SLC12A2 (solute carrier family 12 member 2) - Rat Genome Database

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Gene: SLC12A2 (solute carrier family 12 member 2) Canis lupus familiaris
Analyze
Symbol: SLC12A2
Name: solute carrier family 12 member 2
RGD ID: 12384947
Description: ENCODES a protein that exhibits sodium:potassium:chloride symporter activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell volume homeostasis (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); autism spectrum disorder (ortholog); autosomal dominant nonsyndromic deafness 78 (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell body (ortholog); cell projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: solute carrier family 12 (sodium/potassium/chloride transporters), member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,143,943 - 17,256,248 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,143,943 - 17,253,695 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1115,939,385 - 16,051,806 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,881,289 - 17,994,035 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,881,289 - 17,991,854 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,604,869 - 16,717,534 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,450,079 - 16,562,728 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,054,476 - 17,167,223 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ammonium transmembrane transport  (IEA)
branching involved in mammary gland duct morphogenesis  (ISO)
cell volume homeostasis  (IEA,ISO)
cellular response to chemokine  (IEA)
cellular response to lipopolysaccharide  (ISO)
cellular response to potassium ion  (ISO)
chloride ion homeostasis  (IEA)
chloride transmembrane transport  (IEA)
chloride transport  (ISO)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
hyperosmotic response  (ISO)
inorganic anion import across plasma membrane  (ISO)
inorganic cation import across plasma membrane  (IEA)
intracellular chloride ion homeostasis  (ISO)
intracellular potassium ion homeostasis  (ISO)
intracellular sodium ion homeostasis  (ISO)
maintenance of blood-brain barrier  (ISO)
mammary duct terminal end bud growth  (ISO)
monoatomic ion transport  (IEA)
multicellular organism growth  (ISO)
negative regulation of vascular wound healing  (ISO)
positive regulation of aspartate secretion  (ISO)
positive regulation of cell volume  (ISO)
potassium ion homeostasis  (IEA)
potassium ion import across plasma membrane  (IEA)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (ISO)
regulation of matrix metallopeptidase secretion  (ISO)
regulation of spontaneous synaptic transmission  (ISO)
sodium ion homeostasis  (IEA)
sodium ion import across plasma membrane  (ISO)
sodium ion transmembrane transport  (IEA)
sodium ion transport  (IEA,ISO)
T cell chemotaxis  (IEA)
transepithelial ammonium transport  (IEA)
transepithelial chloride transport  (IEA)
transmembrane transport  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC12A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,143,943 - 17,256,248 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,143,943 - 17,253,695 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1115,939,385 - 16,051,806 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,881,289 - 17,994,035 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,881,289 - 17,991,854 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,604,869 - 16,717,534 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,450,079 - 16,562,728 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,054,476 - 17,167,223 (+)NCBIUU_Cfam_GSD_1.0
SLC12A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385128,083,766 - 128,189,677 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5128,083,766 - 128,189,677 (+)EnsemblGRCh38hg38GRCh38
GRCh375127,419,458 - 127,525,369 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365127,447,382 - 127,553,279 (+)NCBINCBI36Build 36hg18NCBI36
Build 345127,447,381 - 127,553,278NCBI
Celera5123,551,492 - 123,657,387 (+)NCBICelera
Cytogenetic Map5q23.3NCBI
HuRef5122,610,291 - 122,716,113 (+)NCBIHuRef
CHM1_15126,852,070 - 126,957,950 (+)NCBICHM1_1
T2T-CHM13v2.05128,602,602 - 128,708,515 (+)NCBIT2T-CHM13v2.0
Slc12a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391858,011,505 - 58,079,893 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1858,011,750 - 58,079,893 (+)EnsemblGRCm39 Ensembl
GRCm381857,878,512 - 57,946,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1857,878,678 - 57,946,821 (+)EnsemblGRCm38mm10GRCm38
MGSCv371858,038,332 - 58,106,475 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361858,004,047 - 58,072,174 (+)NCBIMGSCv36mm8
Celera1859,157,060 - 59,258,313 (+)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1832.15NCBI
Slc12a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81853,546,263 - 53,614,478 (+)NCBIGRCr8
mRatBN7.21851,348,282 - 51,416,448 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1851,348,302 - 51,416,440 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1853,386,123 - 53,454,234 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01854,100,680 - 54,168,791 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01851,899,024 - 51,967,160 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01852,917,124 - 52,985,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1852,917,124 - 52,985,261 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01852,104,434 - 52,172,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41853,673,215 - 53,741,352 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11853,735,140 - 53,805,295 (+)NCBI
Celera1849,478,614 - 49,546,320 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Slc12a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554151,137,327 - 1,219,241 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554151,138,297 - 1,219,241 (+)NCBIChiLan1.0ChiLan1.0
SLC12A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24123,393,538 - 123,499,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15121,533,101 - 121,638,856 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05123,499,267 - 123,603,777 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15129,260,476 - 129,364,563 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5129,262,134 - 129,364,563 (+)Ensemblpanpan1.1panPan2
