Tnfrsf14 (tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)) - Rat Genome Database
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Gene: Tnfrsf14 (tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)) Mus musculus
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Symbol: Tnfrsf14
Name: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
RGD ID: 1320833
MGI Page MGI
Description: Predicted to have cytokine binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to bacterium; negative regulation of alpha-beta T cell proliferation; and positive regulation of macromolecule metabolic process. Localizes to external side of plasma membrane. Is expressed in liver lobe. Orthologous to human TNFRSF14 (TNF receptor superfamily member 14); INTERACTS WITH 1,1,1-trichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A; Atar; herpes virus entry mediator; herpes virus entry mediator A; herpesvirus entry mediator A; Hv; Hve; HveA; Hvem; MGC123498; MGC123499; Tnfrs14; TR2; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor-like 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,002,944 - 155,013,077 (-)NCBIGRCm39mm39
GRCm384154,918,487 - 154,928,620 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,921,933 - 154,928,563 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,296,319 - 154,302,186 (-)NCBIGRCm37mm9NCBIm37
MGSCv364153,766,010 - 153,771,877 (-)NCBImm8
Celera4157,193,781 - 157,199,645 (-)NCBICelera
Cytogenetic Map4E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:9153189   PMID:12477932   PMID:12787557   PMID:15016549   PMID:15178556   PMID:15568026   PMID:15647361   PMID:15696194   PMID:15905567   PMID:15944326   PMID:16002734   PMID:16237069  
PMID:16272360   PMID:16602821   PMID:17206146   PMID:17431181   PMID:17785848   PMID:17982081   PMID:18005714   PMID:18097025   PMID:18155158   PMID:18178834   PMID:18453584   PMID:18519647  
PMID:19003818   PMID:19023130   PMID:19332782   PMID:19342625   PMID:19587015   PMID:19805039   PMID:19895317   PMID:19915044   PMID:19923459   PMID:20826693   PMID:20948279   PMID:21220749  
PMID:21236258   PMID:21267068   PMID:21283640   PMID:21347711   PMID:21402741   PMID:21533159   PMID:21572030   PMID:21677750   PMID:21679708   PMID:21795335   PMID:21873635   PMID:21877247  
PMID:22080867   PMID:22459947   PMID:22490863   PMID:22801499   PMID:22865366   PMID:23097453   PMID:23184983   PMID:23355893   PMID:24205057   PMID:24287621   PMID:24307582   PMID:24956596  
PMID:25320325   PMID:25595777   PMID:25711213   PMID:26136572   PMID:26245828   PMID:26489863   PMID:26912321   PMID:26924526   PMID:26977880   PMID:27152329   PMID:27480124   PMID:27793593  
PMID:27982078   PMID:28114589   PMID:28422285   PMID:28864473   PMID:29339444   PMID:30092201   PMID:30483269   PMID:31204070  


