SLC5A3 (solute carrier family 5 member 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: SLC5A3 (solute carrier family 5 member 3) Canis lupus familiaris
Analyze
Symbol: SLC5A3
Name: solute carrier family 5 member 3
RGD ID: 12425112
Description: ENCODES a protein that exhibits D-glucose:sodium symporter activity; fucose transmembrane transporter activity; myo-inositol:sodium symporter activity; INVOLVED IN D-glucose transmembrane transport; fucose transmembrane transport; myo-inositol transport; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); bipolar disorder (ortholog); FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 28S ribosomal protein S6, mitochondrial; mitochondrial ribosomal protein S6; MRPS6; Na(+)/myo-inositol cotransporter; SMIT1; sodium/myo-inositol cotransporter; sodium/myo-inositol transporter 1; solute carrier family 5 (inositol transporters), member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13128,610,332 - 28,635,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3128,610,332 - 28,635,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,607,798 - 28,632,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03128,815,044 - 28,839,960 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3128,815,024 - 28,840,301 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13128,681,748 - 28,706,621 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,696,566 - 28,721,418 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03129,195,487 - 29,220,373 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:1372904   PMID:7537337   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC5A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13128,610,332 - 28,635,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3128,610,332 - 28,635,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,607,798 - 28,632,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03128,815,044 - 28,839,960 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3128,815,024 - 28,840,301 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13128,681,748 - 28,706,621 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,696,566 - 28,721,418 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03129,195,487 - 29,220,373 (+)NCBIUU_Cfam_GSD_1.0
SLC5A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,073,578 - 34,106,260 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,073,578 - 34,106,260 (+)EnsemblGRCh38hg38GRCh38
GRCh372135,445,878 - 35,478,559 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362134,367,740 - 34,400,431 (+)NCBINCBI36Build 36hg18NCBI36
Build 342134,389,367 - 34,391,524NCBI
Celera2120,645,433 - 20,678,122 (+)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2120,945,609 - 20,957,018 (+)NCBIHuRef
CHM1_12135,008,142 - 35,040,833 (+)NCBICHM1_1
T2T-CHM13v2.02132,455,648 - 32,488,333 (+)NCBIT2T-CHM13v2.0
Slc5a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,855,210 - 91,884,361 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,855,210 - 91,884,361 (+)EnsemblGRCm39 Ensembl
GRCm381692,058,322 - 92,087,473 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,058,322 - 92,087,473 (+)EnsemblGRCm38mm10GRCm38
MGSCv371692,058,567 - 92,087,718 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361691,965,916 - 91,968,072 (+)NCBIMGSCv36mm8
Celera1693,161,374 - 93,172,132 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.44NCBI
Slc5a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,799,787 - 44,802,233 (+)NCBIGRCr8
mRatBN7.21131,313,847 - 31,316,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,295,476 - 31,318,883 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,008,115 - 40,010,560 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,679,563 - 32,682,008 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,843,057 - 31,845,503 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,229,366 - 32,231,812 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01135,834,279 - 35,836,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,063,275 - 32,065,721 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,119,576 - 32,121,733 (+)NCBI
Celera1130,970,690 - 30,973,136 (+)NCBICelera
Cytogenetic Map11q11NCBI
Slc5a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,494,816 - 33,511,968 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,460,238 - 33,511,889 (+)NCBIChiLan1.0ChiLan1.0
MRPS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22230,191,861 - 30,261,300 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12125,050,026 - 25,119,478 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02120,441,365 - 20,510,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12133,809,456 - 33,879,670 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2133,862,033 - 33,879,670 (+)Ensemblpanpan1.1panPan2
Slc5a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,152,449 - 29,183,192 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365008,284,631 - 8,296,387 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC5A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13197,711,679 - 197,718,695 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113197,688,632 - 197,723,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC5A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,104,938 - 58,131,225 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666071601,202 - 634,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc5a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474522,231,887 - 22,258,965 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474522,231,434 - 22,264,555 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC5A3
18 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000015160   ⟹   ENSCAFP00000014029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3128,610,332 - 28,635,233 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845045352   ⟹   ENSCAFP00845035570
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3128,815,024 - 28,840,301 (+)Ensembl
RefSeq Acc Id: NM_001195140   ⟹   NP_001182069
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13128,610,332 - 28,635,233 (+)NCBI
Dog10K_Boxer_Tasha3128,607,798 - 28,632,691 (+)NCBI
ROS_Cfam_1.03128,815,044 - 28,839,960 (+)NCBI
UMICH_Zoey_3.13128,681,748 - 28,706,621 (+)NCBI
UNSW_CanFamBas_1.03128,696,566 - 28,721,418 (+)NCBI
UU_Cfam_GSD_1.03129,195,487 - 29,220,373 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182069 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000074155.1
  ENSCAFP00030042180.1
  ENSCAFP00040030541.1
  ENSCAFP00805026038
  ENSCAFP00845035570
  ENSCAFP00845035570.1
RefSeq Acc Id: NP_001182069   ⟸   NM_001195140
- UniProtKB: P31637 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSCAFP00000014029   ⟸   ENSCAFT00000015160
Ensembl Acc Id: ENSCAFP00845035570   ⟸   ENSCAFT00845045352


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009546 Ensembl
  ENSCAFG00000055461 UniProtKB/Swiss-Prot
  ENSCAFG00030026072 UniProtKB/Swiss-Prot
  ENSCAFG00040018967 UniProtKB/Swiss-Prot
  ENSCAFG00805018257 UniProtKB/Swiss-Prot
  ENSCAFG00845025693 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000098508.1 UniProtKB/Swiss-Prot
  ENSCAFT00030048209.1 UniProtKB/Swiss-Prot
  ENSCAFT00040035080.1 UniProtKB/Swiss-Prot
  ENSCAFT00805033151 UniProtKB/Swiss-Prot
  ENSCAFT00845045352 ENTREZGENE
  ENSCAFT00845045352.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1730.10 UniProtKB/Swiss-Prot
InterPro Na/Glc_symporter_sf UniProtKB/Swiss-Prot
  Na/solute_symporter UniProtKB/Swiss-Prot
  Na/solute_symporter_CS UniProtKB/Swiss-Prot
  SMIT UniProtKB/Swiss-Prot
KEGG Report cfa:445542 UniProtKB/Swiss-Prot
NCBI Gene SLC5A3 ENTREZGENE
PANTHER SODIUM/MYO-INOSITOL COTRANSPORTER UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 5 UniProtKB/Swiss-Prot
Pfam SSF UniProtKB/Swiss-Prot
PROSITE NA_SOLUT_SYMP_1 UniProtKB/Swiss-Prot
  NA_SOLUT_SYMP_2 UniProtKB/Swiss-Prot
  NA_SOLUT_SYMP_3 UniProtKB/Swiss-Prot
UniProt P31637 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:111727 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 SLC5A3  solute carrier family 5 member 3  SLC5A3  solute carrier family 5 member 3  Data merged from RGD:12298292 737654 PROVISIONAL
2017-09-12 SLC5A3  solute carrier family 5 member 3  MRPS6  mitochondrial ribosomal protein S6  Symbol and/or name change 5135510 APPROVED