TNFRSF14 (TNF receptor superfamily member 14) - Rat Genome Database

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Gene: TNFRSF14 (TNF receptor superfamily member 14) Canis lupus familiaris
Analyze
Symbol: TNFRSF14
Name: TNF receptor superfamily member 14
RGD ID: 12305980
Description: ENCODES a protein that exhibits cytokine binding (ortholog); receptor ligand activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell proliferation (ortholog); defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); ASSOCIATED WITH arteriosclerosis (ortholog); Brain Injuries (ortholog); celiac disease (ortholog); FOUND IN external side of plasma membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HVEM; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,386,190 - 57,416,864 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,411,529 - 57,416,512 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,425,462 - 57,430,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,611,566 - 57,621,030 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,614,515 - 57,621,010 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,607,109 - 57,611,909 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,499,417 - 57,504,217 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,889,145 - 57,893,945 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TNFRSF14Dogarteriosclerosis  ISOTNFRSF14 (Homo sapiens)9068941protein:increased expression:carotid artery and atherosclerotic lesions (human)RGDPMID:11742877 and REF_RGD_ID:2317295
TNFRSF14Dogmyocardial infarction  ISOTnfrsf14 (Rattus norvegicus)9068941protein:increased expression:heart more ...RGDPMID:18353719 and REF_RGD_ID:2317281
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TNFRSF14Dogchromosome 1p36 deletion syndrome  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 1p36 deletion syndromeClinVar 
TNFRSF14Dogdilated cardiomyopathy 1LL  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Left ventricular noncompaction 8ClinVarPMID:28492532
TNFRSF14DogEhlers-Danlos syndrome spondylodysplastic type 2  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome more ...ClinVarPMID:10862081 more ...
TNFRSF14DogGoldberg-Shprintzen syndrome  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Shprintzen-Goldberg syndromeClinVarPMID:23892090 more ...
TNFRSF14Dogimmunodeficiency 16  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Combined immunodeficiency due to OX40 deficiencyClinVarPMID:10862081 more ...
TNFRSF14Dogimmunodeficiency 38  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiencyClinVarPMID:10862081 more ...
TNFRSF14DogJoubert syndrome 25  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Joubert syndrome 25ClinVarPMID:10862081 more ...
TNFRSF14DogNeurodevelopmental Disorders  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
TNFRSF14DogPeroxisome Biogenesis Disorder, Complementation Group 7  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorder and complementation group 7ClinVarPMID:10862081 more ...
TNFRSF14DogShprintzen-Goldberg Craniosynostosis  ISOTNFRSF14 (Homo sapiens)8554872ClinVar Annotator: match by term: Shprintzen-Goldberg syndromeClinVarPMID:23892090 more ...
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TNFRSF14DogBrain Injuries  ISOTNFRSF14 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:23159883
TNFRSF14Dogceliac disease  ISOTNFRSF14 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20190752
TNFRSF14Dogrheumatoid arthritis  ISOTNFRSF14 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20453842


Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TNFRSF14DogCD4-positive, alpha-beta T cell proliferation acts_upstream_ofISOTnfrsf14 (Mus musculus)9068941 PMID:15568026MGIPMID:15568026
TNFRSF14Dogdefense response to Gram-negative bacterium involved_inIBAMGI:2675303 and PANTHER:PTN002929911150520179 GO_CentralGO_REF:0000033
TNFRSF14Dogdefense response to Gram-negative bacterium acts_upstream_of_or_withinISOMGI:35825509068941 PMID:22801499MGIPMID:22801499
TNFRSF14Dogdefense response to Gram-positive bacterium involved_inIBAMGI:2675303 and PANTHER:PTN002929911150520179 GO_CentralGO_REF:0000033
TNFRSF14Dogdefense response to Gram-positive bacterium acts_upstream_of_or_withinISOMGI:35825509068941 PMID:22801499MGIPMID:22801499
TNFRSF14Dognegative regulation of adaptive immune memory response involved_inISOTNFRSF14 (Homo sapiens)9068941 PMID:18193050UniProtPMID:18193050
TNFRSF14Dognegative regulation of alpha-beta T cell proliferation involved_inIBAMGI:2675303 and PANTHER:PTN002929911150520179 GO_CentralGO_REF:0000033
TNFRSF14Dognegative regulation of CD4-positive, alpha-beta T cell proliferation acts_upstream_of_or_withinISOTnfrsf14 (Mus musculus)9068941 PMID:15568026MGIPMID:15568026
TNFRSF14Dognegative regulation of T cell proliferation involved_inISOTNFRSF14 (Homo sapiens)9068941 PMID:15568026UniProtPMID:15568026
TNFRSF14Dogpositive regulation of cytokine production involved in immune response acts_upstream_of_or_withinISOMGI:49403209068941 PMID:21236258MGIPMID:21236258
TNFRSF14Dogpositive regulation of cytokine production involved in immune response involved_inIBAMGI:2675303 and PANTHER:PTN002929911150520179 GO_CentralGO_REF:0000033
TNFRSF14Dogpositive regulation of peptidyl-tyrosine phosphorylation acts_upstream_of_or_withinISOTnfrsf14 (Mus musculus)9068941 PMID:15568026MGIPMID:15568026
TNFRSF14Dogpositive regulation of T cell migration involved_inIBAMGI:2675303 and PANTHER:PTN002929911150520179 GO_CentralGO_REF:0000033
TNFRSF14Dogpositive regulation of T cell migration acts_upstream_of_or_withinISOMGI:49403209068941 PMID:21236258MGIPMID:21236258
TNFRSF14DogT cell costimulation involved_inISOTNFRSF14 (Homo sapiens)9068941 PMID:10754304UniProtPMID:10754304
TNFRSF14DogT cell migration acts_upstream_ofISOMGI:49403209068941 PMID:21236258MGIPMID:21236258
1 to 16 of 16 rows

Cellular Component

  

PMID:22301074   PMID:30032202  



TNFRSF14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,386,190 - 57,416,864 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,411,529 - 57,416,512 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,425,462 - 57,430,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,611,566 - 57,621,030 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,614,515 - 57,621,010 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,607,109 - 57,611,909 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,499,417 - 57,504,217 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,889,145 - 57,893,945 (+)NCBIUU_Cfam_GSD_1.0
TNFRSF14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,554,234 - 2,563,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,555,639 - 2,565,382 (+)EnsemblGRCh38hg38GRCh38
GRCh3712,487,810 - 2,495,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,479,150 - 2,486,613 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412,521,454 - 2,528,915NCBI
Celera190,732 - 98,195 (-)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef11,767,040 - 1,774,503 (+)NCBIHuRef
CHM1_112,474,873 - 2,482,336 (+)NCBICHM1_1
T2T-CHM13v2.011,997,007 - 2,005,473 (+)NCBIT2T-CHM13v2.0
Tnfrsf14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,002,944 - 155,013,077 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,006,390 - 155,013,020 (-)EnsemblGRCm39 Ensembl
GRCm384154,918,487 - 154,928,620 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,921,933 - 154,928,563 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,296,319 - 154,302,186 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,766,010 - 153,771,877 (-)NCBIMGSCv36mm8
Celera4157,193,781 - 157,199,645 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map485.81NCBI
Tnfrsf14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,768,413 - 170,776,749 (-)NCBIGRCr8
mRatBN7.25165,486,069 - 165,494,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,484,262 - 165,493,703 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,191,197 - 168,198,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,012,607 - 170,020,302 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,975,147 - 169,982,843 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,328,259 - 172,337,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,328,262 - 172,335,892 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,784,222 - 175,792,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,727,707 - 171,735,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,738,202 - 171,745,835 (-)NCBI
Celera5163,692,588 - 163,700,221 (-)NCBICelera
Cytogenetic Map5q36NCBI
Tnfrsf14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554868,670,182 - 8,684,677 (-)NCBIChiLan1.0ChiLan1.0
TNFRSF14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,684,004 - 225,692,010 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,344,543 - 224,352,496 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,288,493 - 1,296,532 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,427,421 - 2,435,615 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12,427,631 - 2,435,615 (+)Ensemblpanpan1.1panPan2
Tnfrsf14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,452,172 - 28,456,039 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367371,008,228 - 1,013,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFRSF14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120128,992,572 - 128,999,829 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20128,992,489 - 129,000,338 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605433,335,588 - 33,343,167 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfrsf14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248187,491,473 - 7,505,185 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in TNFRSF14
334 total Variants



adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10



Ensembl Acc Id: ENSCAFT00000030875   ⟹   ENSCAFP00000028709
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl557,411,529 - 57,416,512 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000043591   ⟹   ENSCAFP00000039934
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl557,412,320 - 57,416,113 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032663   ⟹   ENSCAFP00845025548
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl557,614,515 - 57,621,010 (+)Ensembl
RefSeq Acc Id: NM_001284454   ⟹   NP_001271383
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1557,411,595 - 57,416,395 (+)NCBI
Dog10K_Boxer_Tasha557,425,462 - 57,430,262 (+)NCBI
ROS_Cfam_1.0557,615,766 - 57,620,566 (+)NCBI
UMICH_Zoey_3.1557,607,109 - 57,611,909 (+)NCBI
UNSW_CanFamBas_1.0557,499,417 - 57,504,217 (+)NCBI
UU_Cfam_GSD_1.0557,889,145 - 57,893,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038664116   ⟹   XP_038520044
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0557,614,062 - 57,621,030 (+)NCBI
RefSeq Acc Id: XM_038664117   ⟹   XP_038520045
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0557,611,566 - 57,621,030 (+)NCBI
RefSeq Acc Id: XM_038664118   ⟹   XP_038520046
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0557,613,867 - 57,621,030 (+)NCBI
RefSeq Acc Id: XM_038664119   ⟹   XP_038520047
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0557,613,867 - 57,621,030 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001271383 (Get FASTA)   NCBI Sequence Viewer  
  XP_038520044 (Get FASTA)   NCBI Sequence Viewer  
  XP_038520045 (Get FASTA)   NCBI Sequence Viewer  
  XP_038520046 (Get FASTA)   NCBI Sequence Viewer  
  XP_038520047 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFR59337 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000028709.4
  ENSCAFP00030003316.1
  ENSCAFP00040009415.1
  ENSCAFP00845025548.1
1 to 10 of 10 rows
RefSeq Acc Id: NP_001271383   ⟸   NM_001284454
- Peptide Label: precursor
- UniProtKB: A0A8C0RYX0 (UniProtKB/TrEMBL),   E2QXY8 (UniProtKB/TrEMBL),   A0A8C0KBI4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000028709   ⟸   ENSCAFT00000030875
Ensembl Acc Id: ENSCAFP00000039934   ⟸   ENSCAFT00000043591
RefSeq Acc Id: XP_038520045   ⟸   XM_038664117
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RYX0 (UniProtKB/TrEMBL),   E2QXY8 (UniProtKB/TrEMBL),   A0A8C0KBI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038520046   ⟸   XM_038664118
- Peptide Label: isoform X2
TNFR-Cys

RGD ID:13683358
Promoter ID:EPDNEW_C1426
Type:initiation region
Name:TNFRSF14_1
Description:TNF receptor superfamily member 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1557,411,521 - 57,411,581EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000019422 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002051 UniProtKB/TrEMBL
  ENSCAFG00040005795 UniProtKB/TrEMBL
  ENSCAFG00845018469 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030875.4 UniProtKB/TrEMBL
  ENSCAFT00030003739.1 UniProtKB/TrEMBL
  ENSCAFT00040010855.1 UniProtKB/TrEMBL
  ENSCAFT00845032663.1 UniProtKB/TrEMBL
Gene3D-CATH Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro TNFR/NGFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFR_14 UniProtKB/TrEMBL
  TNFRSF14/UL144_N UniProtKB/TrEMBL
KEGG Report cfa:479580 UniProtKB/TrEMBL
NCBI Gene TNFRSF14 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14 UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14 UniProtKB/TrEMBL
Pfam TNFR_c6 UniProtKB/TrEMBL
PRINTS TNFACTORR14 UniProtKB/TrEMBL
PROSITE TNFR_NGFR_1 UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
SMART Ephrin_rec_like UniProtKB/TrEMBL
  TNFR UniProtKB/TrEMBL
Superfamily-SCOP TNF receptor-like UniProtKB/TrEMBL
UniProt A0A7T7IMT3_CANLF UniProtKB/TrEMBL
  A0A8C0KBI4 ENTREZGENE
  A0A8C0RYX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P405_CANLF UniProtKB/TrEMBL
  A0A8P0SND5_CANLF UniProtKB/TrEMBL
  E2QXY8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47658 ENTREZGENE
1 to 30 of 30 rows