MPZ (myelin protein zero) - Rat Genome Database

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Gene: MPZ (myelin protein zero) Sus scrofa
Analyze
Symbol: MPZ
Name: myelin protein zero
RGD ID: 14173621
Description: ENCODES a protein that exhibits protein tyrosine kinase activity (inferred); INVOLVED IN cell-cell junction maintenance (ortholog); myelination (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH atrophic muscular disease (ortholog); autoimmune interstitial lung, joint, and kidney disease (ortholog); autosomal dominant distal hereditary motor neuronopathy 14 (ortholog); FOUND IN basolateral plasma membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myelin protein P0
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,169,311 - 89,179,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,174,107 - 89,179,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,031,478 - 97,036,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MPZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,169,311 - 89,179,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,174,107 - 89,179,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,031,478 - 97,036,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,303,600 - 161,309,968 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,304,735 - 161,309,968 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,274,525 - 161,279,758 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,541,151 - 159,546,377 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,087,599 - 158,092,817NCBI
Celera1134,341,666 - 134,346,903 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,631,395 - 132,636,601 (-)NCBIHuRef
CHM1_11162,670,753 - 162,675,990 (-)NCBICHM1_1
T2T-CHM13v2.01160,441,004 - 160,447,413 (-)NCBIT2T-CHM13v2.0
Mpz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,978,282 - 170,988,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,978,280 - 170,988,699 (+)EnsemblGRCm39 Ensembl
GRCm381171,150,713 - 171,161,130 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,150,711 - 171,161,130 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,080,844 - 173,091,254 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,987,388 - 172,997,798 (+)NCBIMGSCv36mm8
Celera1173,598,959 - 173,609,357 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.05NCBI
Mpz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,103,290 - 86,109,156 (+)NCBIGRCr8
mRatBN7.21383,570,811 - 83,576,680 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,570,811 - 83,576,679 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,076,519 - 86,082,418 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,474,755 - 87,480,657 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,706,501 - 84,712,211 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,524,204 - 89,530,070 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,524,329 - 89,530,068 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,151,850 - 94,156,749 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,040,479 - 87,045,378 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,229,362 - 87,234,262 (+)NCBI
Celera1383,202,202 - 83,207,991 (+)NCBICelera
Cytogenetic Map13q24NCBI
Mpz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546813,041,011 - 13,047,284 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546813,041,911 - 13,047,026 (-)NCBIChiLan1.0ChiLan1.0
MPZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,543,449 - 88,573,944 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,233,764 - 88,264,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,691,245 - 136,720,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,603,609 - 140,631,273 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,626,039 - 140,631,273 (-)Ensemblpanpan1.1panPan2
MPZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,205,339 - 21,210,439 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,205,107 - 21,210,451 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,280,251 - 21,285,323 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,323,207 - 21,328,277 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,323,098 - 21,328,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,220,355 - 21,225,416 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,626,466 - 21,631,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,034,738 - 22,039,792 (+)NCBIUU_Cfam_GSD_1.0
Mpz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,375,284 - 7,380,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903583,942 - 589,160 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903583,942 - 589,160 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,662,163 - 2,668,393 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,665,737 - 2,668,393 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,720,210 - 1,725,435 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794100,824 - 106,444 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794101,095 - 106,508 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MPZ
96 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 3 4 1 2 7 7 4 1 3 1

Sequence


Ensembl Acc Id: ENSSSCT00000006961   ⟹   ENSSSCP00000006772
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl489,174,118 - 89,179,925 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000072285   ⟹   ENSSSCP00000074580
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl489,169,311 - 89,179,550 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000095168   ⟹   ENSSSCP00000077438
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl489,174,118 - 89,178,597 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000099799   ⟹   ENSSSCP00000077686
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl489,176,798 - 89,179,925 (+)Ensembl
RefSeq Acc Id: XM_001925003   ⟹   XP_001925038
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1489,174,107 - 89,179,556 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001925038 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAI45376 (Get FASTA)   NCBI Sequence Viewer  
  CAI45377 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000006772.2
  ENSSSCP00000074580.1
  ENSSSCP00000077438
  ENSSSCP00000077438.1
  ENSSSCP00000077686.1
RefSeq Acc Id: XP_001925038   ⟸   XM_001925003
- UniProtKB: A0A8W4FDQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000006772   ⟸   ENSSSCT00000006961
Ensembl Acc Id: ENSSSCP00000074580   ⟸   ENSSSCT00000072285
Ensembl Acc Id: ENSSSCP00000077438   ⟸   ENSSSCT00000095168
Ensembl Acc Id: ENSSSCP00000077686   ⟸   ENSSSCT00000099799
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006352 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006961.4 UniProtKB/TrEMBL
  ENSSSCT00000072285.1 UniProtKB/TrEMBL
  ENSSSCT00000095168 ENTREZGENE
  ENSSSCT00000095168.1 UniProtKB/TrEMBL
  ENSSSCT00000099799.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  6.10.250.2930 UniProtKB/TrEMBL
InterPro Egfr_JX_dom UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Myelin-PO_C UniProtKB/TrEMBL
  Myelin_P0-rel UniProtKB/TrEMBL
  Myelin_P0_Ig-like UniProtKB/TrEMBL
KEGG Report ssc:100153273 UniProtKB/TrEMBL
NCBI Gene MPZ ENTREZGENE
PANTHER PTHR13869 UniProtKB/TrEMBL
  PTHR13869:SF7 UniProtKB/TrEMBL
Pfam Myelin-PO_C UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PRINTS MYELINP0 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A5G2RB71_PIG UniProtKB/TrEMBL
  A0A8W4FDQ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FE40_PIG UniProtKB/TrEMBL
  F1S1B2_PIG UniProtKB/TrEMBL
  Q5JZM5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90334 ENTREZGENE