NOG (noggin) - Rat Genome Database

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Gene: NOG (noggin) Canis lupus familiaris
Analyze
Symbol: NOG
Name: noggin
RGD ID: 12261651
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); axial mesoderm development (ortholog); axon guidance (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Alzheimer's disease (ortholog); cleft lip (ortholog); FOUND IN axon (ortholog); extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,453,604 - 31,456,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha930,695,378 - 30,696,228 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,262,855 - 32,263,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,262,940 - 32,263,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,048,413 - 31,049,269 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,332,204 - 31,333,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,415,982 - 31,416,833 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IEA,ISO)
atrial cardiac muscle tissue morphogenesis  (IEA)
axial mesoderm development  (IEA,ISO)
axon guidance  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
brain development  (IEA,ISO)
cartilage development  (IEA,ISO)
cell differentiation  (IEA)
cell differentiation in hindbrain  (IEA)
cell population proliferation  (IEA)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to hypoxia  (ISO)
central nervous system development  (IEA,ISO)
cranial skeletal system development  (IEA)
dorsal/ventral pattern formation  (IEA)
embryonic digit morphogenesis  (IEA)
embryonic skeletal joint morphogenesis  (IEA)
embryonic skeletal system development  (IEA)
endocardial cushion formation  (IEA)
endoderm development  (IEA,ISO)
endoderm formation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelial to mesenchymal transition  (IEA)
exploration behavior  (IEA)
face morphogenesis  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA)
forebrain development  (IEA,ISO)
heart trabecula morphogenesis  (IEA)
hippocampus development  (ISO)
in utero embryonic development  (IEA,ISO)
limb development  (IEA)
long-term synaptic potentiation  (IEA)
lung morphogenesis  (IEA,ISO)
membranous septum morphogenesis  (IEA)
memory  (ISO)
mesenchymal cell differentiation  (IEA,ISO)
mesoderm formation  (IEA,ISO)
middle ear morphogenesis  (IEA)
motor neuron axon guidance  (IEA,ISO)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of astrocyte differentiation  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cardiac epithelial to mesenchymal transition  (IEA)
negative regulation of cardiac muscle cell proliferation  (IEA)
negative regulation of cartilage development  (IEA,ISO)
negative regulation of cell differentiation  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of SMAD protein signal transduction  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
neural plate anterior/posterior regionalization  (IEA)
neural plate morphogenesis  (IEA,ISO)
neural tube closure  (IEA,ISO)
neural tube development  (IEA,ISO)
nodal signaling pathway  (IEA)
notochord morphogenesis  (IEA,ISO)
ossification  (ISO)
osteoblast differentiation  (IEA)
outflow tract morphogenesis  (IEA)
pattern specification process  (IEA,ISO)
pharyngeal arch artery morphogenesis  (IEA)
pituitary gland development  (IEA,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glomerulus development  (IEA)
positive regulation of oligodendrocyte progenitor proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (IEA)
prostatic bud formation  (IEA,ISO)
regulation of BMP signaling pathway  (IEA,ISO)
regulation of fibroblast growth factor receptor signaling pathway  (IEA)
regulation of neuronal synaptic plasticity  (IEA)
short-term synaptic potentiation  (IEA)
skeletal system development  (IEA,ISO)
smoothened signaling pathway  (IEA)
somatic stem cell population maintenance  (IEA)
somite development  (IEA,ISO)
spinal cord development  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
ureteric bud development  (IEA,ISO)
ureteric bud formation  (IEA)
urogenital system development  (IEA,ISO)
ventricular compact myocardium morphogenesis  (IEA)
ventricular septum morphogenesis  (IEA)
visual learning  (IEA,ISO)
wound healing  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21882044   PMID:22301074   PMID:30032202   PMID:31323019   PMID:34311726  


