Nog (noggin) - Rat Genome Database

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Gene: Nog (noggin) Ictidomys tridecemlineatus
Analyze
Symbol: Nog
Name: noggin
RGD ID: 12531258
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); axial mesoderm development (ortholog); axon guidance (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Alzheimer's disease (ortholog); brachydactyly type B2 (ortholog); FOUND IN axon (ortholog); extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560230,811,040 - 30,812,486 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364906,262,785 - 6,263,483 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364906,262,651 - 6,264,069 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IEA,ISO)
atrial cardiac muscle tissue morphogenesis  (IEA)
axial mesoderm development  (IEA,ISO)
axon guidance  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
BMP signaling pathway involved in heart development  (IEA)
brain development  (IEA,ISO)
cartilage development  (IEA,ISO)
cell differentiation  (IEA)
cell differentiation in hindbrain  (IEA)
cell population proliferation  (IEA)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to hypoxia  (ISO)
central nervous system development  (IEA,ISO)
cranial skeletal system development  (IEA)
dorsal/ventral pattern formation  (IEA)
embryonic digit morphogenesis  (IEA)
embryonic skeletal joint morphogenesis  (IEA)
embryonic skeletal system development  (IEA)
endocardial cushion morphogenesis  (IEA)
endoderm development  (IEA,ISO)
endoderm formation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelial to mesenchymal transition  (IEA)
exploration behavior  (IEA)
face morphogenesis  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation  (IEA)
forebrain development  (IEA,ISO)
heart trabecula morphogenesis  (IEA)
hippocampus development  (ISO)
in utero embryonic development  (IEA,ISO)
limb development  (IEA)
long-term synaptic potentiation  (IEA)
lung morphogenesis  (IEA,ISO)
membranous septum morphogenesis  (IEA)
memory  (ISO)
mesenchymal cell differentiation  (IEA,ISO)
mesoderm formation  (IEA,ISO)
middle ear morphogenesis  (IEA)
motor neuron axon guidance  (IEA,ISO)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of astrocyte differentiation  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cardiac muscle cell proliferation  (IEA)
negative regulation of cartilage development  (IEA,ISO)
negative regulation of cell differentiation  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cytokine activity  (IEA)
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of pathway-restricted SMAD protein phosphorylation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
neural plate morphogenesis  (IEA,ISO)
neural tube closure  (IEA,ISO)
neural tube development  (IEA,ISO)
notochord morphogenesis  (IEA,ISO)
ossification  (ISO)
osteoblast differentiation  (IEA)
outflow tract morphogenesis  (IEA)
pattern specification process  (IEA,ISO)
pharyngeal arch artery morphogenesis  (IEA)
pituitary gland development  (IEA,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glomerulus development  (IEA)
positive regulation of oligodendrocyte progenitor proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (IEA)
prostatic bud formation  (IEA,ISO)
regulation of BMP signaling pathway  (IEA,ISO)
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation  (IEA)
regulation of neuronal synaptic plasticity  (IEA)
short-term synaptic potentiation  (IEA)
skeletal system development  (IEA,ISO)
smoothened signaling pathway  (IEA)
somatic stem cell population maintenance  (IEA)
somite development  (IEA,ISO)
spinal cord development  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
ureteric bud development  (IEA,ISO)
ureteric bud formation  (IEA)
urogenital system development  (IEA,ISO)
ventricular compact myocardium morphogenesis  (IEA)
ventricular septum morphogenesis  (IEA)
visual learning  (IEA,ISO)
wound healing  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Nog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560230,811,040 - 30,812,486 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364906,262,785 - 6,263,483 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364906,262,651 - 6,264,069 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381756,593,699 - 56,595,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1756,593,699 - 56,595,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371754,671,060 - 54,672,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361752,026,274 - 52,027,546 (+)NCBINCBI36Build 36hg18NCBI36
Build 341752,026,273 - 52,027,542NCBI
Celera1751,132,757 - 51,134,648 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1750,031,838 - 50,033,727 (+)NCBIHuRef
CHM1_11754,735,932 - 54,737,820 (+)NCBICHM1_1
T2T-CHM13v2.01757,469,821 - 57,471,732 (+)NCBIT2T-CHM13v2.0
Nog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,191,464 - 89,193,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,191,464 - 89,193,158 (-)EnsemblGRCm39 Ensembl
GRCm381189,300,638 - 89,302,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,300,638 - 89,302,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371189,161,952 - 89,163,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361189,117,412 - 89,118,110 (-)NCBIMGSCv36mm8
Celera1198,919,523 - 98,921,373 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.34NCBI
Nog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21074,128,712 - 74,130,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1074,128,712 - 74,130,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1078,757,906 - 78,759,533 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01078,262,852 - 78,264,479 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01073,730,695 - 73,732,322 (-)NCBIRnor_WKY
Rnor_6.01076,811,759 - 76,813,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1076,811,759 - 76,813,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,677,612 - 76,679,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41077,689,244 - 77,690,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11077,703,801 - 77,704,728 (-)NCBI
Celera1073,029,127 - 73,030,754 (-)NCBICelera
Cytogenetic Map10q26NCBI
Nog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554516,193,042 - 6,193,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554516,192,368 - 6,193,766 (-)NCBIChiLan1.0ChiLan1.0
NOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11755,532,208 - 55,533,782 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1755,532,394 - 55,533,092 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01750,669,186 - 50,671,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,453,604 - 31,456,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha930,695,378 - 30,696,228 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,262,855 - 32,263,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,262,940 - 32,263,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,048,413 - 31,049,269 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,332,204 - 31,333,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,415,982 - 31,416,833 (+)NCBIUU_Cfam_GSD_1.0
NOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1232,891,321 - 32,892,206 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11232,891,321 - 32,892,206 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11636,816,783 - 36,818,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1636,817,476 - 36,818,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660777,642,384 - 7,644,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479511,696,353 - 11,697,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479511,696,102 - 11,697,367 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005321598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000029914   ⟹   ENSSTOP00000018887
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364906,262,785 - 6,263,483 (-)Ensembl
RefSeq Acc Id: XM_005321598   ⟹   XP_005321655
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560230,811,040 - 30,812,486 (+)NCBI
SpeTri2.0NW_0049364906,262,651 - 6,264,069 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321655 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3269317 (Get FASTA)   NCBI Sequence Viewer  
  KAG3269318 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005321655   ⟸   XM_005321598
- UniProtKB: I3N3E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000018887   ⟸   ENSSTOT00000029914


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000024922 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000018887 ENTREZGENE
  ENSSTOP00000018887.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000029914.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Noggin UniProtKB/TrEMBL
NCBI Gene Nog ENTREZGENE
PANTHER PTHR10494 UniProtKB/TrEMBL
PIRSF Noggin UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt I3N3E1 ENTREZGENE, UniProtKB/TrEMBL