Genomics

Comparative Map Data
Tnfrsf14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,002,944 - 155,013,077 (-)NCBIGRCm39mm39
GRCm384154,918,487 - 154,928,620 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,921,933 - 154,928,563 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,296,319 - 154,302,186 (-)NCBIGRCm37mm9NCBIm37
MGSCv364153,766,010 - 153,771,877 (-)NCBImm8
Celera4157,193,781 - 157,199,645 (-)NCBICelera
Cytogenetic Map4E2NCBI
TNFRSF14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12,555,639 - 2,565,382 (+)EnsemblGRCh38hg38GRCh38
GRCh3812,556,371 - 2,563,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712,487,291 - 2,495,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,479,150 - 2,486,613 (-)NCBINCBI36hg18NCBI36
Build 3412,521,454 - 2,528,915NCBI
Celera190,732 - 98,195 (-)NCBI
Cytogenetic Map1p36.32NCBI
HuRef11,767,040 - 1,774,503 (+)NCBIHuRef
CHM1_112,474,872 - 2,484,129 (+)NCBICHM1_1
Tnfrsf14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05172,328,259 - 172,337,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,328,262 - 172,335,892 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,784,222 - 175,792,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,727,707 - 171,735,340 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15171,738,202 - 171,745,835 (-)NCBI
Celera5163,692,588 - 163,700,221 (-)NCBICelera
Cytogenetic Map5q36NCBI
Tnfrsf14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554868,670,182 - 8,684,677 (-)NCBIChiLan1.0ChiLan1.0
TNFRSF14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112,427,421 - 2,435,615 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12,427,631 - 2,435,615 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011,288,493 - 1,296,532 (+)NCBIMhudiblu_PPA_v0panPan3
TNFRSF14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl557,411,529 - 57,416,512 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1557,386,190 - 57,416,864 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tnfrsf14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367371,008,228 - 1,013,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFRSF14
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl20128,992,489 - 129,000,338 (-)Ensembl
ChlSab1.120128,992,572 - 128,999,829 (-)NCBI
Tnfrsf14
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248187,491,473 - 7,505,185 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138859268156508116Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:641
Count of miRNA genes:331
Interacting mature miRNAs:359
Transcripts:ENSMUST00000045919, ENSMUST00000123514, ENSMUST00000137803, ENSMUST00000145296, ENSMUST00000152687
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000123514   ⟹   ENSMUSP00000116757
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4154,922,210 - 154,928,202 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137803   ⟹   ENSMUSP00000151979
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4154,924,474 - 154,928,552 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145296   ⟹   ENSMUSP00000151279
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4154,926,628 - 154,928,563 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152687   ⟹   ENSMUSP00000117890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4154,922,261 - 154,928,552 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219534   ⟹   ENSMUSP00000151575
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4154,921,933 - 154,928,077 (-)Ensembl
RefSeq Acc Id: NM_178931   ⟹   NP_849262
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,006,667 - 155,012,534 (-)NCBI
GRCm384154,922,210 - 154,928,077 (-)NCBI
MGSCv374154,296,319 - 154,302,186 (-)RGD
Celera4157,193,781 - 157,199,645 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538830   ⟹   XP_006538893
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,002,944 - 155,013,077 (-)NCBI
GRCm384154,918,487 - 154,928,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006538831   ⟹   XP_006538894
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,002,944 - 155,013,077 (-)NCBI
GRCm384154,918,487 - 154,928,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006538832   ⟹   XP_006538895
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,002,944 - 155,013,077 (-)NCBI
GRCm384154,918,487 - 154,928,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006538833   ⟹   XP_006538896
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,002,944 - 155,012,523 (-)NCBI
GRCm384154,918,487 - 154,928,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011250244   ⟹   XP_011248546
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,002,944 - 155,012,904 (-)NCBI
GRCm384154,918,487 - 154,928,447 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030253512   ⟹   XP_030109372
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,008,867 - 155,013,077 (-)NCBI
GRCm384154,924,410 - 154,928,620 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_849262   ⟸   NM_178931
- Peptide Label: precursor
- UniProtKB: Q80WM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538893   ⟸   XM_006538830
- Peptide Label: isoform X1
- UniProtKB: A0A1W2P7D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538896   ⟸   XM_006538833
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006538895   ⟸   XM_006538832
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006538894   ⟸   XM_006538831
- Peptide Label: isoform X2
- UniProtKB: Q80WM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011248546   ⟸   XM_011250244
- Peptide Label: isoform X1
- UniProtKB: A0A1W2P7D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030109372   ⟸   XM_030253512
- Peptide Label: isoform X5
RefSeq Acc Id: ENSMUSP00000151279   ⟸   ENSMUST00000145296
RefSeq Acc Id: ENSMUSP00000117890   ⟸   ENSMUST00000152687
RefSeq Acc Id: ENSMUSP00000151575   ⟸   ENSMUST00000219534
RefSeq Acc Id: ENSMUSP00000151979   ⟸   ENSMUST00000137803
RefSeq Acc Id: ENSMUSP00000116757   ⟸   ENSMUST00000123514
Protein Domains
TNFR-Cys

Promoters
RGD ID:6836548
Promoter ID:MM_KWN:41115
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000105633,   OTTMUST00000024355,   OTTMUST00000024356,   OTTMUST00000024357,   OTTMUST00000024358,   UC008WCI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364154,302,151 - 154,303,502 (-)MPROMDB
RGD ID:6885750
Promoter ID:EPDNEW_M6326
Type:initiation region
Name:Tnfrsf14_1
Description:Mus musculus tumor necrosis factor receptor superfamily, member14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384154,928,131 - 154,928,191EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2675303 AgrOrtholog
Ensembl Genes ENSMUSG00000042333 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000116757 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117890 UniProtKB/TrEMBL
  ENSMUSP00000151279 UniProtKB/TrEMBL
  ENSMUSP00000151575 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000151979 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000123514 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000137803 UniProtKB/TrEMBL
  ENSMUST00000145296 UniProtKB/TrEMBL
  ENSMUST00000152687 UniProtKB/TrEMBL
  ENSMUST00000219534 ENTREZGENE, UniProtKB/TrEMBL
InterPro TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFRSF14/UL144_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:230979 UniProtKB/Swiss-Prot
MGD MGI:2675303 ENTREZGENE
NCBI Gene 230979 ENTREZGENE
Pfam TNFR_c6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TNFRSF14 RGD
PhenoGen Tnfrsf14 PhenoGen
PRINTS TNFACTORR14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNFR_NGFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.215147 ENTREZGENE
UniProt A0A1W2P6M8_MOUSE UniProtKB/TrEMBL
  A0A1W2P7D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2P889_MOUSE UniProtKB/TrEMBL
  F6Y2U8_MOUSE UniProtKB/TrEMBL
  Q3SXX1_MOUSE UniProtKB/TrEMBL
  Q71F55_MOUSE UniProtKB/TrEMBL
  Q80WM9 ENTREZGENE
  Q8VC17_MOUSE UniProtKB/TrEMBL
  TNR14_MOUSE UniProtKB/Swiss-Prot