Genomics

Comparative Map Data
NOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,453,604 - 31,456,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha930,695,378 - 30,696,228 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,262,855 - 32,263,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,262,940 - 32,263,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,048,413 - 31,049,269 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,332,204 - 31,333,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,415,982 - 31,416,833 (+)NCBIUU_Cfam_GSD_1.0
NOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381756,593,699 - 56,595,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1756,593,699 - 56,595,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371754,671,060 - 54,672,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361752,026,274 - 52,027,546 (+)NCBINCBI36Build 36hg18NCBI36
Build 341752,026,273 - 52,027,542NCBI
Celera1751,132,757 - 51,134,648 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1750,031,838 - 50,033,727 (+)NCBIHuRef
CHM1_11754,735,932 - 54,737,820 (+)NCBICHM1_1
T2T-CHM13v2.01757,469,821 - 57,471,732 (+)NCBIT2T-CHM13v2.0
Nog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,191,464 - 89,193,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,191,464 - 89,193,158 (-)EnsemblGRCm39 Ensembl
GRCm381189,300,638 - 89,302,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,300,638 - 89,302,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371189,161,952 - 89,163,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361189,117,412 - 89,118,110 (-)NCBIMGSCv36mm8
Celera1198,919,523 - 98,921,373 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.34NCBI
Nog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81074,625,874 - 74,627,501 (-)NCBIGRCr8
mRatBN7.21074,128,712 - 74,130,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1074,128,712 - 74,130,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1078,757,906 - 78,759,533 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01078,262,852 - 78,264,479 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01073,730,695 - 73,732,322 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01076,811,759 - 76,813,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1076,811,759 - 76,813,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,677,612 - 76,679,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41077,689,244 - 77,690,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11077,703,801 - 77,704,728 (-)NCBI
Celera1073,029,127 - 73,030,754 (-)NCBICelera
Cytogenetic Map10q26NCBI
Nog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554516,193,042 - 6,193,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554516,192,368 - 6,193,766 (-)NCBIChiLan1.0ChiLan1.0
NOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21972,764,735 - 72,767,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11777,576,197 - 77,577,597 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01750,669,186 - 50,671,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11755,532,208 - 55,533,782 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1755,532,394 - 55,533,092 (+)Ensemblpanpan1.1panPan2
Nog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560230,811,040 - 30,812,486 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364906,262,785 - 6,263,483 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364906,262,651 - 6,264,069 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1232,891,321 - 32,892,206 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11232,891,321 - 32,892,206 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11636,816,783 - 36,818,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1636,817,476 - 36,818,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660777,642,384 - 7,644,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479511,696,353 - 11,697,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479511,696,102 - 11,697,367 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NOG
46 total Variants

Expression


Sequence


RefSeq Acc Id: ENSCAFT00845031682   ⟹   ENSCAFP00845024800
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl932,262,940 - 32,263,663 (+)Ensembl
RefSeq Acc Id: XM_005624988   ⟹   XP_005625045
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1931,453,604 - 31,456,060 (+)NCBI
Dog10K_Boxer_Tasha930,695,378 - 30,696,228 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038487625   ⟹   XP_038343553
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1931,048,413 - 31,049,269 (+)NCBI
RefSeq Acc Id: XM_038546146   ⟹   XP_038402074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0931,415,982 - 31,416,833 (+)NCBI
RefSeq Acc Id: XM_038610151   ⟹   XP_038466079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0931,332,204 - 31,333,060 (+)NCBI
RefSeq Acc Id: XM_038675217   ⟹   XP_038531145
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0932,262,855 - 32,263,712 (+)NCBI
RefSeq Acc Id: XP_005625045   ⟸   XM_005624988
- UniProtKB: A0A8C0U0I1 (UniProtKB/TrEMBL),   E2RVU0 (UniProtKB/TrEMBL),   A0A8C0N257 (UniProtKB/TrEMBL),   E2RVU3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038343553   ⟸   XM_038487625
RefSeq Acc Id: XP_038466079   ⟸   XM_038610151
RefSeq Acc Id: XP_038531145   ⟸   XM_038675217
- UniProtKB: A0A8C0LJQ4 (UniProtKB/TrEMBL),   E2RVU1 (UniProtKB/TrEMBL),   A0A8C0N257 (UniProtKB/TrEMBL),   E2RVU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038402074   ⟸   XM_038546146
- UniProtKB: A0A8C0N257 (UniProtKB/TrEMBL),   A0A8C0U0I1 (UniProtKB/TrEMBL),   E2RVU0 (UniProtKB/TrEMBL),   E2RVU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845024800   ⟸   ENSCAFT00845031682


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029101 UniProtKB/TrEMBL
  ENSCAFG00030011395 UniProtKB/TrEMBL
  ENSCAFG00040026017 UniProtKB/TrEMBL
  ENSCAFG00845017903 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000047287.3 UniProtKB/TrEMBL
  ENSCAFT00030021088.1 UniProtKB/TrEMBL
  ENSCAFT00040048688.1 UniProtKB/TrEMBL
  ENSCAFT00845031682.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Noggin UniProtKB/TrEMBL
KEGG Report cfa:100683515 UniProtKB/TrEMBL
NCBI Gene NOG ENTREZGENE
PANTHER NOGGIN UniProtKB/TrEMBL
  PTHR10494 UniProtKB/TrEMBL
Pfam Noggin UniProtKB/TrEMBL
PIRSF Noggin UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A516UWM3_CANLF UniProtKB/TrEMBL
  A0A8C0LJQ4 ENTREZGENE
  A0A8C0N257 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0U0I1 ENTREZGENE
  A0A8I3P4Q9_CANLF UniProtKB/TrEMBL
  E2RVU0 ENTREZGENE, UniProtKB/TrEMBL
  E2RVU1 ENTREZGENE, UniProtKB/TrEMBL
  E2RVU3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8C0U0I1 UniProtKB/TrEMBL
VGNC ID VGNC:55663 ENTREZGENE