PTGER2 (prostaglandin E receptor 2)

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Gene: PTGER2 (prostaglandin E receptor 2) Pan paniscus

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Symbol:

PTGER2

Name:

prostaglandin E receptor 2

RGD ID:

12038347

Description:

ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cysteine-type endopeptidase activity (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress (ortholog); ASSOCIATED WITH aspirin-induced respiratory disease (ortholog); asthma, nasal polyps, and aspirin intolerance (ortholog); endometriosis (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

prostaglandin E2 receptor EP2 subtype

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	53,441,812 - 53,459,334 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	52,661,559 - 52,676,942 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	32,910,755 - 32,926,138 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	51,195,381 - 51,209,686 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	51,195,381 - 51,209,686 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aspirin-induced respiratory disease (ISO)

asthma, nasal polyps, and aspirin intolerance (ISO)

endometriosis (ISO)

Experimental Liver Cirrhosis (ISO)

infertility (ISO)

sexual dysfunction (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

cellular response to prostaglandin E stimulus (IEA)

G protein-coupled receptor signaling pathway (IEA)

inflammatory response (IEA)

negative regulation of apoptotic process (ISO)

negative regulation of cysteine-type endopeptidase activity (ISO)

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress (ISO)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of gastric mucosal blood circulation (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

regulation of cell population proliferation (ISO)

response to lipopolysaccharide (ISO)

response to nematode (ISO)

response to progesterone (ISO)

Cellular Component

membrane (IEA)

plasma membrane (IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IEA)

prostaglandin E receptor activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PTGER2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	53,441,812 - 53,459,334 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	52,661,559 - 52,676,942 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	32,910,755 - 32,926,138 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	51,195,381 - 51,209,686 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	51,195,381 - 51,209,686 (+)	Ensembl	panpan1.1		panPan2

PTGER2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	52,314,312 - 52,328,598 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	52,314,305 - 52,329,822 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	52,781,030 - 52,795,316 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	51,850,863 - 51,865,074 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	51,850,862 - 51,865,070	NCBI
Celera	14	32,648,601 - 32,662,908 (+)	NCBI		Celera
Cytogenetic Map	14	q22.1	NCBI
HuRef	14	32,941,341 - 32,955,648 (+)	NCBI		HuRef
CHM1_1	14	52,720,192 - 52,734,499 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	46,521,407 - 46,535,692 (+)	NCBI		T2T-CHM13v2.0

Ptger2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	45,225,568 - 45,241,277 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	45,225,652 - 45,241,277 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	44,988,111 - 45,003,820 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	44,988,195 - 45,003,820 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	45,607,786 - 45,623,495 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	43,910,468 - 43,925,027 (+)	NCBI		MGSCv36	mm8
Celera	14	41,179,301 - 41,195,008 (+)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	22.68	NCBI

Ptger2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	20,694,765 - 20,708,475 (+)	NCBI		GRCr8
mRatBN7.2	15	18,215,013 - 18,228,714 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	18,217,285 - 18,228,714 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	21,008,805 - 21,020,249 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	21,965,749 - 21,977,190 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	20,222,303 - 20,233,747 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	19,336,029 - 19,349,759 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	19,338,175 - 19,350,210 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	23,301,463 - 23,315,207 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	20,205,443 - 20,216,872 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	20,878,084 - 20,889,615 (+)	NCBI
Celera	15	18,649,190 - 18,660,619 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

Ptger2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	10,757,888 - 10,774,688 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	10,760,801 - 10,775,197 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTGER2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	28,523,318 - 28,536,936 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	28,522,681 - 28,536,922 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	28,274,789 - 28,288,408 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	28,698,142 - 28,712,635 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	28,699,025 - 28,712,635 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	28,369,315 - 28,383,055 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	28,428,898 - 28,442,522 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	28,777,540 - 28,791,160 (+)	NCBI		UU_Cfam_GSD_1.0

Ptger2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	76,666,763 - 76,679,725 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936697	2,440,901 - 2,453,975 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936697	2,440,943 - 2,453,897 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTGER2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	181,994,560 - 182,009,953 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	181,993,961 - 182,009,959 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	202,268,089 - 202,282,621 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTGER2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	29,395,799 - 29,410,723 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	29,396,464 - 29,409,575 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	17,664,018 - 17,678,316 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptger2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	16,726,975 - 16,741,557 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	16,729,846 - 16,741,529 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003831712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000053138 ⟹ ENSPPAP00000030279

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	51,195,381 - 51,209,686 (+)	Ensembl

RefSeq Acc Id:

XM_003831712 ⟹ XP_003831760

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	53,441,812 - 53,459,334 (+)	NCBI
NHGRI_mPanPan1	14	52,661,559 - 52,676,942 (+)	NCBI
Mhudiblu_PPA_v0	14	32,910,755 - 32,926,138 (+)	NCBI
PanPan1.1	14	51,195,381 - 51,209,686 (+)	NCBI

