MPZ (myelin protein zero) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: MPZ (myelin protein zero) Canis lupus familiaris
Analyze
Symbol: MPZ
Name: myelin protein zero
RGD ID: 12262483
Description: INVOLVED IN cell-cell junction maintenance (ortholog); myelination (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH anxiety disorder (ortholog); atrophic muscular disease (ortholog); autosomal dominant distal hereditary motor neuronopathy 2 (ortholog); FOUND IN basolateral plasma membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myelin protein P0; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,205,339 - 21,210,439 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,205,107 - 21,210,451 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3821,280,251 - 21,285,323 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03821,323,207 - 21,328,277 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,323,098 - 21,328,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,220,355 - 21,225,416 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,626,466 - 21,631,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,034,738 - 22,039,792 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MPZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,205,339 - 21,210,439 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,205,107 - 21,210,451 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3821,280,251 - 21,285,323 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03821,323,207 - 21,328,277 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,323,098 - 21,328,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,220,355 - 21,225,416 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,626,466 - 21,631,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,034,738 - 22,039,792 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MPZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,303,600 - 161,309,968 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,304,735 - 161,309,974 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371161,274,525 - 161,279,758 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,541,151 - 159,546,377 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341158,087,599 - 158,092,817NCBI
Celera1134,341,666 - 134,346,903 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,631,395 - 132,636,601 (-)NCBIHuRef
CHM1_11162,670,753 - 162,675,990 (-)NCBICHM1_1
T2T-CHM13v2.01160,441,004 - 160,447,413 (-)NCBIT2T-CHM13v2.0
Mpz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,978,282 - 170,988,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,978,280 - 170,988,699 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381171,150,713 - 171,161,130 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,150,711 - 171,161,130 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371173,080,844 - 173,091,254 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361172,987,388 - 172,997,798 (+)NCBIMGSCv36mm8
Celera1173,598,959 - 173,609,357 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.05NCBI
Mpz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,103,290 - 86,109,156 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,103,290 - 86,109,155 (+)EnsemblGRCr8
mRatBN7.21383,570,811 - 83,576,680 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,570,811 - 83,576,679 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1386,076,519 - 86,082,418 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,474,755 - 87,480,657 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,706,501 - 84,712,211 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1385,471,212 - 85,477,075 (+)NCBI
Lyon_Normotensive1385,682,307 - 85,688,173 (+)NCBI
Lyon_Hypertensive1385,612,871 - 85,618,737 (+)NCBI
F344_StmMcwi1385,677,380 - 85,683,255 (+)NCBI
Rnor_6.01389,524,204 - 89,530,070 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,524,329 - 89,530,068 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01394,151,850 - 94,156,749 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41387,040,479 - 87,045,378 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1383,202,202 - 83,207,991 (+)NCBICelera
RGSC_v3.11387,229,362 - 87,234,262 (+)NCBI
Cytogenetic Map13q24NCBI
Mpz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546813,041,011 - 13,047,284 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495546813,041,911 - 13,047,026 (-)NCBIChiLan1.0ChiLan1.0
MPZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,543,449 - 88,573,944 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,233,764 - 88,264,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,691,245 - 136,720,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,603,609 - 140,631,273 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,626,039 - 140,631,273 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
Mpz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap111116,655,280 - 116,660,506 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_0244050587,375,284 - 7,380,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903583,942 - 589,160 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936903583,942 - 589,160 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,169,311 - 89,179,925 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1489,174,107 - 89,179,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,031,478 - 97,036,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1201,980,582 - 1,985,793 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660381,720,210 - 1,725,435 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1202,662,163 - 2,668,393 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,665,737 - 2,668,393 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Mpz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624794101,095 - 106,508 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_004624794100,824 - 106,444 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl2818,855,437 - 18,861,746 (+)Ensembl
Mpz
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11050,316,357 - 50,322,011 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in MPZ
75 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 21 15 5 6 5 6 32 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000020580   ⟹   ENSCAFP00000019099
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3821,205,107 - 21,210,451 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051323   ⟹   ENSCAFP00845040261
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3821,323,098 - 21,328,270 (+)Ensembl
RefSeq Acc Id: XM_038448172   ⟹   XP_038304100
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03821,323,207 - 21,328,277 (+)NCBI
RefSeq Acc Id: XM_038522643   ⟹   XP_038378571
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13821,220,355 - 21,225,416 (+)NCBI
RefSeq Acc Id: XM_038585926   ⟹   XP_038441854
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03822,034,738 - 22,039,792 (+)NCBI
RefSeq Acc Id: XM_038650308   ⟹   XP_038506236
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03821,626,466 - 21,631,518 (+)NCBI
RefSeq Acc Id: XM_545771   ⟹   XP_545771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13821,205,339 - 21,210,439 (+)NCBI
Dog10K_Boxer_Tasha3821,280,251 - 21,285,323 (+)NCBI
Sequence:
RefSeq Acc Id: XP_545771   ⟸   XM_545771
- UniProtKB: A0A8C0JJ98 (UniProtKB/TrEMBL),   A0A8I3Q1X6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000019099   ⟸   ENSCAFT00000020580
RefSeq Acc Id: XP_038378571   ⟸   XM_038522643
RefSeq Acc Id: XP_038506236   ⟸   XM_038650308
RefSeq Acc Id: XP_038304100   ⟸   XM_038448172
- UniProtKB: A0A8C0JJ98 (UniProtKB/TrEMBL),   A0A8I3Q1X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441854   ⟸   XM_038585926
- UniProtKB: A0A8C0JJ98 (UniProtKB/TrEMBL),   A0A8I3Q1X6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845040261   ⟸   ENSCAFT00845051323


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012964 Ensembl
  ENSCAFG00845029003 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845051323 ENTREZGENE
  ENSCAFT00845051323.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Myelin_P0-rel UniProtKB/TrEMBL
  Myelin_P0_CS UniProtKB/TrEMBL
  Myelin_P0_Ig-like UniProtKB/TrEMBL
  MYP0_C UniProtKB/TrEMBL
KEGG Report cfa:488654 UniProtKB/TrEMBL
NCBI Gene MPZ ENTREZGENE
PANTHER PTHR13869 UniProtKB/TrEMBL
  PTHR13869:SF7 UniProtKB/TrEMBL
Pfam Myelin-PO_C UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PRINTS MYELINP0 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  MYELIN_P0 UniProtKB/TrEMBL
SMART IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8C0JJ98 ENTREZGENE
  A0A8I3Q1X6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43353 ENTREZGENE