GLB1 (galactosidase beta 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: GLB1 (galactosidase beta 1) Canis lupus familiaris
Analyze
Symbol: GLB1
Name: galactosidase beta 1
RGD ID: 12221620
Description: ENCODES a protein that exhibits beta-galactosidase activity (ortholog); galactoside binding (ortholog); INVOLVED IN galactose catabolic process (ortholog); response to cortisone (ortholog); response to Thyroglobulin triiodothyronine (ortholog); PARTICIPATES IN Fabry disease pathway; galactose metabolic pathway; galactosemia pathway; ASSOCIATED WITH GM1 gangliosidosis; atopic dermatitis (ortholog); bone development disease (ortholog); FOUND IN lysosome (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acid beta-galactosidase; beta-galactosidase; lactase; lysosomal beta-galactosidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,721,768 - 3,814,209 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl233,732,040 - 3,814,191 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,776,393 - 3,858,177 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0233,992,209 - 4,074,051 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl233,992,152 - 4,074,337 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,826,915 - 3,908,721 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,954,230 - 4,036,008 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0233,927,851 - 4,009,519 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:8725782   PMID:18088383   PMID:19607915   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GLB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,721,768 - 3,814,209 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl233,732,040 - 3,814,191 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,776,393 - 3,858,177 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0233,992,209 - 4,074,051 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl233,992,152 - 4,074,337 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,826,915 - 3,908,721 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,954,230 - 4,036,008 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0233,927,851 - 4,009,519 (+)NCBIUU_Cfam_GSD_1.0
GLB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38332,961,108 - 33,097,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl332,996,609 - 33,097,202 (-)EnsemblGRCh38hg38GRCh38
GRCh37333,002,600 - 33,138,638 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36333,013,104 - 33,113,698 (-)NCBINCBI36Build 36hg18NCBI36
Build 34333,013,234 - 33,113,632NCBI
Celera332,980,743 - 33,081,754 (-)NCBICelera
Cytogenetic Map3p22.3NCBI
HuRef332,977,821 - 33,078,667 (-)NCBIHuRef
CHM1_1332,988,097 - 33,088,744 (-)NCBICHM1_1
T2T-CHM13v2.0332,962,888 - 33,098,917 (-)NCBIT2T-CHM13v2.0
Glb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,230,146 - 114,303,447 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9114,230,144 - 114,303,966 (+)EnsemblGRCm39 Ensembl
GRCm389114,401,078 - 114,474,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,401,076 - 114,474,898 (+)EnsemblGRCm38mm10GRCm38
MGSCv379114,310,237 - 114,383,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369114,249,817 - 114,323,075 (+)NCBIMGSCv36mm8
Celera9114,872,858 - 114,948,660 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map964.4NCBI
Glb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88122,963,718 - 123,036,326 (+)NCBIGRCr8
mRatBN7.28114,085,508 - 114,158,127 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,085,508 - 114,158,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8119,702,274 - 119,775,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08117,901,534 - 117,974,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08115,744,315 - 115,817,349 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08122,439,328 - 122,511,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,439,328 - 122,511,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08121,752,146 - 121,824,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48118,791,550 - 118,864,281 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,332,049 - 113,404,466 (+)NCBICelera
Cytogenetic Map8q32NCBI
Glb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955421231,076 - 312,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955421230,957 - 311,504 (-)NCBIChiLan1.0ChiLan1.0
GLB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2232,943,061 - 33,083,071 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1332,947,825 - 33,088,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0332,892,039 - 33,031,959 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1333,231,208 - 33,336,804 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl333,231,209 - 33,336,804 (-)Ensemblpanpan1.1panPan2
Glb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118190,209,844 - 190,301,836 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647323,348,416 - 23,440,196 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647323,348,431 - 23,440,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1318,878,612 - 18,953,146 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11318,878,407 - 18,978,999 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GLB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11577,480,895 - 77,592,130 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1577,480,598 - 77,592,120 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604150,859,532 - 50,971,400 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478810,970,652 - 11,111,722 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478810,970,657 - 11,110,839 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GLB1