Sequence:

show sequence

CGGCCTTGGCCGGCGCGGGTAGGCGCGGGAGCCCCGAGCGCCGCTCGGATGCAGCAGCCGAGCC
GCCACTCGGCGCGCGGCGGGAGACCCAGGGCAAGCCGCCGTCGGCGCGCTGGGTGCGGGAAGGG
GGCTCTGGATTTCGGTCCCTCCCCTTTTTCCTCTGAGTCTCGGAACGCTCCGGCTCTCAGACCC
TCTTCCTCCCAGGTAAAGGCCGGGAGAGGAGGGCGCATCTCTTTTCCAGGCACCCCACCATGGG
CAATGCCTCCAATGACTCCCGGTCTGAGGACTGCGAGACGCGACAGTGGCTTCCCCCAGGCGAA
AGCCCAGCCATCAGCTCCGTCATGTTCTCGGCCGGGGTGCTGGGGAACCTCATAGCACTGGCGC
TGCTGGCGCGCCGCTGGCGGGGGGACGTGGGGTGCAGCGCCGGCCGCAGGAGCTCCCTCTCCTT
GTTCCACGTGCTGGTGACCGAGCTGGTGTTCACCGACCTGCTCGGGACCTGCCTCATCAGCCCA
GTGGTACTGGCTTCGTACGCGCGGAACCAGACCCTGGTGGCACTGGCGCCCGAGAGCCGCGCGT
GCACCTACTTCGCTTTCGCCATGACCTTCTTCAGCCTGGCCACGATGCTCATGCTCTTCGCCAT
GGCCCTGGAGCGCTACCTCTCGATCGGGCACCCCTACTTCTACCAGCGCCGCGTCTCGCGCTCC
GGGGGCCTGGCCGTGCTGCCTGTCATCTATGCAGTCTCCCTGCTCTTCTGCTCGCTGCCGCTGC
TGGACTATGGGCAGTACGTCCAGTACTGCCCCGGGACCTGGTGCTTCATCCGGCACGGGCGGAC
CGCTTACCTGCAGCTGTACGCCACCCTGCTGCTGCTTCTCATCGTCTCGGTGCTCGCCTGCAAC
TTCAGTGTCATTCTCAACCTCATCCGCATGCACCGCCGAAGCCGGAGAAGCCGCTGCGGACCTT
CCCTGGGCAGTGGCCGGGGCGGCCCCGGGGCCCGCAGGAGAGGGGAAAGGGTGTCCATGGCGGA
GGAGACGGACCACCTCATTCTCCTGGCTATCATGACCATCACCTTCGCCGTCTGCTCCTTGCCT
TTCACGATTTTTGCATATATGAATGAAACCTCTTCCCGAAAGGAAAAATGGGACCTCCAAGCTC
TTAGGTTTTTATCAATTAATTCAATAATTGACCCTTGGGTCTTTGCCATCCTTAGGCCTCCTGT
TCTGAGACTAATGCGTTCAGTCCTCTGTTGTCGGATTTCATTAAGAACACAAGATGCAACACAA
ACTTCCTGTTCTACACAGTCAGATGCCAGTAAACAGGCTGACCTTTGAGGTCAGTAGTTTAAAA
GTTCTTAGTTATATAGCATCTGGAAGATCCTTTTGAAATTGTTCCTTGGAGAAATGAAAACAGT
GTGTAAACAGAATGAAGCTGCCCTAATAAAAAGGAGTATACAAACATTTAAGCTGTGGTCAAGG
CTACAGACATGCTGACAAGGCACTTCATGTAAAGTGTCAGAAGGAGCTACAAAACCTACCCTCA
ATGAGCATGGTACTTGGCCTTTGGAGGAACAATCGGCTGCATTGAAGATCCAGCTGCCTATTGA
TTTAAGCTTTCCTGTTGAAGGACAAAGTATGTGGTTTTGTAATTTGTTTGAAACCCCAAACAGT
GACTGTACTTTCTATTTTAATCTTGCTACTACCGTTATAAACATATAGTGTACAGCCAGACCAG
ATTAAACTTCATATGTAATCTCTAGGAAGTCAATATGTGGAAGCAACCAAGCCTGCTGTCTTGT
GATCACTTAGCGAACCCTTTATTTGAACAATGAAGTTGAAAATCATAGGCACTTTTTACTGTGA
TGTTTGTGTATGTGGGAGTACTCTCATCACTACAGTATTACTCTTACAAGAGTGGACTCAGTCG
GTTAACATCAGTTTTGTTTACTCATCCTCCAGGAACTGCAGGTCAAGTTGTCAGGTTATTTATT
TTATAATGTCCATATGCTAATAGTGATCAAGAAGACTTTAGGAATGGCTCTCTCAACAAGAAAT
AATAGAAATGTCTCAAGGCAGTTAATTCTCATTAATACTCTTTATTTATTCTATTTCTGGGGGA
GGATGTACGTGGCCATGTATGAAGCCAAATATTAGGCTTAAAAACTGAAAAATCTGGTTCATTC
TTCAGATATACTGGAACCCTTTTAAAGTTGATATTGGGGCCATGAGTAAAATAGATTTTATAAG
ATGACTGTGTTGTACCAAAATTCATCTGTCTATATTTTATTTAGGGAACATGGTTTGACTCATC
TTATATGGGAAACCATGTAGCAGTGAGTCATATCTTAATATATTTCTAAATGTTTGGCATGTAA
ATGTAAACTCAGCATCAAAATATTTCAGTGAATTTGCACTGTTTAATCATAGTTACTGTGTAAA
CTCATCTGAAATGTTACAAAAATAAACTATAAAACAAAAATTTGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003831760	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000030279
	ENSPPAP00000030279.1

RefSeq Acc Id:

XP_003831760 ⟸ XM_003831712

- UniProtKB:

A0A2R9BKS0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGNASNDSRSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSL
SLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLF
AMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHG
RTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSM
AEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRP
PVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL

hide sequence

Ensembl Acc Id:

ENSPPAP00000030279 ⟸ ENSPPAT00000053138

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038128	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000053138.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Prostanoid_rcpt	UniProtKB/TrEMBL
	Prostglndn_EP2_rcpt	UniProtKB/TrEMBL
KEGG Report	pps:100969154	UniProtKB/TrEMBL
NCBI Gene	PTGER2	ENTREZGENE
PANTHER	PTHR11866	UniProtKB/TrEMBL
	PTHR11866:SF8	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	PROSTANOIDR	UniProtKB/TrEMBL
	PRSTNOIDEP2R	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A2R9BKS0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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