Slc12a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213139,804,839 - 139,891,490 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365041,378,810 - 1,465,623 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365041,378,812 - 1,465,463 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2131,016,418 - 131,109,299 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12131,016,430 - 131,109,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22136,368,254 - 136,460,658 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC12A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12331,028,514 - 31,132,263 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2331,029,026 - 31,132,289 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603446,918,396 - 47,021,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477413,236,306 - 13,335,412 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC12A2
1490 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 13 1 6 1 12 8 7 1
Low 5 9 6 5 6 5 3 5
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000000989   ⟹   ENSCAFP00000000906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1117,143,943 - 17,253,695 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090231   ⟹   ENSCAFP00000055781
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1117,143,943 - 17,253,695 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090606   ⟹   ENSCAFP00000046349
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1117,143,943 - 17,251,807 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845021516   ⟹   ENSCAFP00845016909
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1117,881,289 - 17,991,854 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845021637   ⟹   ENSCAFP00845017007
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1117,881,289 - 17,991,854 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845021745   ⟹   ENSCAFP00845017101
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1117,881,289 - 17,991,854 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845021835   ⟹   ENSCAFP00845017175
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1117,881,289 - 17,991,854 (+)Ensembl
RefSeq Acc Id: XM_038489987   ⟹   XP_038345915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11116,604,869 - 16,717,534 (+)NCBI
RefSeq Acc Id: XM_038552056   ⟹   XP_038407984
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01117,054,476 - 17,167,223 (+)NCBI
RefSeq Acc Id: XM_038552057   ⟹   XP_038407985
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01117,054,476 - 17,167,223 (+)NCBI
RefSeq Acc Id: XM_038615920   ⟹   XP_038471848
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01116,450,079 - 16,562,728 (+)NCBI
RefSeq Acc Id: XM_038615921   ⟹   XP_038471849
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01116,450,079 - 16,562,728 (+)NCBI
RefSeq Acc Id: XM_038669176   ⟹   XP_038525104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1115,939,385 - 16,051,806 (+)NCBI
RefSeq Acc Id: XM_038681414   ⟹   XP_038537342
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01117,881,289 - 17,994,035 (+)NCBI
RefSeq Acc Id: XM_038681415   ⟹   XP_038537343
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01117,881,289 - 17,994,035 (+)NCBI
RefSeq Acc Id: XM_538611   ⟹   XP_538611
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11117,143,943 - 17,256,248 (+)NCBI
Dog10K_Boxer_Tasha1115,939,385 - 16,051,806 (+)NCBI
Sequence:
RefSeq Acc Id: XP_538611   ⟸   XM_538611
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S6N4 (UniProtKB/TrEMBL),   A0A8C0P7G9 (UniProtKB/TrEMBL),   A0A8C0QPV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000906   ⟸   ENSCAFT00000000989
RefSeq Acc Id: ENSCAFP00000055781   ⟸   ENSCAFT00000090231
RefSeq Acc Id: ENSCAFP00000046349   ⟸   ENSCAFT00000090606
RefSeq Acc Id: XP_038345915   ⟸   XM_038489987
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038471848   ⟸   XM_038615920
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038471849   ⟸   XM_038615921
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038537342   ⟸   XM_038681414
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NAD4 (UniProtKB/TrEMBL),   A0A8C0P7G9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038537343   ⟸   XM_038681415
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NAK7 (UniProtKB/TrEMBL),   A0A8C0P7P4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038525104   ⟸   XM_038669176
- Peptide Label: isoform X2
- UniProtKB: A0A8P0T7Z5 (UniProtKB/TrEMBL),   A0A8C0P7P4 (UniProtKB/TrEMBL),   A0A8C0QGM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407984   ⟸   XM_038552056
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P7G9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407985   ⟸   XM_038552057
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P7P4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845017175   ⟸   ENSCAFT00845021835
RefSeq Acc Id: ENSCAFP00845016909   ⟸   ENSCAFT00845021516
RefSeq Acc Id: ENSCAFP00845017101   ⟸   ENSCAFT00845021745
RefSeq Acc Id: ENSCAFP00845017007   ⟸   ENSCAFT00845021637

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000637 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022550 UniProtKB/TrEMBL
  ENSCAFG00040007872 UniProtKB/TrEMBL
  ENSCAFG00845011539 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000989.6 UniProtKB/TrEMBL
  ENSCAFT00000090231.2 UniProtKB/TrEMBL
  ENSCAFT00000090606.2 UniProtKB/TrEMBL
  ENSCAFT00000095974.1 UniProtKB/TrEMBL
  ENSCAFT00000109070.1 UniProtKB/TrEMBL
  ENSCAFT00030042950.1 UniProtKB/TrEMBL
  ENSCAFT00030043052.1 UniProtKB/TrEMBL
  ENSCAFT00040015530.1 UniProtKB/TrEMBL
  ENSCAFT00040015571.1 UniProtKB/TrEMBL
  ENSCAFT00845021516 ENTREZGENE
  ENSCAFT00845021516.1 UniProtKB/TrEMBL
  ENSCAFT00845021637 ENTREZGENE
  ENSCAFT00845021637.1 UniProtKB/TrEMBL
  ENSCAFT00845021745.1 UniProtKB/TrEMBL
  ENSCAFT00845021835.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/TrEMBL
  AA_permease_N UniProtKB/TrEMBL
  NKCC1 UniProtKB/TrEMBL
  SLC12_C UniProtKB/TrEMBL
  SLC12A1/SLC12A2 UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/TrEMBL
NCBI Gene SLC12A2 ENTREZGENE
PANTHER PTHR11827 UniProtKB/TrEMBL
  PTHR11827:SF58 UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/TrEMBL
  AA_permease_N UniProtKB/TrEMBL
  SLC12 UniProtKB/TrEMBL
PRINTS NAKCLTRNSPRT UniProtKB/TrEMBL
  NAKCLTRSPRT1 UniProtKB/TrEMBL
UniProt A0A8C0P7G9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0P7P4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QGM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QPV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NAD4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NAK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NL98_CANLF UniProtKB/TrEMBL
  A0A8I3RZA7_CANLF UniProtKB/TrEMBL
  A0A8P0NWM8_CANLF UniProtKB/TrEMBL
  A0A8P0PM67_CANLF UniProtKB/TrEMBL
  A0A8P0S6N4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0T7Z5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TS18_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:46219 ENTREZGENE