798 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001037641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022408379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022408380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF056084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF170795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY633753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY639622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY756094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY756095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY789110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY789111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY789112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY897615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ196436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000007487   ⟹   ENSCAFP00000006929
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl233,732,040 - 3,814,191 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000038223   ⟹   ENSCAFP00000033911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl233,735,936 - 3,814,191 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000067124   ⟹   ENSCAFP00000048229
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl233,735,936 - 3,814,191 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000068885   ⟹   ENSCAFP00000051318
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl233,732,040 - 3,814,191 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000077663   ⟹   ENSCAFP00000063630
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl233,732,040 - 3,814,191 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000084237   ⟹   ENSCAFP00000054350
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl233,734,402 - 3,814,191 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845041332   ⟹   ENSCAFP00845032404
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl233,992,152 - 4,074,337 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845041426   ⟹   ENSCAFP00845032482
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl234,013,322 - 4,074,337 (+)Ensembl
RefSeq Acc Id: NM_001037641   ⟹   NP_001032730
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1233,732,097 - 3,813,918 (+)NCBI
Dog10K_Boxer_Tasha233,776,393 - 3,858,177 (+)NCBI
ROS_Cfam_1.0233,992,209 - 4,074,051 (+)NCBI
UMICH_Zoey_3.1233,826,915 - 3,908,721 (+)NCBI
UNSW_CanFamBas_1.0233,954,230 - 4,036,008 (+)NCBI
UU_Cfam_GSD_1.0233,927,851 - 4,009,519 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001032730   ⟸   NM_001037641
- Peptide Label: precursor
- UniProtKB: O62800 (UniProtKB/Swiss-Prot),   Q3HTI1 (UniProtKB/Swiss-Prot),   Q9TRY9 (UniProtKB/Swiss-Prot),   A0A8C0SB70 (UniProtKB/TrEMBL),   A0A8I3PJJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000051318   ⟸   ENSCAFT00000068885
Ensembl Acc Id: ENSCAFP00000054350   ⟸   ENSCAFT00000084237
Ensembl Acc Id: ENSCAFP00000063630   ⟸   ENSCAFT00000077663
Ensembl Acc Id: ENSCAFP00000033911   ⟸   ENSCAFT00000038223
Ensembl Acc Id: ENSCAFP00000048229   ⟸   ENSCAFT00000067124
Ensembl Acc Id: ENSCAFP00000006929   ⟸   ENSCAFT00000007487
Ensembl Acc Id: ENSCAFP00845032404   ⟸   ENSCAFT00845041332
Ensembl Acc Id: ENSCAFP00845032482   ⟸   ENSCAFT00845041426
Promoters
RGD ID:13687381
Promoter ID:EPDNEW_C5451
Type:initiation region
Name:GLB1_1
Description:galactosidase beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1233,732,051 - 3,732,111EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004652 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030026124 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040011223 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805018250 UniProtKB/Swiss-Prot
  ENSCAFG00845023378 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007487.6 UniProtKB/Swiss-Prot
  ENSCAFT00000038223.4 UniProtKB/TrEMBL
  ENSCAFT00000067124.2 UniProtKB/TrEMBL
  ENSCAFT00000084237.2 UniProtKB/TrEMBL
  ENSCAFT00030048317.1 UniProtKB/Swiss-Prot
  ENSCAFT00030048324.1 UniProtKB/TrEMBL
  ENSCAFT00030048325.1 UniProtKB/TrEMBL
  ENSCAFT00040020956.1 UniProtKB/Swiss-Prot
  ENSCAFT00040021042.1 UniProtKB/TrEMBL
  ENSCAFT00040021164.1 UniProtKB/TrEMBL
  ENSCAFT00805033184 UniProtKB/Swiss-Prot
  ENSCAFT00845041332 ENTREZGENE
  ENSCAFT00845041332.1 UniProtKB/Swiss-Prot
  ENSCAFT00845041426.1 UniProtKB/TrEMBL
Gene3D-CATH Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B-gal_1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BetaGal1-like_ABD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BetaGal_gal-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcineurin-like_PHP_ApaH UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gly_Hdrlase_35_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_35_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_Hdrlase_35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
KEGG Report cfa:403873 UniProtKB/Swiss-Prot
NCBI Gene GLB1 ENTREZGENE
PANTHER BETA-GALACTOSIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23421 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BetaGal_ABD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BetaGal_gal-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallophos UniProtKB/TrEMBL
PIRSF B-gal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLHYDRLASE35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56300 UniProtKB/TrEMBL
UniProt A0A8C0PME1_CANLF UniProtKB/TrEMBL
  A0A8C0SB70 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PJJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SQ95_CANLF UniProtKB/TrEMBL
  BGAL_CANLF UniProtKB/Swiss-Prot
  O62800 ENTREZGENE
  Q29395_CANLF UniProtKB/TrEMBL
  Q3HTI1 ENTREZGENE
  Q5UD51_CANLF UniProtKB/TrEMBL
  Q5UD52_CANLF UniProtKB/TrEMBL
  Q6DW09_CANLF UniProtKB/TrEMBL
  Q9MZQ4_CANLF UniProtKB/TrEMBL
  Q9TRY9 ENTREZGENE
UniProt Secondary A0A8P0P3T2 UniProtKB/TrEMBL
  O62800 UniProtKB/Swiss-Prot
  Q3HTI1 UniProtKB/Swiss-Prot
VGNC ID VGNC:41249 ENTREZGENE