325,220 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	61,676,897 - 61,697,557 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPP2CB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	28,903,074 - 28,930,300 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	28,903,240 - 28,930,376 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	13,168,625 - 13,195,901 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppp2cb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624780	13,332,636 - 13,369,301 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005343111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005343111 ⟹ XP_005343168

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	56,729,981 - 56,742,299 (+)	NCBI
SpeTri2.0	NW_004936792	622,105 - 633,800 (-)	NCBI

Sequence:

show sequence

TCCCCAAGGTACTAGGGATTTGAACCCAGGAGCATTTTATCATTGAGTTACATCCCCAGCCTCA
GTCCATCAGTTTGTGGATGGTTTCCATTTTGGGACTATTAGGAATAACGCTGCCATGAATGCTA
AGGAAATTTTAACGAAAGAGTCAAATGTGCAAGAAGTTCGGTGTCCTGTTACTGTCTGTGGAGA
TGTACATGGCCAATTCCATGACCTTATGGAACTCTTTAGAATTGGTGGAAAATCACCAGATACA
AACTATCTATTCATGGGTGACTATGTAGACAGAGGTTATTATTCTGTGGAGACTGTGACTCTTC
TTGTAGCATTAAAGGTGCGTTATCCAGAACGCATTACAATATTGAGAGGAAATCATGAAAGCCG
ACAAATTACCCAAGTGTATGGCTTTTATGATGAATTTCTATGAAAGTATGGAAATGCCAATGTT
TGGAAATATTTTACAGATCTATTTGATTATCTTCCACTTACAGCTTTAGTAGATGGACAGATAT
TCTGCCTCCATGGTGGCCTCTCTCCATCCATAGATACACTGGATCATATAAGAGCCCTGGATCG
TTTACAAGAAGTTCCACATGAGGGCCCAATGTGTGATCTGTTATGGTCAGATCCAGATGATCGT
GGTGGCTGGGGTATTTCACCACGTGGTGCTGGCTACACATTTGGACAAGACATTTCGGAAACAT
TTAACCATGCCAATGGTCTCACACTGGTTTCACGTGCTCACCAGCTTGTAATGGAAGGATATAA
TTGGTGCCATGATCGGAATGTGGTTACCATTTTCAGTGCACCCAATTACTGTTACCGTTGTGGG
AACCAGGCTGCTATCATGGAACTAGATGACACTTTAAAATATTCTTTTCTTCAGTTTGACCCAG
CACCTCGTCGTGGAGAGCCTCATGTTACCCGGCGCACCCCAGACTACTTCCTGTAAATTCCTCC
TGGAAAACCTGCCTTTGTATGTGGAAGTATACCTGGCTTTAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005343168	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000027514.1

RefSeq Acc Id:

XP_005343168 ⟸ XM_005343111

- UniProtKB:

A0A287D1V2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVET
VTLLVALKVRYPERITILRGNHESRQITQVYGFYDEFLXKYGNANVWKYFTDLFDYLPLTALVD
GQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDI
SETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQ
FDPAPRRGEPHVTRRTPDYFL

hide sequence

Protein Domains

Serine/threonine specific protein phosphatases

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000032331	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000041147.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.21.10	UniProtKB/TrEMBL
InterPro	Calcineurin-like_PHP_ApaH	UniProtKB/TrEMBL
	Metallo-depent_PP-like	UniProtKB/TrEMBL
	PPA2-like	UniProtKB/TrEMBL
	Ser/Thr-sp_prot-phosphatase	UniProtKB/TrEMBL
NCBI Gene	Ppp2cb	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED	UniProtKB/TrEMBL
Pfam	Metallophos	UniProtKB/TrEMBL
PRINTS	STPHPHTASE	UniProtKB/TrEMBL
PROSITE	SER_THR_PHOSPHATASE	UniProtKB/TrEMBL
SMART	PP2Ac	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56300	UniProtKB/TrEMBL
UniProt	A0A287D1V2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - PID (archival)